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Production of bacterial cellulose with high active components loading capacity for skin wound repair

International Journal of Biological Macromolecules 2025年第PT 3期311卷 143963页

作者： Xu, Jia Wang, Qiuhui Hu, Yishen Guo, Qingfeng Zhu, Hu Wang, Honglin Hu, Hongxin Wang, Shouan Ye, Jianbin Putian University School of Basic Medicine Science Key Laboratory of Translational Tumor Medicine in Fujian Province Fujian Province Putian City351100 China Fujian Province 351100 China Fujian Medical University School of Pharmacy Fujian Province Fuzhou City350004 China Department of Orthopedic Surgery The Affiliated Dazu's Hospital of Chongqing Medical University Chongqing402360 China The Affiliated Hospital of Putian University Fujian Province Putian City351100 China Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering Engineering Research Center of Industrial Biocatalysis College of Chemistry and Materials Science Fujian Normal University Fuzhou350007 China

Scutellaria baicalensis extracts (SBACs), a herb that contains a variety of bioactive flavonoids like baicalein and baicalin, which impart antibacterial, antioxidant, and other biological activities, were used to create bacterial cellulose (BC) with a high components-loading capacity in-situ. Higher S-L ratios raised the quantities of the active ingredients (baicalin and baicalein), enhancing antibacterial and antioxidant activities. Considering both components-loading efficiency (322 mg/g of baicalin and 8.79 mg/g of baicalein) and production viability, an S-L ratio of 1:20 was determined as the optimal for preparing BC/SBACs membranes. These membranes exhibited superior mechanical strength and thermal stability compared to pure BC. Furthermore, when compared to membranes made via physical adsorption, the in-situ produced BC/SBACs exhibited a higher capacity for loading components and a more effective release of those components. A three-dimensional network structure was discovered using morphological analysis, which facilitated the integration of active ingredients. In vitro biocompatibility tests showed that BC/SBACs hydrogel was safe, exhibiting no hemolysis and low cytotoxicity. In vivo experiments on a full-thickness skin defect model in mice demonstrated a significantly higher wound-healing rate. The study highlights the potential of BC to improve clinical treatment outcomes by providing an easy way to combine it with traditional Chinese medicine. © 2025 Elsevier B.V.

关键词： Tissue regeneration

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A Mechanized Pediatric Elbow Joint Powered by a De-Based Artificial Skeletal Muscle*

A Mechanized Pediatric Elbow Joint Powered by a De-Based Art...

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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： A. Behboodi C. DeSantis J. Lubsen S.C.K. Lee Venture Development Center University of Delaware Newark DE USA Mechanical Engineering Department University of Delaware Newark DE USA Departments of Physical Therapy Biomedical Engineering and Interdisciplinary Graduate Program in Biomechanics and Movement Science University of Delaware Newark DE USA

ISBN: (数字)9781728119908

ISBN: (纸本)9781728119915

To increase the acceptability of exoskeletons, there is growing attention toward finding an alternative soft actuator that can safely perform at close vicinity of the human body. In this study, we investigated the capability of the dielectric elastomer actuators (DEAs), for muscle-like actuation of rehabilitation robots. First, an artificial skeletal muscle was configured using commercially available stacked DEAs arranged in a 3×4 array of three parallel fibers consisting of four DEAs connected in series. The shortening and force generation capabilities of this artificial muscle were then measured. An alternate 3×5 version of this muscle was mounted on the forearm of an upper extremity phantom model to actuate its elbow joint. The actuation capability of this muscle was then tested under various tensile loads, 1 N to 4 N, placed at the center of mass of the forearm+hand of the phantom model. The active range of motion and angular velocity of the phantom model's tip of the hand were measured using a motion capture system. The 3×4 artificial muscle produced 30.47 N of force and 5.3 mm of maximum shortening. The 3×5 artificial muscle was capable of actuating the elbow flexion 19.5 o with 16.2 o /s angular velocity in the sagittal plane, under a 1 N tensile load. The active range of motion was substantially reduced as the tensile loads increased, which limits the capability of these muscles in the current upper extremity exoskeleton design.

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Valorization of lignin biowaste into Schiff base copper(II) complex as a magnetically reusable electrocatalyst for hydrogen evolution reaction

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International Journal of Biological Macromolecules 2025年 314卷 144249页

作者： Sajjadi, Mohaddeseh Ghaffarinejad, Ali Ghafuri, Hossein Dong, Yahao Henan Key Laboratory of Green Chemistry Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials Key Laboratory of Green Chemical Media and Reactions Ministry of Education School of Chemistry and Chemical Engineering Henan Normal University Xinxiang453007 China Catalysts and Organic Synthesis Research Laboratory Department of Chemistry Iran University of Science and Technology Tehran16846-13114 Iran Tehran*** Iran Tehran*** Iran

This work describes a cost-effective and sustainable copper(II) complex as an electrocatalyst for the hydrogen-evolution reaction (HER) under alkaline and acid conditions. A magnetic lignin-supported tetrazole Schiff base copper(II) complex was incorporated into a carbon paste electrode (MLS@SchTet-Cu(II)/CPE) by a surface modification and cross-linking method. The catalytic HER of the MLS@SchTet-Cu(II)/CPE electrodes was analyzed by electrochemical techniques, including linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS), chronopotentiometry (CP), and cyclic voltammetry (CV). The effects of solution pH and complex amount in the paste electrode on HER performance were evaluated. The results demonstrated that the MLS@SchTet-Cu(II) nanocomposite exhibits good electrocatalytic activity in both acidic and basic media. In particular, in 0.5 M H2SO4, the modified CPE electrode with 2.5 % MLS@SchTet-Cu(II) demonstrated an overpotential of 581 mV at 10 mA cm−2 (η10) and a Tafel slope of 258 mV dec−1, surpassing the performance of both the bare and other modified CPEs. These findings highlight the potential of MLS@SchTet-Cu(II) as a promising candidate for sustainable HER catalysis. © 2025

关键词： Cyclic voltammetry

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Single-Component High-Resolution Dual-Tone EUV Photoresists Based on Precision Self-Immolative Polymers

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Angewandte Chemie 2024年第3期137卷

作者： Dr. Jie Cen Wen Liu Dr. Jie Xu Xiuxia Wang Jialin Zhang Jin Zhang Prof. Dr. Zhengyu Deng Dr. Chenggang Zhou Prof. Dr. Jinming Hu Prof. Dr. Shiyong Liu Department of Pharmacy The First Affiliated Hospital of University of Science and Technology of China and Laboratory of Precision and Intelligent Chemistry Department of Polymer Science and Engineering University of Science and Technology of China 96 Jinzhai Road 230026 Hefei Anhui Province China Center for Micro- and Nanoscale Research and Fabrication Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China 96 Jinzhai Road 230026 Hefei Anhui Province China School of Chemistry and Materials Science University of Science and Technology of China and School of Biomedical Engineering Division of Life Sciences and Medicine University of Science and Technology of China 96 Jinzhai Road 230026 Hefei Anhui Province China and Suzhou Institute for Advanced Research University of Science and Technology of China 215123 Suzhou Jiangsu Province China

Electron beam (EB) and extreme ultraviolet (EUV) lithography are advanced techniques capable of achieving sub-10 nm resolutions, critical for fabricating next-generation nanostructures and semiconductor devices. However, developing EUV photoresists that meet all demands for resolution, line edge roughness (LER), and sensitivity (RLS) remains a significant challenge. Herein, we introduce high-performance photoresists based on single-component self-immolative polymers (SIPs) with inherent signal amplification via cascade degradation. These SIPs function as dual-tone photoresists under both EB and EUV lithography, with performance primarily determined by the exposure dose. Lithographic evaluations show that discrete SIPs provide significant improvements over disperse counterparts, achieving higher resolution and reduced LER. Specifically, a discrete SIP with a DP of 12 produces a line-space pattern with a resolution of approximately 18 nm and an LER of 1.8 nm, compared to 21 nm resolution and 2.5 nm LER for disperse SIPs. Additionally, these SIP-based photoresists, enriched with aromatic structures, exhibit excellent etch resistance. The single-component nature and potential to address the RLS trade-off underscore the promise of discrete SIPs for EUV lithography.

关键词： self-immolative polymer precision polymer dual-tone photoresist electron beam lithography EUV lithography

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Transcriptomic Profiling of JEG-3 cells using human leiomyoma derived matrix

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Biomaterials and Biosystems 2022年 7卷 100056页

作者： Barmaki, Samineh Al-Samadi, Ahmed Leskinen, Katarzyna Wahbi, Wafa Jokinen, Ville Vuoristo, Sanna Salo, Tuula Kere, Juha Wedenoja, Satu Saavalainen, Päivi Department of Pharmacology Faculty of Medicine University of Helsinki Helsinki 00290 Finland Department of Oral and Maxillofacial Disease University of Helsinki Helsinki 00290 Finland Translational Immunology Research Program Department of Clinical and Medical Genetics University of Helsinki Helsinki 00290 Finland Department of Chemistry and Materials Science School of Chemical Engineering Aalto University Espoo 00076 Finland Obstetrics and Gynecology University of Helsinki and Helsinki University Hospital Helsinki 00290 Finland Department of Biosciences and Nutrition Karolinska Institutet Huddinge 14183 Sweden Folkhälsan Research Center Helsinki 00290 Finland Stem Cells and Metabolism Research Program University of Helsinki Helsinki 00014 Finland Stem Cells and Metabolism Research Program University of Helsinki and Folkhälsan Research Center Helsinki 00290 Finland

Oxygen tension varies during placental and fetal development. Although hypoxia drives early trophoblast invasion, low placental oxygen levels during pregnancy show association with pregnancy complications including fetal growth restriction and preeclampsia. JEG-3 cells are often used as a trophoblast model. We studied transcriptional changes of JEG-3 cells on a uterine leiomyoma derived matrix Myogel. This might be the closest condition to the real uterine environment that we can get for an in vitro model. We observed that culturing JEG-3 cells on the leiomyoma matrix leads to strong stimulation of ribosomal pathways, energy metabolism, and ATP production. Furthermore, Myogel improved JEG-3 cell adherence in comparison to tissue culture treated plastic. We also included PDMS microchip hypoxia creation, and observed changes in oxidative phosphorylation, oxygen related genes and several hypoxia genes. Our study highlights the effects of Myogel matrix on growing JEG-3 cells, especially on mitochondria, energy metabolism, and protein synthesis. © 2022 The Author(s)

关键词： Biomaterials Hypoxia JEG-3 Microenvironment Microfluidic Myogel Oxygen scavenger PDMS Placenta Pre-eclampsia

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Automated Assessment of Balance Rehabilitation Exercises With a Data-Driven Scoring Model: Algorithm Development and Validation Study

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JMIR Rehabilitation and Assistive Technologies 2022年第3期9卷 e37229页

作者： Tsakanikas, Vassilios Gatsios, Dimitris Pardalis, Athanasios Tsiouris, Kostas M. Georga, Eleni Bamiou, Doris-Eva Pavlou, Marousa Nikitas, Christos Kikidis, Dimitrios Walz, Isabelle Maurer, Christoph Fotiadis, Dimitrios Unit of Medical Technology and Intelligent Information Systems Department of Materials Science and Engineering University of Ioannina Ioannina Greece Ear Institute University College London London United Kingdom Biomedical Research Centre Hearing and Deafness University College London Hospitals London United Kingdom Centre for Human and Applied Physiological Sciences King's College London London United Kingdom First Department of Otolaryngology-Head and Neck Surgery Hippokrateio General Hospital National Kapodistrian University of Athens Athens Greece Department of Neurology and Neuroscience Medical Center University of Freiburg Faculty of Medicine University of Freiburg Freiburg Germany Biomedical Research Institute Ioannina Greece

Background: Balance rehabilitation programs represent the most common treatments for balance disorders. Nonetheless, lack of resources and lack of highly expert physiotherapists are barriers for patients to undergo individualized rehabilitation sessions. Therefore, balance rehabilitation programs are often transferred to the home environment, with a considerable risk of the patient misperforming the exercises or failing to follow the program at all. Holobalance is a persuasive coaching system with the capacity to offer full-scale rehabilitation services at home. Holobalance involves several modules, from rehabilitation program management to augmented reality coach presentation. Objective: The aim of this study was to design, implement, test, and evaluate a scoring model for the accurate assessment of balance rehabilitation exercises, based on data-driven techniques. Methods: The data-driven scoring module is based on an extensive data set (approximately 1300 rehabilitation exercise sessions) collected during the Holobalance pilot study. It can be used as a training and testing data set for training machine learning (ML) models, which can infer the scoring components of all physical rehabilitation exercises. In that direction, for creating the data set, 2 independent experts monitored (in the clinic) 19 patients performing 1313 balance rehabilitation exercises and scored their performance based on a predefined scoring rubric. On the collected data, preprocessing, data cleansing, and normalization techniques were applied before deploying feature selection techniques. Finally, a wide set of ML algorithms, like random forests and neural networks, were used to identify the most suitable model for each scoring component. Results: The results of the trained model improved the performance of the scoring module in terms of more accurate assessment of a performed exercise, when compared with a rule-based scoring model deployed at an early phase of the system (k-statistic valu

关键词： balance rehabilitation exercises exercise evaluation persuasive coaching system scoring model

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Marangoni convection-driven laser fountains and waves on free surfaces of liquids

arXiv

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arXiv 2021年

作者： Lin, Feng Quraishy, Aamir Nasir Tong, Tian Li, Runjia Yang, Guang Mohebinia, Mohammadjavad Qiu, Yi Vishal, Talari Zhao, Junyi Zhang, Wei Zhong, Hong Zhang, Hang Zhou, Chaofu Tong, Xin Yu, Peng Hu, Jonathan Dong, Suchuan Liu, Dong Wang, Zhiming Schaibley, John R. Bao, Jiming Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China ChengduSichuan610054 China Department of Electrical and Computer Engineering University of Houston HoustonTX77204 United States Department of Physics University of Arizona TucsonAZ85721 United States James C. Wyant College of Optical Sciences University of Arizona TucsonAZ85721 United States Department of Mechanical Engineering University of Houston HoustonTX77204 United States Materials Science and Engineering Program University of Houston HoustonTX77204 United States School of Science Southwest Petroleum University ChengduSichuan610500 China Department of Electrical and Systems Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Electrical & Computer Engineering Baylor University WacoTX76798 United States Department of Mathematics Purdue University West LafayetteIN47907 United States Department of Physics Texas Center for Superconductivity University of Houston HoustonTX77204 United States

It is well accepted that an outward Marangoni convection from a low surface tension region will make the surface depressed. Here, we report that this established perception is only valid for thin liquid films. Using surface laser heating, we show that in deep liquids a laser beam actually pulls up the fluid above the free surface generating fountains with different shapes. Whereas with decreasing liquid depth a transition from fountain to indentation with fountain-in-indentation is observed. Further, high-speed imaging reveals a transient surface process before steady elevation is formed, and this dynamic deformation is subsequently utilized to resonantly excite giant surface waves by a modulated laser beam. Computational fluid dynamics models reveal the underlying flow patterns and quantify the depth-dependent and time-resolved surface deformations. Our discoveries and techniques have upended the century-old perception and opened up a new regime of interdisciplinary research and applications of Marangoni-induced interface phenomena and optocapillary fluidic surfaces - the control of fluids with light. © 2021, CC BY.

关键词： Deformation

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Multivalent‐Interaction‐Driven Assembly of Discrete, Flexible, and Asymmetric Supramolecular Protein Nano‐Prisms

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Angewandte Chemie 2020年第51期132卷 23444-23451页

作者： Suyeong Han Dr. Yu‐na Kim Gyunghee Jo Dr. Young Eun Kim Prof. Dr. Ho Min Kim Dr. Jeong‐Mo Choi Prof. Dr. Yongwon Jung Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Korea These authors contributed equally to this work. Biomedical Science and Engineering Interdisciplinary Program KAIST Daejeon 34141 Korea Graduate School of Medical Science & Engineering KAIST Daejeon 34141 Korea Center for Biomolecular & Cellular Structure Institute for Basic Science (IBS) Daejeon 34126 Korea Natural Science Research Institute KAIST Daejeon 34141 Korea Department of Chemistry Busan National University Busan 46241 Korea

Multivalent interactions between protein‐oligomer‐fused binding pairs allowed highly monodisperse assembly of two protein oligomers, where spacing between oligomers can be widely varied. Two different oligomers or three oligomers can also be discretely assembled into protein layer structures via this *** approaches to design monodisperse protein assemblies require rigid, tight, and symmetric interactions between oligomeric protein units. Herein, we introduce a new multivalent‐interaction‐driven assembly strategy that allows flexible, spaced, and asymmetric assembly between protein oligomers. We discovered that two polygonal protein oligomers (ranging from triangle to hexagon) dominantly form a discrete and stable two‐layered protein prism nanostructure via multivalent interactions between fused binding pairs. We demonstrated that protein nano‐prisms with long flexible peptide linkers (over 80 amino acids) between protein oligomer layers could be discretely formed. Oligomers with different structures could also be monodispersely assembled into two‐layered but asymmetric protein nano‐prisms. Furthermore, producing higher‐order architectures with multiple oligomer layers, for example, 3‐layered nano‐prisms or nanotubes, was also *** a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the *** note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

关键词： multivalent interaction protein assembly protein design protein engineering protein–protein interactions

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Nanostructure formation on Ti-Nb alloys promote better surface properties designed for biological applications

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Nano-Structures & Nano-Objects 2025年 43卷

作者： M.C. Rossi N. Rangel DM. Silva e Silva P.AB. Kuroda V. Amigó C.R.M. Afonso Materials Engineering Department (DEMa) Universidade Federal de São Carlos (UFSCar) São Carlos SP 13.565-905 Brazil Graduation Program in Materials Science and Engineering (PPG-CEM) Universidade Federal de São Carlos (UFSCar) São Carlos SP 13.565-905 Brazil UNILA – Universidade Federal da Integração Latino-Americana Foz do Iguaçu PR 85870-650 Brazil Universitat Politècnica de València Institut de Tecnologia de Materials Camí de Vera S/n València 46022 Spain

Anodizing was employed to produce organized TiO₂ nanotubular structures (NTs) on two titanium alloys: Ti-15Nb (TN15), which exhibits both bcc and hcp crystal structures (α′ + β phases), and Ti-40Nb (TN40), characterized by a stable β phase. The electrochemical treatment was conducted under different potentials (10 V and 20 V) and durations (1 h and 2 h). Following anodization, samples underwent thermal treatment to transform the initially amorphous NT layers into crystalline phases. X-ray diffraction (XRD) confirmed the amorphous nature of the as-anodized surfaces, which crystallized into anatase and rutile phases after heating. Structural and microstructural features were analyzed via XRD, scanning electron microscopy (SEM), and atomic force microscopy (AFM), which were used to assess surface roughness, NT length, and diameter. Wettability and surface free energy were evaluated using the sessile drop contact angle method. This study investigates how anodization parameters and alloy composition affect the crystallinity, morphology, and surface properties of TiO₂ NTs. TN15 samples exhibited α-phase Ti with a mix of anatase and rutile, while TN40 samples showed dominant β-phase Ti and greater rutile content. NTs on TN15 were more uniformly aligned, whereas TN40 formed NTs in isolated domains. Longer anodization times and higher voltages increased NT length and diameter. Notably, surface wettability improved with greater anatase content—particularly in TN15–2h-10V (contact angle ∼7°)—highlighting the influence of Nb content, anodization conditions, and heat treatment on tuning NT functionality for biomedical applications.

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Deformation mechanism and dynamic precipitation in a Mg-7Al-2Sn alloy processed by surface mechanical attrition treatment

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Journal of materials science & Technology 2019年第7期35卷 1473-1478页

作者： Xiaoying Shi Yangxin Li Xiaoqin Zeng Yong Liu Bin Chen Jian Lu Dejiang Li National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai200240China Commercial Aircraft Engine Company Limited Aero Engine Corporation of ChinaShanghai200241China Key Laboratory of Near Net Forming of Jiangxi Province Nanchang UniversityNanchang330031China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai200240 Department of Mechanical and Biomedical Engineering City University of Hong KongKow-loonHong Kong999077China

The effect of second phases on the deformation mechanism of as-cast, solution-treated and aged Mg-7Al-2Sn (AT72) alloys during surface mechanical attrition treatment (SMAT) was investigated. Twinning was suppressed in the alloys containing second phases, which can provide nonuniform microstructures and phase boundaries as dislocation sources. Dynamic precipitation in AT72 alloys was studied during SMAT deformation as ***2Sn particles can dynamically precipitate on the surface of all AT72 alloys during SMAT process. The quantity of Mg2Sn particles in the as-cast alloy, which is determined by the initial quantity of second phases, is larger than that of T4 and T6 alloys after the SMAT process.

关键词： Magnesium alloys Surface mechanical attrition treatment Deformation mechanism Dynamic precipitation

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