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Tissue clearing and its applications in neuroscience (vol 21, pg 61, 2020)

NATURE REVIEWS NEUROscience 2020年第5期21卷 298-298页

作者： Ueda, Hiroki R. Ertuerk, Ali Chung, Kwanghun Gradinaru, Viviana Chedotal, Alain Tomancak, Pavel Keller, Philipp J. Department of Systems Pharmacology University of Tokyo Tokyo Japan Laboratory for Synthetic Biology RIKEN BDR Suita Japan Institute for Stroke and Dementia Research Klinikum der Universität München Ludwig-Maximilian University of Munich Munich Germany Institute of Tissue Engineering and Regenerative Medicine Helmholtz Zentrum München Neuherberg Germany Munich Cluster for Systems Neurology (SyNergy) Munich Germany Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA USA Picower Institute for Learning and Memory Massachusetts Institute of Technology Cambridge MA USA Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA USA Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA USA Eli & Edythe Broad Institute of MIT and Harvard Cambridge MA USA Center for NanoMedicine Institute for Basic Science Seoul Republic of Korea Graduate Program of Nano Biomedical Engineering Yonsei-IBS Institute Yonsei University Seoul Republic of Korea Division of Biology and Biological Engineering California Institute of Technology Pasadena CA USA Institut de la Vision Sorbonne Université INSERM CNRS Paris France Max Planck Institute of Molecular Cell Biology and Genetics Dresden Germany IT4Innovations Technical University of Ostrava Ostrava Czech Republic Janelia Research Campus Howard Hughes Medical Institute Ashburn VA USA

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

关键词： Immunological techniques Light-sheet microscopy Neuroscience

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Curvy surface conformal ultra-thin transfer printed Sioptoelectronic penetrating microprobe arrays

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npj Flexible Electronics 2018年第1期2卷 8-13页

作者： Kyoseung Sim Zhoulyu Rao Yanbin Li Dong Yang Cunjiang Yu Materials Science and Engineering Program University of HoustonHoustonTX 77204USA Department of Mechanical Engineering University of HoustonHoustonTX 77204USA Department of Electrical and Computer Engineering University of HoustonHoustonTX 77204USA Department of Biomedical Engineering University of HoustonHoustonTX 77204USA

Penetrating neural probe arrays are powerful bio-integrated devices for studying basic neuroscience and applied neurophysiology,underlying neurological disorders,and understanding and regulating animal and human *** paper presents a penetrating microprobe array constructed in thin and flexible fashion,which can be seamlessly integrated with the soft curvy *** function of the microprobes is enabled by transfer printed ultra-thin Si *** a proof-of-concept device,microprobe array with Si photodetector arrays are demonstrated and their capability of mapping the photo intensity in space are *** design strategies of utilizing thin polyimide based microprobes and supporting substrate,and employing the heterogeneously integrated thin optoelectronics are keys to accomplish such a *** experimental and theoretical investigations illustrate the materials,manufacturing,mechanical and optoelectronic aspects of the *** this paper primarily focuses on the device platform development,the associated materials,manufacturing technologies,and device design strategy are applicable to more complex and multi-functionalities in penetrating probe array-based neural interfaces and can also find potential utilities in a wide range of bio-integrated systems.

关键词： optoelectronic arrays transfer

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Psychometric Evaluation of Multi-Point Bone-Conducted Tactile Stimulation on the Three Bony Landmarks of the Elbow

Psychometric Evaluation of Multi-Point Bone-Conducted Tactil...

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IEEE/RAS-EMBS International Conference on biomedical Robotics and Biomechatronics (BioRob)

作者： Raphael M. Mayer Alireza Mohammadi Ying Tan Gursel Alici Peter Choong Denny Oetomo Human Robotics Laboratory The University of Melbourne Australia School of Mechanical Materials Mechatronic and Biomedical Engineering University of Wollongong Australia ARC Centre of Excellence for Electromaterials Science Department of Surgery The University of Melbourne Australia

ISBN: (数字)9781728159072

ISBN: (纸本)9781728159089

Sensory feedback is highly desirable in upper limb prostheses as well as in human robot interaction and other human machine interfaces. Bone conduction as sensory feedback interface is a recently studied approach showing promising properties. A combination of different feedback information is often necessary for prosthetic grasping, thus multiple feedback channels are required for effective sensory feedback. The use of multiple bone conduction stimulation sites simultaneously has not yet been studied. In this paper, the psychometric evaluation of multiple stimulation sites on the physiologically given bony landmarks on the elbow is investigated. The proposed approach is evaluated on human-subject experiments with six able-bodied subjects and one subject with transradial amputation. Vibrotactile transducers are placed on the bony landmarks of the elbow to determine the identification rate of each stimulation point separately as well as the identification rate of the number of active stimulation points for different frequencies. The outcomes show high identification rates for a frequency range from 100 to 750 Hz whilst performance deteriorates to at chance level at higher frequencies. A decreasing performance in identifying the number of active stimulation sites for an increasing number of simultaneous active transducers was observed. The obtained good performance in location identification suggests that information can be encoded via the location of the stimulation.

关键词： Bones Transducers Robot sensing systems Elbow Prosthetics Skin Force

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Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device (Dec, 10.1038/s41551-020-00654-0, 2020)

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NATURE biomedical engineering 2021年第1期5卷 125-125页

作者： Cheong, Jiyong Yu, Hojeong Lee, Chang Yeol Lee, Jung-uk Choi, Hyun-Jung Lee, Jae-Hyun Lee, Hakho Cheon, Jinwoo Center for Nanomedicine Institute for Basic Science (IBS) Seoul Republic of Korea Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul Republic of Korea Center for Systems Biology Massachusetts General Hospital Research Institute Boston MA USA Department of Radiology Massachusetts General Hospital Harvard Medical School Boston MA USA Department of Chemistry Yonsei University Seoul Republic of Korea Department of Laboratory Medicine Chonnam National University Hospital Chonnam National University Medical School Gwangju Republic of Korea

In the version of this Article originally published, in Fig. 3f, in the first and third schematics of the synchronized Ferris wheel system shown in the bottom row, the labels of the samples were incorrect as ‘1’ and ‘3’;in the first schematic these should have been ‘3’ and ‘2’, and in the third ‘2’ and ‘1’. The original and corrected Fig. 3f is shown below. All versions of the Article have been amended. (Figure presented.). © 2020, The Author(s), under exclusive licence to Springer Nature Limited.

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Corrigendum to’Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering’[Bioactive ***.6,Issue 7,Pages 2039-2057]

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Bioactive materials 2021年第10期6卷 3192-3193页

作者： Yong Tang Keyu Luo Yin Chen Yueqi Chen Rui Zhou Can Chen Jiulin Tan Moyuan Deng Qijie Dai Xueke Yu Jian Liu Chengmin Zhang Wenjie Wu Jianzhong Xu Shiwu Dong Fei Luo National & Regional United Engineering Lab of Tissue Engineering Department of Orthopedics Southwest Hospital Third Military Medical University Chongqing China State Key Laboratory of Trauma Burns and Combined Injury Institute of Combined Injury Chongqing Engineering Research Center for Nanomedicine College of Preventive Medicine Third Military Medical University Chongqing China Department of Orthopaedics 72nd Group Army Hospital Huzhou University Huzhou Zhejiang China Department of Spine Surgery Center for Orthopedics Daping Hospital Third Military Medical University Chongqing China Department of Biomedical Materials Science Third Military Medical University Chongqing China Jianzhong Xu Shiwu Dong and Fei Luo contributed equally to this work and should be considered as Corresponding authors.

Yong Tang a,d,e,2,Keyu Luo a,c,2,Yin Chen d,2,Yueqi Chen a,b,Rui Zhou a,Can Chen a,Jiulin Tan a,Moyuan Deng a,Qijie Dai a,Xueke Yu a,Jian Liu a,Chengmin Zhang a,Wenjie Wu a,Jianzhong Xu a,**,1,Shiwu Dong a,b,***,1,Fei Luo a,*,1 a National&Regional United engineering Lab of Tissue engineering,department of Orthopedics,Southwest Hospital,Third Military Medical University,Chongqing,China b department of biomedical materials science,Third Military Medical University,Chongqing,China c department of Spine Surgery,Center for Orthopedics,Daping Hospital,Third Military Medical University,Chongqing,China d State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Combined Injury,Chongqing engineering Research Center for Nanomedicine,College of Preventive Medicine,Third Military Medical University,Chongqing,China e department of Orthopaedics,72nd Group Army Hospital,Huzhou University,Huzhou,Zhejiang,China The authors regret that the published version of the above article contained several errors which were not identified during the proofing ***,figures 2D,3A and 5A have been *** authors apologize for these errors and state that these corrections do not change the scientific conclusions of the article in any ***.2.(D)High-resolution laser scanning confocal microscopy images of the cytoskeleton(red,phalloidin)and nuclei(blue,DAPI),showing MSCs cultured on identified scaffold struts for 1,4 and 7 *** bar,100μ***.3.(A)Transwell assays for the migration of MSCs using 152RM(n=5 each).Representative crystal violet staining images are shown in the left *** of cell migration is shown in the right *** bar,100μm.

关键词： correction figures replaced

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Semiconductor-metal ultrafast laser welding with relocated filaments 21

Semiconductor-metal ultrafast laser welding with relocated f...

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Frontiers in Ultrafast Optics: biomedical, Scientific, and Industrial Applications XXI 2021

作者： Chambonneau, Maxime Li, Qingfeng Fedorov, Vladimir Y. Blothe, Markus Tzortzakis, Stelios Nolte, Stefan Institute of Applied Physics Abbe Center of Photonics Friedrich Schiller University Jena Albert-Einstein-Straße 15 Jena07745 Germany Science Program Texas AandM University at Qatar P.O. Box 23874 Doha Qatar P. N. Lebedev Physical Institute of the Russian Academy of Sciences 53 Leninskiy Prospekt Moscow119991 Russia P.O. Box 1527 HeraklionGR-71110 Greece Materials Science and Technology Department University of Crete Heraklion71003 Greece Fraunhofer Institute for Applied Optics and Precision Engineering Iof Center of Excellence in Photonics Albert-Einstein-Straße 7 Jena07745 Germany

ISBN: (数字)9781510641884

ISBN: (纸本)9781510641877

Ultrafast laser welding is a fast, clean, and contactless technique for joining a broad range of materials. Nevertheless, this technique cannot be applied for bonding semiconductors and metals. By investigating the nonlinear propagation of picosecond laser pulses in silicon, it is elucidated how the evolution of filaments during propagation prevents the energy deposition at the semiconductor-metal interface. While the restrictions imposed by nonlinear propagation effects in semiconductors usually inhibit countless applications, the possibility to perform semiconductor-metal ultrafast laser welding is demonstrated. This technique relies on the determination and the precompensation of the nonlinear focal shift for relocating filaments and thus optimizing the energy deposition at the interface between the materials. The resulting welds show remarkable shear joining strengths (up to 2.2 MPa) compatible with applications in microelectronics. Material analyses shed light on the physical mechanisms involved during the interaction. © 2021 SPIE. All rights reserved.

关键词： Ultrafast lasers

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Transdermally administered nanozymes-infused F127/methylcellulose hydrogel for osteoarthritis relief via immunomodulatory pathways

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International Journal of Biological Macromolecules 2025年 314卷 144114页

作者： Chen, Chih-Kuang Chiu, Hui-Wen Nguyen, Hieu Trung Lu, Hsien-Tsung Chuang, Andrew E.-Y. Graduate Institute of Clinical Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan School of Medicine Chang Gung University Taoyuan Taiwan Department of Orthopedics and Trauma Faculty of Medicine University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh City700000 Viet Nam Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan International Ph.D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Department of Orthopedic Taipei Medical University Hospital Taipei City11031 Taiwan Cell Physiology and Molecular Image Research Center Taipei Medical University-Wan Fang Hospital Taipei11696 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University New Taipei City235603 Taiwan

Osteoarthritis (OA) is a debilitating condition characterized by chronic inflammation, oxidative stress, hypoxia, angiogenesis-driven pain, and cartilage degradation, thus presenting significant therapeutic challenges. Herein, we introduce a wearable percutaneous hydrogel (Pluronic F127/methylcellulose) encapsulation platform, designed to address the multifaceted pathology of OA through a synergistic integration of multifunctional components. This nanomedicine-hydrogel system incorporates platelet-derived extracellular vesicles (pEVs) for inflammation delivery, phototherapeutic molybdenum disulfide (MoS2), capsaicin (CAP) and diferuloylmethane (DIF) for potent anti-inflammatory and antioxidative effects and hydrogen-bonded organic frameworks (HOFs) to enhance drug encapsulation and conductivity. Experimental findings demonstrated the pEV/MoS2/DIF/CAP NZHOF@F127/MC's ability to mitigate inflammation by promoting macrophage polarization from the M1 to the M2 phenotype, alleviate oxidative stress, inhibit angiogenesis, and modulate hypoxic microenvironments through the percutaneous phototherapeutic pEV/MoS2/DIF/CAP NZ-HOF@F127/MC. In vivo studies in a rat model of OA revealed substantial reductions in joint inflammation, enhanced cartilage regeneration, and improved mobility following near-infrared (NIR)-triggered phototherapy. The pEV/MoS2/DIF/CAP NZ-HOF@F127/MC's multifaceted mechanisms, including precise drug delivery, controlled release, and on-demand photo-responsiveness, underscore its transformative potential for OA management. These findings present a promising therapeutic strategy for OA, addressing inflammation, oxidative stress, and joint lesion mitigation, with strong potential for clinical translation. © 2025 Elsevier B.V.

关键词： Controlled drug delivery

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Physical and chemical characterization of synthetic bone mineral ink - For additive manufacturing applications

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Annals of 3D Printed Medicine 2021年 3卷 100024-100024页

作者： Coelho, Paulo G. Eckstein, Daniel Rivera, Cristobal Nayak, Vasudev Vivekanand Smay, James E. Mijares, Dindo Tovar, Nick Witek, Lukasz Department of Biomaterials and Biomimetics New York University College of Dentistry New York NY United States Department of Mechanical and Aerospace Engineering New York University Tandon School of Engineering Brooklyn 11201 NY United States Hansjörg Wyss Department of Plastic Surgery New York University School of Medicine New York NY United States School of Materials Science and Engineering Oklahoma State University Tulsa OK United States Department of Oral and Maxillofacial Surgery NYU Langone Medical Center and Bellevue Hospital Center New York NY United States Department of Biomedical Engineering New York University Tandon School of Engineering Brooklyn NY United States

Bone defects are often linked to congenital disorders, high impact traumas, tumors or oncological resections. Potential treatment options include autografts, allografts, or synthetic grafts, such as bioactive ceramic-based materials which have been successfully utilized in an effort to regenerate bone. β-tricalcium phosphate (β-TCP), is a commonly utilized bioactive ceramic for regenerative purposes with favorable osteoconductive properties. Alternatively, Synthetic Bone Mineral (SBM) has been previously utilized in in vivo experiments as a supplement for bone loss treatment. As a potential alternative to β-TCP, it is also a bioactive ceramic, which consists of a carbonate hydroxyapatite with ionic substitutions such as F⁻, Zn²⁺ and Mg²⁺. The objective of this work was to characterize the physiochemical properties of the colloidal gel obtained from a formulation of SBM and compare the properties directly to β-TCP. Mechanical properties were evaluated for both materials in bulk, using Biaxial Flexural Strength tests. Scanning electron microscopy and micro-computed tomography were utilized to explore the structure of the bulk material and the three dimensionally (3D) printed scaffolds. Inductive coupled plasma (ICP), X-ray diffraction (XRD), and Fourier transform infrared spectrometry (FT-IR), were utilized to determine the calcium-phosphorous ratio (Ca:P), quantitative analysis of crystalline phases, and functional groups, respectively. Thermogravimetric analysis (TGA) was used to quantify the weight percent of water, organic components, carbonate and mineral in the SBM colloidal gel. Flexural strength of SBM discs sintered at 700°C were statistically analogous to β-TCP sintered at 900°C. The Ca:P ratio of the sintered SBM was found to be 1.47 ± 0.04, statistically different from β-TCP sintered at higher temperatures. The carbonate content of the SBM was determined to be ~2.8% ± 0.9. The novel SBM colloidal gel has hence been characte

关键词： 3D printing Bioceramics Bone Graft Material Chemical/Physical Characterization Synthetic Bone Mineral

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High-entropy boride-carbide two-phase ultrahigh temperature ceramics fabricated by reactive spark plasma sintering

arXiv

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arXiv 2020年

作者： Qin, Mingde Gild, Joshua Hu, Chongze Wang, Haoren Bin Hoque, Md Shafkat Braun, Jeffrey L. Harrington, Tyler J. Hopkins, Patrick E. Vecchio, Kenneth S. Luo, Jian Program of Materials Science and Engineering University of California San Diego La JollaCA92093 United States Department of NanoEngineering University of California San Diego La JollaCA92093 United States Department of Mechanical and Aerospace Engineering University of Virginia CharlottesvilleVA22904 United States Department of Materials Science and Engineering University of Virginia CharlottesvilleVA22904 United States Department of Physics University of Virginia CharlottesvilleVA22904 United States

A series of high-entropy boride-carbide two-phase ultrahigh temperature ceramics (UHTCs) are fabricated via a novel reactive spark plasma sintering (SPS) based route, each from five individual commercial powders, including N metal diborides and (5 − N) metal carbides, of equimolar amounts. Greater than ~99% of the theoretical densities have been achieved with virtually no native oxides. These two-phase UHTCs consist of a hexagonal high-entropy boride (HEB) phase and a cubic high-entropy carbide (HEC) phase, where a chemical equilibrium between the two phases that drive them away from equimolar compositions. A thermodynamic relation that governs the compositions of the HEB and HEC phases in equilibrium is discovered and a thermodynamic model is proposed. These two-phase high-entropy UHTCs exhibit tunable grain size (4.2-11.4 μm), Vickers’ microhardness (23-27 GPa), Young’s modulus (462-525 GPa), shear modulus (193-232 GPa), and thermal conductivity (13.2-26.2 Wm-1K-1). A new observation is that the high-entropy two-phase UHTCs have higher hardness than the weighted linear average of the two single-phase HEB and HEC, which are already harder than the rule-of-mixture (RoM) averages of individual UHTCs. Several intriguing observations about the moduli are revealed with accurate acoustic waves measurements. On the one hand, the Young’s moduli of high-entropy two-phase UHTCs are always higher than the theoretical RoM averages. On the other hand, the shear modulus of HEC is higher, but that of HEB is lower, than the theoretical RoM average. The latter unexpected observation is explained by the unique layered structure of the HEB, where an expansion in lattice parameter c is confirmed by X-ray diffraction. This study extends the state of the art by introducing two-phase high-entropy ceramics, which provide a new platform to tailor various properties via changing the phase fraction and microstructure. Copyright © 2020, The Authors. All rights reserved.

关键词： Entropy

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Muscle microenvironment-regulated phase transition and microstructure of injectable conductive hydrogel for injured muscle regeneration

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Chemical engineering Journal 2025年

作者： Tae Min Kim Junyoung Park Kaustuv Roy Hak Soo Choi Kang Moo Huh Eun-Jung Jin Sung Young Park Department of IT and Energy Convergence Korea National University of Transportation Chungju 27469 Republic of Korea Department of Biological Sciences College of Health Sciences Wonkwang University Iksan Jeonbuk 54538 Republic of Korea Gordon Center for Medical Imaging Department of Radiology Massachusetts General Hospital and Harvard Medical School 55 Fruit Street Boston MA 02114 United States of America Department of Polymer Science and Engineering Chungnam National University Daejeon 34134 Republic of Korea Department of Biomedical Materials Science Graduate School of JABA Wonkwang University Iksan Jeonbuk 54538 Republic of Korea Department of Chemical and Biological Engineering Korea National University of Transportation Chungju 27469 Republic of Korea

Volumetric muscle loss, a condition characterized by loss of skeletal muscles, is driven by elevated reactive oxygen species (ROS) resulting from muscle injury. Therefore, the ability of an injectable hydrogel to undergo irreversible phase change {Sol (4 °C)-[Gel (37 °C, before ROS treatment)-Gel (37 °C, after ROS treatment)]-Gel (4 °C)} against reversible phase transition {Sol (4 °C)-[Gel (37 °C)-Gel (37 °C)]-Sol (4 °C)} in normal condition alongside injured muscle microenvironment triggered ROS scavenging ability is an important aspect for regeneration and monitoring of injured muscles. Herein, we developed an injured muscle microenvironment-activated irreversible phase-change injectable conductive hydrogel (MnO₂@PD-HGC), incorporated with ROS-sensitive nanoparticles (MnO 2 @PD). The injured muscle microenvironment-responsive MnO₂@PD-HGC hydrogel influences the promotion of muscle recovery via the cleavage of MnO 2 to Mn 2+ in the presence of ROS. This induces an imbalance of hydrophobic interactions leading to the formation of an ionic network structure thereby generating the irreversible gelation of MnO 2 @PD-HGC. Furthermore, this transformation influenced a significant increase in electrical resistance (ΔR increased by 184 % from 0 h to 12 h) and fluorescence recovery, enabling monitoring capability of the hydrogel. MnO 2 @PD-HGC hydrogel demonstrated potent therapeutic effects in the disease microenvironment by downregulating key muscle degradation markers, Atrogin-1 and MuRF-1, in dexa-treated C2C12 myotubes. Furthermore, in an injured muscle mouse model, the hydrogel promoted skeletal muscle regeneration helping to prevent volumetric muscle loss thereby, demonstrating its potential as a therapeutic platform offering both targeted treatment and monitoring capabilities.

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