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Genomic medicine year in review: 2024

American journal of human genetics 2024年第12期111卷 2585-2588页

作者： Teri A Manolio Jahnavi Narula Alauna Rupert Carol J Bult Rex L Chisholm Geoffrey S Ginsburg Eric D Green Gillian Hooker Gail P Jarvik George A Mensah Erin M Ramos Dan M Roden Robb Rowley Casey Overby Taylor Marc S Williams National Human Genome Research Institute National Institutes of Health Bethesda MD 20892 USA. Electronic address: manolio@nih.gov. National Human Genome Research Institute National Institutes of Health Bethesda MD 20892 USA. The Jackson Laboratory for Mammalian Genetics Bar Harbor ME 04609 USA. Center for Genetic Medicine Feinberg School of Medicine Northwestern University Chicago IL 60611 USA. All of Us Research Program National Institutes of Health Bethesda MD 20892 USA. Concert Nashville TN 37201 USA. Departments of Medicine (Medical Genetics) and Genome Sciences University of Washington Seattle WA 98195 USA. Center for Translation Research and Implementation Science National Heart Lung and Blood Institute National Institutes of Health Bethesda MD 20892 USA. Departments of Medicine Pharmacology and Biomedical Informatics Vanderbilt University Medical Center Nashville TN 37232 USA. Departments of Medicine and Biomedical Engineering Johns Hopkins University School of Medicine Baltimore MD 21218 USA. Department of Genomic Health Geisinger Danville PA 17822 USA.

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An Injectable Hydroxyapatite Microsphere Filler Loaded with Ghk-Cu Tripeptide for Anti-Inflammatory and Antioxidant

SSRN

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SSRN 2025年

作者： Hu, Die Zhang, Xuexun Gong, Shiwen Ma, Wentao Cheng, Bo Yang, Jing Yan, Lesan Li, Binbin Qiu, Tong Wang, Xinyu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan430070 China Sanya Science and Education Innovation Park Wuhan University of Technology Sanya572000 China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu hydrogen Valley Foshan528200 China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology Wuhan430070 China School of Foreign Languages Wuhan University of Technology Wuhan430070 China Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan430060 China

With the wide application of soft tissue fillers, implant material-induced inflammatory reactions have become a key factor affecting the therapeutic efficacy. This study developed an injectable filler with enhanced anti-inflammatory and antioxidant effects by adsorbing glycyl-L-histidyl-L-lysine copper complex (GHK-Cu) onto hydroxyapatite microspheres (HAPs), marking the first combination of HAPs and GHK-Cu to address inflammation caused by soft tissue fillers. GHK-Cu was successfully loaded onto HAPs by electrostatic adsorption. HAPs were then mixed with carboxymethyl cellulose (CMC), glycerol (GLY), and water to form GHK-Cu@CMHA gel. The study focus on the effective combination of HAPs as a carrier for sustained GHK-Cu delivery and the anti-inflammatory properties of GHK-Cu. GHK-Cu@CMHA exhibits sustained release properties for 7 days, which ensures prolonged therapeutic effects, minimizes peptide waste and reduces injection frequency, with good flowability and injectability. In the model of LPS-induced inflammation model in vivo and in vitro, GHK-Cu@CMHA gel reduced levels of inflammatory factors and Reactive oxygen species (ROS) levels decreased, while superoxide dismutase (SOD) activity was enhanced. In this process, H&E staining and Masson staining revealed significant collagen deposition. These findings further confirm that GHK-Cu@CMHA is a novel injectable soft tissue filler with good anti-inflammatory and antioxidant properties, which holds well potential for inflammation inhibition. © 2025, The Authors. All rights reserved.

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Correction to: Efficient tunable plasmonic mode converters infiltrated with nematic liquid crystal layers

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Optical and Quantum Electronics 2021年第8期53卷 1-1页

作者： Kabeel, Randa H. Areed, Nihal F. F. Hameed, Mohamed Farhat O. Obayya, Salah S. A. Department of Electronics and Communications Engineering Faculty of Engineering University of Mansoura Mansoura Egypt Centre for Photonics and Smart Materials Zewail City of Science and Technology Giza Egypt Nanotechnology and Nanoelectronics Engineering Program Zewail City of Science and Technology Giza Egypt Mathematics and Engineering Physics Department Faculty of Engineering University of Mansoura Mansoura Egypt

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Enhanced optical nonlinearities under collective strong light-matter coupling

arXiv

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arXiv 2020年

作者： Ribeiro, Raphael F. Campos-Gonzales-Angulo, Jorge A. Giebink, Noel C. Xiong, Wei Yuen-Zhou, Joel Department of Chemistry and Biochemistry University of California San Diego La JollaCA92093 United States Department of Electrical Engineering Pennsylvania State University University ParkPA16802 United States Materials Science and Engineering Program University of California San Diego La JollaCA92093 United States

Optical microcavities and metallic nanostructures have been shown to significantly modulate the dynamics and spectroscopic response of molecular systems. We present a study of the nonlinear optics of a model consisting of N anharmonic multilevel systems (e.g., Morse oscillators) undergoing collective strong coupling with a resonant infrared microcavity. We find that, under experimentally accessible conditions, molecular systems in microcavities may have nonlinear phenomena significantly intensified due to the high quality of polariton resonances and the enhanced microcavity electromagnetic energy density relative to free space. Particularly large enhancement of multiphoton absorption happens when multipolariton states are resonant with bare molecule multiphoton transitions. In particular, our model predicts two-photon absorption cross section enhancements by several orders of magnitude relative to free space when the Rabi splitting ΩR is approximately equal to the molecular anharmonic shift 2∆. Our results provide rough upper bounds to resonant nonlinear response enhancement factors as relaxation to dark states is treated phenomenologically. Notably, ensembles of two-level systems undergoing strong coupling with a cavity (described by the Tavis-Cummings model) show no such optical nonlinearity enhancements, highlighting the rich phenomenology afforded by multilevel anharmonic systems. Similar conclusions are expected to hold for excitonic systems that share features with our model (e.g., molecular dyes with accessible S0 → S1 → S2 transitions) and strongly interact with a UV-visible cavity. Copyright © 2020, The Authors. All rights reserved.

关键词： Microcavities

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Effects of gold core size on regulating the performance of doxorubicin-conjugated gold nanoparticles

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Nano Research 2018年第6期11卷 3396-3410页

作者： Dongyan Wu Huaisong Wang Xiaoshuang Hou Huan Chen Yu Ma Yanglong Hou Jin Hong Ya Ding State Key Laboratory of Natural Medicines Department of Pharmaceutical Analysis China Pharmaceutical University Nanjing 210009 China Department of Biochemistry School of Life Science and Technology China Pharmaceutical University Nanjing 210009 China Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKLMMD) Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT) Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China Key Laboratory of Biomedical Functional Materials School of Sciences China Pharmaceutical University Nanjing 210009 China

Studies on the influence of one critical parameter （e.g., size）, targeting a specific disease, while keeping other factors unchanged, are important for improving understanding and application of the molecular design of biomedical nanomaterials. In this study, we used doxorubicin （Dox）-conjugated gold nanoparticles （GNPs） to investigate the effects of the size of the gold core （10, 20, or 60 nm） on the performance of their conjugates. We found that all three conjugates differed slightly in their physicochemical properties, facilitating a direct and accurate assessment of the size effects of GNP-Dox conjugates on their in vitro and in vivo performance. The cytological properties （the cell penetration rate and efficiency, as well as the cytotoxicity） and antitumor performance （the intratumoral penetration, treatment efficacy, and biodistribution） were highly correlated to the size of the inorganic core. Among all test groups, although the conjugate with a 60-nm gold core had the highest drug loading and release efficiency, the conjugate with a 10-nm gold core displayed the best antitumor efficacy toward the liver cancer models. This was because it showed the deepest tumor permeability and the highest tumor cell-killing ability of Dox transported by the relatively small GNPs. This study provides important evidence for better understanding the effect of size on in vitro and in vivo properties of potential therapeutic nanosystems and their structure design.

关键词： size effect doxorubicin-conjugated gold nanoparticles antitumor efficacy tumor penetration liver cancer

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Confining and channeling sound through coupled resonators

arXiv

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arXiv 2020年

作者： Zhou, Yun Bandaru, Prabhakar R. Sievenpiper, Daniel F. Department of Mechanical Engineering University of California San Diego San DiegoCA92093 United States Program in Materials Science University of California San Diego San DiegoCA92093 United States Department of Electrical Engineering University of California San Diego San DiegoCA92093 United States

Confining sound is of significant importance for the manipulation and routing acoustic waves. We propose a Helmholtz resonator (HR) based subwavelength sound channel formed at the interface of two metamaterials, for this purpose. The confinement is quantified through (i) a substantial reduction of the pressure, and (ii) an increase in a specific acoustic impedance (defined by the ratio of the local pressure to the sound velocity) - to a very large value outside the channel. The sound confinement is robust to frequency as well as spatial disorder at the interface, as long as the interface related edge mode is situated within the band gap. A closed acoustic circuit was formed by introducing controlled disorder in the HR units at the corners, indicating the possibility of confining sound to a point. Copyright © 2020, The Authors. All rights reserved.

关键词： Acoustic impedance

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Alloying behavior of wide band gap alkaline-earth chalcogenides

arXiv

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arXiv 2020年

作者： Millican, Samantha L. Clary, Jacob M. Bartel, Christopher J. Singstock, Nicholas R. Holder, Aaron M. Musgrave, Charles B. Department of Chemical and Biological Engineering University of Colorado BoulderCO80309 United States Materials and Chemical Science and Technology Center National Renewable Energy Laboratory GoldenCO80401 United States Renewable and Sustainable Energy Institute University of Colorado Boulder BoulderCO80309 United States Materials Science and Engineering Program University of Colorado Boulder BoulderCO80309 United States

Alloying is a powerful tool for tuning materials that facilitates the targeted design of desirable properties for a variety of applications. In this work, we provide a comprehensive investigation of the synthetic accessibility and electronic properties of nine alkaline-earth chalcogenide anion alloys (CaS1-xOx, CaS1-xSex, CaS1-xTex, SrS1-xOx, SrS1-xSex, SrS1-xTex, MgS1-xOx, MgS1-xSex, and MgS1-xTex). We show that isostructural alloying within the rock salt structure is favored for all systems except MgS1-xTex, which is predicted to be a heterostructural alloy between the rock salt and wurtzite structures. Alloys of S and Se are shown to be readily accessible for all cations with low miscibility critical temperatures, enabling continuous tuning of electronic properties across this composition space. Alloys of S and Te have higher critical temperatures but may be accessible through non-equilibrium synthesis strategies and are predicted here to have desirable electronic properties for optoelectronics with wide band gaps and lower effective masses than alloys of S and Se. Anion alloying in MgS1-xTex stabilizes the wurtzite structure across a significant fraction of composition space, which may make it of particular interest as a transparent conducting material due to its lower effective masses and a higher band gap than the rock salt structure. Zero-point corrected random phase approximation (RPA) energies were computed to resolve the small polymorph energy differences of the Mg compounds and are shown to be critical for accurately describing the thermodynamic properties of the corresponding alloys. Copyright © 2020, The Authors. All rights reserved.

关键词： Electronic properties

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Relationship Between Structure and Functional Properties of Ultrafine-Grained Fe-Mn-Si Alloys for Temporary Implants

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Crystals 2025年第5期15卷 424-424页

作者： Rybalchenko, Olga Martynenko, Natalia Anisimova, Natalia Rybalchenko, Georgy Tabachkova, Natalia Lukyanova, Elena Shchetinin, Igor Temralieva, Diana Tokar, Alexey Straumal, Petr Dolzhenko, Pavel Belyakov, Andrey Kiselevskiy, Mikhail Dobatkin, Sergey A.A. Baikov Institute of Metallurgy and Materials Science of the Russian Academy of Sciences Moscow119334 Russia Ministry of Health of the Russian Federation Moscow115478 Russia Research and Education Center for Biomedical Engineering National University of Science and Technology "MISIS" Leninsky Prospect 4 Moscow119049 Russia P.N. Lebedev Physical Institute of the Russian Academy of Sciences Moscow119991 Russia Department of Physical Materials Science National University of Science and Technology "MISIS" Leninsky Prospect 4 Moscow119049 Russia A.M. Prokhorov General Physics Institute of RAS Vavilov Str. 38 Moscow119991 Russia Laboratory of Hybrid Nanostructured Materials National University of Science and Technology "MISIS" Leninsky Prospect 4 Moscow119049 Russia Laboratory of Mechanical Properties of Nanostructured Materials and Superalloys Belgorod State University Belgorod308015 Russia Herbert Gleiter International Institute Liaoning Academy of Materials Shenyang110016 China

This paper presents a study of microstructure formation in bioresorbable Fe-Mn-Si alloys for temporary implants under high-pressure torsion (HPT) at room temperature and at 300 °C. The effect of silicon on the mechanism of microstructure formation under HPT and, as a consequence, on the mechanical, corrosion and biological properties of the alloys is studied. It is established that Si promotes martensitic transformation. HPT leads to an increase in the microhardness values of the studied alloys from ~1560 MPa in the initial state to ~5500 MPa (160–560 HV) due to structure refinement and phase transformation. An increase in the electrochemical corrosion rate of Fe-Mn-Si alloys to ~0.5 mm/year is established due to grain refinement to nanosize and the formation of strain-induced martensite. In vitro cytotoxicity and induced hemolysis studies showed that Fe-Mn, Fe-Mn-3.7Si, and Fe-Mn-5Si alloys after annealing and HPT can be characterized as biocompatible. © 2025 by the authors.

关键词： Microhardness

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人工智能赋能癌症免疫治疗——创新探索与未来机遇（英文）

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engineering 2025年第1期 12-16页

作者： Wei Xiang Lu Yu Xiaoyuan Chen Marco J.Herold Australian Centre for Artificial Intelligence in Medical Innovation La Trobe University School of Computing Engineering and Mathematical Sciences La Trobe University Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore Department of Chemical and Biomolecular Engineering College of Design and Engineering National University of Singapore Department of Biomedical Engineering College of Design and Engineering National University of Singapore Department of Pharmacy and Pharmaceutical Sciences Faculty of Science National University of Singapore Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Theranostics Center of Excellence(TCE) Yong Loo Lin School of Medicine National University of Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research(A*STAR) Olivia Newton-John Cancer Research Institute School of Cancer Medicine La Trobe University The Walter and Eliza Hall Institute of Medical Research Department of Medical Biology University of Melbourne

1. Introduction Cancer continues to be a major cause of global mortality rates, with conventional treatments such as chemotherapy and radiotherapy exhibiting inconsistent efficacy, high costs, and considerable side effects. Over the past decade, a promising alternative has emerged: cancer immunotherapy, which leverages the body's immune system to identify and eradicate cancer cells [1].

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UV nanophotodetector based on a single ZnO:Au nanowire functionalized with Au-nanoparticles 11

UV nanophotodetector based on a single ZnO:Au nanowire funct...

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Oxide-based materials and Devices XI 2020

作者： Postica, V. Pauporté, Th. Viana, B. Cavers, H. Hoppe, M. Adelung, R. Lupan, O. Enter for Nanotechnology and Nanosensors Department of Microelectronics and Biomedical Engineering Technical University of Moldova 168 Stefan cel Mare Blvd. ChisinauMD-2004 Moldova PSL Université Chimie ParisTech-CNRS Institut de Recherche de Chimie Paris UMR8247 11 rue P. et M. Curie Paris75005 France Functional Nanomaterials Institute for Materials Science Kiel University Kiel24143 Germany

ISBN: (纸本)9781510633254

In this work, an individual nanowire of zinc oxide (ZnO-NW), decorated with gold nanoparticles (Au-NPs/ZnO-NW), was integrated in a nanophotodetector using a dual beam focused electron/ion beam (FIB/SEM) system. Au-NPs/ZnO-NW arrays were synthesized by one-step electrochemical deposition at relative low-temperatures (90 °C). The nanodevice fabricated with a single nanowire Au-NPs/ZnO-NW demonstrated fast detection of UV radiation up to the operating temperature of 120 °C. The improved UV sensing properties of an individual Au-NPs/ZnO-NW compared to a single, undecorated, ZnO NW was explained based on the formation of Schottky barriers at the Au/ZnO NW interface, which resulted in a much more narrowed conduction channel and a lower dark current. These results prove that high-performance hybrid nanomaterials may possess superior electrical, optical and sensing properties and are of great interest for further fundamental studies. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

关键词： Zinc oxide

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