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Distribution of the Novel RFRP-3/receptors system in the epididymis of the seasonal desert rodent, Gerbillus tarabuli, during sexual activity

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Morphologie 2021年

作者： Hamidatou Khati, W. Al Mutery, A.F. Moudilou, E.N. Exbrayat, J.-M. Hammouche, S. USTHB Arid Area Research Laboratory Biological Sciences Faculty University of Sciences and Technology of Houari-Boumediene Algiers Algeria Department of Applied Biology College of Sciences University of Sharjah Sharjah United Arab Emirates Human Genetics & Stem Cells Research Group Research Institute of Sciences & Engineering University of Sharjah Sharjah United Arab Emirates Molecular Genetics Research Laboratory University of Sharjah Sharjah United Arab Emirates UMRS 449 – General Biology – Reproduction and Comparative Development UDL École Pratique des Hautes Études PSL Lyon Catholic University Lyon France

RFamide-related peptide (RFRP-3), the Mammalian ortholog of the Avian gonadotropin-inhibitory hormone (GnIH), is a novel neuropeptide known for its inhibitory regulatory effect on reproduction in various mammalian species. However, a stimulatory action has been reported. This paper aims to: i) study the histology of the epididymis (caput) of Gerbillus tarabuli during the breeding period;and ii) to determine the distribution of the “RFRP-3/receptors system” in the epididymis (caput) of this desert rodent during the active season, and thus, to inspect its potential local interfering in sperm maturation. For that, immunohistochemistry was performed to detect the epididymal immunolocalizations of the three molecules, RFRP-3, GPR147, and GPR74. This is the first report of the epididymis histology in Gerbillus tarabuli, as it is the first evidence of the existence of the RFRP-3/Receptor system in the same organ of the same species. During the breeding season, moderate immunostaining of the RFRP-3/receptors system was present in the caput epididymis’ epithelial parts (basal and principal cells) and spermatozoa. In contrast, these three molecules were absent in the peritubular and muscle coat's myoid cells and of the interstitial part of the caput epididymis. The results suggest that the epididymis is a potential source of RFRP-3 in the desert Rodent, Gerbillus tarabuli, which may function as a paracrine and/or autocrine factor affecting the main epididymis’ function: sperm maturation. © 2021 Elsevier Masson SAS

关键词： Epididymis Gerbillus tarabuli GPR147 GPR74 RFRP-3 Sperm maturation

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The effect of dual inflammation on the acute phase clinical outcomes of schizophrenia patients with comorbid COVID-19

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Brain, Behavior, & Immunity - Health 2025年 46卷

作者： Jiahui Zhu Jiamin Shao Peng Wang Yuan Liu Gangming Cheng Qi Zhou Zhuoran Li Jiayi Li Mingqia Wang Zhuokai Zhang Xuan Dong Chuan Shi Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders & National Center for Mental Disorders Beijing Anding Hospital Capital Medical University Beijing China Peking University Sixth Hospital Peking University Institute of Mental Health NHC Key Laboratory of Mental Health (Peking University) National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Beijing China Wuhan Mental Health Center Department of Psychiatry Wuhan Hospital for Psychotherapy Wuhan China The Eighth Clinical College Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan China The Affiliated Brain Hospital of Nanjing Medical University Nanjing China Department of Applied Psychology and Human Development University of Toronto Canada

Background and hypothesis Inflammation plays a crucial role in pathological mechanisms in schizophrenia (SZ) and the coronavirus disease 2019 (COVID-19), but the impact of dual inflammation on SZs’ clinical outcomes is poorly understood. This study aimed to investigate whether dual inflammation impacts acute phase outcomes in patients with schizophrenia comorbid with COVID-19 (COVID-SZs). Study design A total of 114 SZs and 49 COVID-SZs were recruited for this study. Plasma samples were collected and analyzed for levels of routine blood and inflammatory cytokines from all the participants. Then clinical symptoms, cognitive performance, and functional assessments were conducted at recruitment. One-way analysis of covariance examined the differences in inflammatory cytokines and correlation analyses examined the relationship between inflammatory cytokines and clinical outcomes. Study results After controlling for age, gender, substance use status, and antipsychotic medications, levels of inflammatory cytokines increased in COVID-SZs groups compared to SZs groups. There were significantly higher total Positive and Negative Syndrome Scale (PANSS) scores and positive PANSS scores in COVID-SZs groups compared to SZs. As for cognitive performance, the COVID-SZs group had significantly worse performance in processing speed and attention than the SZs. The COVID-SZs group had significantly worse health status compared to the SZs. There were significantly different correlation patterns between the severity of psychiatric symptoms and inflammatory cytokines in COVID-SZs and SZs group. Conclusions Findings indicate that dual inflammation exacerbates the acute phase clinical outcome of COVID-SZs. Suggesting a combined anti-inflammatory drug or the use of potentially anti-inflammatory antipsychotics in the acute phase of treatment to mitigate central nervous system damage. Regular monitoring of inflammatory marker levels can help reduce the risk of fluctuating psychiatric symptoms

关键词： Schizophrenia COVID-19 Dual inflammation Clinical outcomes Inflammatory cytokines

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Charge-Sign Dependent Cosmic-Ray Modulation Observed with the Calorimetric Electron Telescope on the International Space Station

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Physical Review Letters 2023年第21期130卷 211001-211001页

作者： O. Adriani Y. Akaike K. Asano Y. Asaoka E. Berti G. Bigongiari W. R. Binns M. Bongi P. Brogi A. Bruno J. H. Buckley N. Cannady G. Castellini C. Checchia M. L. Cherry G. Collazuol G. A. de Nolfo K. Ebisawa A. W. Ficklin H. Fuke S. Gonzi T. G. Guzik T. Hams K. Hibino M. Ichimura K. Ioka W. Ishizaki M. H. Israel K. Kasahara J. Kataoka R. Kataoka Y. Katayose C. Kato N. Kawanaka Y. Kawakubo K. Kobayashi K. Kohri H. S. Krawczynski J. F. Krizmanic P. Maestro P. S. Marrocchesi A. M. Messineo J. W. Mitchell S. Miyake A. A. Moiseev M. Mori N. Mori H. M. Motz K. Munakata S. Nakahira J. Nishimura S. Okuno J. F. Ormes S. Ozawa L. Pacini P. Papini B. F. Rauch S. B. Ricciarini K. Sakai T. Sakamoto M. Sasaki Y. Shimizu A. Shiomi P. Spillantini F. Stolzi S. Sugita A. Sulaj M. Takita T. Tamura T. Terasawa S. Torii Y. Tsunesada Y. Uchihori E. Vannuccini J. P. Wefel K. Yamaoka S. Yanagita A. Yoshida K. Yoshida W. V. Zober Department of Physics University of Florence Via Sansone 1 - 50019 Sesto Fiorentino Italy INFN Sezione di Firenze Via Sansone 1 - 50019 Sesto Fiorentino Italy Waseda Research Institute for Science and Engineering Waseda University 17 Kikuicho Shinjuku Tokyo 162-0044 Japan JEM Utilization Center Human Spaceflight Technology Directorate Japan Aerospace Exploration Agency 2-1-1 Sengen Tsukuba Ibaraki 305-8505 Japan Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwa-no-Ha Kashiwa Chiba 277-8582 Japan Institute of Applied Physics (IFAC) National Research Council (CNR) Via Madonna del Piano 10 50019 Sesto Fiorentino Italy Department of Physical Sciences Earth and Environment University of Siena via Roma 56 53100 Siena Italy INFN Sezione di Pisa Polo Fibonacci Largo B. Pontecorvo 3 - 56127 Pisa Italy Department of Physics and McDonnell Center for the Space Sciences Washington University One Brookings Drive Saint Louis Missouri 63130-4899 USA Heliospheric Physics Laboratory NASA/GSFC Greenbelt Maryland 20771 USA Center for Space Sciences and Technology University of Maryland Baltimore County 1000 Hilltop Circle Baltimore Maryland 21250 USA Astroparticle Physics Laboratory NASA/GSFC Greenbelt Maryland 20771 USA Center for Research and Exploration in Space Sciences and Technology NASA/GSFC Greenbelt Maryland 20771 USA Department of Physics and Astronomy Louisiana State University 202 Nicholson Hall Baton Rouge Louisiana 70803 USA Department of Physics and Astronomy University of Padova Via Marzolo 8 35131 Padova Italy INFN Sezione di Padova Via Marzolo 8 35131 Padova Italy Institute of Space and Astronautical Science Japan Aerospace Exploration Agency 3-1-1 Yoshinodai Chuo Sagamihara Kanagawa 252-5210 Japan Kanagawa University 3-27-1 Rokkakubashi Kanagawa Yokohama Kanagawa 221-8686 Japan Faculty of Science and Technology Graduate School of Science and Technology Hirosaki University 3 Bunkyo Hirosaki Aomori 036

We present the observation of a charge-sign dependent solar modulation of galactic cosmic rays (GCRs) with the Calorimetric Electron Telescope onboard the International Space Station over 6 yr, corresponding to the positive polarity of the solar magnetic field. The observed variation of proton count rate is consistent with the neutron monitor count rate, validating our methods for determining the proton count rate. It is observed by the Calorimetric Electron Telescope that both GCR electron and proton count rates at the same average rigidity vary in anticorrelation with the tilt angle of the heliospheric current sheet, while the amplitude of the variation is significantly larger in the electron count rate than in the proton count rate. We show that this observed charge-sign dependence is reproduced by a numerical “drift model” of the GCR transport in the heliosphere. This is a clear signature of the drift effect on the long-term solar modulation observed with a single detector.

关键词： Cosmic ray composition & spectra Cosmic ray propagation Cosmic ray sources Cosmic rays & astroparticles

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Stability and Fluctuations in Complex Ecological Systems

arXiv

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arXiv 2023年

作者： Forgoston, Eric Day, Sarah de Ruiter, Peter C. Doelman, Arjen Hartemink, Nienke Hastings, Alan Hemerik, Lia Hening, Alexandru Hofbauer, Josef Kéfi, Sonia Kessler, David A. Klauschies, Toni Kuehn, Christian Li, Xiaoxiao Moore, John C. Morriën, Elly Neutel, Anje-Margriet Pantel, Jelena Schreiber, Sebastian J. Shaw, Leah B. Shnerb, Nadav Siero, Eric Storch, Laura S. Thorne, Michael A.S. van de Leemput, Ingrid van Velzen, Ellen Weinans, Els Department of Applied Mathematics and Statistics Montclair State University MontclairNJ07043 United States Department of Mathematics William & Mary WilliamsburgVA23187 United States Biometris Wageningen University and Research Centre 6708 PB Wageningen Netherlands Institute of Biodiversity and Ecosystem Dynamics University of Amsterdam Amsterdam1098 XH Netherlands Mathematical Institute Leiden University Leiden2300 RA Netherlands Department of Environmental Science and Policy University of California DavisCA95616 United States Santa Fe Institute 1399 Hyde Park Road Santa FeNM87501 United States Department of Mathematics Texas A & M University College StationTX77843 United States Institute for Mathematics University of Vienna Oskar-Morgenstern-Platz 1 Vienna1090 Austria ISEM CNRS Université Montpellier IRD EPHE Montpellier France Department of Physics Bar-Ilan University Ramat-Gan52900 Israel Department of Ecology and Ecosystem Modelling Institute of Biochemistry and Biology University of Potsdam Potsdam Germany Department of Mathematics Technical University of Munich Boltzmannstr. 3 Garching b. München85748 Germany Complexity Science Hub Vienna Josefstädter Str. 39 Vienna1080 Austria School of Ecology Environment and Resources Guangdong University of Technology Guangzhou510006 China Natural Resource Ecology Laboratory Colorado State University Fort CollinsCO80524 United States Department of Ecosystem Science and Sustainability Colorado State University Fort CollinsCO80524 United States University of Amsterdam PO Box 94246 Amsterdam1090 GE Netherlands British Antarctic Survey CambridgeCB3 0ET United Kingdom Ecological Modelling Faculty of Biology University of Duisburg-Essen Essen Germany Department of Evolution and Ecology Center for Population Biology University of California DavisCA95616 United States Mathematics Department Bates College LewistonME04240 United States Department of Environmental Sciences Wage

From 08-12 August, 2022, 32 individuals participated in a workshop, Stability and Fluctuations in Complex Ecological Systems, at the Lorentz Center, located in Leiden, The Netherlands. An interdisciplinary dialogue between ecologists, mathematicians, and physicists provided a foundation of important problems to consider over the next 5-10 years. This paper outlines eight areas including (1) improving our understanding of the effect of scale, both temporal and spatial, for both deterministic and stochastic problems;(2) clarifying the different terminologies and definitions used in different scientific fields;(3) developing a comprehensive set of data analysis techniques arising from different fields but which can be used together to improve our understanding of existing data sets;(4) having theoreticians/computational scientists collaborate closely with empirical ecologists to determine what new data should be collected;(5) improving our knowledge of how to protect and/or restore ecosystems;(6) incorporating socio-economic effects into models of ecosystems;(7) improving our understanding of the role of deterministic and stochastic fluctuations;(8) studying the current state of biodiversity at the functional level, taxa level and genome level. © 2023, CC BY-NC-ND.

关键词： Economic and social effects

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The 2021 report of the Lancet Countdown on health and climate change: code red for a healthy future

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The Lancet 2021年第10311期398卷 1619-1662页

作者： Romanello, Marina McGushin, Alice Di Napoli, Claudia Drummond, Paul Hughes, Nick Jamart, Louis Kennard, Harry Lampard, Pete Solano Rodriguez, Baltazar Arnell, Nigel Ayeb-Karlsson, Sonja Belesova, Kristine Cai, Wenjia Campbell-Lendrum, Diarmid Capstick, Stuart Chambers, Jonathan Chu, Lingzhi Ciampi, Luisa Dalin, Carole Dasandi, Niheer Dasgupta, Shouro Davies, Michael Dominguez-Salas, Paula Dubrow, Robert Ebi, Kristie L Eckelman, Matthew Ekins, Paul Escobar, Luis E Georgeson, Lucien Grace, Delia Graham, Hilary Gunther, Samuel H Hartinger, Stella He, Kehan Heaviside, Clare Hess, Jeremy Hsu, Shih-Che Jankin, Slava Jimenez, Marcia P Kelman, Ilan Kiesewetter, Gregor Kinney, Patrick L Kjellstrom, Tord Kniveton, Dominic Lee, Jason K W Lemke, Bruno Liu, Yang Liu, Zhao Lott, Melissa Lowe, Rachel Martinez-Urtaza, Jaime Maslin, Mark McAllister, Lucy McMichael, Celia Mi, Zhifu Milner, James Minor, Kelton Mohajeri, Nahid Moradi-Lakeh, Maziar Morrissey, Karyn Munzert, Simon Murray, Kris A Neville, Tara Nilsson, Maria Obradovich, Nick Sewe, Maquins Odhiambo Oreszczyn, Tadj Otto, Matthias Owfi, Fereidoon Pearman, Olivia Pencheon, David Rabbaniha, Mahnaz Robinson, Elizabeth Rocklöv, Joacim Salas, Renee N Semenza, Jan C Sherman, Jodi Shi, Liuhua Springmann, Marco Tabatabaei, Meisam Taylor, Jonathon Trinanes, Joaquin Shumake-Guillemot, Joy Vu, Bryan Wagner, Fabian Wilkinson, Paul Winning, Matthew Yglesias, Marisol Zhang, Shihui Gong, Peng Montgomery, Hugh Costello, Anthony Hamilton, Ian Institute for Global Health University College London London UK United Kingdom Institute for Sustainable Resources University College London London UK United Kingdom UCL Energy Institute University College London London UK United Kingdom Institute for Environmental Design and Engineering University College London London UK United Kingdom Department of Geography University College London London UK United Kingdom The Bartlett School of Sustainable Construction University College London London UK United Kingdom Centre for Human Health and Performance University College London London UK United Kingdom School of Agriculture Policy and Development University of Reading Reading United Kingdom Department of Meteorology University of Reading Reading United Kingdom The Walker Institute University of Reading Reading United Kingdom Department of Health Sciences University of York York United Kingdom Institute for Environment and Human Security United Nations University Bonn Germany Centre on Climate Change and Planetary Health London School of Hygiene & Tropical Medicine London UK United Kingdom Centre for Mathematical Modelling of Infectious Diseases London School of Hygiene & Tropical Medicine London UK United Kingdom Department of Public Health Environments and Society London School of Hygiene & Tropical Medicine London UK United Kingdom Department of Earth System Science Tsinghua University Beijing China Department of Environment Climate Change and Health World Health Organization Geneva Switzerland Institute for Environmental Sciences World Health Organization Geneva Switzerland Centre for Climate Change and Social Transformations School of Psychology Cardiff University Cardiff United Kingdom Yale Center on Climate Change and Health Yale University New Haven CT United States School of Government University of Birmingham Birmingham United Kingdom Economic analysis of Climate Impacts and Policy Centro Euro-Mediterraneo sui Cambiamenti Climatic

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Understanding perceived COVID-19 changes, collectivism, and social exclusion: A cross-cultural study in 32 countries

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International Journal of Intercultural Relations 2025年 107卷

作者： Zhou, Xiaoyu English, Alexander Scott Wei, Liuqing Yudiarso, Ananta Dash, Arobindu Tipandjan, Arun Biddle, Ashley Nam, Benjamin H. Boonroungrut, Chinun Chettiar, Cicilia Daniele, Paolini Dubrov, Dmitrii Grigoryev, Dmitry Šakan, Dušana Oliver, Eliza Medosevic - Korjenic, Elma Fabricio Licoa Campos, Adolfo Novaes, Felipe Maricchiolo, Fridanna Navarro-Carrillo, Ginés Belen, Hacer Gunawan, Hendrik Jiang, Huang Hofhuis, Joep Kunst, Jonas R. Park, Joonha Neto, Jose Candido Pereira Huang, Kaiyue Addington-Lefringhausen, Katharina Hossain, Kazi Nur Martínez-Buelvas, Laura Yousefi, Mahdi Yuki, Masaki F. Falavarjani, Mehrdad Schwarzenthal, Miriam Klimek-Tulwin, Monika Kosakowska-Berezecka, Natasza Geeraert, Nicolas Khieowan, Nuannut Chobthamkit, Phatthanakit Sun, Qian Cowden, Richard G. Castro, Rita Thomson, Robert Tong, Rongtian Malik, Sadia Lins, Samuel Batić Očovaj, Sanja Wang, Shuang Aquino, Sibele D. Kulich, Steve Farid, Tahir Alves, Tales Talhelm, Thomas Jovanović, Veljko Yeung, Victoria Wai Lan Li, Xiaoyuan Zhang, Xinyi Computational Communication Research Center Beijing Normal University Zhuhai China School of Journalism and Communication Beijing Normal University Beijing China School of Psychology Wenzhou-Kean University China Department of Psychology Hubei University China Faculty of Psychology University of Surabaya Indonesia Department of Social Sciences International University of Business Agriculture and Technology China International centre for psychological counseling and social research China Social Sciences University of Hawaiʻi Leeward Community College United States School of Education Shanghai International Studies University China Faculty of Education Silpakorn University Thailand Department of Psychology Maniben Nanavati Women's College India Faculty of Human Sciences Education and Sport Pegaso University Italy Center for Sociocultural Research HSE University Russian Federation Department of Psychology Union University Faculty of Law and Business Studies dr Lazar Vrkatić Serbia School of Psychology University of Oslo Norway Department of Psychology University of Sarajevo University of Sarajevo Bosnia and Herzegovina Literature Research Institute Shanghai International Studies University China Department of Psychology Pontifical Catholic University of Rio de Janeiro Brazil Department of Education University of Roma Tre Italy Department of Social Psychology University of Granada Spain Educational Sciences Psychological Counseling and Guidance Bursa Uludag University Turkey Faculty of Social and Behavioural Sciences Utrecht University Netherlands Institute for Language Materials Development Shanghai Foreign Language Education Press China Amsterdam School of International Business (AMSIB) Amsterdam University of Applied Sciences Germany Department of Commuication and Culture BI Norwegian Business School Norway of Education Kyoto University Japan Pontifical Catholic University of Rio de Janeiro Brazil Department of Literature and Media Yulin Normal University

This cross-cultural study examines the relationship between perceived COVID-19 changes due to the impacts on everyday life by the pandemic with social exclusion and across 32 cultures and their levels in collectivism. With data from the start of the first outbreak from March 2020 to June 2020 (N = 9245), multilevel analysis indicated that as individuals perceive greater daily life changes induced by the pandemic, they experience heightened levels of social exclusion, with this association being particularly pronounced in less collectivistic cultures. These findings underscore the importance of considering cultural context in understanding responses to crises such as the COVID-19 pandemic, with implications for culturally sensitive interventions aimed at promoting social inclusion across diverse cultural contexts. © 2025 Elsevier Ltd

关键词： Collectivism Perceived COVID-19 changes Perceived social exclusion

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Direct Measurement of the Cosmic-Ray Helium Spectrum from 40 GeV to 250 TeV with the Calorimetric Electron Telescope on the International Space Station

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Physical Review Letters 2023年第17期130卷 171002-171002页

作者： O. Adriani Y. Akaike K. Asano Y. Asaoka E. Berti G. Bigongiari W. R. Binns M. Bongi P. Brogi A. Bruno J. H. Buckley N. Cannady G. Castellini C. Checchia M. L. Cherry G. Collazuol G. A. de Nolfo K. Ebisawa A. W. Ficklin H. Fuke S. Gonzi T. G. Guzik T. Hams K. Hibino M. Ichimura K. Ioka W. Ishizaki M. H. Israel K. Kasahara J. Kataoka R. Kataoka Y. Katayose C. Kato N. Kawanaka Y. Kawakubo K. Kobayashi K. Kohri H. S. Krawczynski J. F. Krizmanic P. Maestro P. S. Marrocchesi A. M. Messineo J. W. Mitchell S. Miyake A. A. Moiseev M. Mori N. Mori H. M. Motz K. Munakata S. Nakahira J. Nishimura S. Okuno J. F. Ormes S. Ozawa L. Pacini P. Papini B. F. Rauch S. B. Ricciarini K. Sakai T. Sakamoto M. Sasaki Y. Shimizu A. Shiomi P. Spillantini F. Stolzi S. Sugita A. Sulaj M. Takita T. Tamura T. Terasawa S. Torii Y. Tsunesada Y. Uchihori E. Vannuccini J. P. Wefel K. Yamaoka S. Yanagita A. Yoshida K. Yoshida W. V. Zober Department of Physics University of Florence Via Sansone 1–50019 Sesto Fiorentino Italy INFN Sezione di Firenze Via Sansone 1–50019 Sesto Fiorentino Italy Waseda Research Institute for Science and Engineering Waseda University 17 Kikuicho Shinjuku Tokyo 162-0044 Japan JEM Utilization Center Human Spaceflight Technology Directorate Japan Aerospace Exploration Agency 2-1-1 Sengen Tsukuba Ibaraki 305-8505 Japan Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwa-no-Ha Kashiwa Chiba 277-8582 Japan Institute of Applied Physics (IFAC) National Research Council (CNR) Via Madonna del Piano 10 50019 Sesto Fiorentino Italy Department of Physical Sciences Earth and Environment University of Siena via Roma 56 53100 Siena Italy INFN Sezione di Pisa Polo Fibonacci Largo B. Pontecorvo 3–56127 Pisa Italy Department of Physics and McDonnell Center for the Space Sciences Washington University One Brookings Drive St. Louis Missouri 63130-4899 USA Heliospheric Physics Laboratory NASA/GSFC Greenbelt Maryland 20771 USA Center for Space Sciences and Technology University of Maryland Baltimore County 1000 Hilltop Circle Baltimore Maryland 21250 USA Astroparticle Physics Laboratory NASA/GSFC Greenbelt Maryland 20771 USA Center for Research and Exploration in Space Sciences and Technology NASA/GSFC Greenbelt Maryland 20771 USA Department of Physics and Astronomy Louisiana State University 202 Nicholson Hall Baton Rouge Louisiana 70803 USA Department of Physics and Astronomy University of Padova Via Marzolo 8 35131 Padova Italy INFN Sezione di Padova Via Marzolo 8 35131 Padova Italy Institute of Space and Astronautical Science Japan Aerospace Exploration Agency 3-1-1 Yoshinodai Chuo Sagamihara Kanagawa 252-5210 Japan Kanagawa University 3-27-1 Rokkakubashi Kanagawa Yokohama Kanagawa 221-8686 Japan Faculty of Science and Technology Graduate School of Science and Technology Hirosaki University 3 Bunkyo Hirosaki Aomori 036-8561 J

We present the results of a direct measurement of the cosmic-ray helium spectrum with the CALET instrument in operation on the International Space Station since 2015. The observation period covered by this analysis spans from October 13, 2015, to April 30, 2022 (2392 days). The very wide dynamic range of CALET allowed for the collection of helium data over a large energy interval, from ∼40 GeV to ∼250 TeV, for the first time with a single instrument in low Earth orbit. The measured spectrum shows evidence of a deviation of the flux from a single power law by more than 8σ with a progressive spectral hardening from a few hundred GeV to a few tens of TeV. This result is consistent with the data reported by space instruments including PAMELA, AMS-02, and DAMPE and balloon instruments including CREAM. At higher energy we report the onset of a softening of the helium spectrum around 30 TeV (total kinetic energy). Though affected by large uncertainties in the highest energy bins, the observation of a flux reduction turns out to be consistent with the most recent results of DAMPE. A double broken power law is found to fit simultaneously both spectral features: the hardening (at lower energy) and the softening (at higher energy). A measurement of the proton to helium flux ratio in the energy range from 60 GeV/n to about 60 TeV/n is also presented, using the CALET proton flux recently updated with higher statistics.

关键词： Cosmic ray & astroparticle detectors Cosmic ray acceleration Cosmic ray composition & spectra Cosmic ray propagation Cosmic ray sources Cosmic rays & astroparticles

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Direct Measurement of the Spectral Structure of Cosmic-Ray Electrons+Positrons in the TeV Region with CALET on the International Space Station

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Physical Review Letters 2023年第19期131卷 191001-191001页

作者： O. Adriani Y. Akaike K. Asano Y. Asaoka E. Berti G. Bigongiari W. R. Binns M. Bongi P. Brogi A. Bruno J. H. Buckley N. Cannady G. Castellini C. Checchia M. L. Cherry G. Collazuol G. A. de Nolfo K. Ebisawa A. W. Ficklin H. Fuke S. Gonzi T. G. Guzik T. Hams K. Hibino M. Ichimura K. Ioka W. Ishizaki M. H. Israel K. Kasahara J. Kataoka R. Kataoka Y. Katayose C. Kato N. Kawanaka Y. Kawakubo K. Kobayashi K. Kohri H. S. Krawczynski J. F. Krizmanic P. Maestro P. S. Marrocchesi A. M. Messineo J. W. Mitchell S. Miyake A. A. Moiseev M. Mori N. Mori H. M. Motz K. Munakata S. Nakahira J. Nishimura S. Okuno J. F. Ormes S. Ozawa L. Pacini P. Papini B. F. Rauch S. B. Ricciarini K. Sakai T. Sakamoto M. Sasaki Y. Shimizu A. Shiomi P. Spillantini F. Stolzi S. Sugita A. Sulaj M. Takita T. Tamura T. Terasawa S. Torii Y. Tsunesada Y. Uchihori E. Vannuccini J. P. Wefel K. Yamaoka S. Yanagita A. Yoshida K. Yoshida W. V. Zober Department of Physics University of Florence Via Sansone 1–50019 Sesto Fiorentino Italy INFN Sezione di Florence Via Sansone 1–50019 Sesto Fiorentino Italy Waseda Research Institute for Science and Engineering Waseda University 17 Kikuicho Shinjuku Tokyo 162-0044 Japan JEM Utilization Center Human Spaceflight Technology Directorate Japan Aerospace Exploration Agency 2-1-1 Sengen Tsukuba Ibaraki 305-8505 Japan Institute for Cosmic Ray Research The University of Tokyo 5-1-5 Kashiwa-no-Ha Kashiwa Chiba 277-8582 Japan Institute of Applied Physics (IFAC) National Research Council (CNR) Via Madonna del Piano 10 50019 Sesto Fiorentino Italy Department of Physical Sciences Earth and Environment University of Siena via Roma 56 53100 Siena Italy INFN Sezione di Pisa Polo Fibonacci Largo B. Pontecorvo 3–56127 Pisa Italy Department of Physics and McDonnell Center for the Space Sciences Washington University One Brookings Drive St. Louis Missouri 63130-4899 USA Heliospheric Physics Laboratory NASA/GSFC Greenbelt Maryland 20771 USA Center for Space Sciences and Technology University of Maryland Baltimore County 1000 Hilltop Circle Baltimore Maryland 21250 USA Astroparticle Physics Laboratory NASA/GSFC Greenbelt Maryland 20771 USA Center for Research and Exploration in Space Sciences and Technology NASA/GSFC Greenbelt Maryland 20771 USA Department of Physics and Astronomy Louisiana State University 202 Nicholson Hall Baton Rouge Louisiana 70803 USA Department of Physics and Astronomy University of Padova Via Marzolo 8 35131 Padova Italy INFN Sezione di Padova Via Marzolo 8 35131 Padova Italy Institute of Space and Astronautical Science Japan Aerospace Exploration Agency 3-1-1 Yoshinodai Chuo Sagamihara Kanagawa 252-5210 Japan Kanagawa University 3-27-1 Rokkakubashi Kanagawa Yokohama Kanagawa 221-8686 Japan Faculty of Science and Technology Graduate School of Science and Technology Hirosaki University 3 Bunkyo Hirosaki Aomori 036-8561

Detailed measurements of the spectral structure of cosmic-ray electrons and positrons from 10.6 GeV to 7.5 TeV are presented from over 7 years of observations with the CALorimetric Electron Telescope (CALET) on the International Space Station. The instrument, consisting of a charge detector, an imaging calorimeter, and a total absorption calorimeter with a total depth of 30 radiation lengths at normal incidence and a fine shower imaging capability, is optimized to measure the all-electron spectrum well into the TeV region. Because of the excellent energy resolution (a few percent above 10 GeV) and the outstanding e/p separation (105), CALET provides optimal performance for a detailed search of structures in the energy spectrum. The analysis uses data up to the end of 2022, and the statistics of observed electron candidates has increased more than 3 times since the last publication in 2018. By adopting an updated boosted decision tree analysis, a sufficient proton rejection power up to 7.5 TeV is achieved, with a residual proton contamination less than 10%. The observed energy spectrum becomes gradually harder in the lower energy region from around 30 GeV, consistently with AMS-02, but from 300 to 600 GeV it is considerably softer than the spectra measured by DAMPE and Fermi-LAT. At high energies, the spectrum presents a sharp break around 1 TeV, with a spectral index change from −3.15 to −3.91, and a broken power law fitting the data in the energy range from 30 GeV to 4.8 TeV better than a single power law with 6.9 sigma significance, which is compatible with the DAMPE results. The break is consistent with the expected effects of radiation loss during the propagation from distant sources (except the highest energy bin). We have fitted the spectrum with a model consistent with the positron flux measured by AMS-02 below 1 TeV and interpreted the electron+positron spectrum with possible contributions from pulsars and nearby sources. Above 4.8 TeV, a possible contributi

关键词： Cosmic ray acceleration Cosmic ray composition & spectra Cosmic ray propagation Cosmic ray sources Cosmic rays & astroparticles

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Correction to: Retinoic acid receptor γ activation promotes differentiation of human induced pluripotent stem cells into esophageal epithelium

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Journal of gastroenterology 2020年第10期55卷 1010-1011页

作者： Yasufumi Koterazawa Michiyo Koyanagi-Aoi Keiichiro Uehara Yoshihiro Kakeji Takashi Aoi Division of Advanced Medical Science Graduate School of Science Technology and Innovation Kobe University 7-5-1 Kusunoki-cho Chuo-ku Kobe 650-0017 Japan. Department of iPS Cell Applications Graduate School of Medicine Kobe University Kobe Japan. Division of Gastrointestinal Surgery Department of Surgery Graduate School of Medicine Kobe University Kobe Japan. Center for Human Resource Development for Regenerative Medicine Kobe University Hospital Kobe Japan. Division of Pathology Graduate School of Medicine Kobe University Kobe Japan. Division of Advanced Medical Science Graduate School of Science Technology and Innovation Kobe University 7-5-1 Kusunoki-cho Chuo-ku Kobe 650-0017 Japan. takaaoi@med.kobe-u.ac.jp. Department of iPS Cell Applications Graduate School of Medicine Kobe University Kobe Japan. takaaoi@med.kobe-u.ac.jp. Center for Human Resource Development for Regenerative Medicine Kobe University Hospital Kobe Japan. takaaoi@med.kobe-u.ac.jp.

In the original publication of the article, the following errors were noted and corrected in this correction.

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Automatic assessment of individual culture attribute of power distance using a social context-enhanced prosodic network representation 19

Automatic assessment of individual culture attribute of powe...

引用

19th Annual Conference of the International Speech Communication, INTERSPEECH 2018

作者： Tsai, Fu-Sheng Yang, Hao-Chun Chang, Wei-Wen Lee, Chi-Chun Department of Electrical Engineering National Tsing Hua University Taiwan International Human Resource Development National Taiwan Normal University Taiwan MOST Joint Research Center for AI Technology All Vista Healthcare Taiwan

Culture is a collective social norm of human societies that often influences a person's values, thoughts, and social behaviors during interactions at an individual level. In this work, we present a computational analysis toward automatic assessing an individual's culture attribute of power distance, i.e., a measure of his/her belief about status, authority and power in organizations, by modeling their expressive prosodic structures during social encounters with people of different power status. Specifically, we propose a center-loss embedded network architecture to jointly consider the effect of social interaction contexts on individuals' prosodic manifestations in order to learn an enhanced representation for power distance recognition. Our proposed prosodic network achieves an overall accuracy of 78.6% in binary classification task of recognizing high versus low power distance. Our experiment demonstrates an improved discrim-inability (17.6% absolute improvement) over prosodic neural network without social context enhancement. Further visualization reveals that the diversity in the prosodic manifestation for individuals with low power distance seems to be higher than those of high power distance. © 2018 International Speech Communication Association. All rights reserved.

关键词： Speech communication

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