检索结果-内蒙古大学图书馆

engineering LNPs with polysarcosine lipids for mRNA delivery

Bioactive materials 2024年第7期37卷 86-93页

作者： Diana D.Kang Xucheng Hou Leiming Wang Yonger Xue Haoyuan Li Yichen Zhong Siyu Wang Binbin Deng David W.McComb Yizhou Dong Icahn Genomics Institute Precision Immunology InstituteDepartment of Immunology and ImmunotherapyDepartment of Oncological SciencesTisch Cancer InstituteFriedman Brain InstituteBiomedical Engineering and Imaging InstituteIcahn School of Medicine at Mount SinaiNew YorkNY10029USA Division of Pharmaceutics&Pharmacology College of PharmacyThe Ohio State UniversityColumbusOH43210USA Center for Electron Microscopy and Analysis The Ohio State UniversityColumbusOH43212USA Department of Materials Science and Engineering The Ohio State UniversityColumbusOH43210USA

Since the approval of the lipid nanoparticles(LNP)-mRNA vaccines against the SARS-CoV-2 virus,there has been an increased interest in the delivery of mRNA through ***,current LNP formulations contain PEG lipids,which can stimulate the generation of anti-PEG *** presence of these antibodies can potentially cause adverse reactions and reduce therapeutic efficacy after *** the widespread deployment of the COVID-19 vaccines,the increased exposure to PEG may necessitate the evaluation of alternative LNP formulations without PEG *** this study,we investigated a series of polysarcosine(pSar)lipids as alternatives to the PEG lipids to determine whether pSar lipids could still provide the functionality of the PEG lipids in the ALC-0315 and SM-102 LNP *** found that complete replacement of the PEG lipid with a pSar lipid can increase or maintain mRNA delivery efficiency and exhibit similar safety profiles in vivo.

关键词： Lipid nanoparticles mRNA Polyethylene glycol(PEG) Polysarcosine(pSar)

来源：评论

学校读者我要写书评

暂无评论

Wireless,Multifunctional System-Integrated programmable Soft Robot

引用

纳微快报（英文版） 2025年第7期17卷 12-25页

作者： Sungkeun Han Jeong-Woong Shin Joong Hoon Lee Bowen Li Gwan-Jin Ko Tae-Min Jang Ankan Dutta Won Bae Han Seung Min Yang Dong-Je Kim Heeseok Kang Jun Hyeon Lim Chan-Hwi Eom So Jeong Choi Huanyu Cheng Suk-Won Hwang KU-KIST Graduate School of Converging Science and Technology Korea University145 Anam-RoSeongbuk-GuSeoul 02841Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea University145 Anam-RoSeongbuk-GuSeoul 02841Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong-SiGyeonggi-Do 18448Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea University145 Anam-RoSeongbuk-GuSeoul 02841Republic of Korea SK Hynix Icheon 17336Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Neural Engineering The Pennsylvania State UniversityState CollegeUniversity ParkPA 16802USA Department of Mechanical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA KU-KIST Graduate School of Converging Science and Technology Korea University145 Anam-RoSeongbuk-GuSeoul 02841Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok-RoBundang-GuGyeonggi-DoSeongnam-Si 13524Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Materials Science and Engineering The Pennsylvania State UniversityState CollegeUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityState CollegeUniversity ParkPA 16802USA KU-KIST Graduate School of Converging Science and Technology Korea University145 Anam-RoSeongbuk-GuSeoul 02841Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Integrative Energy Engineering Korea UniversitySeoul 02841Republic of Korea

Soft robots have partially or entirely provided versatile opportunities for issues or roles that cannot be addressed by conventional machine robots,although most studies are limited to designs,controls,or physical/mechanical ***,we present a transformable,reconfigurable robotic platform created by the integration of magnetically responsive soft composite matrices with deformable multifunctional *** compounds engineered to undergo phase transition at a low tem-perature can readily achieve reversible magnetization and conduct various changes of motions and *** and flexible electronic system designed with mechanical dynamics does not interfere with movements of the soft electronic robot,and the performances of wireless circuit,sensors,and devices are independent of a variety of activities,all of which are verified by theoretical *** of navigations and electronic operations in an artificial track highlights the potential of the integrated soft robot for on-demand,environments-responsive movements/metamorphoses,and optoelectrical detection and *** improvements to a miniaturized,sophisticated system with material options enable in situ monitoring and treatment in envisioned areas such as biomedical implants.

关键词： Untethered multimodallocomotion Soft robotics Soft electronics Wireless Reprogrammable magnetic soft robot

来源：评论

学校读者我要写书评

暂无评论

Temperature-Responsive and Passive Wireless Mechanical Metamaterial Sensors 14

Temperature-Responsive and Passive Wireless Mechanical Metam...

引用

14th International Workshop on Structural Health Monitoring: Designing SHM for Sustainability, Maintainability, and Reliability, IWSHM 2023

作者： Naidu, Vishnu R. Park, Yujin Loh, Kenneth J. Materials Science and Engineering Program University of California La Jolla San DiegoCA92093 United States Department of Structural Engineering University of California La Jolla San DiegoCA92093 United States

ISBN: (纸本)9781605956930

Knowing the location and environmental conditions of sailors that have fallen overboard can greatly facilitate open water search and rescue operations. Currently, active sensors that trigger an alarm when a sailor falls overboard exist, and it works by detecting a loss of signal from a transmitter. However, their applications have been limited because of the dependence on a working battery, as well as the fact that sailor location cannot be tracked beyond the one-time loss-of-signal event. In this study, a passive, person-overboard sensing concept is proposed, and the focus is to demonstrate monitoring of seawater conditions. The passive sensor was designed by incorporating a temperature-responsive hydrogel with an auxetic star pattern unit cell geometry, which transforms from a two- to three-dimensional geometry when immersed in low temperature liquid. First, the passive sensor was formed by incorporating a temperature-responsive hydrogel at opposite ends of the star pattern. The time-dependent swelling and de-swelling behavior of the copolymer hydrogel was characterized to understand the mechanical strains induced after exposure to low temperature water. Second, the design of the star pattern geometry was optimized, and artificial imperfections in the form of notches were employed to allow shape transformation to take place at appropriate and minimal applied strains. The vision is that these shape morphing structures with integrated antennas can serve as passive sensors, which, when interrogated by a remote reader, can be used to monitor how long overboard sailors have been in a low-temperature open sea environment. © 2023 by DEStech Publi cations, Inc. All rights reserved

关键词： Water temperature

来源：评论

学校读者我要写书评

暂无评论

Nanostructured Effect on Antifouling Conducting Polymers through Interfacial Adhesive Interaction and Protein Adsorption

引用

ACS Applied Polymer materials 2023年第12期5卷 10105-10115页

作者： Lin, Chia-Hsin Wang, Chang-Yun Li, Jie-Ren Luo, Shyh-Chyang Department of Materials Science and Engineering National Taiwan University No. 1 Sec. 4 Roosevelt Road. Taipei10617 Taiwan Department of Chemistry National Cheng Kung University No.1 University Rd. Tainan70101 Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes Keyan Rd. Miaoli County35053 Taiwan

Antifouling properties are indispensable for ensuring the efficiency of biomedical applications in biotechnology. Bioinspired antifouling surfaces have undergone significant development. The adhesive interactions of nanopatterns supply localized force-related data. In this study, a precisely defined conducting polymer (CP), poly(3,4-ethylenedioxythiophene) (PEDOT), was enriched with antifouling phosphorylcholine moieties (PEDOT-PC) for comparison with hydroxyl-functionalized PEDOT (PEDOT-OH) to investigate their effects. Well-defined nanopatterned PEDOT films can be precisely created by controlling the electropolymerization process on a polystyrene (PS) monolayer template using a colloidal lithography approach. Electropolymerized PEDOT coatings have emerged as a surface modification strategy for bioelectrodes due to their facile functionalization and fabrication. The patterns are versatile, depending on the sizes of PS beads and electropolymerization conditions. Atomic force microscopy (AFM) allows for the examination of the adhesion effects of periodic nanostructures in aqueous solutions. Real-time and quantitative assessment of adhesion between the AFM tip and the sample was conducted through force-volume mapping. Furthermore, the study involved the examination of protein adsorption behaviors at these interfaces using a quartz crystal microbalance with dissipation (QCM-D), including bovine serum albumin (BSA), cytochrome c (cyt c), lysozyme (LYZ), and C-reactive protein (CRP). AFM probing near the interface revealed that surface morphology induced higher adhesion forces than pristine polymer films, whereas the PEDOT-PC coating exhibited minimal interaction during tip scanning. Additionally, protein adsorption tests indicated that the nanostructures compromised the antifouling properties of PEDOT-PC films, aligning with water contact angle measurements. The periodic structure enhances the energy barrier, disrupting the preservation of a continuous water layer captu

关键词： Conducting polymers

来源：评论

学校读者我要写书评

暂无评论

Density Functional Theory Study of Surface Stability and Phase Diagram of Orthorhombic CsPbI3

arXiv

引用

arXiv 2024年

作者： Li, Kejia Wang, Mengen Department of Electrical and Computer Engineering and Materials Science and Engineering Program SUNY BinghamtonNY13902 United States

CsPbI3 has been recognized as a promising candidate for optoelectronic device applications. To further improve the efficiency of the devices, it is imperative to better understand the surface properties of CsPbI3, which affect charge carrier transport and defect formation properties. In this study, we perform density functional theory calculations to explore the stability of the (001), (110), and (100) surfaces of orthorhombic CsPbI3, considering different stoichiometries and surface reconstructions. Our results show that, under the chemical potentials confined by the thermodynamically stable region of bulk CsPbI3, the CsI-terminated surfaces of (001) and (110) and the stoichiometric surface of (100) are stable. Among these three surfaces, the CsI-terminated (110) surface has the lowest surface energy and no mid-gap states, which benefits the transport properties of the material. © 2024, CC BY-NC-SA.

关键词： Stoichiometry

来源：评论

学校读者我要写书评

暂无评论

THE EFFECTS OF PRE-COATING LAYERS ON BARRIER LAYER PERFORMANCE

THE EFFECTS OF PRE-COATING LAYERS ON BARRIER LAYER PERFORMAN...

引用

TAPPICon 2023 - Rock the Roll: Unleashing the Harmonies of the Paper Industry

作者： Pokharel, Kritee Wang, Jinwu Bousfield, Douglas Paper Surface Science Program Department of Chemical and Biomedical Engineering University of Maine OronoME04469 United States Forest Products Laboratory MadisonWI United States

CNF (cellulose nanofibrils) layers on paper are an effective barrier against oxygen and grease and improve dispersion-based barrier coatings. The potential to produce paper grades with good oxygen, grease, and moisture barrier properties is clear, but synergies between CNF, other coating layers, and water-borne barrier coatings (WBBC) are not. Different WBBC weights were applied to papers with different CNF films that varied in quality and amounts. WBBC were also applied to pigmented coating layers with different pigment types and pigment to volume concentrations (PVC). Samples are tested for oil and grease resistance (OGR), water vapor transmission rate (WVTR), and oxygen transmission rate (OTR). WVTR reduces by more than ten times when WBBC is applied to a CNF film compared to no layer at the same coat weight. WVTR is reduced when WBBC is applied to pigment coating layers as well. The folding of the samples reduces moisture barrier performance to some degree but not grease resistance when a CNF film is used. WBBC coatings on CNF film have good oxygen barrier properties. © 2023 TAPPICon 2023 - "Rock the Roll: Unleashing the Harmonies of the Paper Industry". All rights reserved.

关键词： Oxygen

来源：评论

学校读者我要写书评

暂无评论

The Dynamic Mortise-and-Tenon Interlock Assists Hydrated Soft Robots Toward Off-Road Locomotion

引用

Research 2023年第1期2022卷 553-564页

作者： Baoyi Wu Yaoting Xue Israt Ali Huanhuan Lu Yuming Yang Xuxu Yang Wei Lu Yinfei Zheng Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201China School of Chemical Sciences University of Chinese Academy of Sciences19A Yuquan RoadBejing 100049China Department of Engineering Mechanics Zhejang UniversityHangzhou 310027China INRS-EMT 1650 Boul.Lionel BouletVarennes J3X OA1Canada College of Chemical Engineering Ningbo PolytechnicNingbo 315800China Key Laboratory for Biomedical Engineering of Ministry of Education Ministry of China Key Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang ProvinceCollege of Biomedical Engineering and Instrument ScienceZhejang UniversityHangzhou 310027China Research Center for Humanoid Sensing Zhejang LabHangzhou 311100China

Natural locomotion such as walking,crawling,and swimming relies on spatially controlled deformation of soft tissues,which could allow efficient interaction with the external *** one of the ideal candidates for biomimetic materials,hydrogels can exhibit versatile bionic ***,it remains an enormous challenge to transfer these insitu deformations to locomotion,particularly above complex ***,inspired by the crawling mode of inchworms,an isotropic hydrogel with thermoresponsiveness could evolve to an anisotropic hydrogel actuator via interfacial diffusion polymerization,further evolving to multisection structure and exhibiting adaptive deformation with diverse degrees of ***,a dynamic mortise-and-tenon interlock could be generated through the interaction between the self-deformation of the hydrogel actuator and rough terrains,inducing continual multidimensional locomotion on various artificial rough substrates and natural sandy ***,benefiting from the powerful mechanical energy transfer capability,the crawlable hydrogel actuators could also be utilized as hydrogel motors to activate static cargos to overstep complex terrains,which exhibit the potential application of a biomimetic mechanical discoloration ***,we believe that this design principle and control strategy may be of potential interest to the field of deformable materials,soft robots,and biomimetic devices.

关键词： terrain versatile utilized

来源：评论

学校读者我要写书评

暂无评论

Electronic structure and optical spectra of MSi2N4 (M = Mo, Ta, V) materials with single-atom decoration: a first-principles study

引用

Journal of materials Chemistry C 2023年第43期11卷 15097-15105页

作者： Wu, Tzu-Cheng Liao, Yin-Song Kao, Jui-Cheng Chou, Jyh-Pin Department of Physics National Tsing Hua University Hsinchu300044 Taiwan The Affiliated Senior High School of National Taiwan Normal University Taipei10658 Taiwan Tsing Hua Interdisciplinary Program National Tsing Hua University Hsinchu300044 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu300044 Taiwan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan Department of Physics National Changhua University of Education Changhua50007 Taiwan

MoSi2N4 has outstanding potential for applications in electronics, spintronics, and semiconducting fabrication. This attractive scenario can be attributed to its remarkable electronic properties. In this study, we investigate the electronic structure and optical spectra of the MSi2N4 (M = Mo, Ta, and V) materials with single atom (H, N, and O) decoration using first-principles calculations. Pristine MoSi2N4 and VSi2N4 are semiconductors, and TaSi2N4 shows the half-metal properties. Decorating MoSi2N4 with single hydrogen and nitrogen atoms induces a magnetic moment. Single oxygen decorated TaSi2N4 does not change its intrinsic electronic properties, which is suitable for spintronic applications. On top of that, the semiconductor VSi2N4 can be turned into a half-metal via single hydrogen atom decoration. The absorption spectra demonstrate an enhancement in optical absorption for VSi2N4 after the decoration with a single nitrogen atom. Single atom decoration is one of the effective methods of tailoring the electronic properties of the two-dimensional MoSi2N4 family. Our findings can accelerate the development of the advanced electronic devices. © 2023 The Royal Society of Chemistry.

关键词： Silicon compounds

来源：评论

学校读者我要写书评

暂无评论

In vitro and in vivo study on fine-grained Mg-Zn-RE-Zr alloy as a biodegradeable orthopedic implant produced by friction stir processing

引用

Bioactive materials 2023年第10期28卷 448-466页

作者： Vasanth C.Shunmugasamy Marwa AbdelGawad Muhammad Umar Sohail Talal Ibrahim Talha Khan Thomas Daniel Seers Bilal Mansoor Mechanical Engineering Program Texas A&M University at QatarEducation CityDohaQatar Department of Mechanical Engineering Texas A&M University3123 TAMUCollege StationTX 77843USA Proteomics Core Weill Cornell MedicineEducation CityDohaQatar Department of Surgery Division of Orthopedic SurgerySidra MedicineDohaQatar Clinical Orthopedic Surgery Weill Cornell MedicineEducation CityDohaQatar Petroleum Engineering Program Texas A&M University at QatarEducation CityDohaQatar Department of Materials Science and Engineering Texas A&M University3003 TAMUCollege StationTX 77843USA

Magnesium alloys containing biocompatible components show tremendous promise for applications as temporary biomedical devices. However, to ensure their safe use as biodegradeable implants, it is essential to control their corrosion rates. In concentrated Mg alloys, a microgalvanic coupling between the α-Mg matrix and secondary precipitates exists which results in increased corrosion rate. To address this challenge, we engineered the microstructure of a biodegradable Mg-Zn-RE-Zr alloy by friction stir processing (FSP), improving its corrosion resistance and mechanical properties simultaneously. The FS processed alloy with refined grains and broken and uniformly distributed secondary precipitates showed a relatively uniform corrosion morphology accompanied with the formation of a stable passive layer on the alloy surface. In vivo corrosion evaluation of the processed alloy in a small animal model showed that the material was well-tolerated with no signs of inflammation or harmful by-products. Remarkably, the processed alloy supported bone until it healed till eight weeks with a low in vivo corrosion rate of 0.7 mm/year. Moreover, we analyzed blood and histology of the critical organs such as liver and kidney, which showed normal functionality and consistent ion and enzyme levels, throughout the 12- week study period. These results demonstrate that the processed Mg-Zn-RE-Zr alloy offers promising potential for osseointegration in bone tissue healing while also exhibiting controlled biodegradability due to its engineered microstructure. The results from the present study will have profound benefit for bone fracture management, particularly in pediatric and elderly patients.

关键词： Biodegradable magnesium Bone healing Friction stir processing Microstructure Corrosion resistance

来源：评论

学校读者我要写书评

暂无评论

A mussel-inspired,antibacterial,antioxidant,injectable composite hydrogel for the sustain delivery of salvianolic acid B for the treatment of frozen shoulder

引用

Bioactive materials 2024年第10期40卷 396-416页

作者： Yan Yan Xinhao Li Chen Chen Dedong Cui Zhuo Wang Ming Li Yi Long Jinming Zhang Cheng Li Zhiling Wang Chuanhai Zhou Zeyu Yao Dan Wang Jingyi Hou Rui Yang Department of Orthopedics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510000China Department of Geriatric Dentistry NMPA Key Laboratory for Dental Materials National Engineering Laboratory for Digital and Material Technology of StomatologyPeking University School and Hospital of StomatologyBeijing100081China School of Biomedical Science The Chinese University of Hong KongHong Kong999077China

Frozen shoulder(FS)manifests as progressively worsening pain and a reduction in shoulder range of motion(ROM).Salvianolic acid B(SaB)is recently expected to be used in the treatment of fibrosis diseases including *** firstly demonstrate that SaB can effectively hinder the progression of oxidative stress,inflammation,and pathological fibrosis within the synovial tissue in FS,potentially leading to the reduction or reversal of capsule fibrosis and joint *** further clinical application,we design and synthesize a novel,superior,antioxidant and antibacterial CSMA-PBA/OD-DA(CPDA)hydrogel for the delivery of *** vitro experiments demonstrate that the CPDA hydrogel exhibits excellent biocompatibility and rheological properties,rendering it suitable for intra-articular *** injection into the contracted joint cavity of FS model rat,the SaBCPDA hydrogel accelerate the recovery of ROM and exhibit superior anti-fibrosis effect,presenting the promise for the treatment of FS in vivo.

关键词： Frozen shoulder Hydrogel Salvianolic acid b Fibrosis NF-κB/IL-6 signaling pathway

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：