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Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2298-2316页

作者： Jie Shan Xu Jin Cong Zhang Muchen Huang Jianghao Xing Qingrong Li Yuyu Cui Qiang Niu Xu Lin Chen Xianwen Wang Department of Burns the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Provincial Institute of Translational MedicineAnhui Medical UniversityHefei 230032China Division of Gastroenterology the First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China The Second Clinical Medical College Anhui Medical UniversityHefei 230022China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China College and Hospital of Stomatology Anhui Medical UniversityKey Lab.of Oral Diseases Research of Anhui ProvinceHefei 230032China

Bacterial infection hampers wound repair by impeding the healing ***,inflammation at the wound site triggers the production of reactive oxygen species(ROS),causing oxidative stress and damage to proteins and *** can lead to chronic wounds,posing severe ***,eliminating bacterial infection and reducing ROS levels are crucial for effective wound ***,possessing enzyme-like catalytic activity,can convert endogenous substances into highly toxic substances,such as ROS,to combat bacteria and biofilms without inducing drug ***,the current nanozyme model with single enzyme activity falls short of meeting the complex requirements of antimicrobial ***,developing nanozymes with multiple enzymatic activities is ***,we engineered a novel metalloenzyme called Ru-procyanidin nanoparticles(Ru-PC NPs)with diverse enzymatic activities to aid wound healing and combat bacterial *** acidic conditions,due to their glutathione(GSH)depletion and peroxidase(POD)-like activity,Ru-PC NPs combined with H2O2 exhibit excellent antibacterial ***,in a neutral environment,the Ru-PC NPs,with catalase(CAT)activity,decompose H2O2 to O2,alleviating hypoxia and ensuring a sufficient oxygen ***,Ru-PC NPs possess exceptional antioxidant capacity through their superior superoxide dismutase(SOD)enzyme activity,effectively scavenging excess ROS and reactive nitrogen species(RNS)in a neutral *** maintains the balance of the antioxidant system and prevents ***-PC NPs also promote the polarization of macrophages from M1 to M2,facilitating wound *** importantly,Ru-PC NPs show good biosafety with negligible *** vivo wound infection models have confirmed the efficacy of Ru-PC NPs in inhibiting bacterial infection and promoting wound *** focus of this work highlights the quadruple enzymatic activity of Ru-PC NPs and its potential to reduce inf

关键词： Nanozymes Quadruple enzymatic activity Antibacterial therapy Wound therapy RNA-seqAnti-inflammatory Reactive oxygen species Reactive nitrogen species

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Multidisciplinary Control Co-Design Optimization of Anguilliform-Swimming Soft Fluidic Robots

Multidisciplinary Control Co-Design Optimization of Anguilli...

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IEEE International Conference on Soft Robotics (RoboSoft)

作者： Andrew Fletcher Ru Xiang Luca Scotzniovsky Jacobo Cervera-Torralba Michael T. Tolley John T. Hwang Department of Mechanical and Aerospace Engineering Materials Science and Engineering Program University of California San Diego (UCSD) La Jolla CA USA

ISBN: (数字)9798331520205

ISBN: (纸本)9798331520212

Anguilliform-swimming soft fluidic robots hold great promise for a range of underwater applications. However, because they leverage the complex dynamics of soft bodies interacting with fluids, it is challenging to use intuition to determine design parameters. Multidisciplinary design optimization offers a promising solution to this challenge by providing an automated and systematic method for leveraging computational models to find optimal design parameters. This study investigates a method for multidisciplinary control co-design optimization of anguilliform-swimming soft robots, using physics-based models to optimize shape and control parameters. The modeling framework includes a geometry-centric approach for geometry modeling and parameterization, a three-dimensional finite element model for structural mechanics, and an unsteady panel method for fluid dynamics. The approach is tested by applying it to the optimization of a pre-existing eel-inspired soft robot. Model parameters are estimated from existing experimental data, and two control co-design optimizations, with high-level and multilevel shape parameterizations, are performed to minimize energy cost. The optimized actuator module is manufactured, and used to collect additional data for re-estimating the structural model parameters. The optimization is performed again with the updated model parameters, showing a simulated energy cost reduction of 45% and the prescribed 128% speed increase compared to the baseline design with optimized control and updated model parameters. These results demonstrate the potential of the proposed optimization approach to advance the performance of anguilliform-swimming soft fluidic robots.

关键词： Geometry Solid modeling Costs Shape Computational modeling Fluid dynamics Soft robotics Data models Manufacturing Optimization

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Conductive Mof Coating for Suppressing the Mn Dissolution in Limn2o4 Toward Long-Life Lithium-Ion Batteries

SSRN

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SSRN 2024年

作者： Kim, Eunji Lee, Jeongmin Park, Junghyun Nam, Kwan Woo Department of Chemical Engineering and Materials Science Graduate Program in System Health Science and Engineering Ewha Womans University Seoul03760 Korea Republic of

Spinel lithium manganese oxide (LiMn2O4, denoted LMO) is one of the promising cathode materials with non-toxicity, high operating voltage, and low cost. However, structural collapse during battery cycling — caused by Mn dissolution and the Jahn-Teller effect — is a critical disadvantage, reducing cycle retention, particularly at high temperatures. In this investigation, to solve these critical issues of LMO cathode, we introduce Cu3(HITP)2, a conductive two-dimensional (2D) MOF as a surface coating material through a simple process. Coating the conductive 2D Cu3(HITP)2 MOF increases the electrical conductivity and shows the effect of suppressing the dissolution of Mn by enriching the surface of LMO with Mn4+. By suppressing Mn dissolution, structural stability also improves, resulting in offsetting all the inherent problems of LMO. As a result, at 50 °C, CuHITP–LMO exhibits an initial capacity of 98.7 mAh g–1 at 100 mA g–1 and achieved a capacity of 74.5 mAh g–1 after 100 cycles, indicating outstanding cyclability. This research highlights the potential of conductive 2D MOF to improve the electrochemical performances of battery cathode. © 2024, The Authors. All rights reserved.

关键词： Cathodes

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Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection

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Research 2022年第3期2022卷 91-104页

作者： Xiaohui Mou Hongbo Zhang Hua Qiu Wentai Zhang Ying Wang Kaiqin Xiong Nan Huang Hélder A.Santos Zhilu Yang Affiliated Dongguan Hospital Southern Medical UniversityDongguanGuangdong 523059China Guangdong Provincial Key Laboratory of Shock and Microcirculation GuangzhouGuangdong 510080China Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Pharmaceutical Sciences Laboratory Åbo Akademi UniversityTurku Biosciences CenterUniversity of Turku andÅbo Akademi University20520 TurkuFinland State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200438China Department of Biomedical Engineering and W.J.Kolff Institute for Biomedical Engineering and Materials Science University Medical Center Groningen/University of GroningenAnt.Deusinglaan 19713 AV GroningenNetherlands Drug Research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiFI-00014 HelsinkiFinland

Thrombosis and infections are the two major complications associated with extracorporeal circuits and indwelling medical devices,leading to significant mortality in *** address this issue,here,we report a biomimetic surface engineering strategy by the integration of mussel-inspired adhesive peptide,with bio-orthogonal click chemistry,to tailor the surface functionalities of tubing and *** by mussel adhesive foot protein,a bioclickable peptide mimic(DOPA)4-azidebased structure is designed and grafted on an aminated tubing robustly based on catechol-amine ***,the dibenzylcyclooctyne(DBCO)modified nitric oxide generating species of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid(DOTA)chelated copper ions and the DBCO-modified antimicrobial peptide(DBCO-AMP)are clicked onto the grafted surfaces via bio-orthogonal *** combination of the robustly grafted AMP and Cu-DOTA endows the modified tubing with durable antimicrobial properties and ability in long-term catalytically generating NO from endogenous snitrosothiols to resist adhesion/activation of platelets,thus preventing the formation of ***,this biomimetic surface engineering technology provides a promising solution for multicomponent surface functionalization and the surface bioengineering of biomedical devices with enhanced clinical performance.

关键词： DOTA generating Engine

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Temperature-Dependent Hydrogen Modulations of Ultra-Scaled a-IGZO Thin Film Transistor Under Gate Bias Stress

IEEE Open Journal of Nanotechnology

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IEEE Open Journal of Nanotechnology 2024年 5卷 9-16页

作者： Aslam, Muhammad Chang, Shu-Wei Chuang, Min-Hui Chen, Yi-Ho Lee, Yao-Jen Li, Yiming Parallel and Scientific Computing Laboratory National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Electrical Engineering and Computer Science International Graduate Program National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Electrical Engineering National Cheng Kung University Tainan701401 Taiwan Institute of Communications Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Graduate Degree Program of College of Electrical and Computer Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Institute of Pioneer Semiconductor Innovation National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Institute of Biomedical Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan Department of Electronics and Electrical Engineering National Yang Ming Chiao Tung University Hsinchu300093 Taiwan

Recently, a-IGZO has advanced toward the next-generation electronics system because of its compatibility with complementary metal oxide semiconductor (CMOS) and back-end-of-line (BOEL) based systems. A systematic electrical characterization of a-IGZO TFT related to reliability issues, such as positive bias temperature stress (PBTS) and negative bias temperature stress (NBTS), would entitle its integration into novel electronics systems. Unexpectedly, PBTS is characterized by the transition of positive Vth shift to negative Vth shift (ΔVth, the positive shift followed by the stress and temperature activated negative shift). This transition is attributed to charge trapping/trap-site generations and hydrogen migration to the active layer. The ΔVth shift mechanism depends on the temperature and voltage stress. On the other hand, a negative ΔVth shift has been observed during the NBTS operation and could be attributed to the hole trapping at the interface of GI/IGZO. An effective suppression of the gate leakage current has also been observed during reliability tests. Simulation results reveal a pronounced potential at the edges of source and drain regions, and considered the origin of hydrogen migration into the IGZO layer. Thermal image results also reveal the strong temperature/potential distribution at the edges of the source/drain regions, indorsing the simulation results. © 2020 IEEE.

关键词： Oxide semiconductors

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How do molecular interactions affect fluorescence behavior of AIEgens in solution and aggregate states?

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science China Chemistry 2022年第1期65卷 135-144页

作者： Ying Yu Hao Xing Zhicong Zhou Junkai Liu Herman H-YSung Ian D.Williams Jonathan E.Halpert Zheng Zhao Ben Zhong Tang Department of Chemistry the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionDepartment of Chemical and Biomedical EngineeringInstitute for Advanced Studyand Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Shenzhen Institute of Molecular Aggregate Science and Engineering School of Science and EngineeringChinese University of Hong KongShenzhenGuangdong518172China Department of chemistry The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina AIE Institute Guangzhou Development DistrictHuangpuGuangzhou 510530China

Molecular interactions are crucial in diverse fields of protein folding,material science,nanotechnology,and life *** mounting experimental research controls luminescent behavior by adjusting molecular interactions in light-emitting materials,it remains elusive to correlate microscopic molecular interactions with macroscopic luminescent behavior ***,we synthesized three red luminogens with subtle structural variation and investigated the influence of molecular interactions on their luminescent behavior in solution and aggregate *** results indicate that strongπ-πand D-A interactions in both dilute solution(between luminogen and solvent molecules)and aggregate(between luminogens)states cause the redshift in emission,while weak interactions(e.g.,Van der Waals,C–H…π,and C–H…F interactions)enhance the quantum *** work provides a thoughtful investigation into the complicated influence of various molecular interactions on luminescent behavior.

关键词： molecular interactions fluorescence behaviors AIEgens aggregates

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Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

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Bioactive materials 2022年第11期7卷 289-299页

作者： Muxue Wang Xi Zhou Yunhong Li Yuqing Dong Jiashen Meng Shuai Zhang Linbo Xia Zhaozhi He Lei Ren Zhiwei Chen Xingcai Zhang Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen361005People’s Republic of China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen361005People’s Republic of China John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA

The abuse of antibiotics makes bacterial infection an increasingly serious global health threat. Reactive oxygen species (ROS) are the ideal alternative antibacterial approach for quick and effective sterilization. Although various antibacterial strategies based on ROS have been developed, many of them are still limited by insufficient antibacterial efficiency. Here, we have developed an acid-enhanced dual-modal antibacterial strategy based on zeolitic imidazolate frameworks-8 (ZIF8) -derived nanozyme. ZIF8, which can release Zn2+, is chosen as the carrier to integrate glucose oxidase (GOx) and gold nanoparticles (Au NPs) which can produce ROS via a cascade catalytic reaction. Thus, the bactericidal capability of ROS and Zn2+ have been integrated. More importantly, gluconic acid, a “by-product” of the catalytic reaction, can generate an acidic environment to promote both the ROS-producing and Zn2+-releasing, enhancing the overall antibacterial performance further. This triple-synergistic strategy exhibits extraordinary bactericidal ability at a low dosage of 4 μg/mL (for S. aureus) and 8 μg/mL (for E. coli), which shows a great potential of MOF-derived nanozyme for efficient bacterial eradication and diverse biomedical applications.

关键词： Metal-organic frameworks Nanozyme Reactive oxygen species Antibacterial Zinc ion

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Universal hydrogel adhesives with robust chain entanglement for bridging soft electronic materials

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npj Flexible Electronics 2024年第1期8卷 509-522页

作者： Yejin Jo Yurim Lee Jeong Hyun Heo Yeonzu Son Tae Young Kim Kijun Park Soye Kim Seo Jung Kim Yoonhee Jin Seongjun Park Jungmok Seo School of Electrical and Electronic Engineering Yonsei UniversitySeoul03722Republic of Korea Department of Physiology Yonsei University College of MedicineSeoul03722Republic of Korea Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon34141Republic of Korea Department of Pediatrics Severance Children’s HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon34141Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon34141Republic of Korea KAIST Institute for Nano Century(KINC) 291 Daehak-roYuseong-guDaejeon34141Republic of Korea

Ensuring stable integration of diverse soft electronic components for reliable operation under dynamic conditions is ***,integrating soft electronics,comprising various materials like polymers,metals,and hydrogels,poses challenges due to their different mechanical and chemical *** study introduces a dried-hydrogel adhesive made of poly(vinyl alcohol)and tannic acid multilayers(d-HAPT),which integrates soft electronic materials through moisture-derived chain entanglement.d-HAPT is a thin(~1μm)and highly transparent(over 85%transmittance in the visible light region)adhesive,showing robust bonding(up to 3.6 MPa)within a short time(<1 min).d-HAPT demonstrates practical application in wearable devices,including a hydrogel touch panel and strain ***,the potential of d-HAPT for use in implantable electronics is demonstrated through in vivo neuromodulation and electrocardiographic recording experiments while confirming its biocompatibility both in vitro and in *** is expected that d-HAPT will provide a reliable platform for integrating soft electronic applications.

关键词： properties hydrogel electronic

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An enzyme-free interdigitated electrode for ketamine detection

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Journal of the Chinese Institute of Engineers, Transactions of the Chinese Institute of Engineers,Series A 2023年第5期46卷 441-452页

作者： Phan, Thien Luan Van Hieu, Nguyen Lin, Jing-Jenn Wu, Hsing-Ju Chu, Pei-Yi Hsiao, Chin-Sung Yao, Fiona Yan-Dong Lin, Yung-Kai Ching, Congo Tak Shing Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung Taiwan Viet Nam Department of Applied Materials and Optoelectronic Engineering National Chi Nan University Taiwan Research Assistant Center Show Chwan Memorial Hospital Taiwan Department of Medical Research Chang Bing Show Chwan Memorial Hospital Taiwan Department of Pathology Show Chwan Memorial Hospital Taiwan School of Medicine College of Medicine Fu Jen Catholic University Taiwan Computer Science and Information Engineering Asia University Taiwan Division of Science Engineering and Health Studies College of Professional and Continuing Education The Hong Kong Polytechnic University Hong Kong Department of Food Science National Taiwan Ocean University Taiwan Department of Electrical Engineering National Chi Nan University Nantou County Taiwan

Ketamine is an anesthetic, which when used wrongly would affect judgment and behavior, increasing risks to individual such as unwanted or risky sexual behavior. This study reports the development of an admittance- and capacitance-spectroscopy-based sensor to detect ketamine in solution, such as whiskey, a popular alcoholic drink. The result confirms the proposed method is capable of detecting the presence of ketamine in whiskey, in concentration as low as 6.25 ng/μL, by using admittance and capacitance measured at 6.75 MHz, as well as quantifying the measured admittance (sensitivity: 300 μΩ−1/Log (ng/μL);limit of detection (LOD): 0.16 ng/μL) or capacitance data (sensitivity: 2 nF/Log (ng/μL);LOD: 0.73 ng/μL) at 18 kHz and 7.69 MHz, respectively. © 2023 The Chinese Institute of Engineers.

关键词： Capacitance

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Editorial

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European Physical Journal E 2024年第6期47卷 1-4页

作者： Andelman, David Di Meglio, Jean-Marc Safinya, Cyrus R. Tel Aviv University School of Physics and Astronomy Ramat Aviv Tel Aviv69978 Israel MSCmed Lab Université Paris Cité Paris75006 France Materials Department Molecular Cellular and Developmental Biology Department Department of Physics and Biomolecular Science & ampEngineering Program University of California Santa Barbara Santa BarbaraCA93106 United States

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