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Methacrylated gelatin and platelet-rich plasma based hydrogels promote regeneration of critical-sized bone defects

Regenerative Biomaterials 2024年第4期3卷 66-81页

作者： Shichao Lian Zhiyu Mu Zhengchao Yuan Muhammad Shafiq Xiumei Mo Weidong Mu Department of Traumatic Orthopaedics Shandong Provincial HospitalShandong UniversityJinanShandong 250012China Zoucheng People’s Hospital ZouchengShandong 273500China Department of Medical Physics and Biomedical Engineering University of LondonLondon WC1E 6BTUK State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620PR China Innovation Center of NanoMedicine(iCONM) Kawasaki Institute of Industrial PromotionKawasaki-KuKawasaki 210-0821Japan

Physiological repair of large-sized bone defects requires instructive scaffolds with appropriate mechanical properties,biocompatibility,biodegradability,vasculogenic ability and *** objective of this study was to fabricate in situ injectable hydrogels using platelet-rich plasma(PRP)-loaded gelatin methacrylate(GM)and employ them for the regeneration of large-sized bone *** performed various biological assays as well as assessed the mechanical properties of GM@PRP hydrogels alongside evaluating the release kinetics of growth factors(GFs)from *** GM@PRP hydrogels manifested sufficient mechanical properties to support the filling of the tissue *** biofunction assay,the GM@PRP hydrogels significantly improved cell migration and ***,transcriptome RNA sequencing of human umbilical vein endothelial cells and bone marrow-derived stem cells were performed to delineate vascularization and biomineralization abilities of GM@PRP *** GM@PRP hydrogels were subcutaneously implanted in rats for up to 4 weeks for preliminary biocompatibility followed by their transplantation into a tibial defect model for up to 8 weeks in *** defects treated with GM@PRP hydrogels manifested significant bone regeneration as well as angiogenesis,biomineralization,and collagen *** on the biocompatibility and biological function of GM@PRP hydrogels,a new strategy is provided for the regenerative repair of large-size bone defects.

关键词： large-sized bone defect repair platelet-rich plasma hydrogel tissue scaffold gelatin methacrylate

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Advances in powder nano-photocatalysts as pollutant removal and as emerging contaminants in water:Analysis of pros and cons on health and environment

Advanced Powder Materials

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Advanced Powder materials 2024年第6期3卷 33-69页

作者： Sahil Thakur Abhijeet Ojha Sushil Kumar Kansal Navneet Kumar Gupta Hendrik C.Swart Junghyun Cho Andrej Kuznetsov Shuhui Sun Jai Prakash Department of Chemistry National Institute of Technology HamirpurHamirpur(H.P.)177005India Department of Materials Science and Engineering National Institute of Technology HamirpurHamirpur(H.P.)177005India Dr.S.S.Bhatnagar University Institute of Chemical Engineering and Technology Panjab UniversityChandigarh 160014India Center for Sustainable Technologies Indian Institute of Science(IISc)Gulmohar MargMathikereBengaluru 560012India Department of Physics University of the Free State(UFS)BloemfonteinZA 9300South Africa Department of Mechanical Engineering&Materials Science and Engineering Program State University of New York(SUNY)BinghamtonNY 13902-6000USA University of Oslo Department of Physics and Centre for Materials Science and NanotechnologyPO Box 1048 BlindernN-0316OsloNorway Institut National de la Recherche Scientifique(INRS)-CentreEnergie Materiaux et Telecommunications VarennesQuebec J3X 1P7Canada

Photocatalysis is an advanced oxidation process where light exposure triggers a semiconducting nanomaterial(nano-photocatalyst)to generate electron-hole(e^(-)/h^(+))pairs and free *** phenomenon is widely used for the photocatalysis-assisted removal of organic and other contaminants using wide range of nanophotocatalysts,offering an efficient approach to environmental ***,the introduction of powdered nano-photocatalysts into water systems often leads to unintended secondary pollution in the form of residual nano-photocatalysts,ion leaching,free radicals,toxic by-products *** practices potentially introduce emerging secondary contaminants into aquatic environments,posing risks to both aquatic life and human *** resulting chemical by-products and intermediates can effectively induce chronic toxicity,neurological and developmental disorders,cardiovascular defects,and intestinal ailments in humans and aquatic *** having a range of health and environmental consequences,this dark side of nano-photocatalysts has been comparatively less explored and discussed in the *** this review,the pros and cons of powder nanophotocatalysts are discussed in view of their advantages as well as disadvantages in wastewater *** discussion encompasses their classification based on composition,dimensions,structure,and activity,as well as recent advancements in improving their photocatalytic *** article also explores the recent advances on their applications in photocatalytic removal of various water pollutants/contaminants of emerging concern(i.e.,organic pollutants,micro/nano plastics,heavy ions,disinfections,etc.)Furthermore,an emphasis on the role of such nano-photocatalysts as emerging(secondary)contaminants in water system,along with a thorough discussion of latest studies related to the health and environmental issues,has been ***,it addresses critical issues in applying powder nano-photo

关键词： Powder nano-photocatalysts Advanced oxidation processes Wastewater treatment Pros and cons Emerging contaminants Health and environment issues

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Boxcar gating for time-resolved mid-infrared photothermal imaging of axon-bundle water boundaries

Boxcar gating for time-resolved mid-infrared photothermal im...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Samolis, Panagis D. Zhu, Xuedong Sander, Michelle Y. Department of Electrical and Computer Engineering BU Photonics Center Boston University BostonMA02215 United States Department of Biomedical Engineering Boston University BostonMA02215 United States Division of Materials Science and Engineering Boston University BrooklineMA02446 United States

ISBN: (纸本)9781957171258

关键词： Infrared devices

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Efficient Automatic External Defibrillator Using the Slope of Hilbert Transformed ECG Signals 11

Efficient Automatic External Defibrillator Using the Slope o...

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11th International Japan-Africa Conference on Electronics, Communications, and Computations, JAC-ECC 2023

作者： Elsagheer, Samir A. Sayed, Mohammed S. Hassan, Mohsen A. Egypt-Japan University of Science and Technology Computer Science and Information Technology Alexandria21934 Egypt Aswan Universty Facurlty of Engineering Aswan Egypt Egypt-Japan University of Science and Technology Department of Electronics and Communications Engineering Alexandria21934 Egypt Zagazig University Department of Electronics and Communications Engineering Zagazig Egypt Egypt-Japan University of Science and Technology Materials science and engineering program IDE Alexandria21934 Egypt

ISBN: (纸本)9798350369328

Sudden cardiac arrest (SCA) is a life-threatening condition that demands immediate intervention. The key to survival often lies in the timely and precise analysis of electrocardiogram (ECG) signals to determine the necessity of a shock from an Automatic External Defibrillator (AED). In this paper, we address the critical need for improved accuracy in AED decision-making by presenting a novel approach that leverages the Hilbert Transform to calculate the slope of ECG signals by harnessing the analytical power of Hilbert Transformed ECG signals. By scrutinizing the heart's electrical activity through this method, we aim to enhance the AED's ability to differentiate between cases of ventricular fibrillation and other non-shockable rhythms, ultimately leading to more efficient and effective treatment. Our research explores two distinct approaches for signal analysis and correlates their findings to achieve higher precision in defibrillation decisions. To validate the effectiveness of our approach, we employ a diverse and publicly available dataset containing various heart conditions, allowing us to demonstrate the robustness of our method across a wide spectrum of cases. This study represents a significant advancement in the field of automatic external defibrillation, with the potential to save countless lives through more accurate and timely interventions. © 2023 IEEE.

关键词： Defibrillators

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Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s

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CCS Chemistry 2023年第4期5卷 994-1004页

作者： Ximian Xiao Min Zhou Zihao Cong Longqiang Liu Jingcheng Zou Zhemin Ji Ruxin Cui Yueming Wu Haodong Zhang Sheng Chen Maoquan Li Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237 Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 Department of Interventional and Vascular Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072

Poly(β-peptoid)is a class of polypeptide mimics that possesses excellent biocompatibility and resistance to ***,the synthesis of poly(β-peptoid)s with functionalities is a long-standing challenge that greatly hinders the functional study and application of poly(β-peptoid)*** report a controllable and easy synthesis of poly(β-peptoid)s bearing diverse functionalities via the ring-opening polymerization on N-substitutedβ-alanine N-thiocarboxyanhydrides(β-NNTAs).The polymerization can be carried out in openvesselsundermildconditions usingaminesas the initiators to provide poly(β-peptoid)s with targeted molecular weights,narrow dispersities,and diverse functionalities in the side chains and ***β-NNTAs polymerization is even compatible with initiators bearing unprotected hydroxyl *** amphiphilic/cationic poly(β-peptoid)s exhibit a broad spectrum and potent antibacterial activities against multidrug-resistant *** addition,the highly favored stability ofβ-NNTAmonomers for purification and storage highlights the advantages of thisβ-NNTA polymerization strategy for poly(β-peptoid)s synthesis,functional study,and application as a synthetic mimic of polypeptides.

关键词： ring-opening polymerization poly(β-peptoid) β-NNTA functionlization

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Development of Low-cost and Robust IoT Field Station for Coffee Plantation 15

Development of Low-cost and Robust IoT Field Station for Cof...

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15th International Conference on Knowledge and Smart Technology, KST 2023

作者： Siyang, Satetha Kerdcharoen, Teerakiat Mahidol University Faculty of Science Materials Science and Engineering Program Bangkok10400 Thailand Mahidol University National Nanotechnology Center Faculty of Science and Research Network of NANOTEC Department of Physics Bangkok Thailand

ISBN: (纸本)9781665477123

Thailand has a growing demand in coffee consumption every year. Currently, the nation's capacity for producing coffee is limited, necessitating a significant amount of imports from overseas. The Arabica coffee in the north of Thailand, where the scent and taste of coffee have a distinct identity based on varied cultivation locations, has reasonably good quality. Because of the impact of the environment, it is still challenging to maintain the quality of coffee beans from season to season. Moreover, fierce competition with nearby nations like Laos and Vietnam leads to lower prices of coffee beans. This forces Thai farmers and entrepreneurs to embrace more advanced technologies in order to comprehend the environment of each plantation region and boost their level of competition. This project aims to develop a trustworthy and cost-effective IoT field monitoring solution to assist farmers in understanding the climate conditions in various plantation areas. In order to examine the relationship between the environments, the data collected by the devices can be transferred back to the public cloud server. Then, it can be used as knowledge to raise Thai coffee beans' quality to a premium level so they can continue to compete with coffee beans from other countries. © 2023 IEEE.

关键词： Cultivation

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Tm-doped Chirped-pulse-amplification Fiber Laser System at 1.9 μm

Tm-doped Chirped-pulse-amplification Fiber Laser System at 1...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Xu, Shutao Turnali, Ahmet Lim, Timothy Sander, Michelle Y. Department of Electrical and Computer Engineering BU Photonics Center Boston University BostonMA02215 United States Division of Materials Science and Engineering Boston University BrooklineMA02446 United States Department of Biomedical Engineering Boston University BostonMA02215 United States

We report a high-energy Tm-doped chirped-pulse-amplification fiber laser system seeded by dissipative solitons at 1902 nm. The system provides output pulses with a pulse energy of 120 nJ and a pulse duration of 940 fs... 详细信息

ISBN: (纸本)9781957171258

关键词： Fiber lasers

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Acceptor engineering Produces Ultrafast Nonradiative Decay in NIR-Ⅱ Aza-BODIPY Nanoparticles for Efficient Osteosarcoma Photothermal Therapy via Concurrent Apoptosis and Pyroptosis

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Research 2024年第1期2023卷 625-635页

作者： Zhenxiong Shi Hua Bai Jiaxing Wu Xiaofei Miao Jia Gao Xianning Xu Yi Liu Jiamin Jiang Jiaqi Yang Jiaxin Zhang Tao Shao Bo Peng Huili Ma Dan Zhu Guojing Chen Wenbo Hu Lin Li Wei Huang Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Key Laboratory of Flexible Electronics(KLOFE)and IAM Nanjing Tech UniversityNanjing 211800China Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China Department of Orthopedics Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China

Small-molecule photothermal agents(PTAs)with intense second near-infrared(NIR-Ⅱ,1,000 to 1,700 nm)absorption and high photothermal conversion efficiencies(PCEs)are promising candidates for treating deep-seated tumors such as *** date,the development of small-molecule NIR-Ⅱ PTAs has largely relied on fabricating donor–acceptor–donor(D–A–D/D′)structures and limited success has been ***,through acceptor engineering,a donor–acceptor–acceptor(D–A–A′)-structured NIR-Ⅱ aza-boron-dipyrromethene(aza-BODIPY)PTA(SW8)was readily developed for the 1,064-nm laser-mediated phototheranostic treatment of *** the donor groups to acceptor groups produced remarkable red-shifts of absorption maximums from first near-infrared(NIR-Ⅰ)regions(~808 nm)to NIR-Ⅱ ones(~1,064 nm)for aza-BODIPYs(SW1 to SW8).Furthermore,SW8 self-assembled into nanoparticles(SW8@NPs)with intense NIR-Ⅱ absorption and an ultrahigh PCE(75%,1,064 nm).This ultrahigh PCE primarily originated from an additional nonradiative decay pathway,which showed a 100-fold enhanced decay rate compared to that shown by conventional pathways such as internal conversion and vibrational ***,SW8@NPs performed highly efficient 1,064-nm laser-mediated NIR-Ⅱ photothermal therapy of osteosarcoma via concurrent apoptosis and *** work not only illustrates a remote approach for treating deep-seated tumors with high spatiotemporal control but also provides a new strategy for building high-performance small-molecule NIR-Ⅱ PTAs.

关键词： donor BODIPY intense

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Analysis of Gait Data Based on Deep Learning to Predict Multiple Balance Scale Scores

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IEEE Sensors Journal 2024年第1期24卷 920-930页

作者： Lin, Chueh-Ho Peng, Chih-Wei Lee, I-Jung Wu, Chi-Ming Lin, Bor-Shing Taipei Medical University International Ph.D. Program in Gerontology and Long-Term Care Taipei City110 Taiwan Taipei Medical University Research Center in Nursing Clinical Practice Wan Fang Hospital Taipei City110 Taiwan Taipei Medical University School of Biomedical Engineering College of Biomedical Engineering Taipei City110 Taiwan Taipei Medical University School of Gerontology and Long-Term Care College of Nursing Taipei City110 Taiwan National Taipei University Department of Computer Science and Information Engineering New Taipei City237 Taiwan National Taipei University College of Electrical Engineering and Computer Science New Taipei City237 Taiwan

Unbalanced walking is increasingly common among older adults;therefore, routinely assessing the balance of older adults is crucial. The traditional method of assessing balance uses scales, requires the supervision of a physical therapist (PT), and is time-consuming. The present study, therefore, proposes a deep learning (DL) model architecture that combines a convolutional neural network (CNN) and a long short-term memory (LSTM) network model to predict the scores of three scales, namely the Berg balance scale (BBS), timed up and go (TUG), and single-leg stance (SLS). The gait data of 15 m of walking were collected from seven inertial measurement units (IMUs) and input into the CNN-LSTM model for evaluation. The BBS and TUG only require the participants to wear two IMUs on the left and right thighs, respectively, for accurate predictions. The mean absolute errors (MAEs) of predicting the scores of the BBS and TUG are 1.2562 and 1.4016 s, respectively;however, the MAE of score predictions of SLS is higher than that of the BBS and TUG, indicating that gait data cannot be used for assessing SLS;moreover, participants only wear one IMU on the right calf for BBS and TUG evaluations, which yield MAEs of 1.4334 and 1.5229 s, respectively. The proposed system can quickly and accurately predict the scores of the BBS and TUG. The proposed model can assist PTs with making clinical decisions. © 2001-2012 IEEE.

关键词： Long short-term memory

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Mechanical plasticity of cell membranes enhances epithelial wound closure

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Physical Review Research 2024年第1期6卷 L012036-L012036页

作者： Andrew T. Ton Arthur K. MacKeith Mark D. Shattuck Corey S. O'Hern Department of Physics Yale University New Haven Connecticut 06520 USA Integrated Graduate Program in Physical and Engineering Biology Yale University New Haven Connecticut 06520 USA Department of Mechanical Engineering & Materials Science Yale University New Haven Connecticut 06520 USA Benjamin Levich Institute and Physics Department City College of New York New York New York 10031 USA Department of Applied Physics Yale University New Haven Connecticut 06520 USA

During epithelial wound healing, cell morphology near the healed wound and the healing rate vary strongly among different developmental stages even for a single species like Drosophila. We develop deformable particle (DP) model simulations to understand how variations in cell mechanics give rise to distinct wound closure phenotypes in the Drosophila embryonic ectoderm and larval wing disc epithelium. We find that plastic deformation of the cell membrane can generate large changes in cell shape consistent with wound closure in the embryonic ectoderm. Our results show that the embryonic ectoderm is best described by cell membranes with an elasto-plastic response, whereas the larval wing disc is best described by cell membranes with an exclusively elastic response. By varying the mechanical response of cell membranes in DP simulations, we recapitulate the wound closure behavior of both the embryonic ectoderm and the larval wing disc.

关键词： Cell mechanics Jamming Cell membrane Epithelial cells

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