检索结果-内蒙古大学图书馆

Donor strategy for promoting nonradiative decay to achieve an efficient photothermal therapy for treating cancer

science China Chemistry 2021年第9期64卷 1530-1539页

作者： Fei Ren Zeshun Li Kai Li Xiaoyan Zheng Jianbing Shi Chen Zhang Heng Guo Bin Tong Lei Xi Zhengxu Cai Yuping Dong Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing100081China Shenzhen Key Laboratory of Smart Healthcare Engineering Department of Biomedical EngineeringSouthern University of Science and Technology(SUSTech)Shenzhen518055China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science of Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China

Photothermal therapy(PTT)is emerging as an effective treatment for superficial carcinoma.A key challenge to the effectiveness of PTT is to develop photosensitizers with high photothermal conversion *** to address this challenge,we develop a series of multi-arylpyrrole derivatives with different donors that contain different multi-rotor structures to explore highly efficient PTT *** these multi-arylpyrrole derivatives,MAP4-FE nanoparticles with a small size of their donor groups and better-donating ability exhibit a high photothermal conversion efficiency(up to 72%)when they are encapsulated by an amphiphilic *** a result,the MAP4-FE nanoparticles have shown satisfactory PTTeffects on in vivo tumor eradication under the guidance of photoacoustic *** findings of this study provide significant insights for the development of high-efficiency PTT photosensitizers for cancer treatment by making full use of the nonradiative decay of small size donors as rotors.

关键词： aggregation-induced emission multi-arylpyrroles photothermal therapy photoacoustic imaging

来源：评论

学校读者我要写书评

暂无评论

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

引用

Food science and Human Wellness 2024年第5期13卷 2353-2362页

作者： Ammad Ahmad Farooqi Iqra Mobeen Rukset Attar Khalida I.Noel Baojun Xu William C.Cho Institute of Biomedical and Genetic Engineering(IBGE) Islamabad 44000Pakistan Khursheed Rasheed Hospital Lahore Lahore 53720Pakistan Department of Obstetrics and Gynecology Yeditepe UniversityAtaşehir 34755Turkey Human Anatomy Department College of MedicineAl-Mustansiriyah UniversityBaghdad 10036Iraq Food Science and Technology Program Department of Life SciencesBNU-HKBU United International CollegeZhuhai 519087China Department of Clinical Oncology Queen Elizabeth HospitalHong Kong G514TFChina

High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and ***-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of *** researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).Importantly,garlic and its biologically active chemicals targeted oncogenic signaling *** this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

关键词： Cancer Nutrigenomics Signaling Apoptosis Allium sativum

来源：评论

学校读者我要写书评

暂无评论

Heart Failure: Machine Learning Prediction Within a 5-Year Framework 24

Heart Failure: Machine Learning Prediction Within a 5-Year F...

引用

24th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2024

作者： Tsarapatsani, Konstantina-Helen Tsakanikas, Vasilios D. Sakellarios, Antonis Trampisch, Hans J. Karapintzou, Efterpi Rudolf, Henrik Matsopoulos, George K. Fotiadis, Dimitrios I. Biomedical Research Institute Foundation for Research and Technology-Hellas Ioannina Greece Ruhr University Bochum Department of Medical Informatics Biometry and Epidemiology Bochum Germany University of Ioannina Unit of Medical Technology and Intelligent Information Systems Dept. of Materials Science and Engineering Greece Institute for Biostatistics and Informatics in Medicine and Ageing Research University Medical Center Rostock Germany School of Electrical and Computer Engineering National Technical University of Athens Athens Greece University of Ioannina and Biomedical Research Institute-FORTH Unit of Medical Technology and Intelligent Information Systems Dept. of Materials Science and Engineering Ioannina Greece

ISBN: (纸本)9798331518622

Heart failure (HF) is a complex syndrome that is affected by many factors and causes. It is crucial to early recognize the disease subtypes and the unidentified clinical pathways that give rise to it. Machine learning (ML) is the tool that assist to deal with these challenges and improve the prediction of HF. In this work, the HF risk prediction was implemented by employed ML classifiers, such as Random Forest (RF), Extreme Grading Boosting (XGBoost) and Light Gradient-Boosting Machine (LGBM). We utilized the data from the German epidemiological trial on ankle brachial index - getABI cohort, which includes 6,454 patients. The performance of classifiers was estimated by Accuracy (ACC), Sensitivity, Specificity and the area under the receiver operating characteristic curve (AUC) in mean values for each ML classifier. The results were also interpreted using the Explainable artificial intelligence (XAI) approach, the Shapley Additive exPlanations (SHAP) values. Our work reveals that LGBM classifier predict the HF risk within 5 years follow-up in general population with 68 % accuracy. Moreover, the N-terminal pro-B-type natriuretic peptide (NT-proBNP) was identified as the most important feature for HF risk prediction. © 2024 IEEE.

关键词： Risk perception

来源：评论

学校读者我要写书评

暂无评论

Characterizing catalyst function and transformations in the plasma reduction of CO₂ on atomic layer deposition-synthesized catalysts

RSC Applied Interfaces

引用

RSC Applied Interfaces 2024年第3期1卷 552-563页

作者： Conlin, Samuel K. Mehrabi, Hamed Parette, David N. Nichols, Eva M. Coridan, Robert H. Department of Chemistry and Biochemistry University of Arkansas Fayetteville 72701 AR United States Materials Science and Engineering Program University of Arkansas Fayetteville 72701 AR United States Department of Chemistry University of British Columbia Vancouver V6T 1Z1 BC Canada

The enhancement of CO2 reduction in atmospheric-pressure, non-thermal plasma has been shown using a variety of catalyst systems with ranging composition, particle sizes, and morphologies. Improvements in CO2 conversio...

The enhancement of CO₂ reduction in atmospheric-pressure, non-thermal plasma has been shown using a variety of catalyst systems with ranging composition, particle sizes, and morphologies. Improvements in CO₂ conversion can be attained by choice of catalyst material. However, inhomogeneity in the material distribution arising from the synthesis affects the catalytically active surface area and dielectric environment that modulates the plasma properties near the catalyst. Atomic layer deposition (ALD) can be used to control the composition of ultra-thin layers on support materials. We used ALD to synthesize metal oxide catalyst coatings on high surface area supports. We found that TiO₂ achieved significantly higher yields of CO₂ conversion (to CO and O₂) at low reactor power compared to ZnO or Al₂O₃, materials commonly used as a support for other catalysts. We also observed an unexpected increase in the catalytic activity on ZnO with increasing power. The results here suggest that ALD can unambiguously isolate the catalytic effects of materials in plasma reactors. © 2024 RSC.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Angiogenesis-osteogenesis coupling and anti-osteoclastogenesis zoledronate intermixed calcium silicate metal-organic/inorganic hybrid coating on biodegradable zinc-based intramedullary nails for osteoporotic fracture healing

引用

Bioactive materials 2025年第2期44卷 46-67页

作者： Junyu Qian Haotian Qin En Su Jiaming Hou Hui Zeng Tianbing Wang Deli Wang Guojiang Wan Yingqi Chen Department of Bone and Joint Surgery Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen518036PR China Institute of Biomedical Engineering College of MedicineKey Laboratory of Advanced Technologies of MaterialsMinistry of EducationSouthwest Jiaotong UniversityChengdu610031PR China Trauma Medicine Center Peking University People’s HospitalBeijing100044PR China

Osteoporotic(OP)fractures remain a tough clinical challenge owing to their impaired healing outcome,which requires novel biomaterials with osteogenicity for effective *** zinc(Zn)is attracting increasing attention for biodegradable intramedullary nails(IMNs)for OP fracture healing thanks to their comprehensive mechanical properties,biosafety,and ***,the multiple biofunctions required for OP fracture healing have not been fully met by ***,a zoledronate(ZA)-mediated calcium-zinc silicate(Ca(Zn)Si)metal-organic/inorganic hybrid coating was fabricated on Zn-based IMN by coordination chemistry driven via interactions between ZA and Ca^(2+)/Zn^(2+)as well as in-situ directional growth of Ca(Zn)Si *** ZA&Ca(Zn)Si hybrid coating exhibited a homogeneous micro/nanostructure with a granular morphology,which prevented premature fracture failure of IMN in rat femur by ameliorating corrosion mode and decreasing degradation rate of the Zn *** importantly,this hybrid coating enabled sustained release of Zn^(2+)/Ca^(2+)/Si4+and ZA in the long term,achieving a remarkable effect on vascularized bone *** coated IMN enhanced angiogenesis-osteogenesis coupling through autocrine and paracrine effects between endothelial cells and bone marrow mesenchymal stem *** was repressed by Zn^(2+)and *** approach offers a new strategy for surface-engineering of biodegradable metals for bone fracture healing.

关键词： Angiogenesis-osteogenesis coupling Anti-osteoclastogenesis Biodegradable zinc Metal-organic/inorganic hybrid coating Intramedullary nail

来源：评论

学校读者我要写书评

暂无评论

X-ray scattering tensor tomography based finite element modelling of heterogeneous materials

引用

npj Computational materials 2024年第1期10卷 2724-2734页

作者： Robert M.Auenhammer Jisoo Kim Carolyn Oddy Lars P.Mikkelsen Federica Marone Marco Stampanoni Leif EAsp Material and Computational Mechanics Department of Industrial and Materials ScienceChalmers University of TechnologySE-41296 GöteborgSweden Composites Manufacturing and Testing Department of Wind and Energy SystemsTechnical University of DenmarkDK-4000 RoskildeDenmark Institute for Biomedical Engineering University and ETH Zürich8092 ZürichSwitzerland Swiss Light Source Paul Scherrer Institut5232 VilligenSwitzerland Department of Automation and Composite Technologies GKN Aerospace SwedenSE-46138 TrollhättanSweden Advanced Instrumentation Institute Korea Research Institute of Standards and Science34113 DaejeonRepublic of Korea

Among micro-scale imaging technologies of materials,X-ray micro-computed tomography has evolved as most popular choice,even though it is restricted to limited field-of-views and long acquisition *** recent progress in small-angle X-ray scattering these downsides of conventional absorption-based computed tomography have been overcome,allowing complete analysis of the micro-architecture for samples in the dimension of centimetres in a matter of minutes.

关键词： tensor element overcome

来源：评论

学校读者我要写书评

暂无评论

Skeletal interoception and prospective application in biomaterials for bone regeneration

引用

Bone Research 2025年第1期13卷 1-14页

作者： Long Bai Jilong Li Guangfeng Li Dongyang Zhou Jiacan Su Changsheng Liu Organoid Research Center Institute of Translational MedicineShanghai UniversityShanghaiChina National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghaiChina Wenzhou Institute of Shanghai University WenzhouZhejiangChina Department of Orthopedics Shanghai Zhongye HospitalShanghaiChina Department of Orthopedics Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of the Ministry of EducationEast China University of Science and TechnologyShanghaiChina

Accumulating research has shed light on the significance of skeletal interoception,in maintaining physiological and metabolic homeostasis related to bone *** review provides a comprehensive analysis of how skeletal interoception influences bone homeostasis,delving into the complex interplay between the nervous system and skeletal *** key focus of the review is the role of various factors such as prostaglandin E2(PGE2)in skeletal health via skeletal *** explores how nerves innervating the bone tissue communicate with the central nervous system to regulate bone remodeling,a process critical for maintaining bone strength and ***,the review highlights the advancements in biomaterials designed to utilize skeletal interoception for enhancing bone regeneration and treatment of bone *** biomaterials,tailored to interact with the body’s interoceptive pathways,are positioned at the forefront of innovative treatments for conditions like osteoporosis and *** represent a convergence of bioengineering,neuroscience,and orthopedics,aiming to create more efficient and targeted therapies for bone-related *** conclusion,the review underscores the importance of skeletal interoception in physiological regulation and its potential in developing more effective therapies for bone *** emphasizes the need for further research to fully understand the mechanisms of skeletal interoception and to harness its therapeutic potential fully.

关键词： homeostasis biomaterials utilize

来源：评论

学校读者我要写书评

暂无评论

Achieving Near-Intrinsic Exciton Linewidth at Room Temperature in Monolayer WS2 Coupled with a Mie Resonator

Achieving Near-Intrinsic Exciton Linewidth at Room Temperatu...

引用

CLEO: science and Innovations, S and I 2022

作者： Fang, Jie Yao, Kan Zheng, Yuebing Materials Science & Engineering Program Texas Materials Institute The University of Texas at Austin AustinTX78712 United States Walker Department of Mechanical Engineering The University of Texas at Austin AustinTX78712 United States

ISBN: (纸本)9781557528209

Strong multiparticle interactions at room temperature (RT) lead to broadened homogeneous exciton linewidths in 2D semiconductors, degrading the quality of excitonic mode and emission. By coupling a Mie resonator with monolayer WS2, we achieve narrowed linewidths at RT, approaching the theoretical limit at 0 Kelvin. © Optica Publishing Group 2022, © 2022 The Author(s)

关键词： Linewidth

来源：评论

学校读者我要写书评

暂无评论

Doxycycline-laden fibrous microparticles as a therapeutic ingredient for etch-and-rinse adhesive systems: Effects on optical, physical and bonding properties to dentin

引用

Dental materials 2025年第7期41卷 862-871页

作者： Silveira, Bianca Tatsch Piva, Evandro Paim, Julia Stela Xavier Bottino, Marco Cícero Münchow, Eliseu Aldrighi Graduate Program in Dentistry School of Dentistry Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2492 Porto Alegre Brazil Graduate Program in Dentistry School of Dentistry Federal University of Pelotas Rua Gonçalves Chaves 457 Pelotas Brazil Department of Biomedicine Health Basic Science Institute Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2600 Porto Alegre Brazil Department of Biomedical Engineering College of Engineering University of Michigan Ann Arbor United States Department of Conservative Dentistry School of Dentistry Federal University of Rio Grande do Sul Rua Ramiro Barcelos 2492 Porto Alegre Brazil

Objectives: To evaluate the effects of the modification of an etch-and-rinse (ER) adhesive system with fibrous particles with or without doxycycline (DOX) as a therapeutic ingredient. Methods: Polymeric fibers were synthesized via electrospinning using a 10 wt% polymer solution based on poly-(Ε-caprolactone) (PCL). The PCL solution was separated into two aliquots: one was kept unchanged, and the other was laden with 25 wt% of DOX. Each electrospun fiber mat was further processed in a cryogenic impact mill to obtain small-sized fibrous particles, which were characterized with morphological, chemical (FTIR), and antibacterial activity (against Streptococcus mutans and Lactobacillus) analyses. The 2-step ER adhesive One-Step (Bisco) was separated into three aliquots: one was kept unmodified to serve as an unfilled control, and the other two aliquots were added with 20 wt% of DOX or PCL fibrous microparticles. The fiber-modified adhesives were tested for degree of conversion (DC), optical properties (color change [ΔE00], translucency, and refractive index [RI]), wettability properties, and bonding potential (microtensile bond strength/µTBS) to dentin after immediate testing and one-year of water storage. The data were statistically analyzed using ANOVA and Kruskal-Wallis tests with α= 5 %. The bond strength data was also analyzed using Weibull analysis. Results: The morphology of the PCL and DOX particles demonstrated a nonuniform diameter distribution similar to each other. While the PCL particles did not inhibit the growth of S. mutans and Lactobacillus, the DOX particles resulted in significant inhibition halos greater than chlorhexidine (control). The incorporation of the fibrous particles into the adhesive altered the color appearance of the material (ΔE00>1.8 – above the acceptability threshold);translucency was slightly reduced only in the PCL adhesive, and the RI was similar among the tested adhesives. DC was similar among the adhesive groups, but their wetting

关键词： Bond strength (chemical)

来源：评论

学校读者我要写书评

暂无评论

Phase/Interfacial-Engineered Two-Dimensional-Layered WSe2 Films by a Plasma-Assisted Selenization Process: Modulation of Oxygen Vacancies in Resistive Random-Access Memory

引用

ACS Applied materials and Interfaces 2023年第28期15卷 33858-33867页

作者： Chaudhary, Mayur Shih, Yu-Chuan Tang, Shin-Yi Yang, Tzu-Yi Kuo, Tzu-Wen Chung, Chia-Chen Shen, Ying-Chun Anbalagan, Aswin kumar Lee, Chih-Hao Hou, Tuo-Hung He, Jr-Hau Chueh, Yu-Lun Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan College of Semiconductor Research National Tsing Hua University Hsinchu30013 Taiwan Department of Physics National Sun Yat-Sen University Kaohsiung80424 Taiwan Department of Engineering and System Science National Tsing Hua University Hsinchu30013 Taiwan Department of Electronic Engineering National Yang Ming Chiao Tung University Hsinchu30013 Taiwan Department of Materials Science and Engineering City University of Hong Kong Hong Kong999077 Hong Kong Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu30013 Taiwan Semiconductor Research Center Hon Hai Research Institute Taipei11492 Taiwan

Here, we propose phase and interfacial engineering by inserting a functional WO3 layer and selenized it to achieve a 2D-layered WSe2/WO3 heterolayer structure by a plasma-assisted selenization process. The 2D-layered WSe2/WO3 heterolayer was coupled with an Al2O3 film as a resistive switching (RS) layer to form a hybrid structure, with which Pt and W films were used as the top and bottom electrodes, respectively. The device with good uniformity in SET/RESET voltage and high low-/high-resistance window can be obtained by controlling a conversion ratio from a WO3 film to a 2D-layered WSe2 thin film. The Pt/Al2O3/(2D-layered WSe2/WO3)/W structure shows remarkable improvement to the pristine Pt/Al2O3/W and Pt/Al2O3/2D-layered WO3/W in terms of low SET/RESET voltage variability (−20/20)%, multilevel characteristics (uniform LRS/HRS distribution), high on/off ratio (104-105), and retention (∼105 s). The thickness of the obtained WSe2 was tuned at different gas ratios to optimize different 2D-layered WSe2/WO3 (%) ratios, showing a distinctive trend of reduced and uniform SET/RESET voltage variability as 2D-layered WSe2/WO3 (%) changes from 90/10 (%) to 45/55 (%), respectively. The electrical measurements confirm the superior ability of the metallic 1T phase of the 2D-layered WSe2 over the semiconducting 2H phase. Through systemic studies of RS behaviors on the effect of 1T/2H phases and 2D-layered WSe2/WO3 ratios, the low-temperature plasma-assisted selenization offers compatibility with the temperature-limited 3D integration process and also provides much better thickness control over a large area. © 2023 American Chemical Society.

关键词： Aluminum oxide

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：