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Degradation behavior of pure Mg in the physiological medium and growth mechanism of surface corrosion product films

Journal of Magnesium and Alloys 2025年第4期13卷 1523-1535页

作者： Chenyu Wang Mingshan Sun Chao Yang Haiyang Wang Jie Wang Lin Mao Yao Yang Tao Ying Paul K.Chu Xiaoqin Zeng National Engineering Research Center of Light Alloy Net Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Kunming Branch of the 705 Research Institute of CSSC Kunming 650101China Shanghai Institute for Minimally Invasive Therapy School of Medical Instrument and Food EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of Physics Department of Materials Science&Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

Pure Mg boasting a relatively small corrosion rate is a potential biodegradable metal material for ***,its degradation behavior in the complex physiological environment is still a lack of *** this work,we investigated the effect of corrosion product film layers on the degradation behavior of pure Mg in physiological *** Mg shows a faster corrosion rate in simulated body fluid(SBF)compared to NaCl *** evolution experiments indicate that the degradation rate of pure Mg in SBF decreases rapidly within the first 12 h but stabilizes *** rapid deposition of low-solubility calcium phosphate on the pure Mg in SBF provides protection to the substrate,resulting in a gradual decrease in the degradation ***,the corrosion product film of pure Mg formed in SBF exhibits a layered structure,with the upper layer consisting of dense Ca_(3)(PO_(4))_(2)/Mg_(3)(PO_(4))_(2) and the lower layer consisting of Mg(OH)_(2)/*** impedance spectroscopy(EIS)shows that the resistance of the corrosion product film increases over time,indicating gradual strengthening of the corrosion *** 4-week degradation results in the femoral marrow cavity of mice are consistent with the result in SBF in vitro.

关键词： Pure Mg Physiological environment Degradation behavior Corrosion product film Calcium phosphate

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Inflammation and Microbiota Regulation Potentiate Pneumonia Therapy by Biomimetic Bacteria and Macrophage Membrane Nanosystem

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Research 2023年第4期2023卷 399-413页

作者： Yuan Li Xiangmei Liu Zhenduo Cui Yufeng Zheng Hui Jiang Yu Zhang Zhaoyang Li Shengli Zhu Paul K Chu Shuilin Wu School of Materials Science and Engineering Peking UniversityBeijing 100871China The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China School of Materials Science and EngineeringTianjin UniversityTianjin 300072China Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer MaterialsMinistry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan430062China School of Health Science and Biomedical Engineering Hebei University of TechnologyXiping Avenue 5340Beichen DistrictTianjin 300401China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongKowloon 999077Hong KongChina.

While conventional nanosystems can target infected lung tissue,they cannot achieve precise cellular targeting and enhanced therapy by modulating inflammation and microbiota for effective ***,we designed a nucleus-targeted nanosystem with adenosine triphosphate(ATP)and reactive oxygen species stimuli-response to treat pneumonia coinfected with bacteria and virus that is enhanced through inflammation and microbiota *** nucleus-targeted biomimetic nanosystem was prepared through the combined bacteria-macrophage membrane and loaded hypericin and ATP-responsive dibenzyl oxalate(MMHP)*** MMHP despoiled the Mg^(2+)of intracellular cytoplasm in bacteria to achieve an effective bactericidal ***,MMHP can target the cell nucleus and inhibit the H1N1 virus duplication by inhibiting the activity of *** possessed an immunomodulatory ability to reduce the inflammatory response and activate CD8^(+)T cells for assisted infection *** the mice model,the MMHP effectively treated pneumonia coinfected with Staphylococcus aureus and H1N1 ***,MMHP mediated the composition of gut microbiota to enhance the pneumonia ***,the dual stimuli-responsive MMHP possessed promising clinical translational potential to therapy infectious pneumonia.

关键词： inflammation H1N1 lung

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Stimuli-responsive peptide assemblies:Design,self-assembly,modulation,and biomedical applications

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Bioactive materials 2024年第5期35卷 181-207页

作者： Rongqiu Mu Danzhu Zhu Sama Abdulmalik Suranji Wijekoon Gang Wei Sangamesh G.Kumbar College of Chemistry and Chemical Engineering Qingdao University266071QingdaoChina Department of Biomedical Engineering&Department of Materials Science and Engineering University of ConnecticutStorrs06269USA Department of Orthopaedic Surgery University of Connecticut HealthFarmington06030USA

Peptide molecules have design flexibility,self-assembly ability,high biocompatibility,good biodegradability,and easy functionalization,which promote their applications as versatile biomaterials for tissue engineering and *** addition,the functionalization of self-assembled peptide nanomaterials with other additive components enhances their stimuli-responsive functions,promoting function-specific applications that induced by both internal and external *** this review,we demonstrate recent advance in the peptide molecular design,self-assembly,functional tailoring,and biomedical applications of peptide-based *** strategies on the design and synthesis of single,dual,and multiple stimuli-responsive peptide-based nanomaterials with various dimensions are analyzed,and the functional regulation of peptide nanomaterials with active components such as metal/metal oxide,DNA/RNA,polysaccharides,photosensitizers,2D materials,and others are *** addition,the designed peptide-based nanomaterials with temperature-,pH-,ion-,light-,enzyme-,and ROS-responsive abilities for drug delivery,bioimaging,cancer therapy,gene therapy,antibacterial,as well as wound healing and dressing applications are presented and *** comprehensive review provides detailed methodologies and advanced techniques on the synthesis of peptide nanomaterials from molecular biology,materials science,and nanotechnology,which will guide and inspire the molecular level design of peptides with specific and multiple functions for function-specific applications.

关键词： Peptide assemblies Molecular design Functional modulation Stimuli-responsive nanomaterials biomedical applications

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The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy

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Chinese Chemical Letters 2025年第4期36卷 9-19页

作者： Han Wu Yumei Wang Zekai Ren Hailin Cong Youqing Shen Bing Yu College of Chemistry and Chemical Engineering College of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao 266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao 266071China School of Materials Science and Engineering Shandong University of TechnologyZibo 255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China

Glioma is the most common malignant tumor of the brain. The postoperative recurrence rate was high,and the 2-year survival rate only increased by 20%–25%. The reason is the blood-brain barrier(BBB). BBB is a physical barrier that stabilizes the physiological environment of brain tissue and protects the central nervous system from the invasion of harmful substances. Drug delivery based on nanotechnology and nanocarriers has attracted much attention due to its biological safety, continuous drug release time,increasing solubility, biological drug activity, and enhanced BBB permeability. By modifying different substances on the surface of nanocarriers, the BBB is bypassed by receptor-mediated and cell endocytosis and exocytosis. In addition, the purpose of bypassing BBB-targeted drug delivery can also be achieved by intranasal administration and local administration. This paper reviews different target transport mechanisms, mainly in invasive and non-invasive strategies, the nanocarriers that have made progress and the nanocarrier strategy of bypassing BBB are listed.

关键词： Glioma Blood-brain barrier Nanocarriers Drug delivery Adsorption-mediated transport Receptor-mediated transport

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Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine

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science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang Wang Xiaohua Li Huanchen Yao Xin Liu Yan Gao Hailin Cong Bing Yu Youqing Shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine

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Entropy-modulated and interlayer-doped transition metal layered oxides enable high-energy-density sodium-ion capacitors

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Nano Research 2024年第10期17卷 8785-8793页

作者： Tiansheng Wang Yadong Li Zhengyuan Chen Qingshan Liu Jian Lang Langyuan Wu Wendi Dong Zhengyu Ju Hongsen Li Xiaogang Zhang Guihua Yu College of Physics Qingdao UniversityQingdao 266071China Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016China Materials Science and Engineering Program and Walker Department of Mechanical Engineering The University of Texas at AustinAustin 78712USA

In recent years,sodium-ion capacitors have attracted attention due to their cost-effectiveness,high power density and similar manufacturing process to lithium-ion ***,the utilization of oxide electrodes in traditional sodium-ion capacitors restricts their further advancement due to the inherent low operating voltage and electrolyte consumption based on their energy storage *** address these challenges,we incorporated Zn,Cu,Ti,and other elements into Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2) to synthesize P2-type Na_(0.7)Ni_(0.28)Mn_(0.6)Zn_(0.05)Cu_(0.02)Ti_(0.05)O_(2) with a modulated entropy and pillaring *** the synergistic interplay between the interlayer pillar and the entropy modulation within the layers,the material exhibits exceptional toughness,effectively shielding it from detrimental phase transitions at elevated voltage *** a result,the material showcases outstanding kinetic properties and long-term cycling stability across the voltage *** integrating these materials with hierarchical porous carbon nanospheres to form a"rocking chair"sodium-ion capacitor,the hybrid full device delivers a high energy density(171 Wh·kg^(-1))and high power density(5245 W·kg^(-1)),as well as outstanding cycling stability(77% capacity retention after 3000 cycles).This work provides an effective material development route to realize simultaneously high energy and power for next-generation sodium-ion capacitors.

关键词： sodium-ion capacitors entropy modulation high power density long-term cycling layered oxide

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Anisotropic growth of nano-precipitates governed by preferred orientation and residual stress in an Al-Zn-Mg-Cu alloy

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Journal of materials science & Technology 2024年第21期188卷 234-251页

作者： Runze Wang Hongyun Luo Sujun Wu Tianshu Zhao Xin Wang Robert O.Ritchie School of Materials Science and Engineering Beihang UniversityBeijing 100191China Key Laboratory of Aerospace Materials and Performance Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100191China Surface Engineering Institution AECC Beijing Institute of Aeronautical MaterialsBeijing 100095China Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA

Through an understanding of diffusion,precise control of the size distribution of nano-precipitates can be essential to developing superior properties in precipitation-strengthened *** a significant influence of crystallographic orientation on the diffusion process is known to exist in low-symmetry hexagonal close-packed alloys,such anisotropic diffusion is still unidentified in high-symmetry cubic *** this work,we reveal the diffusion-controlled coarsening induced anisotropic growth process of nano-precipitates in an Al-Zn-Mg-Cu *** experimental and theoretical studies demonstrate that with an increase in the residual stress,the diffusion-controlled coarsening rate is slow along the<112>fiber texture in the alloy matrix with smaller grain *** such,we find that the diffusion activation energy will be increased along the preferred orientation with largest residual stress,which leads to a reduced diffusion-controlled coarsening ***,we demonstrate that the increase in the volume fraction of nano-precipitates originates from the rapid grain-boundary controlled coarsening of the grainboundary *** on these results,an underlying microstructural design strategy is proposed,involving the crystallographic orientation,the residual stress and the grain boundaries to manipulate the precipitate size distribution in this class of alloys.

关键词： Aluminum alloy Precipitate coarsening behavior Preferred orientation Diffusion coefficient Residual stress

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Unveiling the size effect of nitrogen-doped carbon-supported copper-based catalysts on nitrate-to-ammonia electroreduction

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Nano Research 2024年第4期17卷 2438-2443页

作者： Ran Li Taotao Gao Wenxi Qiu Minghao Xie Zhaoyu Jin Panpan Li College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Institute for Advanced Study Chengdu UniversityChengdu 610106China Materials Science and Engineering Program and Walker Department of Mechanical Engineering The University of Texas at AustinAustinTexas 78712USA Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

The electrocatalytic nitrate reduction reaction(NitRR)represents a promising approach toward achieving economically and environmentally sustainable ***,it remains a challenge to regulate the size effect of electrocatalysts to optimize the catalytic activity and ammonia ***,the Cu-based catalysts were tailored at the atomic level to exhibit a size gradient ranging from single-atom catalysts(SACs,0.15–0.35 nm)to single-cluster catalysts(SCCs,1.0–2.8 nm)and nanoparticles(NPs,20–30 nm),with the aim of studying the size effect for the NO_(3)^(-)-to-NH_(3) reduction ***,the Cu SCCs exhibit enhanced metal–substrate and metal–metal interactions by taking advantageous features of Cu SACs and Cu ***,Cu SCCs achieve exceptional electrocatalytic performance for the NitRR with a maximum Faradaic efficiency of ca.96%NH_(3)and the largest yield rate of ca.1.99 mg·h^(-1)·cm^(-2) at-0.5 V *** hydrogen electrode(RHE).The theoretical calculation further reveals the size effect and coordination environment on the high catalytic activity and selectivity for the *** work provides a promising various size-controlled design strategy for aerogel-based catalysts effectively applied in various electrocatalytic reactions.

关键词： nitrate electroreduction ammonia electrosynthesis size effect single-cluster catalyst

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Enhancing corrosion resistance of MAO coatings on Al alloy LY12 through in situ co-doping with zinc phosphate and cerium phosphate

Corrosion Communications

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Corrosion Communications 2025年第1期17卷 35-43页

作者： Chao Yang Tao Ying Aihui Huang Jian Huang Pinghu Chen Paul K.Chu Xiaoqin Zeng National Engineering Research Center of Light Alloy Net Forming School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai Key Laboratory of Advanced High-Temperature Materials and Precision Forming School of Materials Science and Engineering Shanghai Jiao Tong University Department of Chemistry University of Munich(LMU) College of Mechanical Engineering Key Laboratory of Hunan Province of Equipment Safety Service Technology under Extreme Environment University of South China Department of Physics Department of Materials Science&Engineering and Department of Biomedical Engineering City University of Hong Kong

Corrosion of aluminum（Al） alloys during service limits many applications. Micro-arc oxidation（MAO） coatings can enhance corrosion resistance, but porous defects in the films undermine their effectiveness. Here, by mixing a phosphate electrolyte with soluble Zn and Ce salts, zinc phosphate and cerium phosphate co-doped MAO corrosion-resistant coating is prepared on Al alloy LY12. Zinc phosphate and cerium phosphate are incorporated in situ to form an amorphous encapsulated nanocrystalline structure. During long-term corrosion, Zn2+is released and deposited as corrosion products Zn（OH）2to cover weak corrosion micro-regions in the coating. Simultaneously, Ce3+released from MAO coating co-doped with zinc phosphate/cerium phosphate forms Zn（OH）2/Ce（OH）3due to the small solubility product Kspto further enhance corrosion resistance. Compared to pristine Al alloy,corrosion potential increases from -1.306 to -0.819 VSCE, and corrosion current density decreases by 4 orders of magnitude from 2.6 × 10-6to 2.5 × 10-10A·cm-2. Co-doped MAO coating significantly enhances corrosion resistance of Al alloy LY12 and shows great potential for a wide range of applications.

关键词： Aluminum alloys Micro-arc oxidation coating Corrosion resistance Zinc phosphate Cerium phosphate

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Structure-function integrated biodegradable Mg/polymer composites:Design,manufacturing,properties,and biomedical applications

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Bioactive materials 2024年第9期39卷 74-105页

作者： Xianli Wang Cheng Wang Chenglin Chu Feng Xue Jun Li Jing Bai School of Materials Science and Engineering Southeast UniversityJiangningNanjing211189JiangsuChina Jiangsu Key Laboratory for Advanced Metallic Materials JiangningNanjing211189JiangsuChina Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore119276Singapore

Mg is a typical biodegradable metal widely used for biomedical applications due to its considerable mechanical properties and *** polymers have attracted great interest owing to their favorable processability and ***,it is challenging for the degradation rates of Mg or polymers to precisely match tissue repair processes,and the significant changes in local pH during degradation hinder tissue *** concept of combining Mg with polymers is proposed to overcome the shortcomings of materials,aiming to meet repair needs from various aspects such as mechanics and ***,it is essential to systematically understand the behavior of biodegradable Mg/polymer composite(BMPC)from the design,manufacturing,mechanical properties,degradation,and biological *** this review,we elaborate on the design concepts and manufacturing strategies of high-strength BMPC,the“structure-function”relationship between the microstructures and mechanical properties of composites,the variation in the degradation rate due to endogenous and exogenous factors,and the establishment of advanced degradation research ***,the interplay among composite components during degradation and the biological function of composites under nonresponsive/stimuli-responsive platforms are also ***,we hope that this review will benefit future clinical applications of“structure-function”integrated biomaterials.

关键词： Mechanical property Interface Biodegradation Stimuli-responsiveness Tissue engineering

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