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SSRN 2019年

作者： Jo, Seohyeon Raj, Rishi Materials Science Program Department of Mechanical Engineering University of Colorado Boulder BoulderCO80302 United States

We report in-situ measurements of impedance spectroscopy during flash experiments with single crystals of cubic-yttria stabilized zirconia, conducted in ambient air at 300 °C to 700 °C under a direct current electric field. Platinum electrodes transition from blocking to non-blocking behavior just before the onset of flash, indicating a transition to partial electronic conductivity during the incubation period. Even though the conductivity continued to increase with temperature the electron transport remained at a plateau of 0.25. This result has ramifications not only in the fundamental understanding but also in technological significance of the flash phenomenon. © 2019, The Authors. All rights reserved.

关键词： Single crystals

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Achieving increased resolution and reconstructed image quality with gradient variance modified super-resolution radial fluctuations

Research Square

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Research Square 2021年

作者： Gong, Xingyu Zhou, Li Yao, Longfang Zhang, Li Chen, Liwen Fei, Yiyan Mi, Lan Wang, Baoju Ma, Jiong Department of Optical Science and Engineering Shanghai Engineering Research Center of Ultra-precision Optical Manufacturing Key Laboratory of Micro and Nano Photonic Structures Ministry of Education Green Photoelectron Platform Fudan University 220 Handan Road Shanghai200433 China School of Life Sciences Fudan University 220 Handan Road Shanghai200433 China Centre for Optical and Electromagnetic Research Guangdong Provincial Key Laboratory of Optical Information Materials and Technology South China Academy of Advanced Optoelectronics South China Normal University Guangzhou510006 China Institute of Biomedical Engineering and Technology Academy for Engineer and Technology Fudan University 220 Handan Road Shanghai200433 China

Based on the calculation of the degree of gradient convergence, the super-resolution radial fluctuations (SRRF) algorithm can achieve higher resolution by combining temporal fluctuation analysis with localization microscopy methods. The algorithm is also capable of processing high-density fluorescence images. However, there are considerable artifacts due to high density, which lead to a loss of image resolution and low fidelity of images. This study demonstrates the use of fluorescence gradient fluctuations in super-resolution analysis and proposes gradient variance modified SRRF (gmSRRF) algorithm. The gmSRRF algorithm resolves finer structures and compensates for the loss of resolution caused by artifacts in SRRF images using relatively high-density stochastic optical reconstruction microscopy (STORM) data and conventional widefield, confocal, or structured illumination microscopy (SIM) imaging sequences. The effectiveness of this algorithm is proven by means of relevant simulations and experiments, which allow the reconstructed SRRF image to improve resolution and reduce artifacts and background noise. © 2021, CC BY.

关键词： Image resolution

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A nanoparticle platform for the co-delivery of multiple antigen epitope peptides and STING agonist to lymph nodes for cancer immunotherapy

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International journal of pharmaceutics 2025年 680卷 125757页

作者： Xiyu Ke Brady A Campbell Xiaoya Lu Betul Celiker Lei Zheng May Tun Saung Hai-Quan Mao Institute for NanoBioTechnology Johns Hopkins University Baltimore MD USA Department of Materials Science and Engineering Whiting School of Engineering Johns Hopkins University Baltimore MD USA. The Sidney Kimmel Cancer Center Johns Hopkins University School of Medicine Baltimore MD USA. The Sidney Kimmel Cancer Center Johns Hopkins University School of Medicine Baltimore MD USA Department of Oncology Johns Hopkins University School of Medicine Baltimore MD USA. Department of Oncology Johns Hopkins University School of Medicine Baltimore MD USA Pancreatic Cancer Precision Medicine Center of Excellence Johns Hopkins University School of Medicine Baltimore MD USA The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care Johns Hopkins University School of Medicine Baltimore MD USA. Electronic address: lzheng6@jhmi.edu. Pancreatic Cancer Precision Medicine Center of Excellence Johns Hopkins University School of Medicine Baltimore MD USA. Electronic address: msaung1@jhmi.edu. Department of Materials Science and Engineering Whiting School of Engineering Johns Hopkins University Baltimore MD USA Translational Tissue Engineering Center Johns Hopkins University School of Medicine Baltimore MD USA Department of Biomedical Engineering Johns Hopkins School of Medicine Baltimore MD USA. Electronic address: hmao@jhu.edu.

Nanoparticles loaded with cancer epitope peptides have shown great potential for cancer immunotherapy. However, preparing small-sized nanoparticles with a narrow size distribution for the co-delivery of multiple antigen peptides has been a challenge. The lack of scalable and reproducible nanoparticle preparation methods has also hindered the widespread application of nanoparticles in cancer immunotherapy. In this study, we developed lymph node-targeted nanoparticles for the co-delivery of a group of sixteen pancreatic cancer antigen peptides and a STING agonist as an adjuvant using the flash nanocomplexation (FNC) method. The nanoparticles generated by FNC had a smaller particle size and a narrower size distribution compared to the nanoparticles prepared by bulk mixing. The FNC-generated nanoparticles enhanced human monocyte activation, demonstrated lymph node-targeting effect, and activated dendritic cells in vivo, all without any observable toxicity. Additionally, in vivo studies demonstrated the strong anti-tumor efficacy of these nanoparticles in an orthotopic pancreatic cancer mouse model. This nanoparticle platform enables the effective co-delivery of multiple antigen epitope peptides and an adjuvant to the lymph nodes. Furthermore, the scalability and reproducibility of the FNC method could facilitate the rapid clinical translation of this nanoparticle platform.

关键词： Cancer immunotherapy Cancer vaccine Nanoparticle formulation Pancreatic cancer STING agonist

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Quantitative contributions of solution atoms, precipitates and deformation to microstructures and properties of Al-Sc-Zr alloys

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Transactions of Nonferrous Metals Society of China 2019年第5期29卷 907-918页

作者： Ren-guo GUAN Hong-mei JIN Wensen JIANG Xiang WANG Yu-xiang WANG Zheng LI Jian ZHANG Huinan LIU Center of Advanced Lubrication and Seal Materials State Key Laboratory of Solidification ProcessingNorthwestern Polytechnical UniversityXi’an 710072China School of Material Science and Engineering Northeastern UniversityShenyang 110819China Materials Science and Engineering Program University of California at Riverside900 University AvenueRiversideCalifornia 92521USA Department of Bioengineering University of California at Riverside900 University AvenueRiversideCalifornia 92521USA

In order to investigate the effects of solid solution atoms, precipitated particles and cold deformation on the microstructures and properties of Al-Sc-Zr alloys, the Al-Sc-Zr alloys prepared by continuous rheo-extrusion were treated by thermomechanical treatment, analyzed for conductivity and mechanical properties by tensile and microhardness testing, and characterized using optical microscope, TEM and STEM. A mathematical model was established to quantitatively characterize the contribution of solid solution atoms, precipitates and cold deformation to the conductivity of the alloy. The results show that the strength of Al alloy can be significantly improved by solid solution, aging and cold deformation, and the quantitative impacts of solution atoms, precipitates and cold deformation on the conductivity of Al alloy are 10.5%(IACS), 2.3%(IACS) and 0.5%(IACS), respectively. Aging and cold deformation treatments are the keys to obtain high-strength and high-conductivity aluminum alloy wires.

关键词： Al.Sc.Zr alloy thermal treatment cold deformation mechanical properties conductivity

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Nanoscale dynamics during self-organized ion beam patterning of Si: II. Kr+ bombardment

arXiv

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arXiv 2020年

作者： Myint, Peco Ludwig, Karl F. Wiegart, Lutz Zhang, Yugang Fluerasu, Andrei Zhang, Xiaozhi Headrick, Randall L. Department of Physics Division of Materials Science and Engineering Boston University BostonMA02215 United States X-ray Science Division Argonne National Laboratory LemontIL60439 United States National Synchrotron Light Source II Brookhaven National Lab UptonNY11973 United States Department of Physics and Materials Science Program University of Vermont BurlingtonVT05405 United States

Understanding the self-organized ion beam nanopatterning of elemental semiconductors, particularly silicon, is of intrinsic scientific and technological interest. This is the second component of a two-part coherent x-ray scattering and X-ray Photon Correlation Spectroscopy (XPCS) investigation of the kinetics and fluctuation dynamics of nanoscale ripple development on silicon during 1 keV Ar+ (Part I [18]) and Kr+ bombardment at 65 ◦ polar angle. Here, it’s found that the ion-enhanced viscous flow relaxation is essentially equal for Kr+-induced patterning as previously found for Ar+ patterning despite the difference in ion masses. However, the magnitude of the surface curvature-dependent roughening rate in the early-stage kinetics is larger for Kr+ than for Ar+, consistent with expectations that the heavier ion gives an increased mass redistributive contribution to the initial surface instability. As with the Ar+ case, fluctuation dynamics in the late stage show a peak in correlation times at the length scale corresponding to the dominant structural feature on the surface - the ripples. Finally, it’s shown that speckle motion during the surface evolution can be analyzed to determine spatial inhomogeneities in erosion rate and ripple velocity. This allows the direction and speed of ripple motion to be measured in a real time experiment. In the present case, ripple motion is found to be into the projected direction of the ion source, in contrast to expectations from an existing sputter erosion driven model with parameters derived from binary collision approximation simulations. Copyright © 2020, The Authors. All rights reserved.

关键词： Nanotechnology

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Terahertz time-domain polarimetry for generalized anistropic and chiral materials 12

Terahertz time-domain polarimetry for generalized anistropic...

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Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications XII 2019

作者： Cheng, Gong Choi, Won Jin Jang, Hee-Jeong Kotov, Nicholas A. Norris, Theodore B. Department of Physics University of Michigan Ann ArborMI48109 United States Center for Ultrafast Optical Science University of Michigan Ann ArborMI48109 United States Department of Materials Science and Engineering University of Michigan Ann ArborMI48109 United States Department of Chemical Engineering University of Michigan Ann ArborMI48109 United States Biointerfaces Institute University of Michigan Ann ArborMI48109 United States Program in Macromolecular Science and Engineering University of MI Ann ArborMI48109 United States Department of Electrical Engineering and Computer Science University of Michigan Ann ArborMI48109 United States

ISBN: (纸本)9781510624764

We have developed two terahertz (THz) polarimetric methodologies based on terahertz time-domain spectroscopy (THz-TDS) incorporating three wire-grid polarizers. They require no change to existing THz-TDS setups and are free of any complicated electronic controls and synchronizations. In addition to the standard quantities measured by THz-TDS such as transmission and optical constants, they provide complete information on the anisotropy and chirality for a generalized material through measurements of the full electric field vector and hence the Jones matrix, and calculating specific quantities. Thus terahertz time-domain polarimetry (THz-TDP) can be considered as an upgrade of the conventional THz-TDS, needed for full characterization of anisotropic and chiral materials. In this paper, we describe the details of the experimental settings, mathematical procedures and property quantifications in these methodologies. We present experimental results on an anisotropic polymer sheet showing the effectiveness of the methods, and preliminary data for chiral DNA molecules for the first time in the THz frequency range. © 2019 SPIE.

关键词： Polarimeters

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The failure of the Classical Nucleation Theory at low temperatures resolved

arXiv

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arXiv 2019年

作者： Cassar, Daniel R. Serra, André H. Peitl, Oscar Rodrigues, Alisson M. Zanotto, Edgar D. Vitreous Materials Laboratory Department of Materials Engineering Federal University of São Carlos São Carlos SP Brazil Federal University of Sao Carlos Graduate Program in Materials Science and Engineering

A relevant observation about crystal nucleation kinetics in glass-forming substances has been a matter of intense debate for several decades. The Classical Nucleation Theory (CNT) allegedly fails to describe the temperature dependence of the homogeneous crystal nucleation rates below the temperature of maximum nucleation rate. This failure was reported for several glass-forming substances and is known as nucleation "breakdown". Some reasonable explanations for this apparent break have been advanced in the literature, however, the simplest hypothesis has never been tested: that this break is a byproduct of nucleation datasets that have not reached the steady-state regime. In this work, we tested this hypothesis by thoroughly analyzing new and published nucleation data for supercooled Li2Si2O5, BaSi2O5, Na4CaSi3O9, and Na2Ca2Si3O9liquids, using only datasets for which steady-state conditions (likely) have been reached. For that purpose, we used three restraining conditions: i) Nucleation and diffusion data were measured in the same glass batch, and each batch was individually analyzed;ii) only nucleation rate data that passed a steady-state regime test were used in the analysis;iii) the uncertainty and regression confidence bands were computed and considered. With this strategy, we proved that the alleged nucleation break is indeed an experimental artifact! This result ends a four decade-old dilemma and corroborates the use of CNT for analyses of crystal nucleation rates. Copyright © 2019, The Authors. All rights reserved.

关键词： Silicates

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Correction to: Innovative aerodynamic grain separation system for plant harvesting in sloped areas: problems, research and optimization of parameters

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Archives of Civil and Mechanical engineering 2021年第2期21卷 1-1页

作者： Jerzy Bieniek Piotr Komarnicki Jerzy Detyna Institute of Agricultural Engineering The Faculty of Life Sciences and Technology Wrocław University of Environmental and Life Sciences Wrocław Poland Department of Mechanics Materials and Biomedical Engineering Faculty of Mechanical Engineering Wrocław University of Science and Technology Wrocław Poland

A correction to this paper has been published: https://***/10.1007/s43452-021-00213-7

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Hierarchical electrospun nanofibers treated by solvent vapor annealing as air filtration mat for high-efficiency PM2.5 capture

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science China materials 2019年第3期62卷 423-436页

作者： Xinxin Huang Tifeng Jiao Qingqing Liu Lexin Zhang Jingxin Zhou Bingbing Li Qiuming Peng State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004China Department of Chemistry Science of Advanced Materials Doctoral ProgramCentral Michigan UniversityMount PleasantMI 48859USA

Recently, air pollution has become more serious and started to have a dramatic effect on the health of humans in many large cities. Generally, outdoor personal protection,such as commercial masks, cannot effectively prevent the inhalation of many pollutants. Particulate matter(PM) pollutants are a particularly serious threat to human health. Here we introduce a new efficient air filtration mat that can be used for outdoor protection. The new efficient air filter’s nanocomposite materials were successfully fabricated from poly(ε-caprolactone)/polyethylene oxide(PCL/PEO) using an electrospinning technique and solvent vapor annealing(SVA).SVA treatment endows the wrinkled fiber surface and enhances the PM2.5 capture capacity of protective masks. This nanowrinkled air filtration mat can effectively filter PM2.5 with a removal efficiency of 80.01% under seriously polluted conditions(PM2.5 particle concentration above 225 mg m-3).Our field test in Qinhuangdao indicated that the air filtration mat had a high PM2.5 removal efficiency under thick *** to commercial masks, the fabricated SVA-treated PCL/PEO air filter mat demonstrated a simpler and ecofriendly preparation process with excellent degradation characteristics, showing wide potential applications with a high filtration efficiency.

关键词： electrospinning nanofiber mat solvent vapor annealing air filtration PM2.5 removal

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Outer-Membrane Protease (OmpT) Based E. coli Sensing with Anionic Polythiophene and Unlabeled Peptide Substrate

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Angewandte Chemie 2020年第41期132卷

作者： Sinsinbar G. Gudlur S. Wood S.E. Ammanath G. Yildiz H.U. Alagappan P. Mrksich M. Liedberg B. Centre for Biomimetic Sensor Science School of Materials Science Engineering Nanyang Technological University 50 Nanyang Drive Singapore 637553 Singapore Departments of Chemistry and Biomedical Engineering Northwestern University 2145 Sheridan Road Evanston IL 60208 United States Department of Chemistry Izmir Institute of Technology Urla Izmir 35430 Turkey

E. coli and Salmonella are two of the most common bacterial pathogens involved in foodborne and waterborne related deaths. Hence, it is critical to develop rapid and sensitive detection strategies for near-outbreak applications. Reported is a simple and specific assay to detect as low as 1 CFU mL−1 of E. coli in water within 6 hours by targeting the bacteria's surface protease activity. The assay relies on polythiophene acetic acid (PTAA) as an optical reporter and a short unlabeled peptide (LL37FRRV) previously optimized as a substrate for OmpT, an outer-membrane protease on E. coli. LL37FRRV interacts with PTAA to enhance its fluorescence while also inducing the formation of a helical PTAA-LL37FRRV construct, as confirmed by circular dichroism. However, in the presence of E. coli LL37FRRV is cleaved and can no longer affect the conformations and optical properties of PTAA. This ability to distinguish between an intact and cleaved peptide was investigated in detail using LL37FRRV sequence variants. © 2020 Wiley-VCH GmbH

关键词： enzymes fluorescence membrane proteins pathogens peptides

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