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Targeting formyl peptide receptor 1 with anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome

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British journal of pharmacology 2023年第16期180卷 2120-2139页

作者： Shun-Chin Yang Yi-Hsuan Wang Chiu-Ming Ho Yung-Fong Tsai Ping-Jyun Sung Tony Eight Lin Tsong-Long Hwang Department of Anesthesiology Taipei Veterans General Hospital and National Yang Ming Chiao Tung University Taipei 112 Taiwan. Graduate Institute of Natural Products and Graduate Institute of Biomedical Sciences College of Medicine Chang Gung University Taoyuan 333 Taiwan. Department of Anesthesiology Chang Gung Memorial Hospital Linkou Medical Center Taoyuan Taiwan. Graduate Institute of Clinical Medical Sciences College of Medicine Chang Gung University Taoyuan 333 Taiwan. National Museum of Marine Biology and Aquarium Pingtung 944 Taiwan. Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Ph.D. Program for Cancer Molecular Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei 110 Taiwan. Research Center for Chinese Herbal Medicine and Graduate Institute of Health Industry Technology College of Human Ecology Chang Gung University of Science and Technology 333 Taoyuan Taiwan. Healthy Aging Research Center Chang Gung University 333 Taoyuan Taiwan. Department of Chemical Engineering Ming Chi University of Technology New Taipei City 243 Taiwan.

BACKGROUND AND PURPOSE:Acute respiratory distress syndrome (ARDS) is a catastrophic pulmonary inflammatory dysfunction with a high mortality rate. An overwhelming immune response by neutrophils is a key feature in infective or sterile ARDS. The formyl peptide receptor 1 (FPR1) is a crucial damage-sensing receptor for inflammatory reactions in the initiation and progression of neutrophil-mediated ARDS. However, effective targets for controlling dysregulated neutrophilic inflammatory injuries in ARDS are limited. EXPERIMENTAL APPROACH:Human neutrophils were used to explore the anti-inflammatory effects of cyclic lipopeptide anteiso-C13-surfactin (IA-1) from marine Bacillus amyloliquefaciens. The lipopolysaccharide-induced model of ARDS in mice was used to determine the therapeutic potential of IA-1 in ARDS. Lung tissues were harvested for histology analyses. KEY RESULTS:The lipopeptide IA-1 inhibited immune responses of neutrophils, including respiratory burst, degranulation, and expression of adhesion molecules. IA-1 inhibited the binding of N-formyl peptides to FPR1 in human neutrophils and in hFPR1-transfected HEK293 cells. We identified IA-1 as a competitive FPR1 antagonist, thus diminishing the downstream signalling pathways involving calcium, mitogen-activated protein kinases and Akt. Furthermore, IA-1 ameliorated the inflammatory damage to lung tissue, by decreasing neutrophil infiltration, reducing elastase release and oxidative stress in endotoxemic mice. CONCLUSION AND IMPLICATIONS:The lipopeptide IA-1 could serve as a therapeutic option for ARDS by inhibiting FPR1-mediated neutrophilic injury.

关键词： ARDS FPR1 N-formyl peptides lipopeptide marine Bacillus neutrophils

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Evolution of Surface Chemistry in Two-Dimensional MXenes: From Mixed to Tunable Uniform Terminations

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Angewandte Chemie 2024年第37期136卷

作者： Mengni Jiang Di Wang Young-Hwan Kim Prof. Chunying Duan Prof. Dmitri V. Talapin Prof. Chenkun Zhou School of Chemistry and Material Science Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Nanjing Normal University 210023 Nanjing Jiangsu China Department of Chemistry University of Chicago 60637 Chicago Illinois United States Pritzker School of Molecular Engineering University of Chicago 60637 Chicago Illinois United States State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University 210023 Nanjing Jiangsu China Center for Nanoscale Materials Argonne National Laboratory 60439 Argonne Illinois United States

Surface chemistry of MXenes is of great interest as the terminations can define the intrinsic properties of this family of materials. The diverse and tunable terminations also distinguish MXenes from many other 2D materials. Conventional fluoride-containing reagents etching approaches resulted in MXenes with mixed fluoro-, oxo-, and hydroxyl surface groups. The relatively strong chemical bonding of MXenes’ surface metal atoms with oxygen and fluorine makes post-synthetic covalent surface modifications of such MXenes unfavorable. In this minireview, we focus on the recent advances in MXenes with uniform surface terminations. Unconventional methods, including Lewis acidic molten salt etching (LAMS) and bottom-up direct synthesis, have been proven successful in producing halide-terminated MXenes. These synthetic strategies have opened new possibilities for MXenes because weaker surface chemical bonds in halide-terminated MXenes facilitate post-synthetic covalent surface modifications. Both computational and experimental results on surface termination-dependent properties are summarized and discussed. Finally, we offer our perspective on the opportunities and challenges in this exciting research field.

关键词： materials science Surface chemistry 2D MXenes Organic-inorganic hybrids

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Charge transfer vs. proton transfer in the excited-state dynamics of biomimetic pyranoflavylium cations

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Journal of Photochemistry and Photobiology 2022年 10卷

作者： Espinoza, Eli M. Clark, John A. Silva, Cassio Pacheco da. Derr, James B. Silva, Gustavo Thalmer de Medeiros Billones, Mimi K. Morales, Maryann Quina, Frank H. Vullev, Valentine I. Department of Chemistry University of California Riverside 92521 CA United States Department of Bioengineering University of California Riverside 92521 CA United States Instituto de Química Universidade de São Paulo Avenida Lineu Prestes 748 Cidade Universitaá5 ria São Paulo 05508-000 Brazil Department of Biochemistry University of California Riverside 92521 CA United States Department of Biology University of California Riverside 92521 CA United States Materials Science and Engineering Program University of California Riverside 92521 CA United States

Pyranoflavylium cations are synthetic analogues of pyranoanthocyanin, colored pigments, formed from grape anthocyanins during the maturation of red wines. Studies of a series of monosubstituted pyranoflavylium cations, ranging from methoxy (PF⁺-OMe) to cyano (PF⁺-CN), have shown that they display fluorescence and form triplet states that sensitize singlet oxygen formation in acidified acetonitrile. In alcohol-water mixtures, they behave as photoacids, undergoing adiabatic excited state proton transfer (ESPT) to water on a picosecond timescale, as confirmed in this report by femtosecond pump-probe spectroscopy. In contrast, the corresponding dimethylamino substituted pyranoflavylium cation (PF⁺-NMe₂) is virtually non-fluorescent under the same conditions and exhibits a long-wavelength absorption band that has been attributed to a charge-transfer (CT) transition. Indeed, pump-probe spectroscopy of PF⁺-NMe₂ in acidified acetonitrile shows ultrafast (<1 ps) formation of a CT state that decays back to the ground state with a 12–13 ps lifetime. In acidified methanol, the initial Franck-Condon CT state (ca. 3 ps lifetime) converts to a 13 ps lifetime CT state analogous to that in acetonitrile. In 50:50 ethanol:water and 30:70 methanol:water mixtures, PF⁺-NMe₂ exhibits a short-lived (3–8 ps) initial CT state, an intermediate lifetime (30 ps) CT state and a much longer lived (130 ps) species attributed to a twisted intramolecular CT state. Thus, in addition to demonstrating that the photophysics of PF⁺-NMe₂ is dominated by CT rather than ESPT, pump-probe spectroscopy provides details of the solvent-dependent dynamics of the CT decay pathways. © 2022 The Author(s)

关键词： Charge transfer Proton transfer Pump-probe spectroscopy Pyranoanthocyanins Pyranoflavylium cations

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Nonreciprocal interactions induced by water in confinement

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Physical Review Research 2020年第4期2卷 043244-043244页

作者： Felipe Jiménez-Ángeles Katherine J. Harmon Trung Dac Nguyen Paul Fenter Monica Olvera de la Cruz Department of Materials Science and Engineering Northwestern University Evanston Illinois 60208 USA Applied Physics Graduate Program Northwestern University Evanston Illinois 60208 USA Department of Chemical and Biological Engineering Northwestern University Evanston Illinois 60208 USA Chemical Sciences and Engineering Division Argonne National Laboratory Lemont Illinois 60439 USA Department of Physics and Astronomy Northwestern University Evanston Illinois 60208 USA Department of Chemistry Northwestern University Evanston Illinois 60208 USA

Water mediates electrostatic interactions via the orientation of its dipoles around ions, molecules, and interfaces. This induced water polarization consequently influences multiple phenomena. In particular, water polarization affects ion adsorption and transport, biomolecular self-assembly, and surface chemical reactions. Therefore, it is of paramount importance to understand water-mediated interactions modulated by nanoconfinement at the nanoscale. Here we investigate the effective interaction between two oppositely charged ions in different positions in water confined between two graphene surfaces. We find that the attraction between physisorbed ions is enhanced in the surface normal direction while the in-plane interaction is almost unaffected. The attraction in the surface normal direction is further enhanced by decreasing the confinement distance. Conversely, when one ion is intercalated into the graphene layers, the interaction becomes repulsive. Moreover, upon exchange of the ions' positions along the surface normal direction, the interaction energy changes by about 5kBT. The nonequivalent and directional properties found here, referred to as nonreciprocal interactions, cannot be explain by current water permittivity models in confinement. Our x-ray reflectivity experiments of the water structure near a graphene surface support our molecular dynamics simulation results. Our work shows that the water structure is not enough to infer electrostatic interactions near interfaces.

关键词： Confinement Dielectric properties Surface & interfacial phenomena Polarization Molecular dynamics X-ray reflectivity

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Rational design of TA/rGO/CNFs aerogel films as self-supporting cathodes for high-performance zinc-ion hybrid capacitors

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Journal of Energy Storage 2025年 125卷

作者： Yu, Xiuwen Liu, Qifan Shi, Shuangyu Zang, Limin Qiu, Jianhui He, Minhua Yang, Chao MOE Key Laboratory of New Processing Technology for Nonferrous Metal & Materials Guangxi Key Laboratory of Optical and Electronic Materials and Devices Guangxi Colleges and Universities Key Laboratory of Natural and Biomedical Polymer Materials Guilin University of Technology Guilin541004 China Guangxi Key Laboratory of Advanced Structural Materials and Carbon Neutralization Guangxi Minzu University Nanning530006 China Department of Machine Intelligence and Systems Engineering Faculty of Systems Science and Technology Akita Prefectural University Yurihonjo015-0055 Japan Guangxi Huazheng New Energy Technology Co. Ltd. Chongzuo532299 China

Wearable flexible electronic devices have been developed rapidly driven by their distinctive characteristics, such as portability, flexibility, comfort, and diverse forms. However, the accelerated pace of technological advancement leads to a considerable increase in non-biodegradable electronic waste, which has a detrimental impact on the natural environment. In this study, flexible aerogel films consisting of tannic acid (TA), reduced graphene oxide (rGO) and cellulose nanofibers (CNFs) were prepared through a simultaneous hydrothermal reduction and self-assembly strategy. As a natural polyphenol, TA can serve as a reducing agent for GO and provide extra capacity owing to its catechol and pyrogallol units. CNFs with large length-to-diameter ratio and oxygen groups can effectively prevent rGO restacking and promote electrolyte penetration. The flexible zinc-ion hybrid capacitors based on the aerogel film cathode and zinc foil anode have excellent electrochemical properties and flexibility. In light of environmentally friendly components, green preparation processes and superior electrochemical performance, this research can pave the way for further development of environmentally friendly aerogel film electrodes for high-performance wearable electronics. © 2025 Elsevier Ltd

关键词： Cellulose films

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Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

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Nature Communications 2023年第1期14卷 7218页

作者： Tan, Kemin Chen, Junjian Kaku, Yu Wang, Yi Donius, Luke Khan, Rafiq Ahmad Li, Xiaolong Richter, Hannah Seaman, Michael S. Walz, Thomas Hwang, Wonmuk Reinherz, Ellis L. Kim, Mikyung Structural Biology Center X-ray Science Division Advanced Photon Source Argonne National Laboratory Lemont IL United States Laboratory of Immunobiology Department of Medical Oncology Dana-Farber Cancer Institute Boston MA United States Department of Medicine Harvard Medical School Boston MA United States Center for Virology and Vaccine Research Beth Israel Deaconess Medical Center Boston MA United States Laboratory of Molecular Electron Microscopy The Rockefeller University New York NY United States Department of Biomedical Engineering Texas A&M University College Station TX United States Department of Materials Science & Engineering Texas A&M University College Station TX United States Department of Physics & Astronomy Texas A&M University College Station TX United States Department of Dermatology Harvard Medical School Boston MA United States Laboratory of Immunology Department of Immunology and Microbiology Zhongshan School of Medicine Sun Yat-sen University Guangdong Guangzhou China NeoCura Bio-Medical Technology Co. Ltd. Beijing China AbbVie Bioresearch Center AbbVie Inc. Worcester MA United States School of Life Sciences Division of Life Sciences and Medicine University of Science and Technology of China Anhui Hefei 230027 China

Broadly neutralizing antibodies (bnAbs) against HIV-1 target conserved envelope (Env) epitopes to block viral replication. Here, using structural analyses, we provide evidence to explain why a vaccine targeting the membrane-proximal external region (MPER) of HIV-1 elicits antibodies with human bnAb-like paratopes paradoxically unable to bind HIV-1. Unlike in natural infection, vaccination with MPER/liposomes lacks a necessary structure-based constraint to select for antibodies with an adequate approach angle. Consequently, the resulting Abs cannot physically access the MPER crawlspace on the virion surface. By studying naturally arising Abs, we further reveal that flexibility of the human IgG3 hinge mitigates the epitope inaccessibility and additionally facilitates Env spike protein crosslinking. Our results suggest that generation of IgG3 subtype class-switched B cells is a strategy for anti-MPER bnAb induction. Moreover, the findings illustrate the need to incorporate topological features of the target epitope in immunogen design. © 2023, The Author(s).

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Two-dimensional Bose-Hubbard model for helium on graphene

arXiv

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arXiv 2021年

作者： Yu, Jiangyong Lauricella, Ethan Elsayed, Mohamed Shepherd, Kenneth Nichols, Nathan S. Lombardi, Todd Kim, Sang Wook Wexler, Carlos Vanegas, Juan M. Lakoba, Taras Kotov, Valeri N. Del Maestro, Adrian Department of Physics University of Vermont BurlingtonVT05405 United States Materials Science Program University of Vermont BurlingtonVT05405 United States Department of Physics and Astronomy University of Missouri ColumbiaMO65211 United States Department of Mathematics & Statistics University of Vermont BurlingtonVT05405 United States Department of Physics and Astronomy University of Tennessee KnoxvilleTN37996 United States Min H. Kao Department of Electrical Engineering and Computer Science University of Tennessee KnoxvilleTN37996 United States

An exciting development in the field of correlated systems is the possibility of realizing two-dimensional (2D) phases of quantum matter. For a systems of bosons, an example of strong correlations manifesting themselves in a 2D environment is provided by helium adsorbed on graphene. We construct the effective Bose-Hubbard model for this system which involves hard-core bosons (U ≈ ∞), repulsive nearest-neighbor (V > 0) and small attractive (V0 4He adsorbed on graphene deep in the commensurate solid phase with 1/3 of the sites on the dual triangular lattice occupied. Because the parameters of the effective Bose-Hubbard model are very sensitive to the exact lattice structure, this opens up an avenue to tune quantum phase transitions in this solid-state system. Copyright © 2021, The Authors. All rights reserved.

关键词： Hubbard model

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Topological carnival: Electrically-powered motions of toron crystallites in chiral liquid crystals

arXiv

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arXiv 2020年

作者： Sohn, Hayley R.O. Smalyukh, Ivan I. Department of Physics and Materials Science and Engineering Program University of Colorado BoulderCO80309 United States Department of Electrical Computer and Energy Engineering and Soft Materials Research Center University of Colorado BoulderCO80309 United States Renewable and Sustainable Energy Institute National Renewable Energy Laboratory University of Colorado BoulderCO80309 United States

Malleability of metals is an example of how dynamics of defects like dislocations induced by external stresses alters material properties and enables technological applications. However, these defects move merely to comply with the mechanical forces applied on macroscopic scales whereas the molecular and atomic building blocks behave like rigid particles. Here we demonstrate how motions of crystallites and defects between them can arise within the soft matter medium in an oscillating electric field applied to a chiral liquid crystal with polycrystalline quasi-hexagonal arrangements of self-assembled topological solitons called "torons". Periodic oscillations of electric field applied perpendicular to the plane of hexagonal lattices prompt repetitive shear-like deformations of the solitons, which synchronize the electrically-powered self-shearing directions. The temporal evolution of deformations upon turning voltage on and off is not invariant upon reversal of time, prompting lateral translations of the crystallites of torons within quasi-hexagonal periodically deformed lattices. We probe how these motions depend on voltage and frequency of oscillating field applied in an experimental geometry resembling that of liquid crystal displays. We study the inter-relations between synchronized deformations of the soft solitonic particles and their arrays and the ensuing dynamics and giant number fluctuations mediated by motions of crystallites, 5-7 defects pairs and grain boundaries in the orderly organizations of solitons. We discuss how our findings may lead to technological and fundamental science applications of dynamic self-assemblies of topologically protected but highly deformable particle-like solitons. Copyright © 2020, The Authors. All rights reserved.

关键词： Self assembly

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Pro-angiogenic functionalized hyaluronic acid-based hydrogel encapsulating metformin coordinates in situ immune-inflammatory modulation for accelerating diabetic wound healing

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International journal of biological macromolecules 2025年 318卷 144944页

作者： Zhen Li Shiyao Guan Xiao Duan Liying Wang Zhen Zhang Jun Wu Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics Shanxi Provincial Shangdang Chinese Medicinal Materials School of Pharmacy Changzhi Medical College Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Changzhi Changzhi 046000 China School of Biomedical Engineering Sun Yat-sen University Guangzhou Guangdong 510006 China. Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology (Guangzhou) Nansha Guangzhou 511400 China. Changzhi Key Laboratory of Drug Molecular Design and Innovative Pharmaceutics Shanxi Provincial Shangdang Chinese Medicinal Materials School of Pharmacy Changzhi Medical College Department-Municipal Key Laboratory Cultivation Base for Quality Enhancement and Utilization of Changzhi Changzhi 046000 China. Department of Hematology The Seventh Affiliated Hospital Sun Yat-sen University Shenzhen 518107 China. Electronic address: wangly53@***. Department of Hematology The Seventh Affiliated Hospital Sun Yat-sen University Shenzhen 518107 China. Electronic address: zhangzhen1@***. Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology (Guangzhou) Nansha Guangzhou 511400 China Division of Life Science The Hong Kong University of Science and Technology 999077 Hong Kong. Electronic address: junwuhkust@ust.hk.

Diabetic wounds present significant challenges due to persistent inflammation and impaired angiogenesis, often resulting in delayed healing or, in severe cases, amputation. Hence, there is an urgent need for innovative wound dressings tailored to the specific needs of diabetic wounds. Deferoxamine (DFO) and metformin (Met) offer promising properties for promoting angiogenesis and modulating the immune-inflammatory response, respectively, but their burst release limits their further application in wound management. Based on this, we developed a novel multifunctional diabetic wound dressing composed of DFO-grafted hyaluronic acid methacrylate (HAMA) hydrogel loaded with Met (Met/DMA hydrogel). In vitro studies demonstrated that the Met/DMA hydrogel enhances fibroblast proliferation and migration, reduces intracellular reactive oxygen species, and accelerates endothelial cell angiogenesis and macrophage polarization to an anti-inflammatory phenotype. Animal experiments further revealed that the hydrogel significantly accelerated wound healing in diabetic rats (41.6±8.7 % improvement vs. control group) by promoting neovascularization, collagen maturation, and regulation of the inflammatory microenvironment at the wound site. In conclusion, this study successfully developed a Met/DMA hydrogel platform that effectively treats diabetic wounds through synergistic promotion of angiogenesis and modulation of the immune-inflammatory response.

关键词： Angiogenesis Anti-inflammatory DFO Diabetic wounds healing Met

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Hopf solitons in helical and conical backgrounds of chiral magnetic solids

arXiv

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arXiv 2020年

作者： Voinescu, Robert Tai, Jung-Shen B. Smalyukh, Ivan I. Department of Physics University of Colorado BoulderCO80309 United States Materials Science and Engineering Program Soft Materials Research Center Department of Electrical Computer and Energy Engineering University of Colorado BoulderCO80309 United States Renewable and Sustainable Energy Institute National Renewable Energy Laboratory University of Colorado BoulderCO80309 United States

Three-dimensional topological solitons attract a great deal of interest in fields ranging from particle physics to cosmology but remain experimentally elusive in solid-state magnets. Here we numerically predict magnetic heliknotons, an embodiment of such nonzero-Hopf-index solitons localized in all spatial dimensions while embedded in a helical or conical background of chiral magnets. We describe conditions under which heliknotons emerge as metastable or ground-state localized nonsingular structures with fascinating knots of magnetization field in widely studied materials. We demonstrate magnetic control of three-dimensional spatial positions of such solitons, as well as show how they interact to form molecule-like clusters and possibly even crystalline phases comprising three-dimensional lattices of such solitons with both orientational and positional order. Finally, we discuss both fundamental importance and potential technological utility of magnetic heliknotons. Copyright © 2020, The Authors. All rights reserved.

关键词： Solitons

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