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Multiplexed Nanoscopy via Buffer Exchange

ACS Nano 2024年第34期18卷 23445-23456页

作者： Chang, Ting-Jui Ben Yang, T. Tony Department of Electrical Engineering National Taiwan University Taipei10617 Taiwan Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei10617 Taiwan Department of Physics National Taiwan University Taipei10617 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei10617 Taiwan

Understanding cellular functions, particularly in their intricate complexity, can greatly benefit from the spatial mapping of diverse molecules through multitarget single-molecule localization microscopy (SMLM). Existing methodologies, primarily restricting the encoding dimensions to color and lifetime or requiring cyclic staining, often involve broad chromatic detection, specialized optical configurations, or sophisticated labeling techniques. Here, we propose a simple approach called buffer-exchange stochastic optical reconstruction microscopy (beSTORM), which introduces an additional dimension to differentiate between single molecules irrespective of their spectral properties. This method leverages the distinguishable photoblinking responses to distinct buffer conditions, offering a straightforward yet effective means of fluorophore discrimination. Through buffer exchanges, beSTORM achieves multitarget SMLM imaging with minimal crosstalk. Direct integration with expansion microscopy (ExM) demonstrates its capability to resolve up to six proteins at the molecular level within a single emission color without chromatic aberration. Overall, beSTORM presents a highly compatible imaging platform, promising significant advancements in highly multiplexed nanoscopy for exploring multiple targets in biological systems with nanoscale precision. © 2024 The Authors. Published by American Chemical Society.

关键词： Stochastic systems

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engineering hierarchical metal-organic@metal-DNA heterostructures for combinational tumor treatment

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Nano Research 2023年第11期16卷 12633-12640页

作者： Xueyan Feng Bei Liu Zehao Zhou Wei Li Jian Zhao Lele Li Yuliang Zhao CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China Department of Nanomedicine&Shanghai Key Lab of Cell Engineering Naval Medical UniversityShanghai 200433China

Development of simple methods for controlled integration of DNA molecules with metal-organic frameworks(MOFs)is important for various biomedical applications,yet remains a ***,a simple and general approach to load DNA on the surface of MOFs is developed via one-pot self-assembly of DNA and FeII ions on nanoscale MOFs,resulting in hierarchical core-shell nanostructures of metal-organic@metal-DNA coordination *** strategy enables assembly of DNA molecules on MOFs with ultra-high contents and precise *** incorporation of a chemotherapeutic drug into the Fe-DNA shell,the systems allow to integrate chemotherapy and gene therapy with photodynamic therapy for combinational tumor ***,the hybrid nanostructures enable light-triggered production of cytotoxic singlet oxygen,which further boosts the endosomal escape of the system for an enhanced gene silencing efficacy and thus improved therapeutic *** work highlights a robust approach for the construction of coordination-based drug delivery systems to combat tumor.

关键词： metal-organic frameworks DNA hierarchical nanostructures coordination combinational tumor treatment

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Recent progress in MXenes incorporated into electrospun nanofibers for biomedical application: Study focusing from 2017 to 2022

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Chinese Chemical Letters 2023年第7期34卷 38-44页

作者： Muheeb Rafiq Sami-ullah Rather Taha Umair Wani Anjum Hamid Rather Rumysa Saleem Khan Anees Ellahi Khan Ibtisam Hamid Haseeb A.Khan Abdullah S.Alhomida Faheem A.Sheikh Nanostructured and Biomimetic Lab Department of NanotechnologyUniversity of Kashmir Hazratbal.Jammu and KashmirSrinagar 190006India Department of Chemical and Materials Engineering King Abdulaziz University.Jeddah 21589Saudi Arabia Research Chair for Biomedical Applications of Nanomaterials Department of BiochemistryCollege of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia

After discovering a new class of two-dimensional(2D) material, i.e., MXene, a further new scope, came into existence for researchers. Due to their remarkable physical, chemical, and biological properties, MXenes find their role in almost every research discipline. They have been used in biosensors, bioimaging,tissue engineering, drug delivery systems, and other areas. The MXenes can be functionalized with a wide range of atoms/molecules, making them diverse materials. Therefore, the potential of using MXenes in nanofibers can be much more than expected. In this review, we will understand the structure, synthesis,and general properties of MXenes. We will explain using MXenes while encasing them into nanofibers,providing their specific properties. For instance, MXenes-incorporated nanofibers are used in biomedical applications, including soft and hard-tissue engineering and delivery of antimicrobials. Furthermore, MXenes, when incorporated into nanofibers, are used in promoting cellular differentiation, wound healing,and neural tissue restoration, which are briefly discussed in this communication.

关键词： MXenes Nanofibers Tissue engineering Antimicrobial Electrospinning

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An intrinsically stretchable multi-biochemical sensor for sweat analysis using photo-patternable ecoflex

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npj Flexible Electronics 2023年第1期7卷 220-228页

作者： Seungwan Kim Joohyuk Kang Injun Lee Jinhyeong Jang Chan Beum Park Wonryung Lee Byeong-Soo Bae Wearable Platform Materials Technology Center(WMC) 291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Center for Theragnosis Biomedical Research InstituteKISTSeoul 02792Republic of Korea

Ecoflex is widely used in bioelectronics due to its outstanding properties of low modulus and large *** its use as an encapsulation layer in multi-channel wearable devices,a patterning procedure is ***,conventional patterning strategies for Ecoflex,such as soft lithography,punching,and laser ablation,lack sufficient quality and process *** address this,we propose a process-compatible method of patterning Ecoflex by developing Photo-patternable Ecoflex(PPE).The PPE layer,used as an encapsulation layer,effectively dissipates strain energy at homogeneous interfaces,resulting in a 50%increase in electrical conductance under 250%*** PPE,we fabricated intrinsically stretchable multi-sensors that monitor bio-signals like glucose,lactate,pH,and humidity in *** sensors maintain durable sensitivity under strain up to 50%and for 1000 cycles at 20%***,we mounted these stretchable multi-chemical sensors on an arm to monitor glucose and lactate levels in sweat.

关键词： lithography pattern intrinsic

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Flexible organic solar cells for biomedical devices

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Nano Research 2021年第9期14卷 2891-2903页

作者： Bin Kan Faheem Ershad Zhoulyu Rao Cunjiang Yu Department of Mechanical Engineering University of HoustonHoustonTX 77204USA Department of Biomedical Engineering University of HoustonHoustonTX 77204USA Materials Science and Engineering Program University of HoustonHoustonTX 77204USA Department of Electrical and Computer Engineering University of HoustonHoustonTX 77204USA Texas Center for Superconductivity University of HoustonHoustonTX 77204USA

Organic solar cells(OSCs),particularly made based on solution processing methods,have made significant progress over the past decades through the concurrent evolution of organic photovoltaic materials and device ***,high power conversion efficiencies around 18%and over 16%have been demonstrated in both rigid and flexible OSCs,*** most of the OSC research has centered on efficiency and cost,their emerging and potential usages in many critical applications,particularly in biomedical fields have been *** this mini-review,we will briefly discuss the high-performance organic photovoltaic materials and the representative flexible OSCs to give a scope on the recent rapid development of ***,we will review some progress on the applications of OSCs in biomedical devices and integrated *** potential challenges associated with integrating OSCs for biomedical devices will be put forward.

关键词： organic solar cells photovoltaic flexible biomedical bioelectronics

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2D graphene oxide-L-arginine-soybean lecithin nanogenerator for synergistic photothermal and NO gas therapy

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Chinese Chemical Letters 2023年第3期34卷 402-408页

作者： Haina Tian Jinyan Lin Fukai Zhu Jiaqi Li Suhua Jiang Liya Xie Yang Li Peiyuan Wang Zhenqing Hou Jinxiao Mi Department of Biomaterials College of MaterialsResearch Center of Biomedical Engineering of Xiamen&Key Laboratory of Biomedical Engineering of Fujian ProvinceXiamen UniversityXiamen 361005China Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350025China Collaborative Innovation Center of Mushroom Health Industry Minnan Normal UniversityZhangzhou 363000China School of Rare earths University of Science and Technology of ChinHefei 230026China The First Affiliated Hospital of Xiamen University Xiamen 361003China Department of Materials Science and Engineering Fujian Provincial Key Laboratory of Advanced Materials(Xiamen University)College of MaterialsXiamen UniversityXiamen 361005China

Nitric oxide(NO) gas therapy has been regarded as a promising strategy for cancer treatment. However,its therapeutic efficiency is still unsatisfying due to the limitations of monotherapy. Previous preclinical and clinical studies have shown that combination therapy could significantly enhance therapeutic efficiency. Herein, a graphene oxide(GO)-L-arginine(L-Arg, a natural NO donor) hybrid nanogenerator is developed followed by surface functionalization of soybean lecithin(SL) for synergistic enhancement of cancer treatment through photothermal and gas therapy. The resultant GO-Arg-SL nanogenerator not only exhibited good biocompatibility and excellent endocytosis ability, but also exhibited excellent photothermal conversion capability and high sensitivity to release NO within tumor microenvironment via inducible NO synthase(i NOS) catalyzation. Moreover, the produced hyperthermia and intracellular NO could synergistically kill cancer cells both in vitro and in vivo. More importantly, this nanogenerator can efficiently eliminate tumor while inhibiting the tumor recurrence because of the immunogenic cell death(ICD) elicited by NIR laser-triggered hyperthermia and the immune response activation by massive NO generation. We envision that the GO-Arg-SL nanogenerator could provide a potential strategy for synergistic photothermal and gas therapy.

关键词： NO gas therapy Photothermal therapy L-Arg Immune activation Reduce recurrence

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Transport and magnetic properties of Hund's metal CaRuO3 under strain modulation

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Physical Review B 2024年第4期110卷 L041403-L041403页

作者： Zhen Wang Arjyama Bordoloi Zhaoqing Ding Enling Wang Xiaofeng Wu Zeguo Lin Mingyu Yang Chenxu Liu Jinglin Zhou Meng Meng Fang Yang Qinghua Zhang Xiaoran Liu Sobhit Singh Huan-hua Wang Jiandong Guo Beijing National Laboratory for Condensed Matter Physics and School of Nuclear Science and Technology Department of Mechanical Engineering School of Physical Sciences Materials Science Program

We synthesized CaRuO3 (001) thin films on a set of substrates and investigated their electronic and magnetic properties via combining magnetotransport measurements with first-principles density-functional theory calculations. The experimental results indicate that a moderate strain can introduce the Kondo effect in the system, leading to a significant modulation of the non-Fermi liquid behavior. Moreover, when the strain reaches a certain threshold, the system undergoes a metal-semiconductor transition, accompanied by a transition from a nonmagnetic state to a plausible G-type antiferromagnetic state. We attribute the observed phenomena in CaRuO3 to strain-induced disruption of the delicate balance between the itinerant and the local Ru 4d electrons. These findings shed light on the intriguing magnetic and non-Fermi liquid behavior of CaRuO3, systematically tailored by heteroepitaxial strain.

关键词： Density of states Kondo effect Transport phenomena Ruthenates Ultrathin films Density functional calculations Physical deposition Resistivity measurements Strain engineering X-ray diffraction X-ray reflectivity

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A Review on Application of Poly(3,4-ethylenedioxythiophene) (PEDOT) in Rechargeable Batteries

Organic Materials

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Organic materials 2022年第4期4卷 292-300页

作者： Su, Laisuo Kumar, Shwetha Sunil Manthiram, Arumugam Reeja-Jayan, B. Materials Science and Engineering Program Texas Materials Institute The University of Texas at Austin Austin 78712 TX United States Department of Mechanical Engineering Carnegie Mellon University Pittsburgh 15213 PA United States

Since the very first patent on poly(3,4-ethylenedioxythiophene) (PEDOT) that was filed in 1988, this polymer has been widely utilized and has achieved great success owing to its high electrical conductivity and excellent stability. The application of the conducting polymer, PEDOT, in renewable energy devices, especially rechargeable batteries, is attracting increasing attention due to its potential to solve the energy and climate crisis. In this review, we summarize the research over the past few decades directed toward the application of PEDOT in rechargeable batteries aimed at improving their electrochemical performance. We focus on PEDOT synthesized via oxidative chemical vapor deposition (oCVD), a relatively new process known for its ability to grow conducting polymer thin films with uniform, pinhole-free properties, and controllable thickness and conformality. For a comparison purpose, PEDOT synthesized via solution-based methods is also briefly summarized. Finally, future research directions for applying oCVD PEDOT in rechargeable batteries are discussed. Introduction PEDOT Synthesis Methods Application of oCVD PEDOT in Rechargeable Batteries Applications of Solution-Based PEDOT in Rechargeable Batteries Conclusions and Outlook. © 2022. The Author(s).

关键词： batteries coating oxidative chemical vapor deposition (oCVD) polyethylene dioxythiophene (PEDOT)

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Plasma-activated interfaces for biomedical engineering

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Bioactive materials 2021年第7期6卷 2134-2143页

作者： Pei Liu Guomin Wang Qingdong Ruan Kaiwei Tang Paul K.Chu Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloon999077Hong KongChina

As an important phenomenon to monitor disease development,cell signaling usually takes place at the interface between organisms/cells or between organisms/cells and abiotic ***,finding a strategy to build the specific biomedical interfaces will help regulate information transmission and produce better therapeutic results to benefit *** the past decades,plasmas containing energetic and active species have been employed to construct various interfaces to meet biomedical demands such as bacteria inactivation,tissue regeneration,cancer therapy,and so *** on the potent functions of plasma modified surfaces,this mini-review is aimed to summarize the state-of-art plasma-activated interfaces and provide guidance to researchers to select the proper plasma and processing conditions to design and prepare interfaces with the optimal biological and related *** a brief introduction,plasma-activated interfaces are described and categorized according to different criteria including direct plasma-cells interfaces and indirect plasma-material-cells interfaces and recent research activities on the application of plasma-activated interfaces are *** authors hope that this mini-review will spur interdisciplinary research efforts in this important area and expedite associated clinical applications.

关键词： Plasma-assisted processes Bioactive interfaces biomedical engineering

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Ethylene Glycol-Manipulated Syntheses of Calcium Carbonate Particles and DNA Capsules toward Efficient ATP-Responsive Cargo Release

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ACS Applied Bio materials 2023年第8期6卷 3351-3360页

作者： Lin, Yu-Hsuan Singuru, Murali Mohana Rao Marpaung, David Septian Sumanto Liao, Wei-Ching Chuang, Min-Chieh Department of Chemistry Tunghai University Taichung407224 Taiwan International Ph.D. Program in Biomedical and Materials Science Tunghai University Taichung407224 Taiwan Department of Biosystems Engineering Institut Teknologi Sumatera Lampung Selatan35365 Indonesia Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung University Taipei112304 Taiwan

Cargo molecule-encapsulated DNA capsules synthesized with a solid sacrificial template have elicited significant interest in the last decade and have been used for active materials in applications ranging from biosensors to drug delivery. However, the correlation between template properties and the subsequent assembly and triggered release behavior of the resultant carriers remain uninvestigated. In this study, ethylene glycol (EG) was added during the CaCO3 precipitation synthesis to yield particles of various sizes and surface properties, and the adenosine triphosphate (ATP)-responsive release characteristics of the fabricated DNA capsules affected by these particle properties were investigated. The geometry, crystallization, and surface morphology of the CaCO3 particles co-precipitated at various EG concentrations were characterized. We discuss the integrity of cross-linking hybridization, fluorescent molecule internalization, degree of leakage, and release efficiency of the resulting DNA capsules and their relevance brought by particle properties. To achieve efficient encapsulation and cargo release, the surface roughness of the CaCO3 particles was explored and was deemed a key determinant of the compactness of the DNA shell after template removal. This effect was particularly strong in CaCO3 particles in connection with high EG concentrations. The DNA capsules fabricated using 83% EG exhibited low leakage, high loading, and moderate release efficiencies as well as a greater apparent association constant with ATP due to their small particle size and the high-integrity DNA shells. © 2023 American Chemical Society.

关键词： Ethylene glycol

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