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New block copolymers to form nanofibers with superior mechanical properties and to conjugate signaling molecules directing tissue regeneration

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materials Today 2025年 86卷 210-227页

作者： Zhou, Tongqing Cavalcante, Rafael C. Ma, Peter X. Macromolecular Science and Engineering Center University of Michigan Ann ArborMI48109 United States Department of Biologic and Materials Sciences University of Michigan Ann ArborMI48109 United States Department of Biomedical Engineering University of Michigan Ann ArborMI48109 United States Department of Materials Science and Engineering University of Michigan Ann ArborMI48109 United States

Tissue engineering is a multidisciplinary field grown rapidly over the past few decades, whose success most often requires bioactive scaffolds to structurally support and biologically direct cell fate and tissue regeneration. Poly(L-lactic acid) (PLLA) is a widely used tissue engineering material with high strength, biocompatibility, biodegradability, and the capability of nanofiber formation through thermally induced phase separation (TIPS). To enable biomolecule conjugation, a new PLLA-based block copolymer, poly(spiro-lactic-co-lactic acid)-block-poly(L-lactic acid) or PSLA-b-PLLA, was developed in this study. The new polymer PSLA-b-PLLA could also form nanofibers through TIPS, and excitingly greatly improved the mechanical properties over PLLA nanofibers, with up to 1.2 times tensile modulus, 12.1 times strain at break, 2.1 times ultimate strength and 35.1 times toughness of PLLA, while being able to conjugate bioactive molecules covalently using click reactions. Its degradation rate was also accelerated to facilitate tissue regeneration. The tissue engineering potential of the new polymer scaffold was evaluated using a mouse critical-sized bone regeneration model, showing 3.6 times more vascularized bone volume regeneration when covalently conjugated with a bone-morphogenetic-protein-2-derived peptide. The block copolymer satisfies multiple criteria for tissue engineering with tunable mechanical properties, degradation rate, and conjugation densities. It can be utilized to impart specific biomolecular signals and mechanical properties potentially for various other tissue engineering applications. © 2025

关键词： Bone

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Fabrication of LCE Microactuator Arrays Through Soft Lithography With Surface Alignment

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Journal of Microelectromechanical Systems 2025年第3期34卷 241-243页

作者： Li, Ke Kim, Jae-Jun Fernandes, Jayer Jiang, Hongrui University of Wisconsin–Madison Department of Electrical and Computer Engineering MadisonWI53705 United States University of Wisconsin–Madison Department of Electrical and Computer Engineering Department of Biomedical Engineering Department of Materials Science and Engineering Department of Ophthalmology and Visual Sciences McPherson Eye Research Institute MadisonWI53706 United States

Liquid crystal elastomers (LCEs) offer potentially programmable actuation through precise molecular alignment, making them ideal for microactuators in soft robotics and optical systems. However, achieving precise microscale alignment for LCE actuator arrays through scalable microfabrication approaches has been challenging. This letter introduces a low-cost surface alignment method to fabricate LCE microactuator arrays, reducing the dependency on expensive equipment, improving accessibility and manufactuarability compared to existing studies using field-assisted alignment methods. Thermal actuation tests demonstrated strong thermal responsiveness and stability. Our method offers a superior approach to integrating LCE microactuator arrays with modern microfabrication processes, promising multitudinous applications in MEMS and beyond. © 2025 IEEE. All rights reserved,.

关键词： Microfabrication

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Constructing a highly efficient multifunctional carbon quantum dot platform for the treatment of infectious wounds

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Regenerative Biomaterials 2024年第6期3卷 137-148页

作者： Hangzhen Zhang Jiafan Bai Xiangli Chen Linyu Wang Wenzhen Peng Yuancong Zhao Jie Weng Wei Zhi Jianxin Wang Kai Zhang Xingdong Zhang Key Laboratory of Advance Technologies of Materials Ministry of EducationCollege of Medicine and School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Department of Biochemistry and Molecular Biology College of Basic and Forensic MedicineSichuan UniversityChengdu 610041China National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China

Antibiotic resistance poses a huge threat to public health,which has increased the difficulty and transmission of disease treatment,as well as the burden and cost of medical *** response to the current problems and challenges in inflammation control and treatment of bacterial infected wounds,inspired by antibacterial mechanisms based on active elements such as N,S,Cu and tannic acid(TA),a highly efficient multifunctional carbon quantum dot platform was proposed in this study and constructed through their special assembly in a solvothermal reaction system for the treatment of infected *** introducing active elements such as N,S and Cu,this carbon quantum dot platform is endowed with antibacterial properties,while also achieving good angiogenesis promoting performance through the use of ion ***,the good antioxidant activity of TA(one of the precursors used)enables this platform to have better immunomodulatory performance in *** research results on the treatment of bacterial infection models indicate that the multifunctional carbon quantum dots obtained can accelerate the healing of infected wounds by inhibiting bacterial infection,regulating immunoreaction,accelerating collagen deposition and promoting *** multifunctional carbon quantum dot platform shows good clinical application prospects in treating bacterial infected ***,the fluorescence characteristics of such carbon dots can be expected to realize visual therapy in the future.

关键词： multifunctional fluorescent carbon dots antibacterial immunomodulation bacterial labeling promoting angiogenesis

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Computing grain boundary“phase”diagrams

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Interdisciplinary materials 2023年第1期2卷 137-160页

作者： Jian Luo Department of Nanoengineering Program of Materials Science and EngineeringUniversity of California San DiegoLa JollaCaliforniaUSA

Grain boundaries(GBs)can be treated as two-dimensional(2-D)interfacial phases(also called“complexions”)that can undergo interfacial phase-like *** bulk phase diagrams and calculation of phase diagram(CALPHAD)methods serve as a foundation for modern materials science,we propose to extend them to GBs to have equally significant *** perspective article reviews a series of studies to compute the GB counterparts to bulk phase ***,a phenomenological interfacial thermodynamic model was developed to construct GB lambda diagrams to forecast high-temperature GB disordering and related trends in sintering and other properties for both metallic and ceramic *** parallel,an Ising-type lattice statistical thermodynamic model was utilized to construct GB adsorption(segregation)diagrams,which predicted first-order GB adsorption transitions and critical *** two simplified thermodynamic models emphasize the GB structural(disordering)and chemical(adsorption)aspects,***,hybrid Monte Carlo and molecular dynamics atomistic simulations were used to compute more rigorous and accurate GB“phase”*** GB diagrams of thermodynamic and structural properties were further extended to include mechanical ***,machine learning algorithms were combined with atomistic simulations to predict GB properties as functions of four independent compositional variables and temperature in a 5-D space for a given GB in high-entropy alloys or as functions of five GB macroscopic(crystallographic)degrees of freedom plus temperature and composition for a binary alloy in a 7-D *** relevant studies are also *** perspective and outlook,including two emerging fields of high-entropy grain boundaries(HEGBs)and electrically(or electrochemically)induced GB transitions,are discussed.

关键词： CALPHAD grain boundary interfacial transition phase diagram

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Killing two birds with one stone:Enhancing the photoelectrochemical water splitting activity and stability of BiVO_(4)by Fe ions association

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Chinese Chemical Letters 2024年第12期35卷 154-159页

作者： Hailang Deng Abebe Reda Woldu Abdul Qayum Zanling Huang Weiwei Zhu Xiang Peng Paul K.Chu Liangsheng Hu Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou515063China Department of Mechanical Engineering Shantou UniversityGuangdong 515063China Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515063China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong KongChina Shantou Huaxing Metallurgical Equipment Co. Ltd.Shantou 515063China

Bi VO_(4)is a promising semiconducting photoanode for photoelectrochemical(PEC)water splitting due to its suitable ***,the dissolution of V^(5+)and sluggish reaction kinetics at the surface in the oxygen evolution reaction(OER)limit its ***,we report a convenient strategy to change the microenvironment by adding Fe(Ⅲ)into the *** the PEC process,Fe(Ⅲ)ions not only improve the current density,but also show excellent stability toward Bi VO_(4).Consequently,the current increases by more than 1.7 times compared to that without Fe(Ⅲ).Photoelectrochemical,morphological,and structural characterizations reveal that the FeOOH co-catalyst produced in situ on the Bi VO_(4)photoanode by cyclical formation of the intermediates at the electrode/electrolyte interface during OER accelerates the OER kinetics and prevents photo-corrosion by suppressing the dissolution of V^(5+).The results reveal a new strategy for the multifunctional modification of photoanodes for efficient solar conversion.

关键词： Photoelectrochemical water splitting Bi VO_(4)photoanodes Fe(Ⅲ)ions Oxygen evolution reaction Dynamic changes

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Sound innovations for biofabrication and tissue engineering

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Microsystems & Nanoengineering 2024年第6期10卷 1-19页

作者： Mengxi Wu Zhiteng Ma Zhenhua Tian Joseph T.Rich Xin He Jianping Xia Ye He Kaichun Yang Shujie Yang Kam W.Leong Luke P.Lee Tony Jun Huang School of Mechanical Engineering Dalian University of TechnologyDalian 116086 LiaoningChina Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24060USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA

Advanced biofabrication techniques can create tissue-like constructs that can be applied for reconstructive surgery or as in vitro three-dimensional(3D)models for disease modeling and drug *** various biofabrication techniques have recently been widely reviewed in the literature,acoustics-based technologies still need to be *** rapidly increasing number of publications in the past two decades exploring the application of acoustic technologies highlights the tremendous potential of these *** this review,we contend that acoustics-based methods can address many limitations inherent in other biofabrication techniques due to their unique advantages:noncontact manipulation,biocompatibility,deep tissue penetrability,versatility,precision in-scaffold control,high-throughput capabilities,and the ability to assemble multilayered *** discuss the mechanisms by which acoustics directly dictate cell assembly across various biostructures and examine how the advent of novel acoustic technologies,along with their integration with traditional methods,offers innovative solutions for enhancing the functionality of *** technologies are poised to address fundamental challenges in biofabrication and tissue engineering and show promise for advancing the field in the coming years.

关键词： acoustics limitations innovative

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Polydopamine nanoparticle-mediated mild photothermal therapy for inhibiting atherosclerotic plaque progression by regulating lipid metabolism of foam cells

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Regenerative Biomaterials 2023年第1期10卷 830-838页

作者： Shuangshuang Tu Wenzhi Ren Jinru Han Haijing Cui Ting Dai Haoxuan Lu Yanqing Xie Wenming He Aiguo Wu Department of Cardiology The First Affiliated Hospital of Ningbo UniversityNingboZhejiang Province 315020China Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices&Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and Engineering CASNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 101408China

Since apoptosis of foam,cells can induce plaque instability,reducing intracellular lipid content while protecting foam cells from apoptosis is beneficial for the safe and efficient therapy of *** this study,osteopontin-coupled polydopamine(PDA-OPN)nanoparticles were synthesized and applied to target mild photothermal therapy(PTT)of *** results from laser confocal microscopy indicate that PDA-OPN nanoparticles can be specially recognized and absorbed by foam *** near-infrared laser irradiation,the mild photothermal generated by PDA-OPN decreases intracellular lipid accumulation but does not induce cell *** vivo treatments demonstrate that mild PTT can substantially reduce plaque area and improve plaque stability by upregulating the expression of plaque fibrosis in ApoE^(−/−)*** findings reinforce that the PDA-OPN nanoparticle-mediated mild PTT can inhibit atherosclerotic progression,which provides new insights for developing safe and effective treatment methods for atherosclerosis.

关键词： polydopamine nanoparticles photothermal therapy atherosclerosis lipid metabolism

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An acoustofluidic device for the automated separation of platelet-reduced plasma from whole blood

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Microsystems & Nanoengineering 2024年第3期10卷 293-303页

作者： Zhehan Ma Jianping Xia Neil Upreti Emeraghi David Joseph Rufo Yuyang Gu Kaichun Yang Shujie Yang Xiangchen Xu Jean Kwun Eileen Chambers Tony Jun Huang Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Pediatrics Duke UniversityDurhamNCUSA Duke Transplant Center Department of SurgeryDuke University School of MedicineDurhamNCUSA

Separating plasma from whole blood is an important sample processing technique required for fundamental biomedical research,medical diagnostics,and therapeutic *** protocols for plasma isolation require multiple centrifugation steps or multiunit microfluidic processing to sequentially remove large red blood cells(RBCs)and white blood cells(WBCs),followed by the removal of small ***,we present an acoustofluidic platform capable of efficiently removing RBCs,WBCs,and platelets from whole blood in a single *** leveraging differences in the acoustic impedances of fluids,our device generates significantly greater forces on suspended particles than conventional microfluidic approaches,enabling the removal of both large blood cells and smaller platelets in a single *** a result,undiluted human whole blood can be processed by our device to remove both blood cells and platelets(>90%)at low voltages(25 Vpp).The ability to successfully remove blood cells and platelets from plasma without altering the properties of the proteins and antibodies present creates numerous potential applications for our platform in biomedical research,as well as plasma-based diagnostics and ***,the microfluidic nature of our device offers advantages such as portability,cost efficiency,and the ability to process small-volume samples.

关键词： remove separation removing

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Acoustofluidics for simultaneous nanopartide-based drug loading and exosome encapsulation

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Microsystems & Nanoengineering 2022年第2期8卷 149-159页

作者： Zeyu Wang Joseph Rich Nanjing Hao Yuyang Gu Chuyi Chen Shujie Yang Peiran Zhang Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA

Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side ***,the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex,time-consuming drug loading ***,we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome *** synergistically leveraging the acoustic radiation force,acoustic microstreaming,and shear stresses in a rotating droplet,the concentration,and fusion of exosomes,drugs,and porous silica nanoparticles is *** final product consists of drug-loaded silica nanocarriers that are encased within an exosomal *** drug loading efficiency is significantly improved,with nearly 30%of the free drug(e.g.,doxorubicin)molecules loaded into the ***,this acoustofluidic drug loading system circumvents the need for complex chemical modification,allowing drug loading and encapsulation to be completed within a matter of *** exosome-encapsulated nanocarriers exhibit excellent efficiency in intracellular transport and are capable of significantly inhibiting tumor cell *** utilizing physical forces to rapidly generate hybrid nanocarriers,this acoustofluidic drug loading platform wields the potential to significantly impact innovation in both drug delivery research and applications.

关键词： exosome loading simultaneous

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Aerosol jet printing of surface acoustic wave microfluidic devices

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Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： Joseph Rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong James L.Doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian Aaron D.Franklin Tony Jun Huang Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA Department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes,including high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and rapid ***,the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based *** simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions,we utilized the additive manufacturing technique of aerosol jet *** successfully fabricated customized SAW microfluidic devices of varying materials,including silver nanowires,graphene,and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol jet printed SAW microfluidic devices with their cleanroom-fabricated counterparts,the wave displacements and resonant frequencies of the different fabricated devices were directly measured through scanning laser Doppler ***,to exhibit the capability of the aerosol jet printed devices for lab-on-a-chip applications,we successfully conducted acoustic streaming and particle concentration ***,we demonstrated a novel solution-based,direct-write,single-step,cleanroom-free additive manufacturing technique to rapidly develop SAW microfluidic devices that shows viability for applications in the fields of biology,chemistry,engineering,and medicine.

关键词： printing wave fluid

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