检索结果-内蒙古大学图书馆

Safe transportation and targeted destruction:Albumin encapsulated aggregation-induced emission photosensitizer nanoaggregate for tumor photodynamic therapy through mitochondria damage-triggered pyroptosis

Aggregate

引用

Aggregate 2024年第6期5卷 379-391页

作者： Juanmei Cao Yong Qu Shaojie Zhu Jinshan Zhan Yiting Xu Yifan Jin Yuqing Wang Zhuoxia Li Chuxing Chai Xiangwei Wu Meng Gao Changzheng Huang Min Li Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina National Engineering Research Center for Tissue Restoration and Reconstruction Key Laboratory of Biomedical Engineering of Guangdong ProvinceKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationInnovation Center for Tissue Restoration and ReconstructionSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhouChina Central Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases Key Laboratory of Xinjiang Endemic and Ethnic DiseasesDepartment of Hepatobiliary SurgeryThe First Affiliated Hospital of Shihezi UniversityShihezi University School of MedicineShiheziChina Department of Dermatology The First Affiliated Hospital of Shihezi UniversityShiheziChina

Photodynamic therapy is a highly recommended alternative treatment for solid tumors,such as cutaneous or luminal tumors,in clinical ***,conventional photosensitizers(PSs)often induce undesirable phototoxic effects because of their normal tissue distribution and a reduction in antitumor effects resulting from aggregation-caused quenching *** present study developed a novel nanoformulated aggregation-induced emission(AIE)-characteristic PS,nab-TTVPHE,which is composed of human serum albumin as a carrier and TTVPHE as a therapeutic agent,as a more effective cancer treatment with lower phototoxic ***,the reactive oxygen species generated by TTVPHE were shielded by the nanoaggregate structure,and the photodynamic activity was after nanostructure ***-TTVPHE was actively internalized in tumor cells via secreted protein,acidic and rich in cysteine and released to form *** accumulated in mitochondria,where it triggered mitochondrial damage under light irradiation via its photodynamic activity and induced pyroptosis via the caspase-3/gasdermin E(GSDME)signaling pathway to kill tumor ***,this nano-formulated AIE-characteristic PS provides an innovative strategy for cancer treatment with lower phototoxic effect and the ability to boost potential antitumor immunity via GSDME-mediated pyroptosis.

关键词： aggregation-induced emission gasdermin E mitochondria damage nanoparticle albumin-bound photodynamic therapy pyroptosis

来源：评论

学校读者我要写书评

暂无评论

Multi-Objective Evolutionary Algorithm based on NSGA-II for Neural Network Optimization Application to the Prediction of Severe Diseases

引用

Informatica (Slovenia) 2023年第10期47卷 27-40页

作者： Sekkal, Mansouria Benzina, Amina Benkrelifa, Lahouaria Badir Electronics and Telecommunications Department Faculty of Science and Technology University of Ain Temouchent Ain Temouchent Algeria Biomedical Engineering Laboratory Tlemcen University Tlemcen Algeria Applied Materials Laboratory Djillali Liabes University Sidi Bel Abbes Algeria

Neural networks have become essential classifiers in various domains, including medicine. The choice of topology, internal structure, and learning algorithm characterizes the type of neural network, resulting in incredible diversity among these networks. Until now, the most challenging problem to solve for classifiers in a neural network has been finding an optimal balance among three selected facets: architecture, synaptic weight, and input variables. To address this problem, we propose a multi-objective neuro-genetic system that simultaneously optimizes these three facets. To demonstrate the effectiveness of our approach, we have implemented and compared two types of classifiers - the classical neural classifier and the multi-objective neuro-genetic classifier - using several medical databases. The results obtained showcase the efficiency of our method, with correct classification rates of up to 100%, which is a very promising outcome. The comparison between the two approaches employed demonstrates the effectiveness of the multi-objective genetic approach. © 2023 Slovene Society Informatika. All rights reserved.

关键词： Genetic algorithms

来源：评论

学校读者我要写书评

暂无评论

Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer

引用

Bioactive materials 2023年第7期25卷 360-373页

作者： Menekse Ermis Natashya Falcone Natan Roberto de Barros Marvin Mecwan Reihaneh Haghniaz Auveen Choroomi Mahsa Monirizad Yeji Lee Jihyeon Song Hyun-Jong Cho Yangzhi Zhu Heemin Kang Mehmet R.Dokmeci Ali Khademhosseini Junmin Lee Han-Jun Kim Terasaki Institute for Biomedical Innovation(TIBI) Los AngelesCA90024USA Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)PohangGyeongbuk37673Republic of Korea College of Pharmacy Kangwon National UniversityChuncheonGangwon24341Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversityIncheon 21983Republic of Korea College of Pharmacy Korea UniversitySejong30019Republic of Korea

The tumor microenvironment consists of diverse,complex etiological *** matrix component of pancreatic ductal adenocarcinoma(PDAC)plays an important role not only in physical properties such as tissue rigidity but also in cancer progression and therapeutic *** significant efforts have been made to model desmoplastic PDAC,existing models could not fully recapitulate the etiology to mimic and understand the progression of ***,two major components in desmoplastic pancreatic matrices,hyaluronic acid-and gelatin-based hydrogels,are engineered to provide matrices for tumor spheroids composed of PDAC and cancer-associated fibroblasts(CAF).Shape analysis profiles reveals that incorporating CAF contributes to a more compact tissue *** expression levels of markers associated with proliferation,epithelial to mesenchymal transition,mechanotransduction,and progression are observed for cancer-CAF spheroids cultured in hyper desmoplastic matrix-mimicking hydrogels,while the trend can be observed when those are cultured in desmoplastic matrix-mimicking hydrogels with the presence of transforming growth factor-β1(TGF-β1).The proposed multicellular pancreatic tumor model,in combination with proper mechanical properties and TGF-β1 supplement,makes strides in developing advanced pancreatic models for resembling and monitoring the progression of pancreatic tumors,which could be potentially applicable for realizing personalized medicine and drug testing applications.

关键词： Pancreatic cancer Desmoplasia Fibrosis Extracellular matrix Tumor microenvironment

来源：评论

学校读者我要写书评

暂无评论

Spectral Learning of Shared Dynamics Between Generalized-Linear Processes 38

Spectral Learning of Shared Dynamics Between Generalized-Lin...

引用

38th Conference on Neural Information Processing Systems, NeurIPS 2024

作者： Oganesian, Lucine L. Sani, Omid G. Shanechi, Maryam M. Ming Hsieh Department of Electrical and Computer Engineering University of Southern California Los AngelesCA United States Ming Hsieh Department of Electrical and Computer Engineering Thomas Lord Department of Computer Science Alfred E. Mann Department of Biomedical Engineering Neuroscience Graduate Program University of Southern California Los AngelesCA United States

Generalized-linear dynamical models (GLDMs) remain a widely-used framework within neuroscience for modeling time-series data, such as neural spiking activity or categorical decision outcomes. Whereas the standard usage of GLDMs is to model a single data source, certain applications require jointly modeling two generalized-linear time-series sources while also dissociating their shared and private dynamics. Most existing GLDM variants and their associated learning algorithms do not support this capability. Here we address this challenge by developing a multi-step analytical subspace identification algorithm for learning a GLDM that explicitly models shared vs. private dynamics within two generalized-linear time-series. In simulations, we demonstrate our algorithm's ability to dissociate and model the dynamics within two time-series sources while being agnostic to their respective observation distributions. In neural data, we consider two specific applications of our algorithm for modeling discrete population spiking activity with respect to a secondary time-series. In both synthetic and real data, GLDMs learned with our algorithm more accurately decoded one time-series from the other using lower-dimensional latent states, as compared to models identified using existing GLDM learning algorithms. © 2024 Neural information processing systems foundation. All rights reserved.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Near infrared light-induced dynamic modulation of enzymatic activity through polyphenol-functionalized liquid metal nanodroplets

引用

Chinese Chemical Letters 2023年第2期34卷 475-480页

作者： Chaojun Zhang Yang Tang Qin Wang Yunxiang He Xiaoling Wang Sebastian Beyer Junling Guo BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China School of Pharmacy Southwest Minzu UniversityChengdu 610225China National Engineering Research Center of Clean Technology in Leather Industry Sichuan UniversityChengdu 610065China Department of Biomedical Engineering Chinese University of Hong KongHong Kong 999077China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China Bioproducts Institute Department of Chemical and Biological EngineeringUniversity of British ColumbiaVancouverBC V6T 1Z4Canada

Dynamic manipulation of enzymatic activity is a challenging task for applications in chemical and pharmaceutical industries due to the difficult modification and variable conformation of various ***, we report a new strategy for reversible dynamic modulation of enzymatic activity by near-infrared light-induced photothermal conversion based on polyphenol-functionalized liquid metal nanodroplets(LM). The metal-phenolic nanocoating not only provides colloidal stability of LM nanodroplets but also generates nanointerfaces for the assembly of various enzymes on the LM nanodroplets. Upon near infrared(NIR) irradiation, the localized microenvironmental heating through photothermal effect of the LM nanodroplets allows tailoring the enzymatic activity without affecting the bulk temperature. A library of functional enzymes, including proteinase K, glucoamylase, glucose oxidase, and Bst DNA polymerase, is integrated to perform a reversible control and enhanced activities even after five times of cycles, demonstrating great potential in bacterial fermentation, bacteriostasis, and target gene amplification.

关键词： Enzymatic activity Photo-modulation Near infrared light Liquid metal nanodroplets Metal-phenolic nanocoating

来源：评论

学校读者我要写书评

暂无评论

An Anti-Plasma Etching Film of Y2O3 Film 10

An Anti-Plasma Etching Film of Y2O3 Film

引用

10th International Conference on Applied System Innovation, ICASI 2024

作者： Wei, Chia-Chih Chen, Hsuan-Jung Lee, Yi-Mu Chang, Shao-Fu Chen, Chien-Chon College of Engineering and Science Ph.D. Program in Materials and Chemical Engineering National United University Miaoli Taiwan Michigan State University Department of Chemistry MI48824 United States National United University Department of Electronic Miaoli Taiwan National United University Department of Energy Engineering Miaoli Taiwan

ISBN: (纸本)9798350394924

In this paper, we have presented our experiment results including (a) use a slowly thermal spray process deposition an yttrium oxide (Y2O3) film with thickness of $200\ \mu\mathrm{m}$ on the aluminum alloy (AA6061). The image analysis showed that the porosity of Y2O3 film can be reduced to less than 2%. The further aerosol deposition can be used filling the pores and can reduce the porosity of the film to less than 0.5%. This low-porosity Y2O3 film will be able to meet the increasingly stringent requirements for surface coating protection of semiconductor vacuum chamber. (b) Compared the corrosion characterization in 3.5 wt. % NaCl solution between naked AA6061 and AA6061 with Y2O3 coating, a high corrosion reactivity ($\mathrm{I}_{\text{corr}}=10^{-3.3}\mathrm{A}/\text{cm}^{2}$) of naked AA6061 then AA6061 with Y2O3 coating ($\mathrm{I}_{\text{corr}}=10^{-5.8}\mathrm{A}/\text{cm}^{2}$). The corrosion reactivity of AA6061 with Y2O3 is reduced by 316 times to a naked AA6061. © 2024 IEEE.

关键词： Porosity

来源：评论

学校读者我要写书评

暂无评论

Multimodal bioelectronics: A pathway to digital health management

引用

Matter 2025年第5期8卷

作者： Gu, Mengxi Guo, Chuan Fei Song, Yu Department of Biomedical Engineering City University of Hong Kong Hong Kong China Department of Materials Science and Engineering Southern University of Science and Technology Guangdong Shenzhen518055 China

Recent advancements in multimodal bioelectronics have demonstrated remarkable promise in transforming digital health. In contrast to conventional hospital-based healthcare systems, multimodal bioelectronics facilitates flexible and continuous physiological monitoring, offering the potential for accurate diagnosis and personalized therapeutics. In this review, we summarize and highlight the latest progress in multimodal bioelectronics and their practical applications. We first introduce emerging material selections and interface design strategies for conformal contact with the human body. Then, we discuss the principles of energy management and the workflow of integrated platforms, especially introducing algorithm utilization for real-time data acquisition, processing, and transmission. Additionally, we focus on the categorized practical applications of multimodal bioelectronics in digital health by emphasizing their role in the healthcare of specific populations, as well as in the diagnosis and monitoring of common diseases. Finally, we provide an outlook to address the challenges and the trends of multimodal bioelectronics toward digital health management. © 2025 Elsevier Inc.

关键词： Electronic health record

来源：评论

学校读者我要写书评

暂无评论

Design and manufacturing of soft electronics for in situ biochemical sensing

引用

International Journal of Extreme Manufacturing 2024年第6期6卷 137-167页

作者： Yi Xing Jiaqi Wang Jinxing Li Department of Biomedical Engineering Institute for Quantitative Health Science&EngineeringMichigan State UniversityEast LansingMI 48824United States of America Department of Chemical Engineering and Materials Science Michigan State UniversityEast LansingMI 48824United States of America Department of Electrical and Computer Engineering Michigan State UniversityEast LansingMI 48824United States of America

Soft(flexible and stretchable) biosensors have great potential in real-time and continuous health monitoring of various physiological factors, mainly due to their better conformability to soft human tissues and organs, which maximizes data fidelity and minimizes biological *** of the early soft sensors focused on sensing physical signals. Recently, it is becoming a trend that novel soft sensors are developed to sense and monitor biochemical signals in situ in real biological environments, thus providing much more meaningful data for studying fundamental biology and diagnosing diverse health conditions. This is essential to decentralize the healthcare resources towards predictive medicine and better disease management. To meet the requirements of mechanical softness and complex biosensing, unconventional materials, and manufacturing process are demanded in developing biosensors. In this review, we summarize the fundamental approaches and the latest and representative design and fabrication to engineer soft electronics(flexible and stretchable) for wearable and implantable biochemical sensing. We will review the rational design and ingenious integration of stretchable materials, structures, and signal transducers in different application scenarios to fabricate high-performance soft biosensors. Focus is also given to how these novel biosensors can be integrated into diverse important physiological environments and scenarios in situ, such as sweat analysis, wound monitoring, and neurochemical sensing. We also rethink and discuss the current limitations,challenges, and prospects of soft biosensors. This review holds significant importance for researchers and engineers, as it assists in comprehending the overarching trends and pivotal issues within the realm of designing and manufacturing soft electronics for biochemical sensing.

关键词： soft materials processing and fabrication biochemical sensing electrode fabrication transducer integration

来源：评论

学校读者我要写书评

暂无评论

Conductive hydrogels with photothermal effects: material design,mechanisms, and multifunctional applications

引用

science China Chemistry 2025年

作者： Mengchao Wang Ruizhuo Ouyang Yuqin Jiang Zhengang Liu Xun Zhou Yulong Shi Cheng He Liangliang Zhu Bingbing Yue School of Materials and Chemistry & Institute of Bismuth and Rhenium University of Shanghai for Science and Technology Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and Reactions Ministry of Education Henan Engineering Research Centre of Chiral Hydroxyl Pharmaceutical Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials School of Chemistry and Chemical Engineering Henan Normal University State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University

Conductive hydrogels with near-infrared(NIR) photothermal effects are a promising class of smart materials. They integrate the unique properties of hydrogels—such as flexibility and biocompatibility—with enhanced electrical conductivity and photothermal responsiveness. These materials use NIR light to induce localized heating through photothermal conversion, enabling precise control over physicochemical properties, including conductivity, mechanical strength, and antibacterial activity. However, comprehensive reviews in this field are limited. This article systematically classifies photothermal materials into four categories: conjugated polymers, carbon-based nanomaterials, inorganic nanomaterials, and metal-phenolic networks, and explains their mechanisms. We highlight recent advancements in applications such as smart wound dressings, soft actuators, and responsive sensors, while addressing challenges like optimizing photothermal efficiency, balancing biocompatibility with conductivity, and scaling up production. By providing a comprehensive analysis of material design strategies and applicationspecific innovations, this review aims to guide future research toward next-generation multifunctional hydrogels for advanced biomedical and technological applications.

关键词：

来源：评论

学校读者我要写书评

暂无评论

生物来源的类玻璃弹性体助力完全可持续性的摩擦纳米发电机

引用

science China materials 2023年第3期66卷 1089-1096页

作者：陈硕郭一凡孙利杰孙巍 Rasoul Esmaeely Neisiany 陈玮昱管清宝游正伟 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Institute of Functional MaterialsCollege of Materials Science and EngineeringResearch Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society)Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineDonghua UniversityShanghai 201620China Department of Materials and Polymer Engineering Faculty of EngineeringHakim Sabzevari UniversitySabzevar ***Iran

具有生物来源、“绿色”制备、稳定的力学和电学性能、可循环利用、可降解的摩擦纳米发电机在绿色能源收集和可穿戴器件应用中意义重大,但是其制备仍存在挑战.据此,本工作发展了具有优异的弹性、生物降解性和可循环性的生物基类玻璃弹... 详细信息

具有生物来源、“绿色”制备、稳定的力学和电学性能、可循环利用、可降解的摩擦纳米发电机在绿色能源收集和可穿戴器件应用中意义重大,但是其制备仍存在挑战.据此,本工作发展了具有优异的弹性、生物降解性和可循环性的生物基类玻璃弹性体来应对上述挑战.我们以弹性体和碳纳米管为原料通过盐粒辅助的3D打印技术制备了具有多级孔结构的摩擦纳米发电机.该摩擦纳米发电机表现出优异的力学和电能输出性能,并能够通过光致加工手段实现回收再利用;而废弃的摩擦纳米发电机也能够通过弹性体的降解和碳纳米管的回收,有效节约资源和减少污染.本工作为完全可持续性摩擦纳米发电机提供了一个新的范例,对可持续性电子器件的发展具有一定的启发意义.

关键词：摩擦纳米发电机多级孔结构可循环利用回收再利用生物降解性可持续性弹性体可穿戴器件

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：