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Spin-state Conversion by Asymmetrical Orbital Hybridization in Ni-doped Co3O4to Boost Singlet Oxygen Generation for Microbial Disinfection

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Angewandte Chemie 2024年第12期136卷

作者： Meilin Duan Chao Huang Gong Zhang Hao Shi Pengfei Zhang Limin Li Tong Xu Zhen Zhao Zhujun Fu Jingrui Han Yuanhong Xu Xiaoteng Ding Institute of Biomedical Engineering College of Life Sciences Qingdao University Qingdao 266071 P.R. China Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu 610031 Sichuan China Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Beijing 100084 China Department of Urology The Affiliated Hospital of Qingdao University Qingdao 266071 P.R. China Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China Qingdao 266100 P.R. China School of Materials Science and Engineering Tianjin University Tianjin 300350 P.R. China

Singlet oxygen ( 1 O 2 ) plays a significant role in environmental and biomedical disinfection fields. Electrocatalytic processes hold great potential for 1 O 2 generation, but remain challenging. Herein, a facile Ni doping converted spin-state transition approach is reported for boosting 1 O 2 production. Magnetic analysis and theoretical calculations reveal that Ni occupied at the octahedral site of Co 3 O 4 can effectively induce a low-to-high spin-state transition. The high-spin Ni−Co 3 O 4 generate appropriate binding strength and enhance electron transfer between the Co centers with oxygen intermediates, thereby improving the catalytic activity of Ni−Co 3 O 4 for effective generating 1 O 2 . In neutral conditions, 1×10 6 CFU mL −1 Gram-negative ESBL-producing Escherichia coli ( E. coli ) could be inactivated by Ni−Co 3 O 4 system within 5 min. Further antibacterial mechanisms indicate that 1 O 2 can lead to cell membrane damage and DNA degradation so as to irreversible cell death. Additionally, the developed Ni−Co 3 O 4 system can effectively inactivate bacteria from wastewater and bioaerosols. This work provides an effective strategy for designing high-spin electrocatalysis to boost 1 O 2 generation for disinfection process.

关键词： singlet oxygen spin-related orbital interaction entropy advanced oxidation processes microbial disinfection ROS regulation

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Light-Harvesting Fluorescent Spherical Nucleic Acids Self-Assembled from a DNA-Grafted Conjugated Polymer for Amplified Detection of Nucleic Acids

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Angewandte Chemie 2022年第12期134卷

作者： Fan Xiao Dr. Xiaofeng Fang Dr. Hongyan Li Dr. Hanbing Xue Zixiang Wei Wenkang Zhang Yulin Zhu Li Lin Prof. Yan Zhao Prof. Changfeng Wu Prof. Leilei Tian School of Materials Science and Engineering Harbin Institute of Technology Nangang District Harbin 150001 Heilongjiang P. R. China Department of Materials Science and Engineering Southern University of Science and Technology Nanshan District Shenzhen 518055 Guangdong P. R. China Department of Biomedical Engineering Southern University of Science and TechnologyInstitution Nanshan District Shenzhen 518055 Guangdong P. R. China School of Life Science Southern University of Science and Technology Nanshan District Shenzhen 518055 Guangdong P. R. China Department of Chemistry Southern University of Science and Technology Nanshan District Shenzhen 518055 Guangdong P. R. China

The ultralow concentration of nucleic acids in complex biological samples requires fluorescence probes with high specificity and sensitivity. Herein, a new kind of spherical nucleic acids (SNAs) is developed by using fluorescent π-conjugated polymers (FCPs) as a light-harvesting antenna to enhance the signal transduction of nucleic acid detection. Specifically, amphiphilic DNA-grafted FCPs are synthesized and self-assemble into FCP-SNA structures. Tuning the hydrophobicity of the graft copolymer can adjust the size and light-harvesting capability of the FCP-SNAs. We observe that more efficient signal amplification occurs in larger FCP-SNAs, as more chromophores are involved, and the energy transfer can go beyond the Förster radius. Accordingly, the optimized FCP-SNA shows an antenna effect of up to 37-fold signal amplification and the limit of detection down to 1.7 pM in microRNA detection. Consequently, the FCP-SNA is applied to amplified in situ nucleic acid detecting and imaging at the single-cell level.

关键词： Light-Harvesting Antenna MicroRNA Detection Spherical Nucleic Acid π-Conjugated Polymer

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Electrically-insulating flexible films with quasi-one-dimensional van-der-waals fillers as efficient electromagnetic shields

arXiv

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arXiv 2021年

作者： Barani, Zahra Kargar, Fariborz Ghafouri, Yassamin Ghosh, Subhajit Godziszewski, Konrad Seyedmahmoudbaraghani, Saba Yashchyshyn, Yevhen Cywiński, Grzegorz Rumyantsev, Sergey Salguero, Tina T. Balandin, Alexander A. Center Department of Electrical and Computer Engineering University of California RiversideCA92521 United States Department of Chemistry University of Georgia AthensGA30602 United States Institute of Radioelectronics and Multimedia Technology Warsaw University of Technology Warsaw00-665 Poland CENTERA Laboratories Institute of High-Pressure Physics Polish Academy of Sciences Warsaw01-142 Poland CEZAMAT Warsaw University of Technology Warsaw02-822 Poland Materials Science and Engineering Program University of California RiversideCA92521 United States

We report polymer composite films containing fillers comprised of quasi-one-dimensional (1D) van der Waals materials, specifically transition metal trichalcogenides containing 1D structural motifs that enable their exfoliation into bundles of atomic threads. These nanostructures are characterized by extremely large aspect ratios of up to ~106. The polymer composites with low loadings of quasi-1D TaSe3 fillers ( Copyright © 2021, The Authors. All rights reserved.

关键词： Fillers

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Biodegradable nanoparticles for enhanced lymph node trafficking and paracortex penetration for malaria transmission blocking vaccines 42

Biodegradable nanoparticles for enhanced lymph node traffick...

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42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

作者： Howard, Gregory P. Verma, Garima Khare, Prachi V. Ke, Xiyu Dinglasan, Rhoel Mao, Hai-Quan Institute for NanoBioTechnology Johns Hopkins University BaltimoreMD United States Department of Biomedical Engineering Johns Hopkins University School of Medicine BaltimoreMD United States Emerging Pathogens Institute University of Florida GainesvilleFL United States Department of Materials Science and Engineering Johns Hopkins University BaltimoreMD United States

ISBN: (纸本)9781510883901

Statement of Purpose: The eradication of malaria from the human population is one of the greatest public health challenges. Current intervention and therapeutic medicines will likely fall short of eliminating the disease. Transmission-blocking vaccines (TBVs) have been identified as a key intervention for reducing malaria spreading [1]. These vaccines are designed to elicit high antibody titers that, once taken up by a mosquito during bloodmeal, block interactions between target antigens on the parasite surface and key surface receptors on the mosquito midgut. By abrogating this binding event, the parasite cannot traverse the mosquito midgut into the salivary glands, thus blocking future infection from that mosquito to a healthy human. In this fashion, TBVs prevent malaria spread within infected mosquitos. A key engineering challenge is to elicit a high, durable antibody response against a selected mosquito midgut surface protein, Anopheline Alanyl aminopeptidase N (AnAPN1) [2]. Nanoparticles have been employed for antigen delivery to potentiate the immune response for both prophylactic and therapeutic applications [2]. NPs for lymph node (LN)-targeted delivery to access the abundant population of immature dendritic cells (DCs), B, and T-lymphocytes, has been shown to be effective for other infectious disease targets, cancer, and autoimmune treatment. In particular, smaller size (25–60 nm) NPs are transported to draining LNs and processed by immature DCs more readily than larger NPs following subcutaneous (s.c.) administration [3, 4]. Here, we report the development and optimization of PLGA-b-PEG NPs for the delivery of mosquito midgut surface antigen AnAPN1 [5] as a TBV, using a biodegradable polyester with proven safety track record in the clinic. © 2019 Omnipress - All rights reserved.

关键词： Vaccines

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Kinetics of autophagic activity in nanoparticle-exposed lung adenocarcinoma (A549) cells

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Autophagy reports 2023年第1期2卷 2186568页

作者： Arnold Sipos Kwang-Jin Kim Constantinos Sioutas Edward D Crandall Will Rogers Institute Pulmonary Research Center and Hastings Center for Pulmonary Research Keck School of Medicine University of Southern California Los Angeles CA USA. Department of Pathology Keck School of Medicine University of Southern California Los Angeles CA USA. Department of Physiology and Neurosciences Keck School of Medicine University of Southern California Los Angeles CA USA. Department of Pharmacology and Pharmaceutical Sciences School of Pharmacy University of Southern California Los Angeles CA USA. Department of Biomedical Engineering Viterbi School of Engineering University of Southern California Los Angeles CA USA. Sonny Astani Department of Civil and Environmental Engineering Viterbi School of Engineering University of Southern California Los Angeles CA USA. Mork Family Department of Chemical Engineering and Materials Science Viterbi School of Engineering University of Southern California Los Angeles CA USA.

Autophagy, a homeostatic mechanism, is crucial in maintaining normal cellular function. Although dysregulation of autophagic processes is recognized in certain diseases, it is unknown how maintenance of cellular homeostasis might be affected by the kinetics of autophagic activity in response to various stimuli. In this study, we assessed those kinetics in lung adenocarcinoma (A549) cells in response to exposure to nanoparticles (NP) and/or Rapamycin. Since NP are known to induce autophagy, we wished to determine if this phenomenon could be a driver of the harmful effects seen in lung tissues exposed to air pollution. A549 cells were loaded with a fluorescent marker (DAPRed) that labels autophagosomes and autolysosomes. Autophagic activity was assessed based on the fluorescence intensity of DAPRed measured over the entire cell volume of live single cells using confocal laser scanning microscopy (CLSM). Autophagic activity over time was determined during exposure of A549 cells to single agents (50 nM Rapamycin; 80 μg/mL, 20 nm carboxylated polystyrene NP (PNP); or, 1 μg/mL ambient ultrafine particles (UFP) (<180 nm)), or double agents (Rapamycin + PNP or Rapamycin + UFP; concomitant and sequential), known to stimulate autophagy. Autophagic activity increased in all experimental modalities, including both single agent and double agent exposures, and reached a steady state in all cases ~2 times control from ~8 to 24 hrs, suggesting the presence of an upper limit to autophagic capacity. These results are consistent with the hypothesis that environmental stressors might exert their harmful effects, at least in part, by limiting available autophagic response to additional stimulation, thereby making nanoparticle-exposed cells more susceptible to secondary injury due to autophagic overload.

关键词： Rapamycin ambient ultrafine particles autophagic capacity autophagy polystyrene nanoparticles

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Simple solution for single final vial filling of ga-68 radiopharmaceuticals in one hot cell isolator at small-scale radiopharmacy laboratories under aseptic conditions 60th

Simple solution for single final vial filling of ga-68 radio...

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60th International Scientific Conference of Riga Technical University Section of materials science and Applied Chemistry, MSAC 2019

作者： Rozensteins, Harijs Zicans, Janis Mutere, Olga Berzina, Rita Meri, Remo Merijs Kusins, Toms Reinholds, Ingars Mazkalnina, Liva Svirksts, Karlis Kovaldins, Ricards Kizane, Gunta Grinbergs, Andrejs Kodolmedicinas Klinika Ltd Riga Latvia Institute of Biomedical Engineering and Nanomedicine Riga Technical University Riga Latvia Institute of Polymer Materials Faculty of Materials Science and Applied Chemistry Riga Technical University Riga Latvia Institute of Microbiology and Biotechnology University of Latvia Riga Latvia Riga East University Hospital Clinical Department of Nuclear Medicine Riga Latvia Institute of Food Safety Animal health and Environment BIOR Riga Latvia Faculty of Chemistry University of Latvia Riga Latvia Institute of Chemical Physics University of Latvia Riga Latvia

ISBN: (纸本)9783035716399

A simple solution to fulfill biosafety and national drug agency demands of radiation and biosafety during Ga-68 radionuclide containing radiopharmaceutical production (RP) by small scale laboratories was demonstrated. The solution based on a novel sterile seal concept of multi-layer bag system prototype. These mid-and inner enclosures of the prototype with vial inside were sterilized by 50 kGy of gamma radiation. Microbial safety validation based on two-week testing confirmed successful sterilization of sealing bags with vails. The analysis of physicochemical properties (mechanical properties and gel fraction studies) revealed that sterilization did not cause any undesired changes in the developed materials if compared to non-irradiated control samples. © 2020 Trans Tech Publications Ltd, Switzerland.

关键词： Safety testing

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Magnetic anisotropy reversal driven by structural symmetry-breaking in monolayer α-RuCl3

arXiv

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arXiv 2022年

作者： Yang, Bowen Goh, Yin Min Sung, Suk Hyun Ye, Gaihua Biswas, Sananda Kaib, David A.S. Dhakal, Ramesh Yan, Shaohua Li, Chenghe Jiang, Shengwei Chen, Fangchu Lei, Hechang He, Rui Valentí, Roser Winter, Stephen M. Hovden, Robert Tsen, Adam W. Institute for Quantum Computing University of Waterloo WaterlooONN2L 3G1 Canada Department of Physics and Astronomy University of Waterloo WaterlooONN2L 3G1 Canada Department of Physics University of Michigan Ann ArborMI48109 United States Department of Materials Science and Engineering University of Michigan Ann ArborMI48109 United States Department of Electrical and Computer Engineering Texas Tech University LubbockTX79409 United States Institut für Theoretische Physik Goethe-Universität Frankfurt Max-von-Laue-Strasse 1 Frankfurt am Main60438 Germany Department of Physics Center for Functional Materials Wake Forest University Winston-SalemNC27109 United States Department of Physics Beijing Key Laboratory of Opto-electronic Functional Materials & Micro-nano Devices Renmin University of China Beijing100872 China Department of Physics Cornell University IthacaNY United States School of Physics and Astronomy Shanghai Jiao Tong University Shanghai China Applied Physics Program University of Michigan Ann ArborMI48109 United States Department of Chemistry University of Waterloo WaterlooONN2L 3G1 Canada

The Kitaev model is a celebrated spin-½ model on the two-dimensional (2D) honeycomb lattice with bond-dependent Ising interactions1, which features a highly entangled quantum spin liquid (QSL) ground state, fractionalized Majorana excitations, and a series of magnetic-field-induced quantum phase transitions1-7. The search for materials realizing the Kitaev model has been an ongoing challenge for over a decade and may potentially lead to applications in fault-tolerant topological quantum computing8. Yet, the unavoidable presence of non-Kitaev interactions (Heisenberg, off-diagonal, next-nearest neighbor, etc.) almost always drives the ground state away from the QSL phase, and a careful tuning of the exchange parameters is needed9-12. α-RuCl3 is a layered van der Waals material that is a particularly promising candidate to realize Kitaev physics13-15. Although the ground state is zigzag (ZZ) antiferromagnetic (AFM), this ordering can be suppressed with the application of an ~ 6-8T in-plane magnetic field. The presence of a half-integer thermal quantum Hall effect has been reported in this intermediate phase at low temperature16,17, while an unusual continuum of magnetic excitations can be seen even without magnetic field that persists far above the Néel temperature (TN ~ 7-8K)18,19. Both observations hint at α-RuCl3 being in proximity to a QSL, making it a current subject of intense scrutiny. Yet from a theoretical point of view, a QSL induced by in-plane field generally cannot be accounted for, as most calculations for α-RuCl3 show Kitaev phases more broadly emerging from an out-of-plane field6,20-23. Due to the strong "easy-plane" magnetic anisotropy of bulk crystals, however, prohibitively high fields above 30T are required to access such states24-26. The strong coupling between the spin, charge, and lattice degrees of freedom in α-RuCl3 presents an exciting opportunity to tune its magnetic interactions via external perturbations. Although pressure27-29, strain30,

关键词： Ground state

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Phosphotungstic acid (H₃PW₁₂O₄₀)-loaded onto titanium porous montmorillonite heterostructure for the effective enhanced kinetics and thermodynamic conversion of citronellal

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Case Studies in Chemical and Environmental engineering 2025年 11卷

作者： Fatimah, Is Yahya, Amri Rubiyanto, Dwiarso Sagadevan, Suresh Oh, Won-Chun Doong, Ruey-an Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Islam Indonesia Kampus Terpadu UII Jl. Kaliurang Km 14 Sleman Yogyakarta Indonesia Nanomaterials and Sustainable Chemistry Research Centre Chemistry Laboratory Universitas Islam Indonesia Kampus Terpadu UII Jl. Kaliurang Km 14 Sleman Yogyakarta Indonesia Chemistry Study Program Nusa Bangsa University JL. KH Sholeh Iskandar KM.4 Tanah Sareal Bogor 16166 Indonesia Nanotechnology & Catalysis Research Centre University of Malaya Kuala Lumpur 50603 Malaysia Department of Advanced Materials Science and Engineering Hanseo University Seosan-si 356-706 South Korea Institute of Analytical and Environmental Sciences National Tsing Hua University 101 Sec 2 Kuang Fu Road Hsinchu 30013 Taiwan

In present work, nanocomposite of phosphotungstic acid (H3PW12O40)-loaded onto titanium-porous clay heterostructure (PTA/Ti–PCH) was prepared using natural montmorillonite as parent material (Mnt). Characterization o... 详细信息

In present work, nanocomposite of phosphotungstic acid (H₃PW₁₂O₄₀)-loaded onto titanium-porous clay heterostructure (PTA/Ti–PCH) was prepared using natural montmorillonite as parent material (Mnt). Characterization of the material was performed using X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy-energy dispersive X-ray fluorescence, transmission electron microscopy, Fourier-Transform Infra-Red spectroscopy, and solid acidity measurement. The material was examined as superacid catalyst in citronellal conversion into isopulegol by varied reaction conditions. Kinetics and thermodynamic studies of catalyzed reaction revealed the role of increased total surface acidity and the Lewis to Brønsted to enhance the reaction conversion and selectivity. Thermodynamic study demonstrated a lower activation energy of the reaction over PTA/Ti–PCH compared to Ti–PCH. A 100 % conversion was exhibited by the sample during 120 min of the reaction at 90°C, and the sample also demonstrated activity at room temperature. Reusability of the sample was expressed by a maintained conversion until 5th cycle. Conclusively, the prepared material showed a potency to be developed for heterogeneously acid-catalyzed organic reactions. © 2025 The Authors

关键词： Acid Citronellal Clay-based nanocomposite Heterogeneous catalysis Porous clay heterostructure

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Infrared block of Na+ and Ca2+ spikes in in crayfish neuromuscular junction

Infrared block of Na+ and Ca2+ spikes in in crayfish neuromu...

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Optogenetics and Optical Manipulation 2019

作者： Zhu, Xuedong Lin, Jen-Wei Sander, Michelle Y. Department of Biomedical Engineering Boston University 44 Cummington Mall BostonMA02215 United States Department of Biology Boston University 5 Cummington Mall BostonMA02215 United States Department of Electrical and Computer Engineering Boston University Photonics Center Boston University BostonMA02215 United States Division of Materials Science and Engineering Boston University BrooklineMA02446 United States

ISBN: (数字)9781510623750

ISBN: (纸本)9781510623743

Pulsed infrared (IR) light in the 1.8-2 μm region can modulate neural activities with high spatial and temporal precision. However, the mechanisms underlying these photothermal interactions are not fully understood. Here we investigate the IR modulation of axon and muscle activities using the crayfish (Procambarus clarkii) opener neuromuscular preparation. A modulated fiber coupled laser diode (λ = 2 μm) is used to deliver pulsed light with durations between 10-500 ms. Twoelectrode current clamp (TECC) is performed to stimulate and monitor the neural activities. Laser-induced temperature changes are measured by an open patch pipette simultaneously with TECC. We find that IR pulses can reversibly inhibit or block axon (Na+) and muscle (Ca2+) spikes. In axons, single IR pulses can suppress the action potential (AP) amplitude and duration and increase the interspike interval. In addition, the rates of AP depolarization and repolarization are also modulated by IR pulses. Individual IR pulses can also block muscle fiber Ca2+ spikes. The IR-induced decrease in the input resistance (8.4%) can be a contributing factor for the inhibition phenomena reported here. © 2019 SPIE.

关键词： Neurons

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Rapid antibiotic sensitivity prediction in Pseudomonas aeruginosa using UV–vis-NIR spectroscopy and gray-box one-vs-all models

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Journal of Microbiological Methods 2025年

作者： Tsung-Han Chou Chi-Wei Chen Su-Hua Huang Ying-Tsong Chen Yen-Wei Chu Doctoral Program in Medical Biotechnology National Chung Hsing University Taichung Taiwan Graduate Degree Program of Smart Healthcare & Bioinformatics I-Shou University Kaohsiung Taiwan Department of Biomedical Engineering I-Shou University Kaohsiung Taiwan Department of Medical Laboratory Science and Biotechnology Asia University Taichung Taiwan Graduate Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan Institute of Molecular Biology National Chung Hsing University Taichung Taiwan Smart Sustainable New Agriculture Research Center (SMARTer) Taichung Taiwan

Pseudomonas aeruginosa is a widespread pathogen known to cause infections in various hosts, particularly threatening immunocompromised patients. Although determining antibiotic sensitivity is crucial for appropriate patient care, existing diagnostic methods remain time-consuming, which can delay targeted therapy. In this study, we propose a novel, interpretable, and cost-effective framework that combines ultraviolet-visible-near-infrared (UV–Vis-NIR) spectroscopy with subgroup discovery and a one-vs-all multilayer perceptron (MLP) model to predict antibiotic sensitivity without the need for traditional culture methods. Unlike prior approaches that depend on expensive instruments or black-box algorithms, our method leverages spectral pattern interpretability to identify key wavelength features associated with distinct resistance categories. Testing on clinical isolates of P. aeruginosa , the model achieved optimal prediction accuracy within 10 min of culture time, significantly reducing the typical 48–72 h turnaround time of conventional culture-based susceptibility testing. This work demonstrates a promising direction for rapid, low-cost, and clinically actionable antimicrobial susceptibility testing that balances performance with explainability.

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