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Biosynthesis, characterisation and biocompatibility of a unique and elastomeric medium chain-length polyhydroxyalkanoates for kidney glomerular tissue engineering

Materials Today Bio

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materials Today Bio 2025年 33卷

作者： Syed Mohammad Daniel Syed Mohamed Jack Tuffin Judy Watson Andrea Mele Annabelle Fricker David A. Gregory Elbaraa Elghazy Moin A. Saleem Simon C. Satchell Gavin I. Welsh Ipsita Roy School of Chemical Materials & Biological Engineering Faculty of Engineering University of Sheffield Sheffield S37HQ UK PHAsT Limited Sheffield S1 4DP UK The Discovery Centre (DISC) AstraZeneca PLC Biomedical Campus Cambridge CB2 0AA UK Renal Bristol Translational Health Sciences Bristol Medical School University of Bristol Bristol BS1 3NY UK Insigneo Institute for in silico Medicine University of Sheffield UK Department of Construction and Building Engineering Arab Academy for Science Technology and Maritime Transport Cairo Egypt

Polyhydroxyalkanoates (PHAs) are bacteria-derived polymers that are being actively explored for their potential in biomedical engineering applications. These polymers are not only highly biocompatible in nature but also sustainable, produced using renewable substrates, and hence considered future biomaterials. In addition to normal fermentation, PHAs can also be produced through a synthetic biology approach. This study explores a medium chain-length PHA (mcl-PHA) produced by Pseudomonas mendocina CH50 by batch fermentation, fed with glucose as the sole carbon source. The polymer was extensively characterised, and it exhibited an elastomeric property of a typical mcl-PHA with 215 ± 52 % elongation at break. The mcl-PHA also had a low melting point, T m , of around 55 °C, making it processable with various fabrication methods. The extracted mcl-PHA was prepared as a solvent-cast film and tested as a potential cell culture substrate for human glomerular cells, the conditionally immortalised human podocytes (CiHP) and conditionally immortalised human glomerular endothelial cells (CiGEnC). Initial resazurin assay under proliferative conditions showed promising cell metabolic activities of the cells cultured on the mcl-PHA film, comparable with those cultured on tissue culture plastic (TCP). Despite the decreased expression of collagen IV under proliferative conditions, the differentiated co-cultured cells on mcl-PHA had comparable values with cells those grown on TCP. These promising results verified the biocompatibility of the mcl-PHA produced by P. mendocina CH50 and established its potential as a bio-based sustainable alternative in biomedical applications including glomerular tissue engineering.

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Publisher Correction: A skin-integrated multimodal haptic interface for immersive tactile feedback

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Nature Electronics 2023年第12期6卷 1041页

作者： Ya Huang Jingkun Zhou Chun Ki Yiu Kuanming Yao Dengfeng Li Jian Li Tsz Hung Wong Yiming Liu Yuyu Gao Xingcan Huang Hu Li Jiyu Li Binbin Zhang Zhenlin Chen Xinge Yu Pingchuan Ke Shaoyu Cai Xingyu Yang Haichen Gao Kening Zhu Xu Guo Zichen Zhao Zhaoqian Xie Yu Zhou Lei Li Huanxi Zheng Zuankai Wang Enming Song Hui Wu Department of Biomedical Engineering City University of Hong Kong Hong Kong China Hong Kong Centre for Cerebro-Cardiovascular Health Engineering Hong Kong Science Park Hong Kong China Shenzhen Research Institute City University of Hong Kong Shenzhen China Department of Sociology Hong Kong Shue Yan University Hong Kong China School of Creative Media City University of Hong Kong Hong Kong China Engineering Design and Innovation Centre College of Design and Engineering National University of Singapore Singapore Singapore State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial Equipment Dalian University of Technology Dalian China Department of Engineering Mechanics Dalian University of Technology Dalian China Ningbo Institute of Dalian University of Technology Ningbo China Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology Hong Kong China National Engineering Research Center of Electric Vehicles Beijing Institute of Technology Beijing China Department of Mechanical Engineering Hong Kong Polytechnic University Hong Kong China Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of Optoelectronics Fudan University Shanghai China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing China

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Low-Tech solutions for the COVID-19 supply chain crisis

arXiv

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arXiv 2020年

作者： Armani, Andrea M. Hurt, Darrell E. Hwang, Darryl McCarthy, Meghan C. Scholtz, Alexis Department of Chemical Engineering and Materials Science University of Southern California United States Bioinformatics and Computational Biosciences Branch Office of Cyber Infrastructure and Computational Biology National Institute of Allergy and Infectious Diseases BethesdaMD20892 United States Department of Biomedical Engineering University of Southern California United States Department of Radiology University of Southern California United States

A global effort is ongoing in the scientific community and in the Maker Movement, which focuses on creating devices and tinkering with them, to reverse-engineer commercial medical equipment and get it to healthcare workers. For these 'low-Tech' solutions to have a real impact, it is important for them to coalesce around approved designs. Copyright © 2020, The Authors. All rights reserved.

关键词： Supply chains

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A facile method for fabrication of nano-structured Ni-Al_2O_3 graded coatings: Structural characterization

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Transactions of Nonferrous Metals Society of China 2018年第1期28卷 77-87页

作者： Arash YAZDANI Taghi ISFAHANI Materials Science and Engineering Program University of California Department of Mechanical and Aerospace Engineering University of California Metallurgy & Materials Engineering Department Golpayegan University of Technology

Powder charges of micron-size Ni and Al2O3were utilized to deposit nano-structured Ni-Al2O3composite coatings on analuminum plate fixed at the top end of a milling vial using a planetary ball *** coatings were fabricated using powdermixtures with a wide range of Ni/Al2O3mass ratio varying from1:1to plain ***,SEM and TEM techniques were employed tostudy the structural characteristics of the *** was found that the composition of the starting mixture strongly affects the Al2O3content and the microstructure of the final *** containing higher contents of Al2O3yield higher volume fractions of theAl2O3particles in the *** Ni-Al2O3composite coatings with about50%of Al2O3particles were successfully deposited,well-compacted and free of cracks and/or voids coatings included less than20%(volume fraction)of Al2O3particles which weredeposited from powder mixtures with Ni/Al2O3mass ratios of4:1or ***,mechanical and metallurgical bondings arethe main mechanisms of the adhesion of the coating to the Al ***,functionally graded composite coatings withnoticeable compaction and integrity were produced by deposition of two separate layers under identical coating conditions.

关键词： metal matrix composite Ni-Al2O3 graded coating structural characterization

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Thermo-responsive poly( N -isopropylacrylamide) (PNIPAM) hydrogel particles improve workability loss and autogenous shrinkage in cement paste

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CEMENT 2022年 10卷

作者： Anastasia N. Aday Mohammad G. Matar Jorge Osio-Norgaard Wil V. Srubar Materials Science and Engineering Program University of Colorado Boulder ECOT 441 UCB 428 Boulder CO 80309-0428 USA Department of Civil Environmental and Architectural Engineering University of Colorado Boulder ECOT 441 UCB 428 Boulder CO 80309-0428 USA Department of Mechanical Engineering University of Colorado Boulder ECOT 441 UCB 428 Boulder CO 80309-0428 USA

In this work, we show that non-superabsorbent, thermo-responsive poly(N-isopropyl acrylamide) (PNIPAM) hydrogel particles (< 250 μm) can reduce autogenous shrinkage in cement paste and improve early-age stiffening that can be caused by traditional superabsorbent polymers (SAPs). Swelling measurements in DI water and cement filtrate solution suggest that SAP-induced early-age stiffening is caused by its super-absorbency in low-ionic solutions – a behavior not exhibited by non-superabsorbent PNIPAM. Addition of PNIPAM resulted in a 29% and 60% reduction in autogenous shrinkage strain at 14 days when used alone (0.3 wt% PNIPAM) and in combination with SAP (0.15% PNIPAM, 0.15% SAP), respectively, compared to a Control with no polymer addition. Furthermore, an addition of 0.3 wt.% PNIPAM exhibited a ∼29% and ∼37% decrease in static yield stress compared to a Control and 0.3 wt% SAP-modified cement pastes, respectively. Taken together, the results provide initial evidence to suggest that the use of hydrogels as internal curing agents may not necessarily require super-absorbency to reduce autogenous shrinkage. Non-superabsorbent hydrogels, like PNIPAM, may help reduce autogenous shrinkage while alleviating the effects of SAP-induced early-age stiffening.

关键词： Superabsorbent polymers Poly( N -isopropyl acrylamide) (PNIPAM) Static yield stress Autogenous shrinkage

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Data-Driven Controlled Synthesis of Oriented Quasi-Spherical CsPbBr3Perovskite materials

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Angewandte Chemie 2024年第14期136卷

作者： Shaohui Liu Zijian Chen Yingming Liu Lingjun Wu Boyuan Wang Zixuan Wang Bobin Wu Xinyu Zhang Jie Zhang Mengyun Chen Hao Huang Junzhi Ye Paul K. Chu Xue-Feng Yu Lakshminarayana Polavarapu Robert L. Z. Hoye Feng Gao Haitao Zhao Center for Intelligent and Biomimetic Systems Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 Guangdong PR China Nano Science and Technology Institute University of Science and Technology of China Suzhou 215000 PR China Wenzhou Institute of Technology Digital Intelligent Manufacturing Research Center Wenzhou 325000 PR China Department of Chemical and Environmental Engineering the University of Nottingham Ningbo China Ningbo 315100 PR China Centre for Photonics Information and Energy Materials Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 Guangdong PR China Department of Physics Chemistry and Biology (IFM) Linköping University Linköping SE-58183 Sweden Materials Interfaces Center Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 Guangdong PR China Inorganic Chemistry Laboratory University of Oxford South Parks Road Oxford OX1 3QR United Kingdom Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong China CINBIO Materials Chemistry and Physics Group University of Vigo Campus Universitario Marcosende Vigo 36310 Spain

Controlled synthesis of lead-halide perovskite crystals is challenging yet attractive because of the pivotal role played by the crystal structure and growth conditions in regulating their properties. This study introduces data-driven strategies for the controlled synthesis of oriented quasi-spherical CsPbBr 3 , alongside an investigation into the synthesis mechanism. High-throughput rapid characterization of absorption spectra and color under ultraviolet illumination was conducted using 23 possible ligands for the synthesis of CsPbBr 3 crystals. The links between the absorption spectra slope (difference in the absorbance at 400 nm and 450 nm divided by a wavelength interval of 50 nm) and crystal size were determined through statistical analysis of more than 100 related publications. Big data analysis and machine learning were employed to investigate a total of 688 absorption spectra and 652 color values, revealing correlations between synthesis parameters and properties. Ex situ characterization confirmed successful synthesis of oriented quasi-spherical CsPbBr 3 perovskites using polyvinylpyrrolidone and Acacia. Density functional theory calculations highlighted strong adsorption of Acacia on the (110) facet of CsPbBr 3 . Optical properties of the oriented quasi-spherical perovskites prepared with these data-driven strategies were significantly improved. This study demonstrates that data-driven controlled synthesis facilitates morphology-controlled perovskites with excellent optical properties.

关键词： Data-driven Controlled synthesis Perovskite

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Biomimetic electroactive materials and devices for regenerative engineering

Nature Reviews Electrical Engineering

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Nature Reviews Electrical engineering 2025年 1-17页

作者： Yang Liu Boon Chin Heng Xuehui Zhang Xuliang Deng Yunyang Bai Yong Wang Thanh D. Nguyen Department of Dental Materials & Dental Medical Devices Testing Center Peking University School and Hospital of Stomatology Beijing PR China NMPA Key Laboratory for Dental Materials Peking University School and Hospital of Stomatology Beijing PR China Institute of Advanced Clinical Medicine Peking University Beijing China Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology Beijing PR China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Peking University School and Hospital of Stomatology Beijing PR China National Center for Stomatology Peking University School and Hospital of Stomatology Beijing PR China National Clinical Research Center for Oral Diseases Peking University School and Hospital of Stomatology Beijing PR China NHC Research Center of Engineering and Technology for Computerized Dentistry Peking University School and Hospital of Stomatology Beijing PR China Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing PR China Center of Digital Dentistry Department of Prosthodontics Peking University School and Hospital of Stomatology Beijing PR China Department of Mechanical Engineering University of Connecticut Storrs CT USA Department of Biomedical Engineering University of Connecticut Storrs CT USA Institute of Materials Science Polymer Program University of Connecticut Storrs CT USA

Electrical signalling cues have an important role in regulating human metabolism. Electrical stimulation is widely used to promote tissue regeneration and functional recovery. Electroactive biomaterials and devices, which convert various physical stimuli and energy sources to electrical signalling cues, have demonstrated much potential in repairing damaged tissues such as bone, cartilage, nerves, skin, muscle, tendons and ligaments, owing to their self-powering and biomimetic properties. In this Review, we examine the design and engineering of biomimetic electroactive devices for tissue repair. We highlight the conductive, piezoelectric and triboelectric properties of materials that can be applied for regenerative engineering as well as the engineering strategies used to develop effective devices with these materials. We also discuss how electroactive materials and devices can target specific tissues and clinical applications, and the mechanisms underlying the successful regeneration of tissue with these devices. Finally, we outline the need for further work on safety, effectiveness and regulation to aid the clinical translation of electroactive devices for regenerative medicine and tissue engineering.

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Ε‑Polylysine-stabilized agarose/polydopamine hydrogel dressings with robust photothermal property for wound healing

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Carbohydrate Polymers 2021年 264卷 118046-118046页

作者： Qi, Xiaoliang Pan, Wenhao Tong, Xianqin Gao, Teng Xiang, Yajing You, Shengye Mao, Ruiting Chi, Jun Hu, Rongdang Zhang, Wenzhen Deng, Hui Shen, Jianliang State Key Laboratory of Ophthalmology Optometry and Vision Science School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou325027 China School & Hospital of Stomatology Wenzhou Medical University Xueyuan West Road Lucheng District Wenzhou325027 China Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province Wenzhou Institute University of Chinese Academy of Sciences Xinsan Road Longwan District Wenzhou325001 China Department of Wound Repair The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou325000 China

Polydopamine (PDA) is emerging as an attractive photothermal agent due to its good photothermal performance and excellent biocompatibility. However, without chemical modification, PDA is normally unstable and usually leached out from the constructed biomaterials, realistically limiting its application space. Here, we constructed a new hydrogel dressing with robust and stable photothermal performance by introduction of Ε-Polylysine (Ε-PL) into agarose/PDA matrix to efficiently lock PDA. By optimizing PDA/Ε-PL rational dose in agarose network structure, a hybrid agarose/PDA/Ε-PL hydrogel (ADPH) with stable photothermal functionality and desirable physicochemical properties could be achieved. ADPH possessed satisfactory microbicidal efficacy in vivo, which enabled the bacteria-infected skin wound to be cured quickly by successful suppressing inflammation, accelerating collagen deposition and promoting angiogenesis in a bacterial-infected wound model. Collectively, this study illustrates a simple, convenient but powerful strategy to design functionally stable ADPH dressing for treating dermal wounds, which could open vistas in clinical wound management. © 2021 Elsevier Ltd

关键词： Chemical modification

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Organic Fluorophores with Large Stokes Shift for the Visualization of Rapid Protein and Nucleic Acid Assays

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Angewandte Chemie 2024年第17期136卷

作者： Jingkai Yang Ziyi Xu Prof. Dr. Le Yu Bingyun Wang Ruibin Hu Jiahu Tang Jiahui Lv Dr. Hongjun Xiao Xuan Tan Guanghui Wang Jia-Xin Li Dr. Ying Liu Prof. Dr. Pan-Lin Shao Prof. Dr. Bo Zhang Guangdong Provincial Key Laboratory of Advanced Biomaterials Department of Biomedical Engineering Southern University of Science and Technology 1088 Xueyuan Road Shenzhen 518055 China Key Laboratory of Synthetic and Nature Molecule Chemistry of Ministry of Education Department of Chemistry & Materials Science Northwest University. Xi'an Xi An Shi 710127 China Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease School of Pharmaceutical Sciences & the Fifth Affiliated Hospital Guangzhou Medical University Guangzhou 511436 China

Organic small-molecule fluorophores, characterized by flexible chemical structure and adjustable optical performance, have shown tremendous potential in biosensing. However, classical organic fluorophore motifs feature large overlap between excitation and emission spectra, leading to the requirement of advanced optical set up to filter desired signal, which limits their application in scenarios with simple settings. Here, a series of wavelength-tunable small-molecule fluorescent dyes ( PTs ) bearing simple organic moieties have been developed, which exhibit Stokes shift up to 262 nm, molar extinction coefficients ranged 30,000–100,000 M −1 cm −1 , with quantum yields up to 54.8 %. Furthermore, these dyes were formulated into fluorescent nanoparticles ( PT-NPs ), and applied in lateral flow assay (LFA). Consequently, limit of detection for SARS-CoV-2 nucleocapsid protein reached 20 fM with naked eye, a 100-fold improvement in sensitivity compared to the pM detection level for colloidal gold-based LFA. Besides, combined with loop-mediated isothermal amplification (LAMP), the LFA system achieved the visualization of single copy level nucleic acid detection for monkeypox (Mpox).

关键词： Organic Fluorophores Fluorescent nanoparticle Large stokes shift lateral flow assay

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Author Correction: Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field

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Nature communications 2023年第1期14卷 4067页

作者： Xiaotu Ma Xiaolong Liang Yao Li Qingqing Feng Keman Cheng Nana Ma Fei Zhu Xinjing Guo Yale Yue Guangna Liu Tianjiao Zhang Jie Liang Lei Ren Xiao Zhao Guangjun Nie CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China. Department of Ultrasound Peking University Third Hospital Beijing 100191 China. IGDB-NCNST Joint Research Center Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China. The Higher Educational Key Laboratory of Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of Xiamen Department of Biomaterials College of Materials Xiamen University Xiamen Fujian 361005 China. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China. zhaox@***. IGDB-NCNST Joint Research Center Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China. zhaox@***. Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China. zhaox@***. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China. niegj@***. Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China. niegj@***. The GBA National Institute for Nanotechnology Innovation Guangdong 510700 China. niegj@***.

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