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Biomimetic three-layered membranes comprising(poly)-e-caprolactone,collagen and mineralized collagen for guided bone regeneration

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Regenerative Biomaterials 2021年第6期8卷 218-229页

作者： Jingjing Wu Mengyu Yao Yonggang Zhang Zefeng Lin Wenwu Zou Jiaping Li Pamela Habibovic Chang Du Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641PR China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006PR China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education and Innovation Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510006PR China Department of Instructive Biomaterials Engineering MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht UniversityMaastricht 6229 ERthe Netherlands

The distinct structural properties and osteogenic capacity are important aspects to be taken into account when developing guided bone regeneration ***,inspired by the structure and function of natural periosteum,we designed and fabricated using electrospinning a fibrous membrane comprising(poly)-e-caprolactone(PCL),collagen-I(Col)and mineralized Col(MC).The three-layer membranes,having PCL as the outer layer,PCL/Col as the middle layer and PCL/Col/MC in different ratios(5/2.5/2.5(PCM-1);3.3/3.3/3.3(PCM-2);4/4/4(PCM-3)(%,w/w/w))as the inner layer,were *** physiochemical properties of the different layers were investigated and a good integration between the layers was *** three-layeredmembranes showed tensile properties in the range of those of natural ***,the membranes exhibited excellent water absorption capability without changes of the *** vitro experiments showed that the inner layer of the membranes supported attachment,proliferation,ingrowth and osteogenic differentiation of human bone marrowderived stromal *** particular cells cultured on PCM-2 exhibited a significantly higher expression of osteogenesis-related *** three-layered membranes successfully supported new bone formation inside a critical-size cranial defect in rats,with PCM-3 being the most *** membranes developed here are promising candidates for guided bone regeneration applications.

关键词： bone regeneration poly(caprolactone),mineralized collagen,electrospinning artificial periosteum

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Dissection Propagation via Avalanches in Aging Human Descending Thoracic Aorta

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SSRN 2025年

作者： Wang, Ruizhi Yu, Xunjie Halvorsen, Samuel C. Suki, Béla Zhang, Yanhang Department of Mechanical Engineering Boston University BostonMA02215 United States Department of Biomedical Engineering Boston University BostonMA02215 United States Divison of Materials Science & Engineering Boston University BostonMA02215 United States

Understanding of the risk factors and underlying mechanisms of aortic dissection (AD) is critical for improved clinical management of the disease. As a prominent risk factor for AD, how aging impairs the dissection resistance capabilities of the aorta has not been elucidated. This study integrated mechanical testing, multiphoton imaging and finite element (FE) modeling to investigate the multiscale dissection behavior of human descending thoracic aortas (DTAs) from a wide range of ages. Mechanical testing demonstrated that aging diminishes bonding between the lamellar layers within the media of human DTA. Moreover, AD propagation is associated with dissection tension drops that follow a power-law distribution. Multiphoton imaging of dissected DTA media revealed less organized elastic lamellae and fewer visible collagen with aging. The discrete FE model of dissection propagation recapitulated the power-law behavior that originates from avalanches of interlamellar collagen fiber (ICF) failures. Simulation revealed prominent interlamellar structural rearrangement of ICFs in the aging DTA, including lower density and higher dispersion, of which the former strongly correlates with the weakened interlamellar bonding while the latter is vital in triggering the fast-propagating avalanches and power-law behavior of AD. Furthermore, small avalanches occur more often with aging, which makes dissection propagation faster and AD more dangerous for the elderly population. © 2025, The Authors. All rights reserved.

关键词： Dissection

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Vibrational entropies of oxygen vacancy formation in metal oxides

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Physical Review materials 2024年第5期8卷 055407-055407页

作者： Bianca Baldassarri Jiangang He Christopher Wolverton Graduate Program in Applied Physics Northwestern University Evanston Illinois 60208 USA Department of Materials Science and Engineering Northwestern University Evanston Illinois 60208 USA

Oxygen vacancies play a key role in many energy-related applications, and the investigation of the thermodynamic forces driving their formation across different materials can be tackled through the use of ab initio methods. In this context, however, computational studies targeting finite-temperature properties such as entropy remain scarce. Wider-ranging studies are of interest to deepen the understanding of the role of the entropy of oxygen vacancy formation and its different components in processes like the ones involved in solar thermochemical hydrogen (STCH) production, and to investigate the existence of common trends and differences between materials. In this work, we use density functional theory and harmonic phonon calculations to compute the vibrational entropy of oxygen vacancy formation (ΔSvib) for 10 different metal oxide compounds. The computation is carried out by taking the difference between the vibrational entropy of a vacancy-containing and a pristine structure, while the entropic contribution from the final gaseous state of the oxygen lost from the material is accounted for separately with a gas entropy term. We first examine the temperature dependence of ΔSvib and highlight the presence of an initial peak around room temperature, followed by a steady decrease resulting from the presence of an additional O atom (the one becoming vacant) in the defect-free structure. We then inspect the atomic contributions to ΔSvib, and highlight similarities and differences between compounds. Finally, we consider other significant sources of entropy, and find ΔSvib to provide a smaller, yet non-negligible, contribution to the total entropy of vacancy formation. We also compare the temperature dependence of ΔSvib to that of the gas entropy, and show that the two largely counterbalance each other at high temperatures.

关键词： Entropy Hydrogen production Density functional theory

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Development of educational software for stainless steel selection and evaluating usability using the System Usability Scale (SUS)

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International Journal of Mechanical engineering Education 2024年

作者： Nery, Macclarck Pessoa dos Santos Neto, Severiano José Alves, Roberty Santos Santana, João Vitor dos Santos Griza, Sandro Martins, Carlos Otávio Damas Materials Science and Engineering Pos-graduation Program – p2cem from Federal University of Sergipe São Cristovão City Brazil Mechanical Engineering Department Federal University of Sergipe São Cristovão City Brazil Department of Materials Science and Engineering Federal University of Sergipe São Cristovão City Brazil

The use of educational technologies is an important part of the learning process. The development of educational apps and software is one of the pillars of this evolution in teaching. Material selection is one of the most important subjects in professional engineering education. Regarding materials used to manufacture products, the stainless steels are the most commonly used materials after traditional steels. In the industrial environment, fatigue, corrosion-fatigue, and stress corrosion cracking are three very important considerations in the selection of materials. This study evaluates the usability of educational software developed in Java using object-oriented programming using the System Usability Scale and compares it with results obtained from other educational technologies. © The Author(s) 2024.

关键词： Software testing

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The Hyperbranched Polymer as a Medical Rising Star: From Synthesis to biomedical Applications

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SSRN 2025年

作者： Jiang, Haoran Li, Yao Cao, Xiaowen Liu, Yang Zhang, Zhixue Hu, Yang Yu, Bing Hu, Hao Shena, Youqing Institute of Biomedical Materials and Engineering College of Materials Science and Engineering Qingdao University Qingdao266071 China Department of Radiation Oncology the Affiliated Hospital of Qingdao University Qingdao266003 China Ministry of Education Beijing Laboratory of Biomedical Materials College of Materials Science and Engineering Beijing University of Chemical Technology Beijing100029 China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao University Qingdao266071 China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineering Department of Chemical and Biological Engineering Zhejiang University Hangzhou310027 China

The advancement of medicine is inextricably linked to the development of biomedical materials. Hyperbranched polymers (HPBs), as a class of highly branched three-dimensional (3D) macromolecules, possess characteristics such as facile chemical modification and multi-cavity structures. Through appropriate design, they can fulfill the requirements of biomedical materials in medical applications. This review comprehensively elaborates on the preparation approaches of three types of HBPs, single-monomer method, double-monomer method, and coupling-monomer method, while also conducting an analysis of the characteristics inherent to each of these methods. Moreover, by taking the multi-cavity and multi-functional group structures of HBPs as well as their correlations with the realization of biomedical functions as the entry points, it systematically reviews the recent applications of HBPs in various biomedical fields, including drug delivery, antibiosis, tissue engineering, bio-glue, and bioimaging. Finally, the future development direction and challenges of HBPs are prospected. © 2025, The Authors. All rights reserved.

关键词： Tissue

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Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains

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Computational and Structural Biotechnology Journal 2024年 23卷 1864-1876页

作者： Do, Duyen Thi Yang, Ming-Ren Vo, Tran Nam Son Le, Nguyen Quoc Khanh Wu, Yu-Wei Graduate Institute of Biomedical Informatics College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Electrical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Business Administration College of Management Lunghwa University of Science and Technology Taoyuan City Taiwan Professional Master Program in Artificial Intelligence in Medicine College of Medicine Taipei Medical University Taipei Taiwan Clinical Big Data Research Center Taipei Medical University Hospital Taipei Taiwan TMU Research Center for Digestive Medicine Taipei Medical University Taipei Taiwan

In current genomic research, the widely used methods for predicting antimicrobial resistance (AMR) often rely on prior knowledge of known AMR genes or reference genomes. However, these methods have limitations, potentially resulting in imprecise predictions owing to incomplete coverage of AMR mechanisms and genetic variations. To overcome these limitations, we propose a pan-genome-based machine learning approach to advance our understanding of AMR gene repertoires and uncover possible feature sets for precise AMR classification. By building compacted de Brujin graphs (cDBGs) from thousands of genomes and collecting the presence/absence patterns of unique sequences (unitigs) for Pseudomonas aeruginosa, we determined that using machine learning models on unitig-centered pan-genomes showed significant promise for accurately predicting the antibiotic resistance or susceptibility of microbial strains. Applying a feature-selection-based machine learning algorithm led to satisfactory predictive performance for the training dataset (with an area under the receiver operating characteristic curve (AUC) of > 0.929) and an independent validation dataset (AUC, approximately 0.77). Furthermore, the selected unitigs revealed previously unidentified resistance genes, allowing for the expansion of the resistance gene repertoire to those that have not previously been described in the literature on antibiotic resistance. These results demonstrate that our proposed unitig-based pan-genome feature set was effective in constructing machine learning predictors that could accurately identify AMR pathogens. Gene sets extracted using this approach may offer valuable insights into expanding known AMR genes and forming new hypotheses to uncover the underlying mechanisms of bacterial AMR. © 2024 The Authors

关键词： Genes

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Meta-optic accelerators for object classification

Meta-optic accelerators for object classification

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2023 Flat Optics: Components to Systems, FLatOptics 2023 in Optica Imaging Congress - Part of Imaging and Applied Optics Congress 2023

作者： Zheng, Hanyu Liu, Quan Zhou, You Kravchenko, Ivan I. Huo, Yuankai Valentine, Jason Department of Electrical and Computer Engineering Vanderbilt University NashvilleTN37212 United States Department of Computer Science Vanderbilt University NashvilleTN37212 United States Department of Mechanical Engineering Vanderbilt University NashvilleTN37212 United States Interdisciplinary Materials Science Program Vanderbilt University NashvilleTN37212 United States Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak RidgeTN37830 United States

A meta-optic platform for accelerating object classification is demonstrated. End-to-end design is used to co-optimize the optical and digital systems resulting in high-speed classifiers that are demonstrated for hand... 详细信息

ISBN: (纸本)9781957171289

关键词： Imaging systems Machine vision Neural networks Optical components Optical neural systems Optical systems

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Clinical progress of nanomedicine-based RNA therapies

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Bioactive materials 2022年第6期7卷 203-213页

作者： Siyoung A.Lim Alysia Cox Madelynn Tung Eun Ji Chung Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCAUSA Mork Family Department of Chemical Engineering and Materials Science University of Southern CaliforniaLos AngelesCAUSA Department of Medicine Division of Nephrology and HypertensionUniversity of Southern CaliforniaLos AngelesCAUSA Department of Surgery Division of Vascular Surgery and Endovascular TherapyUniversity of Southern CaliforniaLos AngelesCAUSA

The clinical application of nanoparticles(NPs)to deliver RNA for therapy has progressed rapidly since the FDA approval of Onpattro®in 2018 for the treatment of polyneuropathy associated with hereditary transthyretin *** emergency use authorization or approval and widespread global use of two mRNA-NP based vaccines developed by Moderna Therapeutics *** Pfizer-BioNTech in 2021 has highlighted the translatability of NP technology for RNA ***,in clinical trials,a wide variety of NP formulations have been found to extend the half-life of RNA molecules such as microRNA,small interfering RNA,and messenger RNA,with limited safety *** this review,we discuss the NP formulations that are already used in the clinic to deliver therapeutic RNA and highlight examples of RNA-NPs which are currently under evaluation for human *** also detail NP formulations that failed to progress through clinical trials,in hopes of guiding future successful translation of nanomedicine-based RNA therapeutics into the clinic.

关键词： Nanoparticles RNA therapy Drug delivery Nanomedicine Clinical trials COVID-19

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Segregation effects of doped VN and ZrN on magnetic and microstructural characteristics of FePt-based films

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Thin Solid Films 2024年 798卷

作者： Tsai, Jai-Lin Lin, Jhih-Hong Chen, Tsung-Yi Lin, Yu-Chun Liu, Li-Xiang Hsieh, Ming-Wei Chen, Jyun-you Department of Materials Science and Engineering National Chung Hsing University Taichung40227 Taiwan Solar Applied Materials Technology Corp. Tainan70955 Taiwan Graduate School of Biomedical Engineering University of New South Wales UNSW SydneyNSW2052 Australia

Segregants are essential materials for forming the complexation or granular microstructure in thin films for magnetic recording media. One such film, FePt-BN, has a metallic L10 FePt main phase as its matrix, in addition to having BN and C segregants at the grain boundaries. Amorphous BN has sufficient mechanical strength to support the columnar growth of FePt grains, however, it has a lower deposition rate resulting in columnar grains with a nonuniform aspect ratio. Moreover, some B diffuses in the interstitial site of FePt lattices. To overcome these limitations, this study added the transition nitride VN and ZrN with equal volume percentages to replace some BN segregants in FePt(BN, Ag, C) films: substantially different segregation behaviors were observed. Microstructural imaging mapping revealed that although VN segregated the FePt grains boundary, ZrN was diffused in the lattice. The FePt-BN-ZrN film thus had more disordered grains contributing to a higher in-plane magnetization and wider hard axis magnetic hysteresis loops than did FePt-BN-VN. The FePt-BN-VN film has the highest perpendicular magnetic anisotropy constant (Ku= 2.17 × 106 J/m3) and coercivity (Hc= 4 T);moreover, parallel remanence magnetization was minimal with a linear in-plane magnetization loop. The FePt-BN-VN film was sputtered directly on MgO(100) but depositing the FePt-BN-ZrN film required a 2-nm-thick FePt nucleation layer. The high atomic number of Zr and high sputter yield ratio (YN/Ymetal) of ZrN may increase the sites occupied by N, potentially affecting ZrN segregation. © 2024 Elsevier B.V.

关键词： Coercive force

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High-Resolution Hydrogen Molecule Detection Utilizing a Nanocandle-Based Optical Sensor 16

High-Resolution Hydrogen Molecule Detection Utilizing a Nano...

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16th Pacific Rim Conference on Lasers and Electro-Optics, CLEO-PR 2024

作者： Park, Nu-Ri Kim, Min-Joong Lee, Jongsu Seo, Minah Ryu, Yong-Sang Kim, Myung-Ki KU-KIST Graduate School of Converging Science and Technology Korea University Seoul02841 Korea Republic of Korea Institute of Science and Technology Sensor System Research Center Seoul02792 Korea Republic of Northwestern University Department of Electrical Engineering and Computer Science EvanstonIL60208 United States School of Biomedical Engineering Korea University Seoul02481 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02481 Korea Republic of

Our research introduces a novel method for safe hydrogen detection. We've developed an advanced nano-candle sensor, combining Pd with nano-candles, enabling accurate detection of low-concentration hydrogen ( ©... 详细信息

ISBN: (纸本)9798350372076

关键词： Nanoclay

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