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pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy

Bioactive materials 2024年第4期34卷 414-421页

作者： Jianhua Zou Zheng Li Yang Zhu Yucen Tao Qing You Fangfang Cao Qinghe Wu Min Wu Junjie Cheng Jianwei Zhu Xiaoyuan Chen Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore119074Singapore Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore117597Singapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore117599Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnologyand Research(A*STAR)61 Biopolis DriveProteosSingapore138673Singapore Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiaotong UniversityShanghai200011PR China Department of Chemistry Center for Bioanalytical Chemistry University of Science and Technology of ChinaHefei230026PR China College of Life Science Nanjing Normal University1 Wenyuan RoadNanjing210023PR China

Tumor hypoxia diminishes the effectiveness of traditional type II photodynamic therapy(PDT)due to oxygen *** I PDT,which can operate independently of oxygen,is a viable option for treating hypoxic *** this study,we have designed and synthesized JSK@PEG-IR820 NPs that are responsive to the tumor microenvironment(TME)to enhance type I PDT through glutathione(GSH)*** approach aims to expand the sources of therapeutic benefits by promoting the generation of superoxide radicals(O_(2)^(-).)while minimizing their *** diisopropyl group within PEG-IR820 serves a dual purpose:it functions as a pH sensor for the disassembly of the NPs to release JSK and enhances intermolecular electron transfer to IR820,facilitating efficient O_(2)^(-).***,the release of JSK leads to GSH depletion,resulting in the generation of nitric oxide(NO).This,in turn,contributes to the formation of highly cytotoxic peroxynitrite(ONOO^(-).),thereby enhancing the therapeutic efficacy of these ***-II fluorescence imaging guided therapy has achieved successful tumor eradication with the assistance of laser therapy.

关键词： TME responsive NO gas therapy NIR-II imaging Type I PDT

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Advanced nerve regeneration enabled by neural conformal electronic stimulators enhancing mitochondrial transport

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Bioactive materials 2024年第9期39卷 287-301页

作者： Hao Bai Siqi Zhang Huiran Yang Jing Wang Hongli Chen Jia Li Lin Li Qian Yang Bo Peng Ziyi Zhu Siyuan Ni Keyin Liu Wei Lei Tiger H.Tao Yafei Feng Department of Orthopedics Xijing HospitalThe Fourth Military Medical UniversityXi’an710032China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai200050China Key Laboratory of Aerospace Medicine of the Ministry of Education School of Aerospace MedicineFourth Military Medical UniversityXi’anChina The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen361005FujianChina Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an710072PR China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai200031China Institute of Brain-Intelligence Technology Zhangjiang LaboratoryShanghai200031China

Addressing peripheral nerve defects remains a significant challenge in regenerative *** as the gold-standard management,however,are hindered by limited availability and potential *** recent studies report the potential of wireless electronic system for nerve defects ***,few has met clinical needs for inadequate electrode precision,poor nerve entrapment andinsufficient bioactivity of the matrix ***,we present an advanced wireless electrical nerve stimulator,based on water-responsive self-curling silk membrane with excellent bioabsorbable and *** constructed a unique bilayer structure with an oriented pre-stretched inner layer and a generalsilk membrane as outer *** wetting,the simultaneous contraction of inner layer and expansion of outerlayer achieved controllable super-contraction from 2D flat surface to 3D structural *** enablesshape-adaptive wrapping to cover around nerves,overcomes the technical obstacle of preparing electrodes on theinner wall of the conduit,and prevents electrode breakage caused by material expansion in *** use of forkcapacitor-like metal interface increases the contact points between the metal and the regenerating nerve,solvingthe challenge of inefficient and rough electrical stimulation methods in the *** developed electronicstimulator is effective in restoring 10 mm rat sciatic nerve defects comparable to autologous *** underlyingmechanism involves that electric stimulation enhances anterograde mitochondrial transport to matchenergy *** newly introduced device thereby demonstrated the potential as a viable and efficaciousalternative to autografts for enhancing peripheral nerve repair and functional recovery.

关键词： Silk materials Electronic stimulator Structural reconfiguration Peripheral nerve regeneration Mitochondrial transport

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Preliminary Investigation of Spring-Based Gravity Compensation for an Upper Limb Assistive Robot

Preliminary Investigation of Spring-Based Gravity Compensati...

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International Conference on Mechatronics (ICM)

作者： Ming Jiang Yang Wang Qizhi Meng Chin-Hsing Kuo Marco Ceccarelli Yusuke Sugahara Yukio Takeda Department of Mechanical Engineering Institute of Science Tokyo Tokyo Japan School of Mechanical Materials Mechatronic and Biomedical Eng. University of Wollongong Wollongong Australia Department of Industrial Engineering University of Rome Tor Vergata Rome Italy

ISBN: (数字)9798331533892

ISBN: (纸本)9798331533908

Upper limb assistive robots have been widely developed due to their ability to aid user movement and reduce caregiver workload. In our previous work, we introduced a wearable end-effector-type upper limb assistive robot, WELiBot. To enhance the robot's portability and reduce the required actuation torque, this work investigates gravity compensation for WELiBot's mechanism using springs. Following the 1-DOF gravity compensation principle, springs were designed for lifting and reaching movement respectively. The effectiveness of this compensation effect was then evaluated by comparing the necessary torque at the actuating joints with and without springs. This work offers insight into gravity compensation for parallel mechanisms and contributes to the future development of WELiBot.

关键词： Limbs Torque Mechatronics Wearable robots Assistive robots Springs Gravity

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Synthesis of poly(lactide-co-glycolide) containing high glycolide contents by ring-opening polymerization as well as their structural characterizations, thermal properties, morphologies, and hydrophilicity

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Journal of Applied Polymer science 2023年第3期140卷 e53328-e53328页

作者： Phan, Van Hoang-Khang Tai, Yi-Hsin Chiang, Tai-Chin Yu, Chin-Yang Department of Materials Science and Engineering National Taiwan University of Science and Technology Taipei Taiwan Global Development Engineering Program National Taiwan University of Science and Technology Taipei Taiwan

Random copolymers, poly(l-lactide-r-glycolide) are synthesized by one-pot ring-opening polymerization of l-lactide and glycolide in the presence of stannous octoate and 1-dodecanol. Block copolymers, poly(l-lactide-b-glycolide) are synthesized by ring-opening polymerization of l-lactide to generate poly(l-lactide) first and then further ring-opening polymerization of glycolide in the presence of poly(l-lactide) and stannous octoate. The composition ratio of l-lactide and glycolide is determined by the integration of the corresponding signals from 1H NMR spectra, which is consistent with the feeding ratio. Very few hetero-sequences can be observed for block copolymers due to well-defined microstructures. The block copolymers are more thermally stable than that of the random copolymers. The degree of crystallinity of the bock copolymers is relatively high compared to that of the random copolymers. The image of the block copolymers determined by field-emission scanning electron microscopy (FESEM) shows partial aggregate domains containing spherical particles with an average diameter of around 200 nm, which is very different from that of the random copolymers. Block copolymers are more hydrophilic than that of the random copolymers due to the ordered structure and amphiphilic behavior of the block series. © 2022 Wiley Periodicals LLC.

关键词： Microstructure

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Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms

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Journal of materials science & Technology 2021年第10期69卷 69-78页

作者： Kecheng Quan Zexin Zhang Yijin Ren Henk J.Busscher Henny C.van der Mei Brandon W.Peterson College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China University of Groningen and University Medical Center Groningen Department of Biomedical Engineering9713 AVGroningenthe Netherlands University of Groningen and University Medical Center Groningen Department of OrthodonticsHanzeplein 19713 GZGroningenthe Netherlands

Targeting of chemotherapeutics towards a tumor site by magnetic nanocarriers is considered promising in *** nanoparticles are also considered for use in infection-control as a new means to prevent antimicrobial resistance from becoming the number one cause of death by the year *** this end,magnetic nanoparticles can either be loaded with an antimicrobial for use as a delivery vehicle or modified to acquire intrinsic antimicrobial *** nanoparticles can also be used for the local generation of heat to kill infectious *** appealing for tumor-and infectioncontrol,injection in the blood circulation may yield reticuloendothelial uptake and physical obstruction in organs that yield reduced targeting *** can be prevented with suitable surface ***,precise techniques to direct magnetic nanoparticles towards a target site are *** problem of precise targeting is aggravated in infection-control due to the micrometer-size of infectious biofilms,as opposed to targeting of nanoparticles towards centimeter-sized *** review aims to identify possibilities and impossibilities of magnetic targeting of nanoparticles for *** first review targeting techniques and the spatial resolution they can achieve as well as surface-chemical modifications of magnetic nanoparticles to enhance their targeting efficiency and antimicrobial *** is concluded that targeting problems encountered in tumor-control using magnetic nanoparticles,are neglected in most studies on their potential application in *** biofilm targeting by smart,self-adaptive and pH-responsive,antimicrobial nanocarriers for instance,seems easier to achieve than magnetic *** leads to the conclusion that magnetic targeting of nanoparticles for the control of micrometer-sized infectious biofilms may be less promising than initially ***,using propulsion rather than pr

关键词： Magnetic nanoparticles Magnetic targeting Biofilm Infection Antimicrobials

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Assessment of Simple Adhesive Substrates as a Method for Quantifying Microplastics and the Factors Influencing Capture

SSRN

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SSRN 2022年

作者： Rieland, Julie M. Hu, Zeyuan Deese, Julian S. Love, Brian J. Department of Materials Science and Engineering United States Department of Biomedical Engineering United States Macromolecular Science and Engineering Graduate Program 2300 Hayward St Ann ArborMI48109 United States

Microplastics are a growing environmental concern, with a large body of evidence documenting substantial distribution of plastic material in virtually all environmental compartments. Countermeasures that help to bind, aggregate, or coalesce these distributed particles might result in lower human and animal exposures. Pressure sensitive adhesives (PSAs) have been identified as a viable microplastic (MP) capture mechanism with a range of potential use conditions. As with any countermeasure, there is a need to evaluate their collection efficiency, cost, ease of installation, etc. Expanding on previous work, submerged, spray-coated PSAs were investigated as a quick and low-cost quantitative method to assess MP binding in water. Two molecular weights of poly(2-ethylhexyl acrylate) PSA (92k, 950k, and 50:50 bimodal distribution) were applied as spray-coated substrates to compare MP-adhesive interactions. Thin films of PSA (92k 6 ± 1 μm, 950k 4 ± 2 μm, 50:50 BD 6.5 ± 1 μm) were sprayed on borosilicate glass slides using a commercial air brush. Polydisperse nylon-12 particles varying in size from 15-30 µm in diameter were dispersed in aqueous solution between 0.01 and 5 mg mL -1 and agitated under ambient conditions as quantitative comparisons of adhesive wettability and net capture. Mixed assays were also performed comparing binding of common MP species including polyethylene, polystyrene, and polyester particles and fibers to understand how varying composition, size, and form factor affect adsorption. The glass slide method demonstrated linear trends associated with the MP binding to glass slides with respect both to exposure time and MP concentration. The adhesive wettability demonstrates bounding parameters under which high wettability adhesives excel at MP capture but may compromise the integrity of the adhesive film. © 2022, The Authors. All rights reserved.

关键词： Adhesives

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A Single-Motor system for 3D Spiral Photoacoustic and Ultrasound Imaging of Rectal Cancer In Vivo

A Single-Motor system for 3D Spiral Photoacoustic and Ultras...

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Photons Plus Ultrasound: Imaging and Sensing 2025

作者： Thakur, Sanskar Nie, Haolin Kou, Sitai Xu, Jinhua Eltahir, Ahmed Chapman, William Zhu, Quing Imaging Science Program Washington University Saint LouisMO63130 United States Department of Biomedical Engineering Washington University Saint LouisMO63130 United States Department of Surgery Washington University School of Medicine Saint LouisMO63110 United States Department of Radiology Washington University School of Medicine St. LouisMO63110 United States

ISBN: (纸本)9781510683860

Colorectal cancer is the 3rd most prevalent cancer in the United States. Photoacoustic imaging reveals vascular contrast of the tumor and can be used to assess and predict treatment response of rectal cancer patient undergoing radiation and neoadjuvant therapy. A compact and portable endorectal acoustic resolution photoacoustic microscopy and ultrasound (ARPAM/US) system was developed and translated to clinics for patient evaluation. The current system utilizes hollow shaft motor, connected to the imaging head for 360o clockwise and anticlockwise rotation to acquire 2D images. Each rotation provides co-registered photoacoustic and ultrasound B-scan images with 1000 A-lines in one second. The characterization of the system with a 7um carbon fiber revealed the axial resolution for ultrasound and photoacoustics to be 35µm and 72µm, and the lateral resolution of 122 µm and 116 µm respectively. Currently, 4 patients have been imaged in-vivo with the hand-held probe in an ongoing clinical trial. We show an in vivo ARPAM/US imaging example to demonstrate the performance of the current system. However, even operated by steady hands of surgeons, it is challenging to acquire 3D images for better visualization of rectal tumors. We designed and implemented a novel 3D imaging probe. The proposed single motor design utilizes a unique rotation and translation coupler design. A =-28 threaded shaft facilitates translation of 0.9mm per rotation with over 2cm translation limit. The images can be stitched together to generate 3D spiral images of co-registered ultrasound and photoacoustics for better visualization of the tumor. © 2025 SPIE.

关键词： Photoacoustic microscopy

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Integrating Intra-Phase Coherence and Intra-Frame Scene Perception for Panoptic Segmentation in Cataract Surgery Video

Integrating Intra-Phase Coherence and Intra-Frame Scene Perc...

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IEEE International Symposium on biomedical Imaging

作者： Mingen Zhang Yuanyuan Gu Xu Chen Lei Mou Feiming Wang Jiang Liu Yitian Zhao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo China University of Chinese Academy of Sciences Beijing China Ningbo Cixi Institute of Biomedical Engineering and Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Cixi China Department of Ophthalmology Shanghai Aier Eye Hospital Shanghai China Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen China

ISBN: (数字)9798350313338

ISBN: (纸本)9798350313345

Panoptic segmentation is fundamental for the development of computer-assisted surgical techniques. Previous works have translated the video object segmentation task into a two-dimensional image segmentation task, that suffers from the interference of instruments with a similar appearance from different surgical phases. In this study, we propose to perform segmentation in a setup wherein the divided surgical phases are considered as separate video sequences, such that the model focuses only on the coherent features of the instruments appearing in the current surgical phase. The edge reconstruction branch is introduced to explore the intra-frame detailed features to enhance the structural perception of surgical scenes for maintaining the segmentation integrity. Considering the ambiguous edges commonly found in surgical scenes, we propose herein an entropy-guided edge reconstruction loss as the constraint. Extensive experiments are performed on a public cataract surgery video benchmark to demonstrate the superiority of our method.

关键词： Cataracts Image segmentation Instruments Video sequences Surgery Object segmentation Interference

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A comparative study of the structural and optoelectronic properties of Al- and Ga-doped ZnO films deposited by atmospheric pressure plasma jet

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Journal of Alloys and Compounds 2025年 1031卷

作者： Chou, Chih-Yun Chiu, Po-Han Chao, Yin-Chun Yen, Hung-Wei Juang, Jia-Yang Program in Nanoengineering and Nanoscience Graduate School of Advanced Technology National Taiwan University Taipei106319 Taiwan Department of Materials Science and Engineering National Taiwan University Taipei106319 Taiwan Department of Mechanical Engineering National Taiwan University Taipei106319 Taiwan

The high cost of gallium has driven interest in aluminum-doped zinc oxide (AZO) as a cost-effective alternative to gallium-doped zinc oxide (GZO). While prior studies have primarily focused on sputtering methods to compare AZO and GZO, research on non-sputtering techniques remains limited. Our previous works demonstrated favorable optoelectronic properties in GZO films deposited via atmospheric pressure plasma jet (APPJ);however, APPJ-deposited AZO has yet to be explored. In this study, we compare AZO and GZO thin films fabricated by APPJ under ambient conditions. We find that the deposition rate of AZO is approximately twice that of GZO under the same processing parameters, due to differences in droplet size from the ultrasonic generator. By adjusting precursor delivery and working distance (the nozzle-to-substrate gap), we can tune film thickness, morphology, and optoelectronic properties, showcasing APPJ's versatility over sputtering. Despite similar precursor concentrations and film thickness, AZO films exhibit lower carrier concentration (∼1 ×1020 cm–3) and mobility (∼7.5 cm2/Vs) than GZO (∼8 ×1020 cm–3 and ∼15 cm²/Vs), attributed to reduced aluminum incorporation (∼0.4 at% vs. ∼2.2 at% in GZO). Reducing the working distance from 2 mm to 1.5 mm improves both films’ structural integrity and optoelectronic performance (figure of merit increases by 140 % for GZO and 100 % for AZO). However, AZO remains inferior to GZO, highlighting the need for further optimization. © 2025 Elsevier B.V.

关键词： Transparent conducting oxides

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Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury

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Bioactive materials 2023年第1期19卷 282-291页

作者： Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A.Ellison Cerise M.Siamof Liang Cheng Todd E.Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai Department of Nuclear Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China National-Regional Key Technology Engineering Laboratory for Medical Ultrasound Guangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingSchool of Biomedical EngineeringShenzhen UniversityShenzhen518060China Departments of Radiology and Medical Physics University of Wisconsin–MadisonMadisonWI53705USA Department of Nuclear Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology1095 Jiefang AveWuhan430030China Key Laboratory for Green Chemical Process of Ministry of Education School of Chemical Engineering and PharmacyWuhan Institute of TechnologyWuhan430073China Institute of Functional Nano&Soft Materials(FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou215123China University of Wisconsin Carbone Cancer Center University of Wisconsin–MadisonMadisonWI53705USA

Acute kidney injury(AKI)leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic ***,a series of polyvinylpyrrolidone(PVP)-curcumin nanoparticles(PCurNP)are designed to meet the renal excretion threshold(~45 kDa),presenting a controllable delivery nanosystem for kidney *** accumulation of the relatively small nanoparticles,^(89)Zr-PCurNP M10 with the diameter between 5 and 8 nm,is found to be 1.7 times and 1.8 times higher than the accumulation of^(89)Zr-PCurNP M29(20-50 nm)and M40(20-50 nm)as revealed by PET ***,serum creatinine analysis,kidney tissues histology,and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced ***,PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials.

关键词： Nanomedicine Acute kidney injury Kidney targeting Positron emission tomography(PET)imaging Zirconium-89(^(89)Zr) Nuclear medicine

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