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Inorganic nanoparticles for photothermal treatment of cancer

Journal of materials Chemistry B 2024年第15期12卷 3569-3593页

作者： Thirumurugan, Senthilkumar Ramanathan, Susaritha Muthiah, Kayalvizhi Samuvel Lin, Yu-Chien Hsiao, Michael Dhawan, Udesh Wang, An-Ni Liu, Wai-Ching Liu, Xinke Liao, Mei-Yi Chung, Ren-Jei No. 1 Sec. 3 Zhongxiao E. Rd Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Genomics Research Center Academia Sinica Taipei115 Taiwan Department and Graduate Institute of Veterinary Medicine School of Veterinary Medicine National Taiwan University Taipei10617 Taiwan Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow GlasgowG116EW United Kingdom Scrona AG Grubenstrasse 9 Zürich8045 Switzerland Faculty of Science and Technology Technological and Higher Education Institute of Hong Kong New Territories Hong Kong999077 Hong Kong College of Materials Science and Engineering Chinese Engineering and Research Institute of Microelectronics Shenzhen University Shenzhen518060 China Department of Electrical and Computer Engineering National University of Singapore Singapore117583 Singapore Department of Applied Chemistry National Pingtung University Pingtung90003 Taiwan Taipei106 Taiwan

In recent years, inorganic nanoparticles (NPs) have attracted increasing attention as potential theranostic agents in the field of oncology. Photothermal therapy (PTT) is a minimally invasive technique that uses nanoparticles to produce heat from light to kill cancer cells. PTT requires two essential elements: a photothermal agent (PTA) and near-infrared (NIR) radiation. The role of PTAs is to absorb NIR, which subsequently triggers hyperthermia within cancer cells. By raising the temperature in the tumor microenvironment (TME), PTT causes damage to the cancer cells. Nanoparticles (NPs) are instrumental in PTT given that they facilitate the passive and active targeting of the PTA to the TME, making them crucial for the effectiveness of the treatment. In addition, specific targeting can be achieved through their enhanced permeation and retention effect. Thus, owing to their significant advantages, such as altering the morphology and surface characteristics of nanocarriers comprised of PTA, NPs have been exploited to facilitate tumor regression significantly. This review highlights the properties of PTAs, the mechanism of PTT, and the results obtained from the improved curative efficacy of PTT by utilizing NPs platforms. © 2024 The Royal Society of Chemistry

关键词： Cancer cells

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The Design of a Drone-Assisted System for Large Wildlife Vaccination Shooting Based on AI Image Identification Technology 20

The Design of a Drone-Assisted System for Large Wildlife Vac...

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20th IEEE International Conference on e-Business engineering, ICEBE 2024

作者： Tsai, Yao-Yu Tsai, Yao-Chuan Tai, Chang-Hsien Chen, Chen-Chih Hsu, Uzu-Kuei National Chung Hsing University National Pingtung University of Science and Technology Sustainable Circular Economy R&d Center Department of Bio-Industrial Mechatronics Engineering Pingtung Taichung Taiwan National Chung Hsing University Department of Bio-Industrial Mechatronics Engineering Taichung Taiwan College of Biomedical Engineering and Technology Tzu Chi University Hualien Taiwan Institute of Wildlife Conservation National Pingtung University of Science and Technology Pingtung Taiwan Program of Artificial Intelligence and Mechatronics National Pingtung University of Science and Technology Pingtung Taiwan

ISBN: (纸本)9798350365856

This study designs a UAV -assisted system integrated with AI image recognition technology to alleviate the difficulty for operators in stabilizing the UAV and accurately administering vaccines. The system uses thermal imaging modules and AI recognition systems to lock onto and track target animals in real-time. Utilizing MAVLink, the UAV adjusts its flight path based on the dynamic behavior of the animals, ensuring that the target remains within shooting range for precise vaccine administration. This technology not only improves the efficiency and accuracy of wildlife vaccination but also significantly reduces the workload on operators, providing a forward-looking solution for wildlife management. © 2024 IEEE.

关键词： Thermography (imaging)

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3D bioprinting of in vitro porous hepatoma models:establishment,evaluation,and anticancer drug testing

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Bio-Design and Manufacturing 2024年第2期7卷 137-152页

作者： Xiaoyuan Wang Zixian Liu Qianqian Duan Boye Zhang Yanyan Cao Zhizhong Shen Meng Li Yanfeng Xi Jianming Wang Shengbo Sang Shanxi Key Laboratory of Micro Nano Sensors and Artificial Intelligence Perception College of Electronic Information and Optical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China Shanxi Institute of 6D Artificial Intelligence Biomedical Science Taiyuan 030031China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China Department of Pathology Shanxi Provincial Cancer HospitalTaiyuan 030024China General Hospital of Taiyuan Iron and Steel Company Taiyuan 030809China

Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted *** address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of *** GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 *** analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the *** with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and ***,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three *** addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude *** evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was *** research therefore acts as a foundation for the application of 3DP-7721 models in drug devel

关键词： 3D bioprinting Hepatoma tumor models Drug screening Antitumor drug development

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In-plane Wilson loop for measurement of quantized non-Abelian Berry flux

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Physical Review B 2024年第19期109卷 195149-195149页

作者： Alexander C. Tyner Shouvik Sur Qunfei Zhou Danilo Puggioni Pierre Darancet James M. Rondinelli Pallab Goswami Graduate Program in Applied Physics Northwestern University Evanston Illinois 60208 USA Department of Physics and Astronomy Northwestern University Evanston Illinois 60208 USA Materials Research Science and Engineering Center Northwestern University Evanston Illinois 60208 USA Center for Nanoscale Materials Argonne National Laboratory Argonne Illinois 60439 USA Department of Materials Science and Engineering Northwestern University Evanston Illinois 60208 USA Northwestern Argonne Institute for Science and Engineering Evanston Illinois 60208 USA

Band topology of anomalous quantum Hall insulators can be precisely addressed by computing the Chern numbers of constituent nondegenerate bands, describing the presence of quantized, Abelian Berry flux through the two-dimensional Brillouin zone. Can Berry flux be captured for the SU(2) Berry connection of two-fold degenerate bands in spinful materials preserving space-inversion (P) and time-reversal (T) symmetries without detailed knowledge of underlying basis? We address this question by investigating the correspondence between a non-Abelian generalization of Stokes' theorem and the manifestly gauge-invariant eigenvalues of Wilson loops computed along in-plane contours which preserve the underlying crystalline symmetry. The importance of this correspondence is elucidated by performing natural number resolved classification of ab initio band structures of three-dimensional, Dirac materials. Our work underscores how identification of quantized Berry flux, both Abelian and non-Abelian, offers a unified framework for addressing first-order and higher-order topology of insulators and semimetals.

关键词： Electronic structure of atoms & molecules First-principles calculations Topological insulators

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The growing memristor industry

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Nature 2025年第8059期640卷 613-622页

作者： Lanza, Mario Pazos, Sebastian Aguirre, Fernando Sebastian, Abu Le Gallo, Manuel Alam, Syed M. Ikegawa, Sumio Yang, J. Joshua Vianello, Elisa Chang, Meng-Fan Molas, Gabriel Naveh, Ishai Ielmini, Daniele Liu, Ming Roldan, Juan B. Department of Materials Science and Engineering National University of Singapore Singapore Singapore Institute for Functional Intelligent Materials National University of Singapore Singapore Singapore Centre for Advanced 2D Materials (CA2DM) National University of Singapore Singapore Singapore Materials Science and Engineering Program Physical Science and Engineering Division King Abdullah University of Science and Technology (KAUST) Thuwal Saudi Arabia Intrinsic Semiconductor Technologies London United Kingdom IBM Research – Zurich Rüschlikon Switzerland Everspin Technologies Chandler AZ United States Department of Electrical and Computer Engineering University of Southern California Los Angeles CA United States CEA-Leti Université Grenoble Alpes Grenoble France Department of Electrical Engineering National Tsing Hua University Hsinchu Taiwan Weebit Nano Hod Hasharon Israel Dipartimento di Elettronica Informazione e Bioingegneria (DEIB) Politecnico di Milano and *** Milano Italy Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing China Departamento de Electrónica y Tecnología de Computadores Universidad de Granada Facultad de Ciencias Granada Spain

The semiconductor industry is experiencing an accelerated transformation to overcome the scaling limits of the transistor and to adapt to new requirements in terms of data storage and computation, especially driven by artificial intelligence applications and the Internet of Things. In this process, new materials, devices, integration strategies and system architectures are being developed and optimized. Among them, memristive devices and circuits—memristors are two-terminal memory devices that can also mimic some basic bioelectronic functions—offer a potential approach to create more compact, energy-efficient or better-performing systems. The memristor industry is growing quickly, raising abundant capital investment, creating new jobs and placing advanced products in the market. Here we analyse the status and prospects of the memristor industry, focusing on memristor-based products that are already commercially available, prototypes with a high technological readiness level that might affect the market in the near future, and discuss obstacles and pathways to their implementation. © Springer Nature Limited 2025.

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Cerium oxide nanozymes alleviate oxidative stress in tenocytes for Achilles tendinopathy healing

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Nano Research 2023年第5期16卷 7364-7372页

作者： Xingquan Xu Rongliang Wang Yixuan Li Rui Wu Wenjin Yan Sheng Zhao Quanyi Liu Yan Du Wenli Gong Weitong Li Hui Wei Dongquan Shi State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing National Laboratory of MicrostructuresJiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210023China State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringChemistry and Biomedicine Innovation Center(ChemBIC)Nanjing UniversityNanjing 210023China

Background:Reactive oxygen species(ROS)is considered as ubiquitous and highly active chemicals that influence tendon integrity and orchestrate tendon *** significant recent advances in nanomaterials,cerium oxide nanoparticles(CeO_(2)NPs)exhibit superoxide dismutase-and catalase-like ***,we introduced a therapeutic approach of CeO_(2)NPs for Achilles tendinopathy(AT)***:CeO_(2)NPs were synthesized to examine their effect as ROS scavengers on AT healing in vitro and in *** mRNA levels of inflammatory factors were evaluated in AT after CeO_(2)NPs treatment in *** mechanisms underlying CeO_(2)NPs-mediated stimulation of NRF2 translocation and ERK signaling were verified through immunofluorescence and Western blot *** efficacy of CeO_(2)NPs was tested in an AT rat model in comparison with the ***:CeO_(2)NPs not only significantly scavenged multiple ROS and suppressed ROS-induced inflammatory reactions but also protected cell proliferation under oxidative stress induced by tert-butyl hydroperoxide(TBHP).Moreover,CeO_(2)NPs could promote NRF_(2)nuclear translocation for anti-oxidation and anti-inflammation through the ERK signaling *** a rat model of collagenase-induced tendon injuries,CeO_(2)NPs showed significant therapeutic efficacy by ameliorating tendon ***:The present study provides valuable insights into the molecular mechanism of CeO_(2)NPs to ameliorate ROS in tenocytes via the ERK/NRF_(2)signaling pathway,which underscores the potential of CeO_(2)NPs for application in the treatment of enthesopathy healing.

关键词： CeO_(2)nanozymes enthesiopathy NRF2 translocation ERK signaling

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Z-Laminating Assembly of Graphene Nanoflakes for Super-Strong Membranes and Functional Coatings

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ACS Applied Nano materials 2024年第13期7卷 14957-14963页

作者： Santos, Ian Daniell Tjarks, Patrick Muthu, Jeyavelan Lin, You-Chen Yen, Zhi-Long Chand, Pradyumna Kumar Raman, Radha Nguyen, Dinh Tuan Rouhani, Mehdi Jeng, Yeau-Ren Hsieh, Ya-Ping Hofmann, Mario Department of Physics National Taiwan University Taipei 106 Taiwan Nano Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Taiwan University Taipei 106 Taiwan J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences Prague 18200 Czech Republic Institute of Atomic and Molecular Sciences Academia Sinica Taipei 106 Taiwan Department of Chemistry National Taiwan University Taipei 106 Taiwan Department of Physics National Central University Taoyuan 320 Taiwan Molecular Science and Technology Program Taiwan International Graduate Program Academia Sinica and National Central University Taipei 106 Taiwan Department of Biomedical Engineering National Cheng Kung University 1 University Road Tainan 70101 Taiwan Department of Materials Science and Engineering National Cheng Kung University Tainan 70101 Taiwan Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng-Kung University (NCKU) Tainan 70101 Taiwan

We demonstrate the strengthening of graphene, an atomically thin carbon allotrope, by out-of-plane folding. Through lateral confinement of graphene at the water-air interface, nanoscale buckling was induced in suspended flakes, leading to an unexpected folding transition beyond a critical surface pressure. The emergence of folding was confirmed by in situ Brewster angle reflectivity and ex situ microscopy, showing a unique “z-laminated” nanostructure. Molecular dynamics simulations indicate that z-lamination yields an enhanced adhesion between neighboring flakes compared to lateral sliding, which was confirmed by a surface pressure hysteresis during the folding process. Mechanical testing reveals superior Young’s modulus and yield strength when compared to conventional graphene assemblies and even compared to composites. We demonstrate the potential of the z-lamination approach for applications in graphene-based structural materials, tribological layers, and functional electrochemical coatings. Finally, the complete recyclability of z-laminated graphene opens up new routes toward sustainable nanostructured materials. © 2024 The Authors. Published by American Chemical Society

关键词： 2D materials composites laminated graphene membranes recyclable

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Fast reconstruction and optical-sectioning three-dimensional structured illumination microscopy

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The Innovation 2025年第3期6卷 50-58,49页

作者： Ruijie Cao Yaning Li Wenyi Wang Yunzhe Fu Xiaoyu Bu Dilizhatai Saimi Jing Sun Xichuan Ge Shan Jiang Yuru Pei Baoxiang Gao Zhixing Chen Meiqi Li Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China National Biomedical Imaging Center College of Future TechnologyPeking UniversityBeijing 100871China China Academy of Space Technology Beijing Institute of Space Mechanics and ElectricityBeijing 100094China Airy Technologies Co. Ltd.Beijing 100081China Key Laboratory of Analytical Science and Technology of Hebei Province College of Chemistry and Materials ScienceHebei UniversityBaoding 071002China College of Future Technology Institute of Molecular MedicineNational Biomedical Imaging CenterBeijing Key Laboratory of Cardiometabolic Molecular MedicinePeking UniversityBeijing 100871China Institute of Biomedical Engineering Beijing Institute of Collaborative InnovationBeijingChina Key Laboratory of Machine Perception(MOE) Department of Machine IntelligencePeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Science Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China School of Life Sciences Peking UniversityBeijing 100871China

Three-dimensional structured illumination microscopy(3DSIM)is a popular method for observing subcellular/cellular structures or animal/plant tissues with gentle phototoxicity and 3D ***,its time-consuming reconstruction process poses challenges for high-throughput imaging and real-time ***,traditional 3DSIM typically requires more than six z layers for successful reconstruction and is susceptible to defocused *** poses a great gap between single-layer 2DSIM and 6-layer 3DSIM,and limits the observation of thicker *** address these limitations,we developed FO-3DSIM,a novel method that integrates spatial-domain reconstruction with optical-sectioning ***-3DSIM enhances reconstruction speed by up to 855.7 times with superior performance with limited z layers and under high defocused *** retains the high-fidelity,low-photon reconstruction capabilities of our previously proposed *** fast reconstruction and optical sectioning,we achieved large field-of-view(FOV)3D super-resolution imaging of mouse kidney actin,covering a region of 0.453 mm×0.453 mm×2.75μm within 23 min of acquisition and 13 min of *** real-time performance was demonstrated in live actin imaging with *** approach reduces photodamage through limited z layer reconstruction,allowing the observation of ER tubes with just three *** anticipate that FO-3DSIM will pave the way for near real-time,large FOV 6D imaging,encompassing xyz super-resolution,multi-color,long-term,and polarization imaging with less photodamage,removed defocused backgrounds,and reduced reconstruction time.

关键词： gentle phototoxicity phototoxicity high throughput imaging fast reconstruction real time observation optical sectioning three dimensional structured illumination microscopy reconstruction process

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Scaled-up synthesis of defect-rich layered double hydroxide monolayers without organic species for efficient oxygen evolution reaction

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Green Energy & Environment 2022年第5期7卷 975-982页

作者： Haoyuan Chi Jingwen Dong Tian Li Sha Bai Ling Tan Jikang Wang Tianyang Shen Guihao Liu Lihong Liu Luyi Sun Yufei Zhao Yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China College of Chemistry Key Laboratory of Theoretical&Computational Photochemistry of Ministry of EducationBeijing Normal UniversityBeijing100875China Polymer Program Institute of Materials Science and Department of Chemical&Biomolecular EngineeringUniversity of ConnecticutStorrsConnecticut06269USA Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing100029China

The scaled-up synthesis of organic-free monolayer nanomaterials is highly desirable,especially in obtaining green energy by *** this study,a method for the scaled-up synthesis of the series of monolayer layered double hydroxides(LDHs)without the addition of organic solvents is reported via the separate nucleation and aging steps *** resulting monolayer LDHs with the thicknesses of less than 1 nm showed a narrow thickness distribution.X-ray absorption fine-structure revealed that monolayer NiFe-LDH nanosheets have a number of oxygen and metal vacancies *** a practical application,monolayer NiFe-LDH nanosheets containing defects showed an enhanced electrocatalytic water oxidation activity compared with that of bulk *** functional theory calculations uncovered that excellent catalytic activity is attributed to vacancies *** proposed method is an economical and universally applicable strategy for the scaled-up production of monolayer LDHs.

关键词： process synthesis monolayer

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Strain-Insensitive Hierarchically Structured Stretchable Microstrip Antennas for Robust Wireless Communication

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Nano-Micro Letters 2021年第8期13卷 1-12页

作者： Jia Zhu Senhao Zhang Ning Yi Chaoyun Song Donghai Qiu Zhihui Hu Bowen Li Chenghao Xing Hongbo Yang Qing Wang Huanyu Cheng Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Division of Life Sciences and Medicine School of Biomedical Engineering(Suzhou)University of Science and Technology of ChinaHefei 230022People’s Republic of China Institute of Biomedical Engineering and Technology Chinese Academy of ScienceSuzhou 215011People’s Republic of China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA School of Engineering and Physical Sciences Heriot-Watt UniversityUniversity ParkEdinburgh EH144ASScotlandUK Department of Electrical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA

As the key component of wireless data transmission and powering,stretchable antennas play an indispensable role in flexible/stretchable ***,they often suffer from frequency detuning upon mechanical deformations;thus,their applications are limited to wireless sensing with wireless transmission capabilities remaining ***,a hierarchically structured stretchable microstrip antenna with meshed patterns arranged in an arched shape showcases tunable resonance frequency upon deformations with improved overall *** almost unchanged resonance frequency during deformations enables robust on-body wireless communication and RF energy harvesting,whereas the rapid changing resonance frequency with deformations allows for wireless *** proposed stretchable microstrip antenna was demonstrated to communicate wirelessly with a transmitter(input power of−3 dBm)efficiently(i.e.,the receiving power higher than−100 dBm over a distance of 100 m)on human bodies even upon 25%*** flexibility in structural engineering combined with the coupled mechanical-electromagnetic simulations,provides a versatile engineering toolkit to design stretchable microstrip antennas and other potential wireless devices for stretchable electronics.

关键词： Stretchable microstrip antennas Strain-insensitive resonance frequency Wireless communication RF energy harvesting Wearable and bio-integrated electronics

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