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Super-assembly of integrated gold magnetic assay with loopmediated isothermal amplification for point-of-care testing

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Nano Research 2023年第1期16卷 1242-1251页

作者： Jianping Liang Jie Zeng Xiaojuan Huang Tengteng Zhu Yonglong Gong Chen Dong Xiangrong Wang Lingzhi Zhao Lei Xie Kang Liang Qiongxiang Tan Yali Cui Biao Kong Wenli Hui The College of life science Northwest UniversityXi’an 710069China Shaanxi Provincial Engineering Research Center for Nano-Biomedical Detection Xi’an 710077China Department of Chemistry Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationNorthwest UniversityXi’an 710069China Provincial Key Laboratory of Biotechnology of Shaanxi Province Northwest UniversityXi’an 710069China School of Chemical Engineering Graduate School of Biomedical Engineeringand Australian Centre for NanoMedicineUniversity of New South WalesNSW 2052Australia

With the increasing global threat of various diseases and infections,it is essential to develop a fast,low-cost,and easy-to-use point-of-care testing(POCT)system for inspections at all levels of medical institutions and self-examination at *** this work,gold magnetic nanoparticles(GMNPs)are used as the key material,and a rapid visual detection method is designed through integrating loop-mediated isothermal amplification(LAMP)and lateral flow assay(LFA)biosensor for detecting a variety of analytes which includes whole blood,buccal swabs,and *** is worth to note that the proposed method does not need DNA ***,uracil DNA glycosylase(UDG)is employed to eliminate carrier contamination for preventing false positive *** whole detection process can be finished within 25 *** accuracy of detection is measured by assessing the polymorphisms of the methylenetetrahydrofolate reductase(MTHFR)*** detection limit of the newly developed extraction-free detection system for MTHFR C677T is 0.16 ng/μL.A preliminary clinical study of the proposed method is carried out by analyzing 600 clinical samples(including 200 whole blood samples,100 buccal swabs,and 300 genomic DNA samples).The results indicate that the proposed method is 100%consistent with the sequencing results which provides a new choice for POCT and shows a broad application prospect in all levels of medical clinics and at home.

关键词： gold magnetic nanoparticles loop-mediated isothermal amplification lateral flow assay system free extraction singlenucleotide polymorphisms genotyping

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Impact of High-k materials and Tube Numbers on CNFET Gate's Performances 5

Impact of High-k Materials and Tube Numbers on CNFET Gate's ...

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5th International Conference on Smart Systems and Inventive Technology, ICSSIT 2023

作者： Yalung, Christofer Tantraviwat, Doldet Uatrongjit, Sermsak Yamwong, Wittawat Doctor of Philosophy Program in Nanoscience and Nanotechnology International Program/Interdisciplinary Center of Excellence in Materials Science and Technology Faculty of Science Chiang Mai University Chiang Mai Thailand Chiang Mai University Faculty of Engineering Department of Electrical Engineering Chiang Mai Thailand Chachoengsao Thailand

ISBN: (纸本)9781665474672

Carbon nanotube field effect transistor (CNFET) performance is primarily influenced by a variety of characteristics, such as nanotube diameter, operating voltage, pitch, the number of tubes, dielectric constant, and contact materials. In this study, the dielectric constant and the number of carbon nanotubes (CNTs) were emphasized to analyze the propagation delay and average power dissipation of basic logic gates. Zirconium dioxide (ZrO2), hafnium oxide (HfO2), and silicon dioxide (SiO2) were used as dielectric materials. In this experiment, the Stanford CNFET model was utilized, and variable factors such as the number of CNTs and the dielectric constant (Kox) accumulated on the nanotube gate's surface were diversified. The correlation coefficients of the delay, the average power, and the CNT numbers were also presented. Furthermore, the multi-objective genetic algorithm and the Rmethod were utilized to find the optimal Kox and the number of CNTs for minimizing the average dissipation power and the propagation delay of some logic gates designed with CNFET. For all the gates considered, the optimal number of CNTs is 4 while the dielectric constant is within the ranges of 19 to 24. © 2023 IEEE.

关键词： Carbon nanotubes

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Recent advances in electronic devices for monitoring and modulation of brain

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Nano Research 2021年第9期14卷 3070-3095页

作者： Yong Won Kwon Yoon Sun Jun Young-Geun Park Jiuk Jang Jang-Ung Park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Graduate Program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoul 03722Republic of Korea

The brain is actuated by billions of neurons with trillions of interconnections that regulate human *** the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science,engineering,and *** advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brains complex nervous *** development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in *** addition,these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral ***,we review the progress of electronic devices interfacing with brain in terms of the materials,fabrication technologies,and device *** activity can be measured and modulated by brain probes based on newly developed nanofabrication ***,in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless *** also consider the key challenges and prospects for further development,and explore the future directions emerging in the latest research.

关键词： neural interfaces neural recording neuromodulation intracranial pressure monitoring microfluidic drug delivery

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Imaging and Understanding 3D Nanoscale Magnetic Structures

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 1398-1399页

作者： Petford-Long, Amanda K. Brajuskovic, Vuk Li, Yue McCray, Arthur R C Phatak, Charudatta Materials Science Division Argonne National Laboratory Lemont IL United States Materials Science and Engineering Department Northwestern University Evanston IL United States Applied Physics Program Northwestern University Evanston IL United States

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Advanced strategies for solid electrolyte interface design with MOF materials

Advanced Powder Materials

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Advanced Powder materials 2024年第1期3卷 114-143页

作者： Guolong Lu Ge Meng Qian Liu Ligang Feng Jun Luo Xijun Liu Yang Luo Paul K.Chu Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry and Chemical EngineeringGuangxi University100 Daxue RoadNanning530004China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures School of ResourceEnvironments and MaterialsGuangxi UniversityNanning530004China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou325035China Institute for Advanced Study Chengdu UniversityChengdu610106China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225002China ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of ChinaLonghua DistrictShenzhen518110China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong Kong SARChina Department of Materials ETH ZürichZürich8093Switzerland

Emerging energy technologies,aimed at addressing the challenges of energy scarcity and environmental pollution,have become a focal point for ***,these actualities present significant challenges for modern energy storage *** metal batteries(LMBs)have gained considerable attention due to their high energy ***,their use of liquid electrolytes raises safety concerns,including dendritic growth,electrode corrosion,and electrolyte *** light of these challenges,solid-state batteries(SSBs)have emerged as a highly promising next-generation energy storage solution by leveraging lithium metal as the anode to achieve improved safety and energy *** organic frameworks(MOFs),characterized by their porous structure,ordered crystal frame,and customizable configuration,have garnered interest as potential materials for enhancing solid-state electrolytes(SSEs)in *** integration of MOFs into SSEs offers opportunities to enhance the electrochemical performance and optimize the interface between SSEs and *** is made possible by leveraging the high porosity,functionalized structures,and abundant open metal sites of ***,the rational design of high-performance MOF-based SSEs for high-energy Li metal SSBs(LMSSBs)remains a significant *** this comprehensive review,we present an overview of recent advancements in MOF-based SSEs for LMSSBs,focusing on strategies for interface optimization and property *** categorize these SSEs into two main types:MOF-based quasi-solid-state electrolytes and MOF-based all solid-state *** these categories,various subtypes are identified based on the combination mode,additional materials,formation state,preparation method,and interface optimization measures *** review also highlights the existing challenges associated with MOF materials in SSBs applications and proposes potential solutions and future development prospects to guide the

关键词： Lithium metal solid-state batteries Metal organic frameworks Quasi-solid-state electrolytes All solid-state electrolytes Interface optimization strategy

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3D-printed biomimetic structures for energy and environmental applications

DeCarbon

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DeCarbon 2024年第1期3卷 16-31页

作者： Jiaming Li Mengli Li J[]Justin Koh John Wang Zhiyang Lyu Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjing211189China Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03Singapore138634Republic of Singapore Department of Materials Science and Engineering National University of Singapore9 Engineering Drive 1117574Singapore NUS Research Institute(Chongqing) Chongqing Liang Jiang New AreaChongqing401120China

Biomimetic structures involve design and fabrication to mimic the natural world,taking inspiration from the unique shapes,patterns,and functions of biological *** approach has proven to be highly effective in building new functional and efficient structures for many *** it is often challenging to fabricate some of the complex biomimetic structures,the development of 3D printing technologies in recent years has made it more feasible,being a powerful tool for fabricating complex structures with high precision and accuracy,at the much reduced use of starting *** this review,we will examine the current state of biomimetic structures fabricated by 3D printing techniques and their specific applications in energy and environmentalfields for the decarbonization *** different selected types of biomimetic structures that have been constructed using 3D printing,the materials used,and the unique properties obtained will be ***,some typical biomimetic structures for energy and environmental applications,such as supercapacitors,zinc-air batteries,oil/water separation,selfcleaning,water collection,droplet manipulation,etc.,will be ***,the opportunities in this rapidly changing area will be analyzed,hoping to provide insights into the innovative pathways that 3D-printed biomimetic structures can be used to address some challenges in energy and environmental areas.

关键词： materials. starting separation

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3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation

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Bioactive materials 2024年第7期37卷 172-190页

作者： Hyun Lee Dong-Sung Won Sinwoo Park Yubeen Park Ji Won Kim Ginam Han Yuhyun Na Min-Ho Kang Seok Beom Kim Heemin Kang Jun-Kyu Park Tae-Sik Jang Sang Jin Lee Su APark Sang Soo Lee Jung-Hoon Park Hyun-Do Jung Department of Biomedical-Chemical Engineering The Catholic University of KoreaBucheon14662Gyeonggi-doRepublic of Korea Department of Biotechnology The Catholic University of KoreaBucheon14662Republic of Korea Biomedical Engineering Research Center Asan Institute for Life SciencesAsan Medical Center88 Olympic-ro 43-gilSongpa-guSeoul05505Republic of Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul05505Republic of Korea Research Center Metamorp IncSeoul08584Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea IMT Inc Gwangju61086Republic of Korea School of Biomedical Convergence Engineering Pusan National UniversityYangsan50612Republic of Korea Biofunctional Materials Division of Applied Oral Sciences and Community Dental CareFaculty of DentistryThe University of Hong Kong34 Hospital RoadSai Ying PunHong Kong SARPR China Nano-Convergence Manufacturing Systems Research Division Korea Institute of Machinery and Materials(KIMM)Daejeon34103Republic of Korea Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of Medicine88Olympic-ro 43-GilSongpa-guSeoul05505Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763Republic of Korea

Biliary strictures are characterized by the narrowing of the bile duct lumen,usually caused by surgical biliary injury,cancer,inflammation,and scarring from *** stent placement is a well-established method for the management of biliary ***,maintaining optimal mechanical properties of stents and designing surfaces that can prevent stent-induced tissue hyperplasia and biofilm formation are challenges in the fabrication of biodegradable biliary stents(BBSs)for customized *** study proposes a novel approach to fabricating functionalized polymer BBSs with nanoengineered surfaces using 3D *** 3D printed stents,fabricated from bioactive silica poly(ε-carprolactone)(PCL)via a sol-gel method,exhibited tunable mechanical properties suitable for supporting the bile duct while ensuring ***,a nanoengineered surface layer was successfully created on a sirolimus(SRL)-coated functionalized PCL(fPCL)stent using Zn ion sputtering-based plasma immersion ion implantation(S-PIII)treatment to enhance the performance of the *** nanoengineered surface of the SRL-coated fPCL stent effectively reduced bacterial responses and remarkably inhibited fibroblast proliferation and initial burst release of SRL in vitro *** physicochemical properties and biological behaviors,including in vitro biocompatibility and in vivo therapeutic efficacy in the rabbit bile duct,of the Zn-SRL@fPCL stent demonstrated its potential as a versatile platform for clinical applications in bile duct tissue engineering.

关键词： 3D printing Biodegradable biliary stent Functionalized polymer Zinc ion implantation Antibiofilm formation Anti-hyperplasia

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可编织、可穿戴的宽带聚合物超声换能器

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science China materials 2024年第8期67卷 2653-2660页

作者：邹君逸郭星奕吴家琦徐冬梅许凯亮陈培宁他得安彭慧胜 State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Institute of Fiber Materials and DevicesLaboratory of Advanced MaterialsFudan UniversityShanghai 200438China Department of Biomedical Engineering Yiwu Research Institute and Shanghai Poda Medical Technology Co.Ltd.Fudan UniversityShanghai 200438China

新兴的物联网技术推动了可穿戴健康监测设备的快速发展.目前,医学超声技术在严重慢性疾病的长时间监测方面具有广阔的应用前景.然而,商用超声探头一般都是刚性的,需要手持,难以满足医疗可穿戴设备对柔性化、小型化和舒适性的要求.本文... 详细信息

新兴的物联网技术推动了可穿戴健康监测设备的快速发展.目前,医学超声技术在严重慢性疾病的长时间监测方面具有广阔的应用前景.然而,商用超声探头一般都是刚性的,需要手持,难以满足医疗可穿戴设备对柔性化、小型化和舒适性的要求.本文提出了一种可编织、可穿戴的聚合物超声换能器,该换能器由匹配层、背衬层和压电层组成.聚合物压电材料的带宽(93%)是压电陶瓷的7倍,并且可以承受超过10,000次的弯曲和扭曲变形.该传感器能监测颈动脉血液流速,心脏血液流速和心脏血管的血管厚度,并具有与商用探头相当的信噪比.它的宽带特性(3.68–10.08 MHz)使其能通过调整频率来监测不同的组织.可编织超声换能器可以制成纤维形式,并编织成透气织物,在不牺牲穿戴舒适性的情况下进行实时血管监测.

关键词：血液流速超声换能器可穿戴设备超声探头扭曲变形匹配层慢性疾病压电材料

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Improving exposure of anodically ordered Ni-Ti-O and corrosion resistance and biological properties of NiTi alloys by substrate electropolishing

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Rare Metals 2021年第12期40卷 3575-3587页

作者： Yong-Hua Sun Ya Zhao Yu-Yu Zhao You-Jie Rong Run-Hua Yao Xiao-Hong Yao Rui-Qiang Hang Paul K.Chu Laboratory of Biomaterial Surfaces and Interfaces Institute of New Carbon MaterialsTaiyuan University of TechnologyTaiyuan 030024China Department of Physics Department of Materials Science and EngineeringDepartment of Biomedical EngineeringCity University of Hong KongKowloon 999077Hong KongChina

Although Ni-Ti-O nanopores(NPs) can be fabricated by anodization of mechanically polished NiTi alloys, the top disordered layer is difficult to remove thus hindering the functionality of the Ni-Ti-O NPs. In this work, an electropolishing(EP) pretreatment was performed on the NiTi substrate prior to anodization to thoroughly expose the NPs. Our results show that the EP pretreatment for 5 min perfectly removes the top disordered layer on the Ni-Ti-O NPs to expose the underlying NPs and consequently, the corrosion resistance and antibacterial ability are enhanced. The exposed NPs can elongate bone marrow mesenchymal stem cells, which may be responsible for the upregulated alkaline phosphatase activity, secretion of Type I collagen, and extracellular matrix mineralization. These results suggest that EP is a desirable pretreatment before anodization of the NiTi alloys because the irregular surface layer on the Ni-Ti-O NPs can be removed to enhance the corrosion resistance and biological functions.

关键词： Nickel-titanium alloy Anodization Corrosion behavior Osteogenic activity Antibacterial ability

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Investigation of SERS Studies on Periodic Patterned ZnO Nanorod Array Fabricated Using Silica Inverse Opal Nanostructure as a Template

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Journal of Physical Chemistry C 2024年第20期128卷 8288-8295页

作者： Hsu, Chih-Hsien Hsu, Li-Cheng Chen, Ching-Hsiang Chen, Liang-Yih Lai, Chao-Sung Biosensor Group Biomedical Engineering Research Center Chang Gung University Taoyuan333 Taiwan Nano-Optoelectronic Materials Lab Department of Chemical Engineering National Taiwan University of Science and Technology No.43 Section 4 Keelung Road Daan District Taipei106 Taiwan CL Technology Co. Ltd. New Taipei City241 Taiwan Department of Electronic Engineering Chang Gung University Taoyuan333 Taiwan Department of Nephrology Chang Gung Memorial Hospital Taoyuan333 Taiwan

In this study, we combined metal oxide semiconductor nanomaterials with metal nanoparticles (NPs) to fabricate surface-enhanced Raman scattering (SERS) substrates and investigated their enhancement effects. Among the various metal oxide semiconductors, zinc oxide (ZnO) was chosen as the candidate due to its numerous advantages, including low processing temperature and the capability to form diverse nanostructures. Additionally, four different structured SERS substrates are designed to gain a deeper understanding of the impact of using two-dimensional planar structures versus three-dimensional structures, as well as the influence of structural periodicity on the sensitivity of the resulting SERS substrate in Raman scattering intensity. Herein, rhodamine 6G (R6G) is used as a probe molecule to explore the magnitude of the enhancement factor (EF) for the four different structured SERS substrates under varying Ag NPs decoration times. Simultaneously, we prepared R6G solutions at different concentrations to analyze the limit of detection (LOD) for the four different structured SERS substrates. The results indicated that when utilizing a periodic patterned ZnO nanorod array (NAR) as a SERS substrate, its EF value could reach 1.8 × 1010 with a LOD of 10-13 M. © 2024 American Chemical Society.

关键词： Metal nanoparticles

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