检索结果-内蒙古大学图书馆

Dry Fiber‑Based Electrodes for Electrophysiology Applications

Advanced Fiber materials 2023年第3期5卷 819-846页

作者： Ladan Eskandarian Elmira Pajootan Amirali Toossi Hani E.Naguib Department of Materials Science and Engineering University of TorontoTorontoON M5S 3E4Canada Department of Chemical Engineering McGill UniversityMontrealQC H3A 0C5Canada Research and Development Department Myant IncTorontoON M9W 1B6Canada Department of Mechanical and Industrial Engineering University of TorontoTorontoON M5S 3G8Canada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoON M5S 3G8Canada

Long-term continuous health care monitoring,using wearable technologies has received considerable interest due to the significant contribution of wearables to the diagnosis of diseases and identification of health *** have been widely applied in human societies due to their unique advantages,including stretchability,small diameters,high dynamic bending elasticity,high length-to-width ratios,and mechanical strength.A new generation of fiber-based electrodes is being integrated into smart textiles and wearables for continuous long-term biosignal *** fiber-based electrodes are breathable,flexible,and durable,unlike conventional disposable gel electrodes,which are difficult to employ for long-term applications because of skin irritation and allergic responses caused by their moist and adhesive interface with the *** this review,we provide a concise summary of recent breakthroughs in the design,and manufacturing of dry fiber-based electrodes for electrophysiology applications,with a particular emphasis on applications in electrocardiography,electromyography,and *** on numerous features of electroactive fiber materials,fiber processing,electrode fabrication,scaled-up manufacturing,standardization of testing and performance criteria,we discuss current limitations and provide an outlook for the future development of this field.

关键词： Electroactive fiber Smart textiles Electrocardiography Wearables Health care monitoring Textile

来源：评论

学校读者我要写书评

暂无评论

Overcoming the Blood-Brain Tumor Barrier with Docetaxel-Loaded Mesoporous Silica Nanoparticles for Treatment of Temozolomide-Resistant Glioblastoma

引用

ACS Applied materials and Interfaces 2024年第17期16卷 21722-21735页

作者： Hsu, Tsung-I Chen, Yi-Ping Zhang, Rong-Lin Chen, Zih-An Wu, Cheng-Hsun Chang, Wen-Chang Mou, Chung-Yuan Chan, Hardy Wai-Hong Wu, Si-Han Ph.D. Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University and National Health Research Institutes Taipei110 Taiwan International Master Program in Medical Neuroscience College of Medical Science and Technology Taipei Medical University Taipei110 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei110 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei110 Taiwan Nano Targeting & Therapy Biopharma Inc. Taipei110 Taiwan Graduate Institute of Medical Sciences College of Medicine Taipei Medical University Taipei110 Taiwan Department of Chemistry National Taiwan University Taipei106 Taiwan

While temozolomide (TMZ) has been a cornerstone in the treatment of newly diagnosed glioblastoma (GBM), a significant challenge has been the emergence of resistance to TMZ, which compromises its clinical benefits. Additionally, the nonspecificity of TMZ can lead to detrimental side effects. Although TMZ is capable of penetrating the blood-brain barrier (BBB), our research addresses the need for targeted therapy to circumvent resistance mechanisms and reduce off-target effects. This study introduces the use of PEGylated mesoporous silica nanoparticles (MSN) with octyl group modifications (C8-MSN) as a nanocarrier system for the delivery of docetaxel (DTX), providing a novel approach for treating TMZ-resistant GBM. Our findings reveal that C8-MSN is biocompatible in vitro, and DTX@C8-MSN shows no hemolytic activity at therapeutic concentrations, maintaining efficacy against GBM cells. Crucially, in vivo imaging demonstrates preferential accumulation of C8-MSN within the tumor region, suggesting enhanced permeability across the blood-brain tumor barrier (BBTB). When administered to orthotopic glioma mouse models, DTX@C8-MSN notably prolongs survival by over 50%, significantly reduces tumor volume, and decreases side effects compared to free DTX, indicating a targeted and effective approach to treatment. The apoptotic pathways activated by DTX@C8-MSN, evidenced by the increased levels of cleaved caspase-3 and PARP, point to a potent therapeutic mechanism. Collectively, the results advocate DTX@C8-MSN as a promising candidate for targeted therapy in TMZ-resistant GBM, optimizing drug delivery and bioavailability to overcome current therapeutic limitations. © 2024 The Authors. Published by American Chemical Society.

关键词： Tumors

来源：评论

学校读者我要写书评

暂无评论

Two-dimensional MXenes:New frontier of wearable and flexible electronics

引用

InfoMat 2022年第4期4卷 1-28页

作者： Abbas Ahmed Sudeep Sharma Bapan Adak Md Milon Hossain Anna Marie LaChance Samrat Mukhopadhyay Luyi Sun Polymer Program Institute of Materials ScienceUniversity of ConnecticutStorrsConnecticutUSA Advanced Sensor and Energy Research(ASER)Lab Department of Electronic EngineeringKwangwoon UniversitySeoulSouth Korea Department of Textile and Fiber Engineering Indian Institute of TechnologyNew DelhiIndia Department of Textile Engineering Chemistry and ScienceNorth Carolina State UniversityRaleighNorth CarolinaUSA Department of Textile Engineering Khulna University of Engineering&TechnologyKhulnaBangladesh Department of Chemical and Biomolecular Engineering University of ConnecticutStorrsConnecticutUSA

Wearable electronics offer incredible benefits in mobile healthcare monitoring,sensing,portable energy harvesting and storage,human-machine interactions,etc.,due to the evolution of rigid electronics structure to flexible and stretchable ***,transition metal carbides and nitrides(MXenes)are highly regarded as a group of thriving two-dimensional nanomaterials and extraordinary building blocks for emerging flexible electronics platforms because of their excellent electrical conductivity,enriched surface functionalities,and large surface *** article reviews the most recent developments in MXene-enabled flexible electronics for wearable *** MXeneenabled electronic devices designed on a nanometric scale are highlighted by drawing attention to widely developed nonstructural attributes,including 3D configured devices,textile and planer substrates,bioinspired structures,and printed ***,the unique progress of these nanodevices is highlighted by representative applications in healthcare,energy,electromagnetic interference(EMI)shielding,and humanoid control of *** emerging prospects of MXene nanomaterials as a key frontier in nextgeneration wearable electronics are envisioned and the design challenges of these electronic systems are also discussed,followed by proposed solutions.

关键词： flexible electronics MXene nanostructures wearable electronics

来源：评论

学校读者我要写书评

暂无评论

Specular inverse Faraday effect in transition metals

引用

Physical Review materials 2023年第12期7卷 125202-125202页

作者： Victor H. Ortiz Shashi B. Mishra Luat Vuong Sinisa Coh Richard B. Wilson Department of Mechanical Engineering and Materials Science and Engineering Program University of California Riverside 92521 CA United States

The inverse Faraday effect is an optomagnetic phenomenon that describes the ability of circularly polarized light to induce magnetism in solids. The capability of light to control magnetic order in solid state materials and devices is of interest for a variety of applications, such as magnetic recording, quantum computation, and spintronic technologies. However, significant gaps in understanding about the effect persist, such as what material properties govern the magnitude of the effect in metals. In this work, we report time-resolved measurements of the specular inverse Faraday effect in nonmagnetic metals, i.e., the magneto-optic Kerr effect induced by circularly polarized light. We measure this specular inverse Faraday effect in Cu, Pd, Pt, W, Ta, and Au at a laser wavelength of 783 nm. For Ta and W, we investigate both α and β phases. We observe that excitation of these metals with circularly polarized light induces significant circular dichroism. This nonlinear magneto-optical response to circularly polarized light is an order of magnitude larger in α-W than other metals, e.g., Pt or Au, and is greater than nearly all other reported values for the inverse Faraday effect in other materials. Our results benchmark the range of the inverse Faraday effect that can be observed in nonmagnetic metals and provide insight into what material properties govern the inverse Faraday effect in metals.

关键词： Light-induced magnetic effects Magneto-optics Ultrafast optics Magneto-optical Kerr effect Sputtering Ultrafast femtosecond pump probe

来源：评论

学校读者我要写书评

暂无评论

Understanding microstructural evolution during three-axial thermo-mechanical processing involving severe plastic deformation of magnesium alloys

引用

materials Technology 2024年第1期39卷

作者： Misra, R.D.K. Chung, Tsai-Fu Lin, Shan-Chiao Department of Metallurgical Materials and Biomedical Engineering University of Texas at El Paso El PasoTX United States Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu Taiwan

Magnesium-rare earth alloy was selected as a model alloy system to explore and fundamentally understand the evolution of microstructure during three-axial thermo-mechanical processing involving severe plastic deformation. The microstructural evolution was studied via electron backscatter diffraction technique in a scanning electron microscope. Dynamic recrystallization mechanism during severe plastic deformation led to significant grain refinement of the alloy to ultrafine/fine-grained structure with random orientation of grains. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

关键词： Magnesium alloys

来源：评论

学校读者我要写书评

暂无评论

Deep learning model for pleural effusion detection via active learning and pseudo-labeling: a multisite study

引用

BMC Medical Imaging 2024年第1期24卷 92页

作者： Chang, Joseph Lin, Bo-Ru Wang, Ti-Hao Chen, Chung-Ming Department of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University No. 1 Sec. 1 Jen-Ai Road Taipei 100 Taipei 100 Taiwan EverFortune.AI Co. Ltd Taichung Taiwan The Data Science Degree Program College of Electrical Engineering and Computer Science National Taiwan University and Academia Sinica Taipei Taiwan Department of Radiation Oncology China Medical University Hospital Taichung Taiwan Department of Medicine China Medical University Taichung Taiwan

Background: The study aimed to develop and validate a deep learning-based Computer Aided Triage (CADt) algorithm for detecting pleural effusion in chest radiographs using an active learning (AL) framework. This is aimed at addressing the critical need for a clinical grade algorithm that can timely diagnose pleural effusion, which affects approximately 1.5 million people annually in the United States. Methods: In this multisite study, 10,599 chest radiographs from 2006 to 2018 were retrospectively collected from an institution in Taiwan to train the deep learning algorithm. The AL framework utilized significantly reduced the need for expert annotations. For external validation, the algorithm was tested on a multisite dataset of 600 chest radiographs from 22 clinical sites in the United States and Taiwan, which were annotated by three U.S. board-certified radiologists. Results: The CADt algorithm demonstrated high effectiveness in identifying pleural effusion, achieving a sensitivity of 0.95 (95% CI: [0.92, 0.97]) and a specificity of 0.97 (95% CI: [0.95, 0.99]). The area under the receiver operating characteristic curve (AUC) was 0.97 (95% DeLong’s CI: [0.95, 0.99]). Subgroup analyses showed that the algorithm maintained robust performance across various demographics and clinical settings. Conclusion: This study presents a novel approach in developing clinical grade CADt solutions for the diagnosis of pleural effusion. The AL-based CADt algorithm not only achieved high accuracy in detecting pleural effusion but also significantly reduced the workload required for clinical experts in annotating medical data. This method enhances the feasibility of employing advanced technological solutions for prompt and accurate diagnosis in medical settings. © The Author(s) 2024.

关键词： Active learning Chest radiographs Deep learning Pleural effusion X-rays

来源：评论

学校读者我要写书评

暂无评论

Development of clam shell derived hydroxyapatite reinforced epoxy based biomedical implant

引用

Discover Chemistry 2025年第1期2卷 1-23页

作者： Oladele, Isiaka Oluwole Falana, Samuel Olumide Akpan, Vincent Andrew Adenle, Sumayyah Adejumoke Onuh, Linus Nnabuike Department of Metallurgical and Materials Engineering Federal University of Technology Akure Nigeria Centre for Nanomechanics and Tribocorrosion School of Metallurgy Chemical and Mining Engineering University of Johannesburg Johannesburg South Africa Department of Materials Science and Engineering Iowa State University Ames USA Department of Biomedical Technology The Federal University of Technology Akure Nigeria Faculty of Materials and Chemical Engineering University of Miskolc Miskolc Hungary

This study explores the impact of using hydroxyapatite (HAp) reinforcements obtained from clam shells on the mechanical and wear properties of epoxy-based composites. The main objective is to evaluate the suitability and effectiveness of these bio-composites for biomedical applications based on their properties. We collected waste from clam shells and processed it to obtain hydroxyapatite particles with a size of 45 μm. The hydroxyapatite-based epoxy composites were then created using the open mould stir-cast method, which involves mixing hydroxyapatite with epoxy resin and hardener before pouring the mixture into molds for curing. We conducted Scanning Electron Microscope (SEM) and X-ray Diffraction (XRD) analyses on the hydroxyapatite particles obtained from clam shells and thoroughly assessed the mechanical and wear properties of the resulting composites. Furthermore, we examined SEM images of the fracture surfaces. The results revealed significant improvements achieved by incorporating hydroxyapatite derived from clam shells into the epoxy resin in the composites. We consistently achieved optimal values for various properties with a reinforcement content of 12–15 wt.%. At this weight fraction, the maximum flexural strength ranged from 41.40 to 61.31 MPa, hardness from 52.6 to 60.9 HRA, impact resistance from 14.37 to 15.91 J, and wear index from 0.04 to 0.08. These findings highlight the potential of these composites for applications in biomedical implants, prosthetics, and structural components in load-bearing environments.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Injectable Platelet-Rich Fibrin in Contact with Bone Substitutes, Porous Zirconia, or Laser-Textured Implant Surfaces: A Detailed Morphological Analysis

引用

biomedical materials and Devices 2024年第1期2卷 415-426页

作者： Oliveira, Miguel Noronha Varela, Hugo Almeida Nascimento, Rubens M. Sahoo, Narayan Carvalho, Oscar Henriques, Bruno Souza, Júlio C. M. Ceramic and Composite Materials Research Group (CERMAT) Department of Mechanical Engineering (EMC) Federal University of Santa Catarina (UFSC) Post-graduate Program in Materials Science and Engineering Federal University of Rio Grande Norte (UFRN) Center for MicroElectroMechanical Systems (CMEMS-UMINHO) Universidade do Minho LABBELS - Associate Laboratory University of Minho University Institute of Health Sciences (IUCS) CESPU

The aim of the present study was to perform a detailed morphological analysis of an injectable platelet rich fibrin after combination with two different particulate hydroxyapatite-based granules, a porous zirconia block, and laser-textured zirconia or titanium surfaces. Blood samples were harvested from three participants to prepare the flowable injectable PRF in contact or not with particulate hydroxyapatite (Hap), bone mineral granules (DBBM), porous zirconia blocks, laser-textured titanium or zirconia surfaces. Optical and scanning electron microscopy (SEM) were used to evaluate the fibrin network density, fibrin fibers’ diameter, blood cells, and the interaction of PRF with the biomaterials. Histomorphometry of the flowable PRF was also performed using the hematoxylin–eosin staining protocol. Specimens were independently evaluated by two blinded and well-trained researchers in histomorphometry and microscopy. Particulate Hap and DBBM shown different morphological aspects by SEM analyses since DBBM revealed macro- and micro-scale pores while Hap revealed a dense structure. Hydroxyapatite and DBBM granules were entirely embedded by the fibrin-network in the presence of leukocytes and blood platelets. The zirconia porous structured was filled with PRF and its components. Also, the laser-structured zirconia or implant surfaces were entirely coated with the PRF fibrin network embedding leukocytes and blood platelets. Laser-textured titanium surfaces revealed macro- and micro-scale irregularities that increase the surface area and retention of the injectable PRF. Histomorphometric analyses revealed complementary details on the distribution of lymphocytes, red blood cells, and fibrin associated with platelet aggregation. The flowing and viscosity of an injectable platelet rich fibrin provided an agglomeration of synthetic or xenogeneic particulate bone substitutes and the coating of porous zirconia and textured implant surfaces as inspected by scanning electron microsc

关键词： Bone healing Bone substitutes Histology Morphology Platelet-rich fibrin

来源：评论

学校读者我要写书评

暂无评论

DVasMesh: Deep Structured Mesh Reconstruction from Vascular Images for Dynamics Modeling of Vessels 6th

DVasMesh: Deep Structured Mesh Reconstruction from Vascular...

引用

6th International Workshop on Graphs in biomedical Image Analysis, GRAIL 2024

作者： Jia, Dengqiang Yang, Xinnian Xiong, Xiaosong Huang, Shijie Hou, Feiyu Qin, Li Sun, Kaicong Chan, Kannie Wai Yan Shen, Dinggang Hong Kong Centre for Cerebro-Cardiovascular Health Engineering China School of Data Science City University of Hong Kong China School of Biomedical Engineering and State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech University Shanghai201210 China School of Mechanical and Automotive Engineering Shanghai University of Engineering Science Shanghai201620 China JinFeng Laboratory Chongqing401329 China Department of Biomedical Engineering City University of Hong Kong China Shanghai United Imaging Intelligence Co. Ltd. Shanghai200230 China Shanghai Clinical Research and Trial Center Shanghai201210 China

ISBN: (纸本)9783031832420

Vessel dynamics simulation is vital in studying the relationship between geometry and vascular disease progression. Reliable dynamics simulation relies on high-quality vascular meshes. Most of the existing mesh generation methods highly depend on manual annotation, which is time-consuming and laborious, usually facing challenges such as branch merging and vessel disconnection. This will hinder vessel dynamics simulation, especially for the population study. To address this issue, we propose a deep learning-based method, dubbed as DVasMesh to directly generate structured hexahedral vascular meshes from vascular images. Our contributions are threefold. First, we propose to formally formulate each vertex of the vascular graph by a four-element vector, including coordinates of the centerline point and the radius. Second, a vectorized graph template is employed to guide DVasMesh to estimate the vascular graph. Specifically, we introduce a sampling operator, which samples the extracted features of the vascular image (by a segmentation network) according to the vertices in the template graph. Third, we employ a graph convolution network (GCN) and take the sampled features as nodes to estimate the deformation between vertices of the template graph and target graph, and the deformed graph template is used to build the mesh. Taking advantage of end-to-end learning and discarding direct dependency on annotated labels, our DVasMesh demonstrates outstanding performance in generating structured vascular meshes on cardiac and cerebral vascular images. It shows great potential for clinical applications by reducing mesh generation time from 2 h (manual) to 30 s (automatic). © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.

关键词： Mesh generation

来源：评论

学校读者我要写书评

暂无评论

NIR-Ⅱ-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition

引用

Acta Pharmaceutica Sinica B 2025年第2期15卷 1159-1170页

作者： Yijian Gao Yachao Zhang Yujie Ma Xiliang Li Yu Wang Huan Chen Yingpeng Wan Zhongming Huang Weimin Liu Pengfei Wang Lidai Wang Chun-Sing Lee Shengliang Li College of Pharmaceutical Sciences the Fourth Affiliated Hospital of Soochow UniversitySuzhou Medical CollegeSoochow UniversitySuzhou 215123China Key Laboratory of Biomedical Imaging Science and System Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China Center of Super-Diamond and Advanced Films(COSDAF) Department of ChemistryCity University of Hong KongHong Kong SAR 999077China Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China Joint Laboratory of Nano-organic Functional Materials and Devices(TIPC and CityU) City University of Hong KongHong Kong SAR 999077China

High-performance phototheranostics with combined photothermal therapy and photoacoustic imaging have been considered promising approaches for efficient cancer diagnosis and ***,developing phototheranostic materials with efficient photothermal conversion efficiency(PCE),especially over the second near-infrared window(NIR-Ⅱ,1000-1700 nm),remains ***,we report an ultraefficient NIR-Ⅱ-activated nanomedicine with phototheranostic and vaccination capability for highly efficient in vivo tumor elimination and metastasis *** NIR-Ⅱnanomedicine of a semiconducting biradical oligomer with a motor-flexible design was demonstrated with a record-breaking PCE of 87%upon NIR-Ⅱ*** nanomedicine inherently features extraordinary photothermal stability,good biocompatibility,and excellent photoacoustic performance,contributing to high-contrast photoacoustic imaging in living mice and high-performance photothermal elimination of ***,a whole-cell vaccine based on a NIR-Ⅱnanomedicine with NIR-Ⅱ-activated performance was further designed to remotely activate the antitumor immunologic memory and effectively inhibit tumor occurrence and metastasis in vivo,with good ***,this work paves a new avenue for designing NIR-Ⅱactive semiconducting biradical materials as a promising theranostics platform and further promotes the development of NIR-Ⅱnanomedicine for personalized cancer treatment.

关键词： NIR-Ⅱ Semiconducting oligomer Photothermal therapy Vaccine Nanoparticles Theranostics Breast carcinoma Immunotherapy

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：