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Lithium-functionalized graphene oxide with a low load of Pt as an efficient counter electrode for dye-sensitized solar cells

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Journal of Applied Electrochemistry 2024年第2期54卷 275-287页

作者： Mohammadnejad, S. Mohammadi, M. Reza Ghartavol, H. Mokarami Askari, M. Department of Materials Science and Engineering Sharif University of Technology Azadi Ave. Tehran Iran Department of Chemistry Universidad Técnica Federico Santa María Avenida España Valparaíso1680 Chile Department of Biomedical Engineering National Cheng Kung University Tainan City701 Taiwan

Low-cost materials with excellent chemical stability, high conductivity, and catalytic properties have attracted much attention as an alternative to conventional Pt counter electrodes in dye-sensitized solar cells (DSSCs). Herein, graphene oxide (GO) sheets were successfully synthesized via the improved Hummers’ method, functionalized with lithium and characterized by SEM, AFM, XRD, Raman, UV–Vis, and FTIR techniques. The impact of GO thickness, heat treatment temperature, and hybridization with Pt particles on photovoltaic performance of the counter electrodes (CEs) were studied. A solar efficiency of 2.47% and 2.94% was achieved for the pristine GO and Li-functionalized GO electrodes, respectively, under an optimized condition. A hybrid structure of GO or Li-functionalized GO films coated with an ultra-thin Pt film (i.e., GO-Pt or LiGO-Pt CEs) led to a remarkable efficiency of 7.07% and 8.87%, respectively. Such superior photovoltaic performance of LiGO-Pt CE indicated an increase of 61% in cell efficiency compared to the conventional Pt counter electrodes. The design of GO-based counter electrodes decorated with Pt deposition and Li functionalization will open a new concept for improvement of power conversion efficiency of DSSCs. Graphical Abstract: [Figure not available: see fulltext.]. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.

关键词： Dye-sensitized solar cells

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Development of exosome membrane materialsfused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4983-4998页

作者： Yongho Jang Jeehun Park Pilsu Kim Eun-Joo Park Hyungjin Sun Yujin Baek Jaehun Jung Tai-kyong Song Junsang Doh Hyuncheol Kim Department of Chemical and Biomolecular Engineering Sogang UniversitySeoul 04107Republic of Korea Research Institute of Advanced Materials(RIAM) Institute of Engineering ResearchSeoul National UniversitySeoul 08826Republic of Korea Department of Electronic Engineering Sogang UniversitySeoul 04107Republic of Korea Biomedical Research Institute&Department of Radiology Seoul National University HospitalSeoul 03080Republic of Korea Interdisciplinary Program in Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Engineering Research Bio-MAX InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Biomedical Engineering Sogang UniversitySeoul 04107Republic of Korea

Lipid-coated microbubbles are widely used as an ultrasound contrast agent,as well as drug delivery ***,the two main limitations in ultrasound diagnosis and drug delivery using microbubbles are the short half-life in the blood system,and the difficulty of surface modification of microbubbles for active *** exosome,a type of extracellular vesicle,has a preferentially targeting ability for its original *** this study,exosome-fused microbubbles(Exo-MBs)were developed by embedding the exosome membrane proteins into *** a result,the stability of Exo-MBs is improved over the conventional *** the same principle that under the exposure of ultrasound,microbubbles are cavitated and self-assembled into nano-sized particles,and Exo-MBs are self-assembled into exosome membrane proteins-embedded nanoparticles(Exo-NPs).The Exo-NPs showed favorable targeting properties to their original cells.A photosensitizer,chlorin e6,was loaded into Exo-MBs to evaluate therapeutic efficacy as a drug *** higher therapeutic efficacy of photodynamic therapy was confirmed,followed by cancer immunotherapy from immunogenic cell *** have therefore developed a novel ultrasound image-guided drug delivery platform that overcomes the shortcomings of the conventional ultrasound contrast agent and is capable of simultaneous photodynamic therapy and cancer immunotherapy.

关键词： Exosomes Microbubbles Photodynamic therapy Ultrasound Sonoporation Cancer immunotherapy Drug delivery

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Recent advances in bio-integrated electrochemical sensors for neuroengineering

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Fundamental Research 2025年第1期5卷 29-47页

作者： Shulin Chen Tzu-Li Liu Yizhen Jia Jinghua Li Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA Chronic Brain Injury Program The Ohio State UniversityColumbusOH 43210USA

Detecting and diagnosing neurological diseases in modern healthcare presents substantial challenges that directly impact patient *** complex nature of these conditions demands precise and quantitative monitoring of disease-associated biomarkers in a continuous,real-time *** chemical sensing strategies exhibit restricted clinical effectiveness due to labor-intensive laboratory analysis prerequisites,dependence on clinician expertise,and prolonged and recurrent ***-integrated electronics for chemical sensing is an emerging,multidisciplinary field enabled by rapid advances in electrical engineering,biosensing,materials science,analytical chemistry,and biomedical *** review presents an overview of recent progress in bio-integrated electrochemical sensors,with an emphasis on their relevance to neuroengineering and *** traverses vital neurological biomarkers and explores bio-recognition elements,sensing strategies,transducer designs,and wireless signal transmission *** integration of in vivo biochemical sensors is showcased through *** review concludes by outlining future trends and advancements in in vivo electrochemical sensing,and highlighting ongoing research and technological innovation,which aims to provide inspiring and practical instructions for future research.

关键词： Biochemical sensing Neuroengineering Bioimplants Analytical chemistry Bio-integrated electronics

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Block Sequence Effects on the Self-Assembly Behaviors of Polypeptide-Based Penta-Block Copolymer Hydrogels

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ACS Applied materials and Interfaces 2024年第5期16卷 6674-6686页

作者： Wang, Ke-Hsin Liu, Chung-Hao Tan, Dun-Heng Nieh, Mu-Ping Su, Wei-Fang Department of Materials Science and Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road Taipei10617 Taiwan Polymer program Institute of Materials Science University of Connecticut 25 King Hill Road Unit 3136 StorrsCT06269-3136 United States Department of Chemical and Biomolecular Engineering University of Connecticut StorrsCT06269 United States Department of Materials Engineering Ming-Chi University of Technology 84 Gungjuan Rd. New Taipei City243303 Taiwan

Peptide-based hydrogels have great potential for applications in tissue engineering, drug delivery, and so on. We systematically synthesize, characterize, and investigate the self-assembly behaviors of a series of polypeptide-based penta-block copolymers by varying block sequences and lengths. The copolymers contain hydrophobic blocks of poly(γ-benzyl-l-glutamate) (PBG, Bx) and two kinds of hydrophilic blocks, poly(l-lysine) (PLL, Ky) and poly(ethylene glycol) (PEG, EG34), where x and y are the number of repeating units of each block, where PBG and PLL blocks have unique functions for nerve regeneration and cell adhesion. It shows that a sufficient length of the middle hydrophilic segment capped with hydrophobic end PBG blocks is required. They first self-assemble into flower-like micelles and sequentially form transparent hydrogels (as low as 2.3 wt %) with increased polymer concentration. The hydrogels contain a microscale porous structure, a desired property for tissue engineering to facilitate the access of nutrient flow for cell growth and drug delivery systems with high efficiency of drug storage. We hypothesize that the structure of Bx-Ky-EG34-Ky-Bx agglomerates is beyond micron size (transparent), while that of Ky-Bx-EG34-Bx-Ky is on the submicron scale (opaque). We establish a working strategy to synthesize a polypeptide-based block copolymer with a wide window of sol-gel transition. The study offers insight into rational polypeptide hydrogel design with specific morphology, exploring the novel materials as potential candidates for neural tissue engineering. © 2024 The Authors. Published by American Chemical Society

关键词： Block copolymers

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Application of a Self-Assembly Sensing Layer to Grating Sensor Cabinets for biomedical Sensing of Rheumatoid Arthritis Antigen-Antibodies

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IEEE Sensors Journal 2024年第7期24卷 10039-10047页

作者： Wen, Hsin-Yi Hsu, Hsiang-Cheng Feng, Wen-Kai Jhan, Kai-Siang Yeh, Yao-Tsung Chiang, Chia-Chin National Kaohsiung University of Science and Technology Department of Chemical and Materials Engineering Kaohsiung80778 Taiwan National Kaohsiung University of Science and Technology College of Maritime Department of Ph.D. Program in Maritime Science and Technology Kaohsiung807618 Taiwan National Kaohsiung University of Science and Technology Department of Mechanical Engineering Kaohsiung80778 Taiwan Fooyin University Department of Medical Laboratory Science and Biotechnology Kaohsiung83102 Taiwan

In this article, we harnessed biomedical applications in laser-assisted etching long-period fiber gratings (LLPFGs) sensors, subsequently deploying them within the realm of biomedical applications. The primary aim of this study was to devise a sensitive method for the detection of antigen-antibodies associated with rheumatoid arthritis (RA) using LLPFGs. Sensing the antigen binding took place on the surface of the optical fiber through a self-assembling process. Given the inherent limitations of conventional rheumatoid factor (RF) testing in terms of specificity, we introduced an innovative serum-based approach geared toward the identification of anti-cyclic citrullinated peptide (Anti-CCP) antibodies. This method exhibited an impressive diagnostic accuracy rate of approximately 80% for RA cases, coupled with an exceptional specificity level of 98% for individuals without RA. The incorporation of LLPFGs in the detection of RA antigen-antibodies presents a highly promising avenue for enhancing the precision and reliability of RA diagnosis. Furthermore, this research aligns closely with the United Nations Sustainable Development Goal (SDG)3, which strives to promote well-being across all age groups and advance sustainable development by addressing health-related challenges, including the accurate diagnosis of diseases like RA. © 2023 IEEE.

关键词： Antibodies

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Novel experimental strategy towards temperature inhomogeneity during spark plasma sintering of metallic glasses

Advanced Powder Materials

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Advanced Powder materials 2023年第3期2卷 1-10页

作者： Huaping Ding Xiaoqian Bao Mao Zhang Junsong Jin Lei Deng Kefu Yao Atefeh Solouk Pan Gong Xinyun Wang State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing30 Xue Yuan RoadBeijing 100083China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Biomedical Engineering Department Amirkabir University of Technology(Tehran Polytechnic)TehranIran

Despite the importance of temperature distribution in spark plasma sintering of metallic glasses,its quantiﬁcation has been experimentally *** work proposes an experimental strategy to determine the sintering temperature by establishing a quantitative relationship between the temperature-thermal *** reproduced the thermal proﬁles of spark plasma sintering by isothermal annealing and found a correlation between annealing temperature and isothermal crystallization *** strong correlation indicates the temperature-dependent structural evolution of glassy *** isothermal crystallization time as the measuring gauge,we correlated the annealing temperature to the sintering temperature and obtained the sample temperature *** sample temperature is at least 19C higher than the nominal temperature of 425C measured by the ***,the sample temperature shows a hump-shaped pattern closely correlated with the current *** maximum temperature of 453C occurs on the sample/punches contact *** heterogeneity within the sample induces diverse microstructures and porous *** elucidate that the temperature inhomogeneity is intrinsic,given the presence of contact *** resistances affect the current distribution and heat transfer,resulting in a larger temperature gradient than the traditional powder metallurgy process.

关键词： Metallic glass Spark plasma sintering Temperature inhomogeneity Isothermal crystallization time Current distribution

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Microstructural evolution in lithium plating process and its effect on the calendar storage life

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Nano Research 2024年第10期17卷 8834-8841页

作者： Ki Hwan Koh Dong Ju Lee Anthony Mu Kangwoon Kim Taehee Kim Zheng Chen Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Program of Materials Science and Engineering University of California San DiegoLa JollaCA 92093USA Sustainable Power and Energy Center University of California San DiegoLa JollaCA 92093USA

The growing demand for electric vehicles highlights the need for energy storage solutions with higher densities,spotlighting Li metal anodes as potential successors to traditional Li-ion batteries(LIBs).Achieving longer calendar aging life for Li metal anodes is crucial for their practical use,given their propensity for corrosion due to a low redox potential,which leads to compromised cycling stability and significant capacity loss during *** research investigated that this susceptibility is mainly dependent on the surface area of Li metal anode and the properties of the solid electrolyte interphase(SEI),particularly its stability and growth *** research adds to this understanding by demonstrating that the amount of Li plating is a key factor in its corrosion during open-circuit storage,as assessed across various *** discovered that increasing the Li plating amount effectively reduces Coulombic efficiency(C.E.)loss during aging,due to a lower surface area-to-Li *** implies that the choice of electrolyte for optimal storage life should consider the amount of Li plating,with higher capacities promoting better storage characteristics.

关键词： lithium metal batteries anode-free batteries calendar life of batteries lithium anode corrosion

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Osteochondral regenerative engineering:challenges,state-of-the-art and translational perspectives

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Regenerative Biomaterials 2023年第1期10卷 354-376页

作者： Srimanta Barui Debolina Ghosh Cato T.Laurencin Connecticut Convergence Institute for Translation in Regenerative Engineering University of Connecticut Health CenterFarmingtonCT 06030USA Department of Orthopaedic Surgery University of Connecticut Health CenterFarmingtonCT 06030USA Department of Chemical and Biomolecular Engineering University of ConnecticutStorrsCT 06269USA Department of Biomedical Engineering University of ConnecticutStorrsCT 06269USA Department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA

Despite quantum leaps,the biomimetic regeneration of cartilage and osteochondral regeneration remains a major challenge,owing to the complex and hierarchical nature of compositional,structural and functional *** this review,an account of the prevailing challenges in biomimicking the gradients in porous microstructure,cells and extracellular matrix(ECM)orientation is ***,the spatial arrangement of the cues in inducing vascularization in the subchondral bone region while maintaining the avascular nature of the adjacent cartilage layer is *** rapid advancement in biomaterials science,biofabrication tools and strategies,the state-of-the-art in osteochondral regeneration since the last decade has expansively *** includes conventional and additive manufacturing of synthetic/natural/ECM-based biomaterials,tissue-specific/mesenchymal/progenitor cells,growth factors and/or signaling *** the laboratory-based research and development,the underlying challenges in translational research are also provided in a dedicated section.A new generation of biomaterial-based acellular scaffold systems with uncompromised biocompatibility and osteochondral regenerative capability is necessary to bridge the clinical demand and commercial *** the basic elements of osteochondral research,this review is believed to serve as a standalone guide for early career researchers,in expanding the research horizon to improve the quality of life of osteoarthritic patients affordably.

关键词： osteochondral regeneration additive manufacturing gradient porosity in vivo commercialization

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Recent advances in microsystem approaches for mechanical characterization of soft biological tissues

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Microsystems & Nanoengineering 2022年第4期8卷 1-16页

作者： Enming Song Ya Huang Ningge Huang Yongfeng Mei Xinge Yu John A.Rogers Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of OptoelectronicsFudan UniversityShanghai 200433China International Institute of Intelligent Nanorobots and Nanosystems Fudan UniversityShanghai 200433China Department of Biomedical Engineering City University of Hong KongHong Kong 999077China Department of Materials Science Fudan UniversityShanghai 200433China Querrey Simpson Institute for Bioelectronics Department of Materials Science and EngineeringDepartments of Biomedical EngineeringNeurological SurgeryChemistryMechanical EngineeringElectrical Engineering and Computer ScienceNorthwestern UniversityEvanstonIL 60208USA

Microsystem technologies for evaluating the mechanical properties of soft biological tissues offer various capabilities relevant to medical research and clinical diagnosis of pathophysiologic *** progress includes(1)the development of tissue-compliant designs that provide minimally invasive interfaces to soft,dynamic biological surfaces and(2)improvements in options for assessments of elastic moduli at spatial scales from cellular resolution to macroscopic areas and across depths from superficial levels to deep *** review summarizes a collection of these technologies,with an emphasis on operational principles,fabrication methods,device designs,integration schemes,and measurement *** core content begins with a discussion of platforms ranging from penetrating filamentary probes and shape-conformal sheets to stretchable arrays of ultrasonic *** sections examine different techniques based on planar microelectromechanical system(MEMS)approaches for biocompatible interfaces to targets that span scales from individual cells to *** highlighted example includes miniature electromechanical devices that allow depth profiling of soft tissue biomechanics across a wide range of *** clinical utility of these technologies is in monitoring changes in tissue properties and in targeting/identifying diseased tissues with distinct variations in *** results suggest future opportunities in engineered systems for biomechanical sensing,spanning a broad scope of applications with relevance to many aspects of health care and biology research.

关键词： advances identifying utility

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High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph Rich Chuyi Chen Ruoyu Zhong Ke Jin Ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky Luke P.Lee Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low ***,we report a high-yield(>90%)and rapid(<10 min)EV isolation method called FLocculation via Orbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid *** adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

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