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Polycationic nanoparticles for cascaded antibiosis and LPS- detoxifying via co-delivery of antibiotics and TLR siRNA in bacterial infected diseases treatment

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Chemical engineering Journal 2025年 517卷

作者： Yufeng Zhang Yini Huangfu Ling Xu Zhezhe Zhao Qi Su Hui Li Yumin Zhang Chuangnian Zhang Pingsheng Huang Anjie Dong Zujian Feng Weiwei Wang Department of Polymer Science and Engineering Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University Tianjin 300072 PR China State Key Laboratory of Advanced Medical Materials and Devices Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 300192 PR China Department of Respiratory Critical Care Medicine Binzhou Medical University Hospital PR China Department of Periodontology School and Hospital of Stomatology Tianjin Medical University Tianjin 300070 PR China State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Tianjin Institutes of Health Science Institute of Radiation Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 300192 PR China State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin 300071 PR China

Antimicrobial-resistant (AMR) Gram-negative bacteria emerge due to the overuse of antibiotics. Moreover, current bactericidal drugs or materials inevitably associate with the immunologic risks from the lipopolysaccharide (LPS) released by dead bacteria, which initiates and exacerbates chronic tissue-destructive hyperinflammation, leading to treatment failure. In this study, we describe an orchestrated pH-sensitive cationic polymer nanoparticle encapsulated with rifampicin and toll-like receptor (TLR) siRNA (RNP/siRNA) that exhibits antibacterial and LPS-detoxifying characteristics for treating infected diseases. Under acidic conditions, RNP/siRNA nanoparticle releases rifampicin and cationic polymers displaying synergistically inhibitory activity against AMR bacteria by disrupting bacterial membranes, and facilitating the entry of antibiotics. Furthermore, RNP/siRNA nanoparticle exhibits high cellular uptake and TLR knockdown efficiency, thereby detoxifying the etiological LPS in M1-type macrophages polarization and reducing proinflammatory cytokines. In a mouse pneumonia model, RNP/siRNA nanoparticle treatment inhibits bacterial growth, suppresses inflammation and reduces leukocyte recruitment. In a rat periodontitis model, the administration of RNP/siRNA downregulates proinflammatory cytokines expression and inhibits bone resorption. This work highlights the elevated LPS release is an early trigger of hyperinflammation during the antibacterial process of currently established antimicrobials. The RNP/siRNA nanoparticle represents a promising strategy by integrating antibiosis and immunomodulation in a cascading manner for the treatment of bacterial infections.

关键词： Antibiosis Polycationic nanoparticles siRNA delivery Tissue repair

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Correction to: A mini‑review on plasticrusts: occurrence, current trends, potential threats, and recommendations for coastal sustainability

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Environmental monitoring and assessment 2024年第7期196卷 629页

作者： Minh-Ky Nguyen Md Refat Jahan Rakib Hoang-Lam Nguyen Chitsan Lin Guilherme Malafaia Abubakr M Idris Faculty of Environment and Natural Resources Nong Lam University of Ho Chi Minh City Hamlet 6 Linh Trung Ward Thu Duc City Ho Chi Minh City 700000 Vietnam. Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. Department of Fisheries and Marine Science Faculty of Science Noakhali Science and Technology University Sonapur Noakhali 3814 Bangladesh. Department of Civil Engineering McGill University Montreal Canada. Ph.D. Program in Maritime Science and Technology National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. ctlin@nkust.edu.tw. Department of Marine Environmental Engineering National Kaohsiung University of Science and Technology Kaohsiung 81157 Taiwan. ctlin@nkust.edu.tw. Post‑Graduation Program in Ecology Conservation and Biodiversity Federal University of Uberlandia Uberlandia MG Brazil. guilhermeifgoiano@***. Post‑Graduation Program in Biotechnology and Biodiversity Federal University of Goias Goiania GO Brazil. guilhermeifgoiano@***. Post‑Graduation Program in Conservation of Cerrado Natural Resources Goiano Federal Institute Urutai GO Brazil. guilhermeifgoiano@***. Department of Chemistry College of Science King Khalid University 62529 Abha Saudi Arabia. Research Center for Advanced Materials Science (RCAMS) King Khalid University 62529 Abha Saudi Arabia.

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Comparison of thermoresponsive Diels-Alder linkers for the release of payloads from magnetic nanoparticles via hysteretic heating

JCIS Open

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JCIS Open 2021年 4卷

作者： Arrizabalaga, Julien H. Casey, Jonathan S. Becca, Jeffrey C. Jensen, Lasse Hayes, Daniel J. The Department of Biomedical Engineering The Pennsylvania State University University Park 16802 PA United States The Department of Chemistry The Pennsylvania State University University Park 16802 PA United States Materials Research Institute Millennium Science Complex The Pennsylvania State University University Park 16802 PA United States The Huck Institute of the Life Sciences Millennium Science Complex The Pennsylvania State University University Park 16802 PA United States

Investigation into the use of thermally reversible Diels-Alder chemistry coupled with magnetic iron oxide nanoparticles has grown over the last decade. This technology has been used for a variety of applications such as thermoresponsive materials, catalytic chemistry, and drug delivery systems. In this study, we evaluate two distinct thermally labile Diels-Alder linkers for the release of payloads from the surface of magnetic iron oxide nanoparticles. Density functional theory (DFT) computational predictions of the Gibbs free energy and enthalpy reaction barriers were performed and revealed a dramatic difference in reverse energy barriers between the two linkers. These thiophene-based cycloadducts were then synthesized, conjugated to the surface of iron oxide nanoparticles, and characterized by NMR and ESI-MS. The results of the modeling were confirmed when the functionalized nanoparticles were subjected to immersion heating and the payload release rates observed were in agreement with the DFT calculations. Similarly, AMF-RF hysteretic heating of the functionalized nanoparticles revealed payload release rates that correlated with the DFT calculations and the data from the heat immersion studies. Together, these results indicate that these distinct thermally labile Diels-Alder linkers can be used to fine-tune the kinetics of payload release from nanoparticles. © 2021 The Authors

关键词： Alternating magnetic field Click chemistry Controlled release Diels-alder Iron oxide Magnetic nanoparticles

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Hasel Actuators: HASEL Artificial Muscles for a New Generation of Lifelike Robots—Recent Progress and Future Opportunities (Adv. Mater. 19/2021)

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Advanced materials 2021年第19期33卷

作者： Philipp Rothemund Nicholas Kellaris Shane K. Mitchell Eric Acome Christoph Keplinger Department of Mechanical Engineering University of Colorado Boulder 1111 Engineering Drive Boulder CO 80309 USA Materials Science and Engineering Program University of Colorado Boulder Sustainability Energy & Environment Community Boulder CO 80303 USA

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Disorder and slowing magnetic dynamics in κ−(BEDT−TTF)2Hg(SCN)2Br

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Physical Review B 2020年第18期102卷 184417-184417页

作者： T. Le A. Pustogow J. Wang A. Henderson T. Siegrist J. A. Schlueter S. E. Brown Department of Physics and Astronomy UCLA Los Angeles California 90095 USA Kuang Yaming Honors School Nanjing University Nanjing 210023 China Department of Physics Florida State University Tallahassee Florida 32310 USA National High Magnetic Field Laboratory 1800 E Paul Dirac Drive Tallahassee Florida 32310 USA Department of Chemical and Biomedical Engineering FAMU-FSU College of Engineering Tallahassee Florida 32310 USA Division of Materials Research National Science Foundation Alexandria Virginia 22314 USA

The magnetic properties of κ−(BEDT−TTF)2Hg(SCN)2Br are examined using C13 NMR methods. Measurements of the spin lattice relaxation rate indicate a first-order metal-insulator transition at TMI=90K and a pronounced maximum at 5K, ascribed to dynamical slowing of magnetic fluctuations. TMI is also associated with the onset of weak line broadening, indicative of a disordered form of charge disproportionation. The line width increases strongly for T<40K, exceeding 4000 ppm at 2 K and applied magnetic field B=9.50T. The lack of long-range magnetic order is attributed to the disordered charge disproportionation onsetting at higher temperature.

关键词： Charge order Frustrated magnetism Metal-insulator transition Order parameters Phase transitions Quantum spin liquid Spin dynamics 2-dimensional systems Disordered systems Organic compounds Single crystal materials Strongly correlated systems Nuclear magnetic resonance

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AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1

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Nature Communications 2022年第1期13卷 4836页

作者： Umanah, George K. E. Abalde-Atristain, Leire Khan, Mohammed Repon Mitra, Jaba Dar, Mohamad Aasif Chang, Melissa Tangella, Kavya McNamara, Amy Bennett, Samuel Chen, Rong Aggarwal, Vasudha Cortes, Marisol Worley, Paul F. Ha, Taekjip Dawson, Ted M. Dawson, Valina L. Neuroregeneration and Stem Cell Programs Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore 21205 MD United States Department of Neurology Johns Hopkins University School of Medicine Baltimore 21205 MD United States Cellular and Molecular Medicine Graduate Program Johns Hopkins University School of Medicine Baltimore 21205 MD United States Department of Materials Science and Engineering University of Illinois at Urbana-Champaign Urbana 61801 IL United States Department of Biophysics and Biophysical Chemistry Johns Hopkins University Baltimore 21205 MD United States Solomon H. Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore 21205 MD United States Departments of Biophysics and Biophysical Chemistry Biophysics and Biomedical Engineering JHU Howard Hughes Medical Institute Baltimore 21205 MD United States Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine Baltimore 21205 MD United States Department of Physiology Johns Hopkins University School of Medicine Baltimore 21205 MD United States Division of Neuroscience National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda MD United States Vollum Institute Oregon Health & Science University Portland 97239 OR United States

The mechanistic target of rapamycin (mTOR) signals through the mTOR complex 1 (mTORC1) and the mTOR complex 2 to maintain cellular and organismal homeostasis. Failure to finely tune mTOR activity results in metabolic dysregulation and disease. While there is substantial understanding of the molecular events leading mTORC1 activation at the lysosome, remarkably little is known about what terminates mTORC1 signaling. Here, we show that the AAA + ATPase Thorase directly binds mTOR, thereby orchestrating the disassembly and inactivation of mTORC1. Thorase disrupts the association of mTOR to Raptor at the mitochondria-lysosome interface and this action is sensitive to amino acids. Lack of Thorase causes accumulation of mTOR-Raptor complexes and altered mTORC1 disassembly/re-assembly dynamics upon changes in amino acid availability. The resulting excessive mTORC1 can be counteracted with rapamycin in vitro and in vivo. Collectively, we reveal Thorase as a key component of the mTOR pathway that disassembles and thus inhibits mTORC1. © 2022, The Author(s).

关键词： Cell signalling Lysosomes Mechanisms of disease

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The doctor will polygraph you now

Npj health systems

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Npj health systems 2024年第1期1卷 1页

作者： James Anibal Jasmine Gunkel Shaheen Awan Hannah Huth Hang Nguyen Tram Le Jean-Christophe Bélisle-Pipon Micah Boyer Lindsey Hazen Yael Bensoussan David Clifton Bradford Wood Center for Interventional Oncology Clinical Center National Institutes of Health (NIH) Bethesda MD USA. Computational Health Informatics Lab Institute of Biomedical Engineering Department of Engineering Science University of Oxford Oxford UK. Department of Bioethics National Institutes of Health (NIH) Bethesda MD USA. Department of Communication Sciences & Disorders University of Central Florida Orlando FL USA. Global Infectious Disease Program Georgetown University Washington DC USA. College of Engineering University of South Florida Tampa FL USA. Faculty of Health Sciences Simon Fraser University Burnaby BC Canada. USF Health Voice Center Department of Otolaryngology-Head & Neck Surgery University of South Florida Tampa FL USA.

Artificial intelligence (AI) methods have been proposed for the prediction of social behaviors that could be reasonably understood from patient-reported information. This raises novel ethical concerns about respect, privacy, and control over patient data. Ethical concerns surrounding clinical AI systems for social behavior verification can be divided into two main categories: (1) the potential for inaccuracies/biases within such systems, and (2) the impact on trust in patient-provider relationships with the introduction of automated AI systems for "fact-checking", particularly in cases where the data/models may contradict the patient. Additionally, this report simulated the misuse of a verification system using patient voice samples and identified a potential LLM bias against patient-reported information in favor of multi-dimensional data and the outputs of other AI methods (i.e., "AI self-trust"). Finally, recommendations were presented for mitigating the risk that AI verification methods will cause harm to patients or undermine the purpose of the healthcare system.

关键词： Ethics Machine learning science, technology and society

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Investıgatıon of the adherence and prolıferatıon characterıstıcs of SH-SY5Y neuron model cells on graphene foam surfaces

Investıgatıon of the adherence and prolıferatıon charact...

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2018 International Conferences and Exhibition on Nanotechnologies - Organic Electronics and Nanomedicine, Nanotexnology 2018

作者： Morçimen, Zehra Gül Taşdemir, Şeyma Erdem, Çaǧlar Güneş, Fethullah Şendemir, Aylin Bioengineering Department Ege University Izmir Turkey Department of Nanoscience and Nanotechnology Izmir Katip Celebi University Izmir Turkey Department of Materials Science and Engineering Izmir Katip Celebi University Izmir Turkey Department of Biomedical Technologies Graduate School of Natural and Applied Sciences Ege University Izmir Turkey

Graphene is a promising material for production of biocompatible surfaces with suitable physicochemical properties for effective adhesion, proliferation and differentiation of nerve cells. In this study, 3-dimensional (3D) graphene foam was synthesized via chemical vapour deposition method, and it was aimed to observe the effects of graphene foam scaffolds on SH-SY5Y dopaminergic neuron model cells before applying to clinics. Raman spectroscopy, XRD and SEM analyses were performed to characterize the graphene foam. Viability of SH-SY5Y cells cultured on graphene foam scaffolds was analysed on days 1, 4 and 7 by MTT. Furthermore, cell morphology was determined by fluorescence staining of the actin cytoskeleton. © 2019 Elsevier Ltd. All rights reserved.

关键词： Proteins

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A Novel Aldehyde Scavenging Modification Boosted Pericardium Valve materials against Calcification

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Advanced healthcare materials 2025年 e2500856页

作者： Fei Kong Jingjing Zhang Yang Yang Yunyang Zhang Jian Ge Jingwu Song Changyu Shao Haoran Li Yunjiu Ren Xianghui Kong Chengyao Ni Xiangdong Kong Ruibo Zhao Institute for Smart Biomedical Materials School of Materials Science & Engineering Zhejiang Sci-Tech University Hangzhou Zhejiang 310018 China. Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang Sci-Tech University Hangzhou Zhejiang 310018 China. College of Life Sciences China Jiliang University Hangzhou Zhejiang 310018 China. Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Hangzhou Zhejiang 310016 China. Department of Cardiothoracic Medicine The Central Hospital of Linyi City Linyi Shandong 276400 China. Department of Cardiothoracic Surgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China.

Calcific aortic valve disease is an inexorably degenerative pathology and a common cause of morbidity and mortality in heart disease. Clinically, it has no effective medical therapy but can be managed with artificial heart valve replacement, particularly using bioprosthetic heart valves (BHV), entailing high biocompatibility. Current BHV mainly derives from glutaraldehyde (GA) cross-linked pericardium, however, residual aldehyde groups may inevitably remain during cross-link, potentially binding with calcium and inducing in situ calcification after implantation, thus leading to valve re-failure and posing a significant clinical challenge. Inspired by the high reducibility and clinical potential of sodium thiosulfate (STS), herein, STS as a novel modification post GA cross-linking to eliminate residual aldehyde in pericardium is presented. Notably, in vitro and in vivo studies demonstrated high ability against calcification in STS-modified porcine pericardium (SPP) with over 75% decrease of calcific density compared to GA alone cross-linked pericardium (GPP). More importantly, SPP can reduce macrophages and T cell inflation, as well as their associated proinflammation cytokines, building an immune-privileged microenvironment with a suppressed inflammation response. More generally, given the great potential of STS in treating vascular calcification clinically, these achievements further offer a new generation of BHV materials with boosted anti-calcification.

关键词： anti‐calcification biocompatibility bioprosthetic heart valve glutaraldehyde cross‐linked

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Phase-change metal ink with pH-controlled chemical sintering for versatile and scalable fabrication of variable stiffness electronics

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science advances 2025年第22期11卷 eadv4921页

作者： Simok Lee Gun-Hee Lee Inho Kang Woojin Jeon Semin Kim Yejin Ahn Choong Yeon Kim Do A Kwon Michael D Dickey Steve Park Seongjun Park Jae-Woong Jeong School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. Medical Research Center Seoul National University Seoul 03080 Republic of Korea. Departments of Cogno-Mechatronics Engineering and Optics and Mechatronics Engineering Pusan National University Busan 46241 Republic of Korea. Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. KAIST Information and Electronics Research Institute Daejeon 34141 Republic of Korea. Research Laboratory of Electronics Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA. Department of Mechanical Engineering Massachusetts Institute of Technology (MIT) Cambridge MA 02139 USA. Department of Chemical and Biomolecular Engineering North Carolina State University (NCSU) Raleigh NC 27606 USA. Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea. KAIST Institute for NanoCentury Daejeon 34141 Republic of Korea. Department of Biomedical Sciences College of Medicine Seoul National University Seoul 03080 Republic of Korea. School of Transdisciplinary Innovations Seoul National University Seoul 03080 Republic of Korea. Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul 08826 Republic of Korea. Department of Transdisciplinary Medicine Seoul National University Hospital Seoul 03080 Republic of Korea. KAIST Institute for Health Science and Technology Daejeon 34141 Republic of Korea.

Variable stiffness electronics represent the forefront of adaptive technology, integrating rigid and soft electronics in a single system through dynamic mechanical modulation. While gallium's high modulus tuning ratio and rapid phase transitions make it ideal for transformative electronic systems (TES), its liquid-state instability, high surface tension, and unintended phase transitions during processing pose substantial challenges. Here, we introduce STiffness-Adjustable temperature-Responsive ink (STAR ink), a chemically sinterable gallium composite electronic ink designed to overcome these obstacles. STAR ink enables high-resolution (~50 micrometers) circuit patterning, large-scale batch fabrication, and three-dimensional structure coating at room temperature. Through pH-controlled chemical sintering, STAR ink-based TES exhibits exceptional mechanical tunability (tuning ratio: 1465) and electrical conductivity (2.27 × 10 siemens per meter). Demonstrated applications-from multilayered variable stiffness printed circuit boards (PCBs) matching standard PCBs' complexity to body-temperature responsive neural probe-underscore STAR ink's potential for reconfigurable electronics across consumer electronics and biomedical devices.

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