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Protein hydrogels for biomedical applications

Biosurface and Biotribology 2024年第3期10卷 106-131页

作者： Xinyi Wang Yue Hou Xiong Lu Chaoming Xie Yanan Jiang Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuanChina Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuanChina Obesity and Metabolism Medicine-Engineering Integration Laboratory Department of General SurgeryThe Third People's Hospital of ChengduThe Affiliated Hospital of Southwest Jiaotong UniversityChengduSichuanChina

Hydrogels,characterised as highly hydrophilic three-dimensional polymer networks,have gained increasing attention due to their unique physicochemical properties,finding applications in various *** polymer hydrogels exhibit higher biocompatibility and biodegradability compared to traditional synthetic polymer ***,being the principal materials of natural polymer hydrogels,bear numerous modifiable functional *** resultant hydrogel possesses responsiveness,adjustable degradability,and underway as an excellent *** common raw materials used to construct protein hydrogels are *** terms of comparing natural polymer hydrogels with traditional synthetic polymer hydrogels,the authors conduct a detailed analysis and comparison,highlighting the advantages of natural polymer hydrogels in terms of biocompatibility and biodegradability,and summarising their *** authors also address the limitations of various protein hydrogels and list existing strengthening cross-linking strategies,proposing new insights to overcome the application limits of protein ***,the applications of protein hydrogels in drug delivery,biosensing,bio-inks and tissue engineering are *** authors conclude by summarising the current challenges faced by protein hydrogels and prospecting its future development.

关键词： biomaterials biomedical application

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Recent advances using MXenes in biomedical applications

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materials Horizons 2023年第4期11卷 876-902页

作者： Lee, I-Chi Li, Yi-Chen Ethan Thomas, James L. Lee, Mei-Hwa Lin, Hung-Yin Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu300044 Taiwan Department of Chemical Engineering Feng Chia University Taichung40724 Taiwan Department of Physics and Astronomy University of New Mexico AlbuquerqueNM87131 United States Department of Materials Science and Engineering I-Shou University Kaohsiung84001 Taiwan Department of Chemical and Materials Engineering National University of Kaohsiung Kaohsiung University Rd. Nan-Tzu District Kaohsiung81148 Taiwan

An MXene is a novel two-dimensional transition metal carbide or nitride, with a typical formula of Mn+1XnTx (M = transition metals, X = carbon or nitrogen, and T = functional groups). MXenes have found wide application in biomedicine and biosensing, owing to their high biocompatibility, abundant reactive surface groups, good conductivity, and photothermal properties. Applications include photo- and electrochemical sensors, energy storage, and electronics. This review will highlight recent applications of MXene and MXene-derived materials in drug delivery, tissue engineering, antimicrobial activity, and biosensors (optical and electrochemical). We further elaborate on recent developments in utilizing MXenes for photothermal cancer therapy, and we explore multimodal treatments, including the integration of chemotherapeutic agents or magnetic nanoparticles for enhanced therapeutic efficacy. The high surface area and reactivity of MXenes provide an interface to respond to the changes in the environment, allowing MXene-based drug carriers to respond to changes in pH, reactive oxygen species (ROS), and electrical signals for controlled release applications. Furthermore, the conductivity of MXene enables it to provide electrical stimulation for cultured cells and endows it with photocatalytic capabilities that can be used in antibiotic applications. Wearable and in situ sensors incorporating MXenes are also included. Major challenges and future development directions of MXenes in biomedical applications are also discussed. The remarkable properties of MXenes will undoubtedly lead to their increasing use in the applications discussed here, as well as many others. © 2024 The Royal Society of Chemistry.

关键词： Electrochemical sensors

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Reuse of sodium–doped iridium oxide nanoparticles as a bio–stimulating electrode by a chemical and electrochemical recovery process

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Ceramics International 2024年第4期50卷 6220-6228页

作者： Tso, Kuang-Chih Chen, Chieh-Hsuan Chen, Po-Chun Li, Shao-Sian Chen, Jeng-Lung Ohta, Jun Wu, Pu-Wei Division of Materials Science Graduate School of Science and Technology Nara Institute of Science and Technology Nara630-0192 Japan Graduate Degree Program of Science and Technology of Accelerator Light Source National Yang Ming Chiao Tung University Hsinchu300 Taiwan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu300 Taiwan Institute of Materials Science and Engineering National Taipei University of Technology Taipei106 Taiwan National Synchrotron Radiation Research Center Hsinchu300 Taiwan

A sequential chlorination and electrochemical reduction process is demonstrated to convert Na–doped iridium oxide nanoparticles into useful IrIIICl63−(aq) serving as the precursor for the fabrication of bio–stimulating electrode. The Na–doped iridium oxide nanoparticles are treated in 35 wt% hydrochloric acid at 70 °C for 18 h to form IrIVCl62−(aq) with pH of 0.3, so the latter could be readily reduced to IrIIICl63−(aq) at a potentiostatic mode of 0.6 V (vs. SCE). The oxidation state and the nature of complexing ligands for the regenerated IrIIICl63− and IrIVCl62−, as well as commercially available IrIIICl63− are validated by X–ray Absorption Spectroscopy. UV–Vis profiles of regenerated IrIVCl62−(aq) are recorded and the absorbance at 487 nm signal is benchmarked against that of standard IrIVCl62−(aq) to obtain the effective regeneration ratio of 68.6%. X–ray diffraction patterns of Na–doped iridium oxide nanoparticles before and after the annealing treatment indicate the amorphous structure facilitates the chlorination step. The regenerated IrIIICl63− is reused to synthesize Na–doped iridium oxide thin film serving as a bio–stimulating electrode for implantable bio–electronics. The regenerated Na–doped iridium oxide thin film reveals a charge-storage capacity of 0.32 mC/cm2-nm and impressive stability that are comparable to those of fresh Na–doped iridium oxide thin film derived from commercially available IrIIICl63−. © 2023 Elsevier Ltd and Techna Group S.r.l.

关键词： Transition metal oxides

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Overcoming Cytosolic Delivery Barriers of Proteins Using Denatured Protein-Conjugated Mesoporous Silica Nanoparticles

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ACS Applied materials and Interfaces 2023年第1期15卷 432-451页

作者： Dembélé, Julien Liao, Jou-Hsuan Liu, Tsang-Pai Chen, Yi-Ping Graduate Institute of Biomedical Materials & Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Laboratory of Toxicology Environment and Health Doctorate School of Health University Joseph Ki-Zerbo Ouaga03 BP 7021 Burkina Faso Department of Chemistry National Taiwan University Taipei10617 Taiwan Department of Surgery Mackay Memorial Hospital Taipei10449 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Intracellular delivery of therapeutic proteins has increased advantages over current small-molecule drugs and gene therapies, especially in therapeutic efficacies for a broad spectrum of diseases. Hence, developing the protein therapeutics approach provides a needed alternative. Here, we designed a mesoporous silica nanoparticle (MSN)-mediated protein delivery approach and demonstrated effective intracellular delivery of the denatured superoxide dismutase (SOD) protein, overcoming the delivery challenges and achieving higher enzymatic activity than native SOD-conjugated MSNs. The denatured SOD-conjugated MSN delivery strategy provides benefits of reduced size and steric hindrance, increased protein flexibility without distorting its secondary structure, exposure of the cell-penetrating peptide transactivator of transcription for enhanced efficient delivery, and a change in the corona protein composition, enabling cytosolic delivery. After delivery, SOD displayed a specific activity around threefold higher than in our previous reports. Furthermore, the in vivo biosafety and therapeutic potential for neuron therapy were evaluated, demonstrating the biocompatibility and the effective antioxidant effect in Neuro-2a cells that protected neurite outgrowth from paraquat-induced reactive oxygen species attack. This study offers an opportunity to realize the druggable possibility of cytosolic proteins using MSNs. © 2022 American Chemical Society.

关键词： Peptides

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Exploring the Correlation Between Surface Roughness, Surface Energy, Nano-indentation, Electrical Properties, and Magnetic Characteristics of Annealed Co40Fe40Dy20 Thin Films Deposited on Si(100) Substrates

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Journal of Electronic materials 2024年第8期53卷 4498-4511页

作者： Liu, Wen-Jen Chang, Yung-Huang Hsu, Shuo-Ting Fern, Chi-Lon Chen, Yuan-Tsung Tsao, Shin-Ying Lin, Shih-Hung Department of Materials Science and Engineering I-Shou University Kaohsiung840 Taiwan Bachelor Program in Industrial Technology National Yunlin University of Science and Technology 123 University Road Section 3 Yunlin Douliou64002 Taiwan Graduate School of Materials Science National Yunlin University of Science and Technology 123 University Road Section 3 Yunlin Douliou64002 Taiwan Department of Electronic Engineering National Yunlin University of Science and Technology 123 University Road Section 3 Yunlin Douliou64002 Taiwan

The impact of film thickness and annealing temperature on the structural, electrical, magnetic, and mechanical properties of cobalt–iron–dysprosium (Co40Fe40Dy20 ) thin films deposited on Si(100) substrates have been investigated. X-ray diffraction (XRD) analysis confirmed the film's crystalline microstructure, featuring dysprosium oxide, Dy2O3(440), and cobalt oxide, Co2O3(422) and Co2O3(511), crystallographic phases. Surface energy measurements indicated a noticeable reduction in surface energy following annealing treatments, which could be ascribed to the alleviation of residual stress and enhanced atomic arrangement, resulting in a more stable film structure with reduced surface energy. The film exhibited a decreasing trend in hardness with increasing thickness, and film resistivity was significantly responsive to alterations in thickness and annealing temperature. Notably, the Co40Fe40Dy20 film demonstrated exceptional characteristics, featuring a high saturation magnetization (Ms) of 675 emu/cm3 and a low coercivity (Hc) of 9.5 Oe. Further analysis of magnetic domains and hysteresis loops revealed that larger and brighter domains were associated with higher Hc. To sum up, the surface roughness of CoFeDy films under various annealing temperatures played a pivotal role in shaping their magnetic, electrical, adhesive, and optical characteristics. An improved low-frequency alternating current magnetic susceptibility (χac) value was achieved by minimizing the pinning effect on domain walls through surface smoothing. Moreover, smoother surfaces displayed heightened carrier conductivity, resulting in a decrease in electrical resistance. On the whole, Co40Fe40Dy20 films exhibited outstanding soft magnetic properties, encompassing high saturation magnetization, low coercivity, exceptional mechanical attributes, and decreased surface energy. Graphical Abstract: (Figure presented.) © The Minerals, Metals & materials Society 2024.

关键词： Magnetic susceptibility

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Ultrasonic-assisted decoration of AuNPs on carbon nano-onions as robust electrochemical scaffold for sensing of carcinogenic hydrazine in industrial effluents

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Journal of Industrial and engineering Chemistry 2023年 117卷 227-237页

作者： Gowthaman, N.S.K. Mohapatra, Debananda Arul, P. Chang, Wei Sea School of Engineering Monash University Malaysia Jalan Lagoon Selatan 47500 Selangor Bandar Sunway Malaysia School of Materials Science and Engineering Yeungnam University Gyeongbuk Gyeongsan38541 Korea Republic of Institute of Biochemical and Biomedical Engineering Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei106 Taiwan

This paper describes the decoration of AuNPs on carbon nano-onions (CNO) followed by its fabrication on electrode surface for the sensitive determination of environmental pollutant hydrazine (HZ). A green ultrasonication approach was employed to decorate the AuNPs on CNOs and it follows electroless deposition. HR-TEM results reveal that spherical 10 nm-sized AuNPs were well dispersed on 30 nm-sized CNOs. The obtained 3.7 eV spin–orbit coupling in the XPS Au4f region suggests the successful decoration of Au(0) on CNO. The Au@CNO nanostructure was then directly attached on GC electrode surface by simple immersion and achieved through π–π stacking interaction and the resultant electrode exhibited high electroactive surface area and lower resistivity when compared to the CNO fabricated electrode. The Au@CNO electrode was utilized to determine HZ in effluent samples and delivered higher electrocatalytic activity by showing lower onset potential than the bare and CNO fabricated electrodes. The increased electroactive area and high electronic conductivity of Au@CNO nanostructure are attributed to the offered lowest detection limit of 12 × 10−9 M (S/N = 3) and larger sensitivity of 485.7 µA/mM cm−2. The green and environmentally benign approached Au@CNO nanostructure leads to their successful implementation in the determination of HZ in effluent samples. © 2022 The Korean Society of Industrial and engineering Chemistry

关键词： Sewage

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Wet tissue adhesive polymeric powder hydrogels for skeletal muscle regeneration

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Bioactive materials 2024年第10期40卷 334-344页

作者： Mingyu Lee Daun Seo Junggeon Park Sun Hong Lee Jin Jeon Woochan Kim Jangho Kim Hee Seok Yang Jae Young Lee School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea Department of Nanobiomedical Science&BK21 FOUR NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan31116Republic of Korea Department of Convergence Biosystems Engineering Chonnam National UniversityGwangju61186Republic of Korea Department of Rural and Biosystems Engineering Chonnam National UniversityGwangjuRepublic of Korea Interdisciplinary Program in IT-Bio Convergence System Chonnam National UniversityGwangju61186Republic of Korea

Volumetric muscle loss(VML)frequently results from traumatic incidents and can lead to severe functional *** have been widely employed for VML tissue regeneration,which are unfortunately ineffective because of the lack of intimate contact with injured tissue for structural and mechanical *** hydrogels allow for strong tissue connections for wound ***,conventional adhesive hydrogels exhibit poor tissue adhesion in moist,bleeding wounds due to the hydration layer at the tissue–hydrogel interfaces,resulting in insufficient *** this study,we developed a novel,biocompatible,wet tissue adhesive powder hydrogel consisting of dextran-aldehyde(dex-ald)and gelatin for the regeneration of *** powder absorbs the interfacial tissue fluid and buffer solution on the tissue,spontaneously forms a hydrogel,and strongly adheres to the tissue via various molecular interactions,including the Schiff base *** particular,the powder composition with a 1:4 ratio of dex-ald to gelatin exhibited optimal characteristics with an appropriate gelation time(258 s),strong tissue adhesion(14.5 kPa),and ***-ald/gelatin powder hydrogels presented strong adhesion to various organs and excellent hemostasis compared to other wet hydrogels and fibrin glue.A mouse VML injury model revealed that the dex-ald/gelatin powder hydrogel significantly improved muscle regeneration,reduced fibrosis,enhanced vascularization,and decreased ***,our wet-adhesive powder hydrogel can serve as an effective platform for repairing various tissues,including the heart,muscle,and nerve tissues.

关键词： Powder Hydrogel Wet-adhesive Skeletal muscle regeneration

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Automated Cycling System for Characterizing Ink-Jet Printed Flexible Films for Sensors

Automated Cycling System for Characterizing Ink-Jet Printed ...

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2024 IEEE MetroCon, MetroCon 2024

作者： Hicks, McKenna Tesky, Allyson Kaul, Anupama B. University of North Texas Department of Computer Engineering DentonTX76207 United States University of North Texas Department of Biomedical Engineering DentonTX76207 United States University of North Texas Department of Materials Science and Engineering Electrical Engineering DentonTX76207 United States

ISBN: (纸本)9798331507640

Reliability testing of electronic devices is vital;anything from temperature and humidity resistance to mechanical fatigue of materials needs to be tested to ensure devices can hold up to their needed life expectancy - particularly in the field of biosensors and flexible conductors. Unfortunately, the research for specific techniques can be scarce, and often devices need to be tested in their own unique way. In this work, we have developed an automated system for reliability testing of strain-dependent sensors through the cyclic bending of a polyimide substrate with a conductive graphene film. A device was created using a 180-degree servo motor in combination with an Arduino microcontroller. The servo motor was then paired with a rack and pinion gear set to function as a linear actuator and bound to an independently built sliding mechanism that serves as the control and measurement of repeated bending operations. The substrate with the graphene film was then attached to a source meter to measure the current flow in situ over time. Subsequently, this device was able to repeat multiple bend cycles identically, eliminating the need to do it by hand and creating uniformity toward data gathering for comparative experimental studies. As such, the automated cycling system fulfilled its purpose towards a reliability test for which the graphene film showed the ability to withstand fatigue through repeated loading. © 2024 IEEE.

关键词： Fatigue testing

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Liposome of a synergistic combination of HDP-mimicking polymer and rifampicin for treating bacterial infections in aquaculture via oral administration

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science China materials 2025年第4期68卷 1259-1270页

作者： Haowen Yu Luhang Chen Yueming Wu Wenhui Dai Minzhang Chen Yuan Chen Longqiang Liu Jiangzhou Wang Xinqi Huang Kang Chen Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism Key Laboratory for Ultrafine Materials of Ministry of EducationFrontiers Science Center for Materiobiology and Dynamic ChemistryEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Biomaterials and Stem Cells Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China

The extensive use of antibiotics in high-density aquaculture has accelerated the emergence of antibiotic-resistant *** presence of antibiotics in water and soil,and their transmission through the food chain exacerbate the pressures associated with antibiotic resistance,posing a significant threat to human *** this challenge and serious issue,effective alternatives to antibiotics remain *** this study,we report a potent synergistic effect between an HDP-mimicking polymer,DLLys90-BLG10,and rifampicin against Vibrio *** synergistic combination substantially reduces the required dosage of rifampicin,thereby mitigating the risk of antibiotic resistance development and the release of rifampicin into water and ***,we developed a cell-penetrating peptide-modified liposome system that can co-encapsulate DLLys90-BLG10 and rifampicin,which exerts potent antibacterial activity against Vibrio both in vitro and in vivo,while maintaining ***,oral administration of CPP-Lip@Syn showed effective control of Vibrio *** strategy opens new avenues in exploring antibiotic alternatives in aquaculture and implies potential applications in aquaculture.

关键词： liposomes oral administration aquaculture synergistic combinations Vibrio infections

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Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers

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Aggregate 2023年第5期4卷 207-213页

作者： Yuta Ihara Hiroshi Yamagishi Masanobu Naito Yohei Yamamoto Department of Materials Science Faculty of Pure and Applied Sciencesand Tsukuba Research Center for Energy Materials Science(TREMS)University of TsukubaTsukubaJapan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaJapan Program in Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

Machine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large ***,we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical *** constructing a dataset,four polymers were precipitated from 416 solvent/nonsolvent combinations,and the morphology of the resulting precipitates were *** dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector ***,we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation *** predicted appropriate solvents are those with low hydrogen bonding capability,low polarity,and small molecular ***,we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space,which is the origin of the conventional difficulty in identifying the *** extraordinary axis points toward a void region,indicating the potential value of synthesizing novel solvents located therein.

关键词： chemical space computational chemistry machine learning polymers precipitation

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