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Dual elemental doping activated signaling pathway of angiogenesis and defective heterojunction engineering for effective therapy of MRSA-infected wounds

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Bioactive materials 2024年第7期37卷 14-29页

作者： Jin Huang Shuilin Wu Yi Wang Jie Shen Chaofeng Wang Yufeng Zheng Paul K.Chu Xiangmei Liu Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer MaterialsMinistry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhan430062China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen518036China School of Health Science&Biomedical Engineering Hebei University of TechnologyTianjin300401China School of Materials Science&Engineering Peking UniversityBeijing100871China Department of Physics and Department of Materials Science and Engineering City University of Hong Kong999077China

Multi-drug resistant bacterial infections pose a significant threat to human ***,the development of effective bactericidal strategies is a pressing *** this study,a ternary heterostructure(Zn-CN/P-GO/BiS)comprised of Zn-doped graphite phase carbon nitride(g-C3N4),phosphorous-doped graphene oxide(GO)and bismuth sulphide(Bi_(2)S_(3))is constructed for efficiently treating methicillin-resistant Staphylococcus aureus(MRSA)-infected *** doping-induced defect sites in g-C_(3)N_(4) results in a reduced band gap(ΔE)and a smaller energy gap(ΔEST)between the singlet state S_(1) and triplet state T_(1),which favours two-photon excitation and accelerates electron ***,the formation of an internal electric field at the ternary heterogeneous interface optimizes the charge transfer pathway,inhibits the recombination of electron-hole pairs,improves the photodynamic effect of g-C3N4,and enhances its catalytic ***,the Zn-CN/P-GO/BiS significantly augments the production of reactive oxygen species and heat under 808 nm NIR(0.67 W cm^(-2))irradiation,leading to the elimination of 99.60%±0.07%MRSA within 20 ***,the release of essential trace elements(Zn and P)promotes wound healing by activating hypoxia-inducible factor-1(HIF-1)and peroxisome proliferator-activated receptors(PPAR)signaling *** work provides unique insight into the rapid antibacterial applications of trace element doping and two-photon excitation.

关键词： Methicillin-resistant Staphylococcus aureus Defective heterojunction engineering Wound healing Phototherapy Signaling pathways

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Heterophase junction engineering-induced Co spin-state modulation of CoSe_(2) for large-current hydrogen evolution reaction

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Rare Metals 2024年第6期43卷 2660-2670页

作者： Bao-Chai Xu Ya-Ping Miao Min-Qin Mao Dong-Lian Li Song Xie Wei-Hong Jin Shu Xiao Jing Wen Zaenab Abd-Allah Zhi-Tian Liu Xiang Peng Paul K.Chu Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China School of Textile Science and Engineering Xi'an Polytechnic UniversityXi'an 710048China Institute of Advanced Wear and Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China Institute of Safety Science and Engineering South China University of TechnologyGuangzhou 510641China Department of Engineering Manchester Metropolitan UniversityManchester M156BHUK Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Efficient electrocatalysts are vital to large-current hydrogen production in commercial water splitting for green energy ***,a novel heterophase engineering strategy is described to produce polymorphic CoSe_(2)*** composition of the electrocatalysts consisting of both cubic CoSe_(2)(c-CoSe_(2))and orthorhombic CoSe_(2)(o-CoSe_(2))phases can be controlled *** results demonstrate that junction-induced spin-state modulation of Co atoms enhances the adsorption of intermediates and accelerates charge transfer resulting in superior large-current hydrogen evolution reaction(HER)***,the CoSe_(2)based heterophase catalyst with the optimal c-CoSe_(2)content requires an overpotential of merely 240 mV to achieve 1,000 mA·cm^(-2)as well as a Tafel slope of 50.4 mV·dec^(-1).Furthermore,the electrocatalyst can maintain a large current density of 1,500 mA·cm^(-2)for over 320 h without *** results reveal the advantages and potential of heterophase junction engineering pertaining to design and fabrication of low-cost transition metal catalysts for large-current water splitting.

关键词： Heterophase junction Spin-state Hydrogen evolution reaction Large current electrochemical hydrogen production Water splitting

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Probiotic-based nanoparticles for targeted microbiota modulation and immune restoration in bacterial pneumonia

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National science Review 2023年第2期10卷 183-198页

作者： Jieni Fu Xiangmei Liu Zhenduo Cui Yufeng Zheng Hui Jiang Yu Zhang Zhaoyang Li Yanqin Liang Shengli Zhu Paul K Chu Kelvin Wai Kwok Yeung Shuilin Wu School of Materials Science & Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China Tianjin University School of Materials Science & Engineering Peking University School of Health Science & Biomedical Engineering Hebei University of Technology Department of Orthopedics Guangdong Provincial People's HospitalGuangdong Academy of Medical Sciences Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Department of Orthopaedics & Traumatology Li Ka Shing Faculty of Medicine The University of Hong Kong

While conventional bacterial pneumonia mainly centralizes avoidance of bacterial colonization,it remains unclear how to restore the host immunity for hyperactive immunocompetent primary and immunocompromised secondary bacterial ***,probiotic-based nanoparticles of OASCLR were formed by coating chitosan,hyaluronic acid and ononin on living Lactobacillus *** nanoparticles could effectively kill various clinic common pathogens and antibacterial efficiency was> 99.97%.Importantly,OASCLR could modulate lung microbiota,increasing the overall richness and diversity of microbiota by decreasing pathogens and increasing probiotic and commensal ***,OASCLR could target inflammatory macrophages by the interaction of OASCLR with the macrophage binding site of CD 44 and alleviate overactive immune responses for hyperactive immunocompetent ***,OASCLR could break the state of the macrophage' s poor phagocytic ability by upregulating the expression of the extracellular matrix assembly,immune activation and fibroblast activation in immunocompromised *** macrophage' s phagocytic ability was increased from 2.61% to 12.3 %.Our work provides a potential strategy for hyperactive immunocompetent primary and immunocompromised secondary bacterial pneumonia.

关键词： probiotic-based nanoparticles immunocompetent primary bacterial pneumonia immunocompromised secondary bacterial pneumonia restoring host immunity

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Optical anapole modes in hybrid metal–dielectric nanoantenna for near-field enhancement and optical sensing

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Chinese Physics B 2023年第11期32卷 296-305页

作者：王德宝吕靖薇刘伟任艳茹李薇许鑫辰刘超朱剑豪 School of Physics and Electronic Engineering Northeast Petroleum UniversityDaqing 163318China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Metal–dielectric nanostructures in the optical anapole modes are essential for light–matter interactions due to the low material loss and high near-field enhancement. Herein, a hybrid metal–dielectric nanoantenna composed of six wedgeshaped gold(Au) nanoblocks as well as silica(SiO2) and silicon(Si) nanodiscs is designed and analyzed by the finite element method(FEM). The nanoantenna exhibits flexibility in excitation and manipulation of the anapole mode through the strong coupling between the metal and dielectrics, consequently improving the near-field enhancement at the gap. By systematically optimizing the structural parameters, the electric field enhancement factors at wavelengths corresponding to the anapole modes(AM1 and AM2) can be increased to 518 and 1482, respectively. Moreover, the nanoantenna delivers great performance in optical sensing such as a sensitivity of 550 nm/RIU. The results provide guidance and insights into enhancing the coupling between metals and dielectrics for applications such as surface-enhanced Raman scattering and optical sensing.

关键词： light-matter interaction metal-dielectric nanoantenna anapole mode electric field enhancement optical sensing

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PD-L1 targeted iron oxide SERS bioprobe for accurately detecting circulating tumor cells and delineating tumor boundary

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Chinese Chemical Letters 2025年第1期36卷 408-414页

作者： Ting Pan Dinghu Zhang Guomei You Xiaoxia Wu Chenguang Zhang Xinyu Miao Wenzhi Ren Yiwei He Lulu He Yuanchuan Gong Jie Lin Aiguo Wu Guoliang Shao Department of Interventional Radiology Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Cixi Institute of Biomedical EngineeringInternational Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Early diagnosis and accurate boundary delineation are the key steps of tumor precision *** tumor cells(CTCs)detection of liquid biopsy can provide abundant information for early diagnosis of *** detection specificity and good enrichment features are two key factors for CTCs accurate identification in peripheral blood *** this purpose,iron oxide(IO)-based surface-enhanced Raman scattering(SERS)bioprobes with good biocompatibility,high detection sensitivity,remarkable detection specificity,and good enrichment efficiency,were developed for detecting different types of *** SERS bioprobes combined with programmed death ligand-1(PD-L1)antibody are regarded as an effective way to boost the targeting ability and detection specificity,benefiting for accurately capturing and identifying rare *** types of CTCs with different PD-L1 expression were accurately distinguished among white blood cells via high-resolution SERS mapping images and stable Raman ***,CTCs blood samples obtained from the triple negative breast cancer patients were also successfully recognized compared to that of health people,indicating IO@AR@PDA-a PD-L1 SERS bioprobe possessed great potential for CTCs detection in liquid ***,IO-based bioprobe exhibited excellent dual-modal imaging abilities of high-resolution SERS imaging mode and microimaging magnetic resonance imaging *** two highly complementary imaging modes endowed IO-based bioprobes unrivalled capacity in tumor boundary differentiation,supporting tumor accurate resection and precise *** our best knowledge,this is the first time that biocompatible IO-based SERS bioprobes without noble metal element were reported not only for CTCs accurate detection,but also for precise tumor boundary delineation,showing great advantages in tumor diagnosis and treatment.

关键词： Circulating tumor cells Surface-enhanced Raman scattering PD-L1 Iron oxide bioprobe Dual-modal imaging Tumor boundaries delineation

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Acoustofluidic scanning fluorescence nanoscopy with a large field of view

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Microsystems & Nanoengineering 2024年第3期10卷 159-167页

作者： Geonsoo Jin Neil Upreti Joseph Rich Jianping Xia Chenglong Zhao Tony Jun Huang Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA The MITRE Corporation McLeanVA 22102USA

Large-field nanoscale fluorescence imaging is invaluable for many applications,such as imaging subcellular structures,visualizing protein interactions,and high-resolution tissue ***,conventional fluorescence microscopy requires a trade-off between resolution and field of view due to the nature of the optics used to form the *** overcome this barrier,we developed an acoustofluidic scanning fluorescence nanoscope that simultaneously achieves superior resolution,a large field of view,and strong fluorescent *** acoustofluidic scanning fluorescence nanoscope utilizes the superresolution capabilities of microspheres that are controlled by a programmable acoustofluidic device for rapid fluorescence enhancement and *** acoustofluidic scanning fluorescence nanoscope resolves structures that cannot be resolved with conventional fluorescence microscopes with the same objective lens and enhances the fluorescent signal by a factor of~5 without altering the field of view of the *** improved resolution realized with enhanced fluorescent signals and the large field of view achieved via acoustofluidic scanning fluorescence nanoscopy provides a powerful tool for versatile nanoscale fluorescence imaging for researchers in the fields of medicine,biology,biophysics,and biomedical engineering.

关键词： field resolution utilize

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Texture development and surface reconstruction of BiVO_(4)photoanode via one-pot hydrothermal reaction for enhanced photoelectrochemical water splitting

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Journal of Advanced Ceramics 2025年第3期14卷 133-141页

作者： Sung Won Hwang Yoo Jae Jeong Runfa Tan Indhujasri Saravanan Hyun Soo Han Dong Hoe Kim In Sun Cho Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea Department of Material Science&Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Mechanical Engineering Stanford UniversityStanford 94305USA Department of Material Science&Engineering Korea UniversitySeoul 02841Republic of Korea Materials Science and Engineering Program University of Colorado BoulderBoulder 80303USA

The simultaneous optimization of the bulk and surface characteristics of photoelectrodes is essential to maximize their photoelectrochemical(PEC)*** report a novel one-pot hydrothermal synthesis of textured and surface-reconstructed BiVO_(4)photoanodes(ts-BVO),achieving significant improvements in PEC water *** controlling precursor molarity and ethylene glycol(EG)addition,we developed a stepwise dual reaction(SDR)mechanism,which enables simultaneous bulk texture development and surface *** optimized CoBi/ts-BVO photoanode exhibited a photocurrent density of 4.3 mA∙cm^(−2)at 1.23 V *** hydrogen electrode(RHE)with a high Faradaic efficiency of 98%under one sun *** with nontextured BiVO_(4),the charge transport efficiency increased from 8%to 70%,whereas the surface charge transfer efficiency improved from 9%to 85%.These results underscore the critical role of both bulk and surface engineering in enhancing PEC *** findings offer a streamlined approach for improving the intrinsic properties of photoanodes in solar water splitting.

关键词： BiVO_(4) hydrothermal texture surface reconstruction ethylene glycol(EG) photoelectrochemical water splitting

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Effects of polydimethylsiloxane membrane surface treatments on human uterine smooth muscle cell strain response

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Bioactive materials 2024年第2期32卷 415-426页

作者： Elizabeth E.Marr Brett C.Isenberg Joyce Y.Wong Boston University Division of Materials Science and EngineeringUnited States Charles Stark Draper Laboratory Bioengineering DivisionUnited States Boston University Department of Biomedical EngineeringUnited States

In the United States,1 in 10 infants are born *** majority of neonatal deaths and nearly a third of infant deaths are linked to preterm *** birth is initiated when the quiescent state of the uterus ends prematurely,leading to contractions and parturition beginning as early as 32 weeks,though the origins are not well *** enable research and discovery of therapeutics with potential to better address preterm birth,the capability to study isolated cell processes of pregnant uterine tissue in vitro is *** development of an in vitro model of the myometrium utilizing human uterine smooth muscle cells(uSMCs)responsible for contractions provides a methodology to examine cellular mechanisms of late-stage pregnancy potentially involved in preterm *** discuss culture of uSMCs on a flexible polydimethylsiloxane(PDMS)substrate functionalized with cationic poly-L-lysine(PLL),followed by extracellular matrix(ECM)protein *** work exploring uSMC behavior on PDMS substrates have utilized collagen-I coatings,however,we demonstrated the first exploration of human uSMC response to strain on fibronectin-coated flexible membranes,importantly reflecting the significant increase of fibronectin content found in the myometrial ECM during late-stage *** the model we developed,we conducted proof-of-concept studies to investigate the impact of substrate strain on uSMC cell morphology and gene *** was found that PLL and varied ECM protein coatings(collagen I,collagen III,and fibronectin)altered cell nuclei morphology and density on PDMS ***,varied strain rates applied to uSMC substrates significantly impacted uSMC gene expression of IL-6,a cytokine associated with instances of preterm *** results suggest that both surface and mechanical properties of in vitro systems impact primary human uSMC phenotype and offer uSMC culture methodologies that can be utilized to further the understanding of cellu

关键词： Uterine Myometrium Bioengineered in vitro models Strain Pregnancy Nuclei Interleukin 6 Preterm labor

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One-step fabrication of ultrathin porous Janus membrane within seconds for waterproof and breathable electronic skin

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science Bulletin 2025年第5期70卷 712-721页

作者： Yufeng Ni Bing Li Chengzhen Chu Shaofan Wang Yujie Jia Shichun Cao Rasoul Esmaeely Neisiany Chuanglong He Shuo Chen Zhengwei You State Key Laboratory of Advanced Fiber Materials Institute of Functional MaterialsCollege of Materials Science and EngineeringResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society)Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineShanghai Key Laboratory of Lightweight CompositeDonghua UniversityShanghai 201620China College of Biological Science and Medical Engineering Donghua UniversityShanghai 201620China Department of Materials and Polymer Engineering Faculty of EngineeringHakim Sabzevari UniversitySabzevar***Iran Biotechnology Centre Silesian University of TechnologyGliwice44-100Poland

It remains a challenge for a simple and scalable method to fabricate ultrathin porous Janus membranes for stretchable on-skin ***,we propose a one-step droplet spreading phase separation strategy to prepare an ultrathin and easily collected Janus thermoplastic polyurethane(TPU)membrane within *** metal-ion solvation structure mitigated migration kinetics to delay TPU solution demixing,promoting the further penetration of the coagulating ***,the developed membranes,with an average preparation rate of 25.2 cm^(2)s^(−1),had a thickness of 5μm,and the water vapor transmission rate was determined to be 663 g m^(−2) d^(−1).The small pore layer having an average pore size of 1.7μm effectively blocked external liquid *** porous Janus TPU membrane coated by liquid metal served as a building block to develop a new generation of monolithic stretchable electronics with simultaneous high permeability and waterproofness.

关键词： porous polyurethane kinetics

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Instant formation of nanopores on flexible polymer membranes using intense pulsed light and nanoparticle templates

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International Journal of Smart and Nano materials 2023年第4期14卷 391-405页

作者： Miaoning Ren Tianyu Li Wenxing Huo Yu Guo Zhiqiang Xia Ya Lia Jing Niua M.Serdar Onses Xian Huang Department of Biomedical Engineering Tianjin UniversityTianjinChina ERNAM-Nanotechnology Research and Application Center Department of Materials Science and EngineeringErciyes UniversityKayseriTurkey

The development of simple and high-throughput approaches to yield solid-state nanopores on large surface membranes may facilitate the prevalence of nanopore analysis technology and in-vitro diagnosis using portable ***,solidstate nanopores are typically realized by complex and highend nanofabrication ***,we present a method to achieve nanopores on polymer membranes using,silver nanoparticles(AgNPs)as templates and intense pulsed light(IPL)as a heating *** density and size of nanopores are controllable by adjusting the spin coating rate,the concentration of nanoparticle suspension,and the size of nanoparticles(NPs).The temperature of the AgNPs can rapidly reach 1132 K under instant heating of photothermal effect through light irradiation in 2 ms,resulting in localized melting and decomposition of an underneath polycarbonate(PC)membrane to yield nanopores with sizes ranging from 10 to 270 *** removing the nanoparticle residues,the flexible membrane with nanopores can be integrated into a flow cell to achieve a nanopore sensor that has been used to measure the translocation behaviors of bovine serum albumin(BSA).The results have demonstrated the capability of the sensor in protein denaturation *** low-cost and highthroughput technique to fabricate solid-state nanopores on flexible polymeric membranes may facilitate the development of more nanopore-based flexible sensors that can be integrated with other flexible components for wearable diagnosis.

关键词： Solid-state nanopore intense pulsed light polymer AgNPs flexible membrane

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