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Medical micro-and nanomotors in the body

Acta Pharmaceutica Sinica B 2023年第2期13卷 517-541页

作者： Huaan Li Fei Peng Xiaohui Yan Chun Mao Xing Ma Daniela A.Wilson Qiang He Yingfeng Tu Department of Pharmacy Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China School of Pharmaceutical Science Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical UniversityGuangzhou 510515China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Centre for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361005China National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Sauvage Laboratory for Smart Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Institute for Molecules and Materials Radboud UniversityNijmegen6525 AJthe Netherlands Key Laboratory of Microsystems and Microstructures Manufacturing(Ministry of Education) School of Medicine and HealthHarbin Institute of TechnologyHarbin 150080China

Attributed to the miniaturized body size and active mobility,micro-and nanomotors(MNMs)have demonstrated tremendous potential for medical ***,from bench to bedside,massive efforts are needed to address critical issues,such as cost-effective fabrication,on-demand integration of multiple functions,biocompatibility,biodegradability,controlled propulsion and in vivo ***,we summarize the advances of biomedical MNMs reported in the past two decades,with particular emphasis on the design,fabrication,propulsion,navigation,and the abilities of biological barriers penetration,biosensing,diagnosis,minimally invasive surgery and targeted cargo *** perspectives and challenges are discussed as *** review can lay the foundation for the future direction of medical MNMs,pushing one step forward on the road to achieving practical theranostics using MNMs.

关键词： Micro-and nanomotors Function integration Controlled propulsion In vivo navigation biomedical applications Minimally invasive microsurgery Biosensing Biological barrier penetration

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Fluid-induced corrosion behavior of degradable zinc for stent application

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Journal of materials science & Technology 2021年第32期91卷 134-147页

作者： Kai Chen Xuenan Gu Hui Sun Hongyan Tang Hongtao Yang Xianghui Gong Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Materials Science and Engineering The Ohio State UniversityColumbusOH43210USA

The influence of laminar flow on the corrosion of pure zinc(Zn) and cell response was investigated and compared with the static *** results revealed that laminar flow accelerated the corrosion and enhanced the localized corrosion of pure *** dynamic corrosion rate was 0.184 mm/yr after 168 h *** corrosion products were formed under flow condition,which were mainly composed of Zn_(3)(PO_(4))_(2)·4 H_(2) O,Ca_(3)(PO_(4))_(2),ZnO and Zn_(5)(OH)_(6)(CO_(3))_(2).Moreover,the adhered rat aortic endothelial cells(RAEC) on Zn samples exhibited notably cell loss and round configuration under laminar flow.

关键词： Zinc Laminar flow Dynamic degradation Endothelial cells Biocompatibility

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Understanding age-related middle ear properties and basilar membrane damage in hearing loss: A finite element analysis and retrospective cohort study

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Computers in Biology and Medicine 2025年 184卷 109376-109376页

作者： Shih, Tzu-Ching Yu, You-Cheng Wang, Tang-Chuan Department of Biomedical Imaging and Radiological Science College of Medicine China Medical University Taichung404328 Taiwan The PhD Program for Medical Engineering and Rehabilitation Science College of Biomedical Engineering China Medical University Taichung404328 Taiwan Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404328 Taiwan Department of Otolaryngology-Head and Neck Surgery China Medical University Hsinchu Hospital Zhubei City Hsinchu302056 Taiwan

Age-related hearing loss (ARHL) is primarily attributed to inner-ear factors, yet the role of age-related middle ear characteristics remains elusive. Employing a finite element (FE) model, we conducted a comparative analysis with clinical data extracted from a retrospective cohort study involving 90 younger adults (mean age = 38.1 ± 7.7) and 111 older adults (mean age = 63.8 ± 8.4). The clinical dataset encompassed air-bone gap (ABG) measurements obtained through pure-tone audiometry (PTA) at frequencies of 0.5, 1.0, 2.0, and 4.0 kHz. FE results quantified the normalized stapes displacement value of the simulated form of air-bone gap (ABGSim) between the two age groups. The Mann-Whitney U test, with a significance threshold set at P © 2024

关键词： Bone

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The Diagnosis of Cardiovascular Disease Using Simple Blood Biomarkers Through AI and Big Data 46

The Diagnosis of Cardiovascular Disease Using Simple Blood B...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Pezoulas, Vasileios Ehret, Georg Dobretz, Kevin Fotiadis, Dimitrios I. Sakellarios, Antonis I. Biomedical Resarch Institute FORTH-IMBB Unit of Medical Technology and Intelligent Information Systems Dept. of Materials Science and Engineering IoanninaGR 45110 Greece Universitaires de Genève Department of Internal Medicine Hôpitaux Geneva Switzerland University of Patras Dept. of Mechanical and Aeronautics Engineering Patras Greece University of Ioannina Unit of Medical Technology and Intelligent Information Systems Dept. of Materials Science and Engineering Ioannina Greece

ISBN: (纸本)9798350371499

Cardiovascular disease (CVD) is the leading cause of global mortality, diagnosed primarily through costly imaging modalities which are often overused in asymptomatic patients. Our project aims to develop an AI-based solution for CVD risk stratification using routine blood biomarkers, serving as a pre-imaging test. We used anonymized data from over 500,000 UK Biobank (UKB) patients with CVD assessments. Initially, 701 features including demographics, blood tests, medical conditions, and clinical assessments were selected. The UKB dataset was refined using an automated data curation pipeline to deal with outliers, duplicated fields, and missing values. Then, a hybrid XGBoost classifier was employed, with a scalable loss function, to address overfitting effects during the training process, yielding 0.83 accuracy, 0.82 sensitivity, and 0.84 specificity in diagnosing CVD comorbidities. Key biomarkers identified included blood pressure, BMI, and age. To our knowledge, this is the first case study which utilizes the UKB data towards the identification of cost-effective CVD (non-imaging) risk factors, thus reducing the reliance on imaging modalities. © 2024 IEEE.

关键词： Diseases

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The immune-chemo-embolization effect of temperature sensitive gold nanomedicines against liver cancer

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Nano Research 2023年第2期16卷 2749-2761页

作者： Yiming Liu Dingwen Shi Yanqiao Ren Ling Li Yanbing Zhao Chuansheng Zheng Xiangliang Yang Department of Radiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China National Engineering Research Center for Nanomedicine Key Laboratory of Molecular Biophysics of Ministry of EducationCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China School of Biomedical Engineering Hubei University of Science and TechnologyXianning 437100China Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective MaterialsHuazhong University of Science and TechnologyWuhan 430074China GBA Research Innovation Institute for Nanotechnology Guangzhou 510530China Hubei Province Key Laboratory of Molecular Imaging Wuhan 430022China

Although transcatheter arterial chemo-embolization(TACE)plays a key role on clinical treatment of hepatocellular carcinoma(HCC),it was greatly limited by the poor synergistic effect between chemotherapeutics and physical embolization to tumor-feeding *** the present work,a temperature sensitive polymer poly(N-isopropylacrylamide-b-methacrylic acid)(PNA),which was modified with gold nanoparticles(AuNP@PNA),was successfully used to encapsulate doxorubicin(DOX)by electrostatic binding with their carboxyl *** resultant gold nanomedicines(AuNP@PNA/DOX)exhibited temperature responsive sol-gel phase transition,favorable shear thinning effect and X-ray *** in vivo evaluation of vascular embolization on VX2-tumor-bearing rabbits,AuNP@PNA/DOX exhibited far better antitumor efficacy than Lipiodol/DOX,on either tumor growth inhibition,proliferation,apoptosis,necrosis or *** to sufficient embolization to tumor vascular networks,AuNP@PNA/DOX down-regulated the expression levels of HIF-1α,VEGF and MMP-9,and prompted more efficient activation on CD3+/CD8+T cells and the related cytokines,suggesting the synergistic effect between AuNP@PNA and DOX on the improvement of post-operative tumor immunosuppressive *** their favorable pharmcokinetics and biocompatibility,AuNP@PNA/DOX is promising to be developed as a multi-functional artery-imaging/embolic agent with immune-chemo-embolization for enhancing TACE efficacy on HCC.

关键词： temperature sensitive nanogels gold nanoparticles transcatheter arterial chemo-embolization(TACE) antitumor immune response

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Growth and differentiation of human induced pluripotent stem cell(hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels

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Bioactive materials 2023年第3期21卷 142-156页

作者： Niall J.Treacy Shane Clerkin Jessica L.Davis Ciar´an Kennedy Aline F.Miller Alberto Saiani Jacek K.Wychowaniec Dermot F.Brougham John Crean Diabetes Complications Research Centre University College Dublin(UCD)Conway Institute of Biomolecular and Biomedical Research and BelfieldDublin 4Ireland UCD School of Biomolecular and Biomedical Science BelfieldDublin 4Ireland Department of Materials&Manchester Institute of Biotechnology(MIB) School of Natural SciencesFaculty of Science and EngineeringThe University of ManchesterUK UCD School of Chemistry University College DublinBelfieldDublin 4Ireland

Human induced pluripotent stem cell(hiPSC)-derived kidney organoids have prospective applications ranging from basic disease modelling to personalised ***,there remains a necessity to refine the bio-physical and biochemical parameters that govern kidney organoid *** within fully-controllable and physiologically relevant 3D growth environments will be critical to improving organoid reproducibility and ***,we matured hiPSC-derived kidney organoids within fully synthetic self-assembling peptide hydrogels(SAPHs)of variable stiffness(storage modulus,G′).The resulting organoids con-tained complex structures comparable to those differentiated within the animal-derived matrix,***-cell RNA sequencing(scRNA-seq)was then used to compare organoids matured within SAPHs to those grown within Matrigel or at the air-liquid interface.A total of 13,179 cells were analysed,revealing 14 distinct *** compositional analysis revealed a larger proportion of nephron cell types within Transwell-derived organoids,while SAPH-derived organoids were enriched for stromal-associated cell ***,dif-ferentiation within a higher G’SAPH generated podocytes with more mature gene expression ***-tionally,maturation within a 3D microenvironment significantly reduced the derivation of off-target cell types,which are a known limitation of current kidney organoid *** work demonstrates the utility of syn-thetic peptide-based hydrogels with a defined stiffness,as a minimally complex microenvironment for the selected differentiation of kidney organoids.

关键词： Human kidney organoids Fully synthetic matrices Self-assembling peptide hydrogels Single-cell RNA sequencing

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Dry Fiber‑Based Electrodes for Electrophysiology Applications

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Advanced Fiber materials 2023年第3期5卷 819-846页

作者： Ladan Eskandarian Elmira Pajootan Amirali Toossi Hani E.Naguib Department of Materials Science and Engineering University of TorontoTorontoON M5S 3E4Canada Department of Chemical Engineering McGill UniversityMontrealQC H3A 0C5Canada Research and Development Department Myant IncTorontoON M9W 1B6Canada Department of Mechanical and Industrial Engineering University of TorontoTorontoON M5S 3G8Canada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoON M5S 3G8Canada

Long-term continuous health care monitoring,using wearable technologies has received considerable interest due to the significant contribution of wearables to the diagnosis of diseases and identification of health *** have been widely applied in human societies due to their unique advantages,including stretchability,small diameters,high dynamic bending elasticity,high length-to-width ratios,and mechanical strength.A new generation of fiber-based electrodes is being integrated into smart textiles and wearables for continuous long-term biosignal *** fiber-based electrodes are breathable,flexible,and durable,unlike conventional disposable gel electrodes,which are difficult to employ for long-term applications because of skin irritation and allergic responses caused by their moist and adhesive interface with the *** this review,we provide a concise summary of recent breakthroughs in the design,and manufacturing of dry fiber-based electrodes for electrophysiology applications,with a particular emphasis on applications in electrocardiography,electromyography,and *** on numerous features of electroactive fiber materials,fiber processing,electrode fabrication,scaled-up manufacturing,standardization of testing and performance criteria,we discuss current limitations and provide an outlook for the future development of this field.

关键词： Electroactive fiber Smart textiles Electrocardiography Wearables Health care monitoring Textile

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biomedical imaging and sensing in the near-infrared using fluorescent single-walled carbon nanotubes

Biomedical imaging and sensing in the near-infrared using fl...

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2023 Imaging Systems and Applications, IS 2023 in Optica Imaging Congress - Part of Imaging and Applied Optics Congress 2023

作者： Bisker, Gili Department of Biomedical Engineering Faculty of Engineering The Center for Physics and Chemistry of Living Systems The Center for Nanoscience and Nanotechnology The Center for Light-Matter Interaction The Center for Computational Molecular and Materials Science Tel Aviv University Tel Aviv6997801 Israel

We present an overview of recent advancements in biomedical imaging and sensing using near-infrared fluorescent single-walled carbon nanotubes, providing real-time spatiotemporal information. © 2023 The Author(s).

ISBN: (纸本)9781957171289

关键词： Infrared devices

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Control of skyrmion lattice order in the van der Waals ferromagnet Fe3GeTe2 16

Control of skyrmion lattice order in the van der Waals ferro...

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Spintronics XVI 2023

作者： Li, Yue McCray, Arthur R.C. Wang, Wei Basnet, Rabindra Pandey, Krishna Ma, Xuedan Hu, Jin Petford-Long, Amanda K. Phatak, Charudatta Materials Science Division Argonne National Laboratory LemontIL60439 United States Applied Physics Program Northwestern University EvanstonIL60208 United States Center for Nanoscale Materials Argonne National Laboratory LemontIL60439 United States Department of Physics University of Arkansas FayettevilleAR72701 United States Materials Science and Engineering Program University of Arkansas FayettevilleAR72701 United States Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States

ISBN: (纸本)9781510665262

Van der Waals ferromagnets are an intersting class of materials for exploring fundamental physics of magnetic order in the 2D limit as well as for technological applicaitons due to possibility of creating novel heterostructures. These materials have shown to host magnetic skyrmion lattices with their organization controlled by the magnetic properties such as anisotropy, exchange, and Dzyaloshinkii-Moriya interaction. For technological applications, it is also necessary to understand to the behavior of skyrmions in response to electric currents. In this work, we show the effect of electric current pulses on the magnetic skyrmions formed in Fe3GeTe2which has a Curie temperature of 220 K. We demonstrate via real-space in situ imaging using Lorentz transmission electron microscopy (LTEM) the effect of temperture and pulse width. © 2023 SPIE.

关键词： High resolution transmission electron microscopy

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Overcoming the Blood-Brain Tumor Barrier with Docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma

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ACS Applied materials and Interfaces 2024年第17期16卷 21722-21735页

作者： Hsu, Tsung-I Chen, Yi-Ping Zhang, Rong-Lin Chen, Zih-An Wu, Cheng-Hsun Chang, Wen-Chang Mou, Chung-Yuan Chan, Hardy Wai-Hong Wu, Si-Han Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei110 Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Nano Targeting & Therapy Biopharma Inc. Taipei110 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110 Taiwan Department of Chemistry National Taiwan University Taipei106 Taiwan

While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (DTX), providing a novel approach for treating TMZ-resistant GBM. Our findings reveal that C8-MSN is biocompatible in vitro, and DTX@C8-MSN shows no hemolytic activity at therapeutic concentrations, maintaining efficacy against GBM cells. Crucially, in vivo imaging demonstrates preferential accumulation of C8-MSN within the tumor region, suggesting enhanced permeability across the blood-brain tumor barrier (BBTB). When administered to orthotopic glioma mouse models, DTX@C8-MSN notably prolongs survival by over 50%, significantly reduces tumor volume, and decreases side effects compared to free DTX, indicating a targeted and effective approach to treatment. The apoptotic pathways activated by DTX@C8-MSN, evidenced by the increased levels of cleaved caspase-3 and PARP, point to a potent therapeutic mechanism. Collectively, the results advocate DTX@C8-MSN as a promising candidate for targeted therapy in TMZ-resistant GBM, optimizing drug delivery and bioavailability to overcome current therapeutic limitations. © 2024 The Authors. Published by American Chemical Society.

关键词： Tumors

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