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Injectable biodegradable bi-layered capsule for sustainable delivery of protein therapeutics 42

Injectable biodegradable bi-layered capsule for sustainable ...

42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

作者： Jiang, Pengfei Lannutti, John J. Ohr, Matthew P. Swindle-Reilly, Katelyn E. William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University United States Department of Materials Science and Engineering The Ohio State University United States Department of Ophthalmology & Visual Science The Ohio State University United States Department of Biomedical Engineering The Ohio State University United States

ISBN: (纸本)9781510883901

Statement of Propose: Wet age-related macular degeneration (AMD) is one of the leading causes of blindness in humans over fifty1. Choroidal neovascularization induced by the overexpression of vascular endothelial growth factor (VEGF) can leak fluid and blood into the intraocular region and eventually cause irreversible retinal damage2,3. The current treatment requires monthly intravitreal injection of anti-VEGF such as bevacizumab or ranibizumab to block VEGF from initiating angiogenesis. However, frequent injection often leads to infection, elevated intraocular pressure, rhegmatogenous retinal detachment4, and low patient compliance. Various drug delivery devices have been widely developed to create a more facile and efficient treatment of AMD5 but these devices do not provide sustained drug release due to characteristic burst release and rapid degradation. To address this, we have developed an injectable and biodegradable drug delivery system which can provide drug release for months to potentially improve patient compliance and outcomes, while reducing the need for frequent injections. © 2019 Omnipress - All rights reserved.

关键词： Controlled drug delivery

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Prediction of carbon nanostructure mechanical properties and role of defects using machine learning

arXiv

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arXiv 2021年

作者： Zhao, Qi Winetrout, Jordan J. Xu, Yanxun Wang, Yusu Heinz, Hendrik Halıcıoglu Data Science Institute University of California San Diego San diegoCA92093 United States Department of Chemical and Biological Engineering University of Colorado Boulder BoulderCO80309 United States Materials Science and Engineering Program University of Colorado Boulder BoulderCO80309 United States Department of Applied Mathematics and Statistics Johns Hopkins University BaltimoreMD21218 United States

Carbon fiber and graphene-based nanostructures such as carbon nanotubes (CNTs) and defective structures have extraordinary potential as strong and lightweight materials. A longstanding bottleneck has been lack of understanding and implementation of atomic-scale engineering to harness the theoretical limits of modulus and tensile strength, of which only a fraction is routinely reached today. Here we demonstrate accurate and fast predictions of mechanical properties for CNTs and arbitrary 3D graphitic assemblies based on a training set of over 1000 stress-strain curves from cutting-edge reactive MD simulation and machine learning (ML). Several ML methods are compared and show that our newly proposed hierarchically structured graph neural networks with spatial information (HS-GNNs) achieve predictions in modulus and strength for any 3D nanostructure with only 5-10% error across a wide range of possible values. The reliability is sufficient for practical applications and a great improvement over off-the shelf ML methods with up to 50% deviation, as well as over earlier models for specific chemistry with 20% deviation. The algorithms allow more than 100 times faster mechanical property predictions than traditional molecular dynamics simulations, the identification of the role of defects and random 3D morphology, and high-throughput screening of 3D structures for enhanced mechanical properties. The algorithms can be scaled to morphologies up to 100 nm in size, expanded for chemically similar compounds, and trained to predict a broader range of properties. © 2021, CC BY.

关键词： Defects

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Ultra-Low Temperature Li/CFx Batteries Enabled by Fast-transport and Anion-pairing Liquefied Gas Electrolytes

arXiv

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arXiv 2022年

作者： Yin, Yijie Holoubek, John Liu, Alex Sayahpour, Baharak Raghavendran, Ganesh Cai, Guorui Han, Bing Mayer, Matthew Schorr, Noah B. Lambert, Timothy N. Harrison, Katharine L. Li, Weikang Chen, Zheng Meng, Y. Shirley Materials Science and Engineering Program University of California La Jolla San DiegoCA92093 United States Department of NanoEngineering University of California La Jolla San DiegoCA92093 United States Department of Power Sources R&D Sandia National Laboratories AlbuquerqueNM87123 United States Department of Photovoltaics and Materials Technology Sandia National Laboratories AlbuquerqueNM87123 United States Nanoscale Sciences Department Sandia National Laboratories AlbuquerqueNM87123 United States Sustainable Power and Energy Center University of California La Jolla San DiegoCA92093 United States Pritzker School of Molecular Engineering University of Chicago ChicagoIL60637 United States

Lithium fluorinated-carbon (Li/CFx) is one of the most promising chemistries for high-energy density primary energy storage system in applications where rechargeability is not required. Though Li/CFx demonstrates high energy density (>2100 Wh kg–1) under ambient conditions, achieving such a high energy density when exposed to subzero temperatures remains a challenge, particularly under high current density. Here, we report a liquefied gas electrolyte with an anion-pair solvation structure based on dimethyl ether with a low melting point (−141 oC) and low viscosity (0.12 mPa×S, 20 oC), leading to high ionic conductivity (> 3.5 mS cm–1) between −70 and 60 oC. Besides that, through systematic X-ray photoelectron spectroscopy integrated with transmission electron microscopy characterizations, we evaluate the interface of CFx for low-temperature performance. We conclude that the fast transport and anion-pairing solvation structure of the electrolyte brings about reduced charge transfer resistance at low temperatures, which resulted in significantly enhanced performance of Li/CFx cells (1690 Wh kg–1, −60 oC;1172 Wh kg–1, −70 oC based on active materials). Utilizing 50 mg cm-2 loading electrodes, the Li/CFx still displayed 1530 Wh kg–1 at −60 oC. This work provides insights into the electrolyte design that may overcome the operational limits of batteries in extreme environments. Copyright © 2022, The Authors. All rights reserved.

关键词： Electrolytes

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Amphiphilic gel lubrication and the solvophilic transition

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Biotribology 2021年 26卷

作者： McGhee, Eric O. Chau, Allison L. Cavanaugh, Megan C. Rosa, Jose Gabriel Davidson, Cullen L.G. Kim, Jiho Urueña, Juan Manuel Sumerlin, Brent S. Pitenis, Angela A. Sawyer, W. Gregory Dept. of Materials Science and Engineering Herbert Wertheim College of Engineering University of Florida Gainesville 32611 FL United States Materials Department College of Engineering University of California Santa Barbara Santa Barbara 93106 CA United States Department of Chemical Engineering College of Engineering University of California Santa Barbara Santa Barbara 93106 CA United States Department of Chemical Engineering Herbert Wertheim College of Engineering University of Florida Gainesville 32611 FL United States Department of Chemistry College of Liberal Arts and Sciences University of Florida Gainesville 32611 FL United States Dept. of Mechanical and Aerospace Engineering Herbert Wertheim College of Engineering University of Florida Gainesville 32611 FL United States J. Crayton Pruitt Family Dept. of Biomedical Engineering Herbert Wertheim College of Engineering University of Florida Gainesville 32611 FL United States

Lubrication in biology uses lipids, proteins, and aqueous gels to maintain hydration and provide low shear stress over a range of sliding speeds and contact pressures. The unquestionably amphiphilic nature of proteins and the complexity found in the aqueous solutions suggest that these systems operate near an optimal solvophilic condition. To explore the potential for a solvophilic transition in an amphiphilic gel, we perform tribological and swelling measurements of poly(hydroxyethyl)methacrylate, pHEMA, equilibrated over a range of water-ethanol solutions. Depending on the ethanol concentration, Gemini pHEMA gels achieve either low friction (μ < 0.02) and low adhesion or high friction (μ > 1) and high adhesion. We hypothesize that as the solution becomes increasingly ethanol-rich the alkyl regions of ethanol more fully associate with the aliphatic regions of pHEMA, effectively coating the chains with a hydroxyl presenting surface, promoting hydrogen-bonding and the influx of water and leading to maximum in swelling and mesh size, leading to a dramatic reduction in friction and adhesion. We suggest that the tribological behaviors of amphiphilic Gemini gels reflect the presentation of hydrophobic and hydrophilic domains across the interfaces during sliding. These experiments explore the lubrication and solvophilic transitions in amphiphilic Gemini gels and suggest fundamental mechanisms and solution composition through which biotribological joints leverage lipid and protein-based complex fluids to achieve lubricity. © 2021 Elsevier Ltd

关键词： Ethanol Friction pHEMA

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Selective Catalytic Conversion of Acetylene to Ethylene Powered by Water and Visible Light

Research Square

引用

Research Square 2021年

作者： Arcudi, Francesca Ðorđević, Luka Schweitzer, Neil Stupp, Samuel I. Weiss, Emily A. Department of Chemistry Northwestern University EvanstonIL60208 United States Center for Bio-Inspired Energy Science Northwestern University ChicagoIL60208 United States Simpson Querrey Institute for BioNanotechnology Northwestern University ChicagoIL60611 United States Department of Chemical and Biological Engineering Northwestern University EvanstonIL60208 United States Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States Department of Biomedical Engineering Northwestern University EvanstonIL60208 United States Department of Medicine Northwestern University ChicagoIL60611 United States

The production of polymer-grade ethylene requires the purification of ethylene feed from acetylene contaminant. Accomplishing this task by state-of-the-art thermal hydrogenation requires high temperature, external feed of H2 gas, and noble metal catalysts, and is not only expensive and energy-intensive but also prone to overhydrogenate to ethane. We report a photocatalytic system to reduce acetylene to ethylene with >99% selectivity for ethylene under both non-competitive (no ethylene co-feed) and competitive (ethylene co-feed) conditions, and near 100% conversion under the latter industrially relevant condition. Our system uses a molecular catalyst based on earth-abundant cobalt operating under ambient conditions and sensitized by either [Ru(bpy)3]2+ or an inexpensive organic semiconductor (mpg-CN) under visible light. These features and the use of water as a proton source offer substantial advantages over current hydrogenation technologies with respect to selectivity and sustainability. © 2021, CC BY.

关键词： Hydrogenation

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Anisotropic phase-field modeling of crack growth in shape memory ceramics: Application to Zirconia

Anisotropic phase-field modeling of crack growth in shape me...

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ASME 2019 International Mechanical engineering Congress and Exposition, IMECE 2019

作者： Moshkelgosha, Ehsan Mamivand, Mahmood Boise State University Micron School of Materials Science and Engineering BoiseID83706 United States Boise State University Department of Mechanical and Biomedical Engineering BoiseID83706 United States

ISBN: (纸本)9780791859490

Shape memory ceramics (SMCs) are promising candidates for actuators in extreme environments such as high temperature and corrosive applications. Despite outstanding energy dissipation, compared to metallic shape memory materials, SMCs suffer from sudden brittle fracture. While the interaction of crack propagation and phase transformation in SMCs have been subject of several experimental and theoretical studies, mainly at macroscale, the fundamental understanding of the interaction of crack propagation dynamics with evolving martensitic transformation is poorly understood. In this work we use the phase field technique to fully couple the martensitic transformation to the variational formulation of brittle fracture. The model is parameterized for zirconia which experiences tetragonal to monoclinic transformation during crack propagation. For the mode I of fracture, opening mode, crack shows an unusual propagation path which indicates the effect of phase transformation on crack path. The model is efficiently capable of predicting the crack initiation as well as propagation. The results show the dramatic effect of phase transformation on fracture toughening and crack propagation path. Copyright © 2019 ASME.

关键词： Zirconia

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Atomic-Scale Dynamics of the Initial Stages of Cu and Cu Alloy Oxidation

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Microscopy and Microanalysis 2024年第SUPPLEMENT_1期30卷

作者： Yang, Judith C Li, Meng Zakharov, Dmitri N McEver, Jack Greene Qiao, Linna Qu, Xiaohui Lu, Deyu Curnan, Matthew T House, Stephen D Gleason, Samuel Ciston, Jim Zhou, Guangwen Saidi, Wissam A Chemical and Petroleum Engineering Department University of Pittsburgh Pittsburgh PA United States Physics and Astronomy Department University of Pittsburgh Pittsburgh PA United States Center for Functional Nanomaterials Brookhaven National Lab Upton NY United States Materials Science and Engineering Program & Department of Mechanical Engineering State University of New York at Binghamton Binghamton NY United States Chemical Engineering Department Pohang University of Science and Technology (POSTECH) Pohang Gyeongbuk Republic of Korea Center for Integrated Nanotechnologies Sandia National Laboratories Albuquerque NM United States Chemistry Department University of California Berkeley CA United States National Center for Electron Microscopy The Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA United States Mechanical Engineering and Materials Science Department University of Pittsburgh Pittsburgh PA United States National Energy Technology Laboratory Pittsburgh PA United States

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The Cooperative Effects of the Rh-M Dual-Metal Atomic Pairs in Formic Acid Oxidation

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Angewandte Chemie 2025年

作者： Runze Ma Jin Zhang Jiaxin Gong Yunxiang Lin Jialin Zhang Zheng-Qing Huang Chun-Ran Chang Shoujie Liu Wei Zhu Yuxin Wang Ke Zeng Yu Tao Jinhua Hu Zedong Zhang Xiao Liang Yunhu Han Junjie Mao Zechao Zhuang Jun Yan Dingsheng Wang Yu Xiong Department of Chemistry and Chemical Engineering Central South University Changsha 410083 P.R. China Beijing Key Laboratory of Bioinspired Materials and Devices & School of Energy and Power Engineering Beihang University Beijing 100191 P.R. China Institutes of Physical Science and Information Technology School of Materials Science and Engineering Anhui Key Laboratory of Information Materials and Device Key Laboratory of Structure and Functional Regulation of Hybrid Materials Anhui University Hefei Anhui 230601 P.R. China Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and Technology Xi'an Jiaotong University Xi'an 710049 P.R. China State Key Lab of Organic–Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P.R. China Department of Chemistry Tsinghua University Beijing 100029 P.R. China Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University Xi'an 710072 P.R. China Key Laboratory of Functional Molecular Solids Ministry of Education College of Chemistry and Materials Science Anhui Normal University Wuhu 241002 P.R. China

The continuously increasing mass activity of precious metal in formic acid oxidation reaction (FAOR) is the key to achieving the practical application of direct formic acid fuel cells (DFAFCs). Herein, Rh-based dual-metal atomic pairs supported on nitrogen-doped carbon catalysts [DAP-(M, Rh)/CN] with adjacent interatomic Rh-M (M = V, Cr, Mn, Fe, Co, Ni, Cu) have been synthesized by a “host-guest” strategy. It is discovered that DAP-(Cr, Rh)/CN shows the highest mass activity of 64.1 A mg −1 , which is 3.8 times higher than that of the single atom Rh catalyst (17.0 A mg −1 ) and two orders of magnitude higher than Pd/C (0.58 A mg −1 ). Interestingly, the mass activity of DAP-(M, Rh)/CN first increases from 11.7 A mg −1 (Rh-V) to 64.1 A mg −1 (Rh-Cr) and then decreases to 21.8 A mg −1 (Rh-Cu), forming a volcano curve of the reaction activity. Density functional theory calculations combined with in situ Fourier transform infrared spectrometer (FTIR) spectra reveal that formic acid oxidized on a series of DAP-(M, Rh)/CN catalysts through the formate route with the subsidiary M metal atoms binding the HCOO species and the Rh atom accepting the H atoms. The most suitable adsorption strength of HCOO on the Cr sites luckily contributes to two spontaneous elementary steps and thus accelerates the FAOR rates.

关键词： Dual-metal atomic pairs Formic acid oxidation Synergistic effect Synthetic strategy

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A robust emulsion gel based on κ-carrageenan and dialdehyde starch for stimuli-responsive of hydrophobic bioactive agents

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International journal of biological macromolecules 2025年 318卷

作者： Mohammad Mahdi Rostamabadi Seid Reza Falsafi Maryam Shafieiuon Zahra Abbasi Mahtab Falahati Zahra Mohebi Fariborz Tavangarian M H Enayati Hadis Rostamabadi Department of Food Science and Technology College of Agriculture Isfahan University of Technology Isfahan 84156-83111 Iran Mechanical Engineering Program School of Science Engineering and Technology Penn State Harrisburg Middletown PA 17057 USA. Food Science and Technology Division Agricultural Engineering Research Department Safiabad Agricultural and Natural Resources Research and Education Center (AREEO) Dezful Iran. Department of Materials Engineering Isfahan University of Technology Isfahan 84156-83111 Iran. Department of Food Science and Technology School of Nutrition and Food Science Nutrition and Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran. Department of Food Science and Technology School of Nutrition and Food Science Nutrition and Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran. Electronic address: rostamabadi@nutr.mui.ac.ir.

In this study, a green and sustainable emulsion gel was developed using κ-carrageenan (κC) and dialdehyde starch (DS) for the stimuli-responsive delivery of the hydrophobic bioactive agent, curcumin (CU). Initially, CU was encapsulated within κC-based emulsion gels, with κC serving as a natural stabilizing and gel-forming agent. Subsequently, DS, containing reactive aldehyde groups (AGs), was introduced to chemically cross-link with the hydroxyl groups of κC via a hemiacetal reaction, resulting in a porous and stable emulsion gel structure (κCDS@CU). The presence of DS enhanced the structural integrity of the gels and facilitated safe passage through simulated intestinal conditions. The engineered κCDS@CU emulsion gels demonstrated improved textural properties, high encapsulation efficiency, and sustained release behavior. Moreover, cytotoxicity assessments confirmed their biocompatibility, supporting their suitability for oral delivery. This rationally designed, biopolymer-based emulsion gel offers a promising platform for the effective encapsulation and targeted delivery of hydrophobic bioactive compounds.

关键词： Dialdehyde starch Emulsion gel Hydrophobic bioactive agents Κ-Carrageenan

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Enhancing plasticity in high-entropy refractory ceramics via tailoring valence electron concentration

arXiv

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arXiv 2021年

作者： Sangiovanni, Davide Giuseppe Mellor, William Harrington, Tyler Kaufmann, Kevin Vecchio, Kenneth Linköping University LinköpingSE-581 83 Sweden Department of NanoEngineering UC San Diego San DiegoCA92093 United States Materials Science and Engineering Program UC San Diego San DiegoCA92093 United States

Bottom-up design of high-entropy ceramics is a promising approach for realizing materials with unique combination of high hardness and fracture-resistance at elevated temperature. This work offers a simple yet fundamental design criterion - valence electron concentration (VEC) ⪆ 9.5 e-/f.u. to populate bonding metallic states at the Fermi level - for selecting elemental compositions that may form rocksalt-structure (B1) high-entropy ceramics with enhanced plasticity (reduced brittleness). Single-phase B1 (HfTaTiWZr)C and (MoNbTaVW)C, chosen as representative systems due to their specific VEC values, are here synthesized and tested. Nanoindentation arrays at various loads and depths statistically show that (HfTaTiWZr)C (VEC=8.6 e-/f.u.) is hard but brittle, whilst (MoNbTaVW)C (VEC=9.4 e-/f.u.) is hard and considerably more resistant to fracture than (HfTaTiWZr)C. Ab initio molecular dynamics simulations and electronic-structure analysis reveal that the improved fracture-resistance of (MoNbTaVW)C subject to tensile and shear deformation may originate from the intrinsic material's ability to undergo local lattice transformations beyond tensile yield points, as well as from relatively facile activation of lattice slip. Additional simulations, carried out to follow the evolution in mechanical properties as a function of temperature, suggest that (MoNbTaVW)C may retain good resistance to fracture up to ≈900-1200K, whereas (HfTaTiWZr)C is predicted to remain brittle at all investigated temperatures. © 2021, CC BY.

关键词： Fracture toughness

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