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2024 IEEE International Conference on E-Health Networking, Application and Services, HealthCom 2024

作者： Williams, Christian Lee, Andrew Tolah, Ahmed Einafshar, Mohammadjavad Massaad, Elie Kiapour, Ali Yu, Chen-Hsiang School of Computing and Data Science Wentworth Institute of Technology BostonMA United States Department of Biomedical Engineering Wentworth Institute of Technology BostonMA United States Department of Materials and Production Aalborg University Aalborg Denmark Massachusetts General Hospital Harvard Medical School BostonMA United States College of Engineering Northeastern University BostonMA United States

ISBN: (纸本)9798350350548

Machine learning (ML) and its applications have expanded over the past few years. ML inevitably makes its way to the world of prosthetics and amputees. Smart prosthetics have been studied and growing recently. Through the collection of data from these devices, results can help the user in numerous ways. On the other hand, mobile devices and applications are widely used. However, how to combine mobile applications and ML to enhance the prosthetic device was less addressed. In this research, we studied ML with an IoT-based prosthetic device paired with a mobile application. The hypothesis was that the ML methods could help evaluate the user’s status. The study results showed that some evaluated ML methods were able to see through the average temperature, humidity and contraction percentage of the people who wear a designed prosthetic device. The results also indicated that the users could tell if the contractions reached a concerning level. © 2024 IEEE.

关键词： Adversarial machine learning

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Effect of silver/zinc co-dopant on enhancing cytotoxicity and antibacterial property of spray pyrolyzed bioactive glasses

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Journal of Asian Ceramic Societies 2024年第1期12卷 104-116页

作者： Ningsih, Henni Setia Vietanti, Frizka Wong, Chin-Chean Chou, Yu-Jen Department of Mechanical Engineering National Taiwan University of Science and Technology Taipei Taiwan Department of Orthopedics Taipei Medical University Shuang Ho Hospital New Taipei Taiwan Department of Orthopedics School of Medicine College of Medicine Taipei Medical University Taipei Taiwan Research Center of Biomedical Devices Taipei Medical University Taipei Taiwan International PhD Program for Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei Taiwan

Owing to the advancement of bioactive materials, bioactive glasses (BGs) are progressively being recognized as promising choices in fields of bone and tissue engineering with their superior properties such as bioactivity and biocompatibility. However, their applications are limited by the fact that the material itself does not possess antibacterial properties. To address this limitation, antibacterial BGs with silver-zinc co-dopant were proposed and successfully synthesized via the one-step spray pyrolysis technique in this work. The phase composition, chemical composition, surface morphology, and nanoscale structures of the obtained BG specimens were characterized using X-ray diffraction, energy dispersive spectroscopy, scanning electron microscopy, and transmission electron microscopy. Moreover, in-vitro bioactivity was assessed through immersion of the SBF solution, while the in-vitro antibacterial property was examined using Escherichia coli bacteria. Meanwhile, the viability of MC3T3-E1 osteoblast cells was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Finally, the results showed positive effects of zinc addition, and the influence of silver and zinc dopants on the in-vitro bioactivity, antibacterial property, and cell viability were discussed. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The Korean Ceramic Society and The Ceramic Society of Japan.

关键词： Spray pyrolysis

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Diving into COVID-19: Visualizing SARS-CoV-2 Patient Proteins using Liquid-Electron Microscopy

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 662-664页

作者： Berry, Samantha DiCecco, Liza-Anastasia Gray, Jennifer Boylan, Jack Solares, Maria Kelly, Deborah F. Department of Biomedical Engineering Pennsylvania State University University Park PA United States Department of Materials Science and Engineering McMaster University Hamilton ON Canada Materials Research Institute Pennsylvania State University University Park PA United States Molecular Cellular Integrative Biosciences Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States

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Fragile X Messenger Ribonucleoprotein 1(FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice

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Bone Research 2023年第2期11卷 384-397页

作者： Padmini Deosthale Julián Balanta-Melo Amy Creecy Chongshan Liu Alejandro Marcial Laura Morales Julita Cridlin Sylvia Robertson Chiebuka Okpara David J.Sanchez Mahdi Ayoubi Joaquín N.Lugo Christopher J.Hernandez Joseph M.Wallace Lilian I.Plotkin Department of Anatomy Cell Biology&PhysiologyIndiana University School of MedicineIndianapolisIN46202USA Roudebush Veterans Administration Medical Center IndianapolisIN46202USA Indiana Center for Musculoskeletal Health IndianapolisIN46202USA Universidad del Valle School of Dentistry Cali 760043Colombia Department of Biomedical Engineering Indiana University-Purdue University Indianapolis46202 IndianapolisIN46202USA Sibley School of Mechanical and Aerospace Engineering Cornell UniversityIthacaNY 14853USA Department of Materials Science and Engineering Cornell UniversityIthacaNY14853USA Department of Psychology and Neuroscience Baylor UniversityWacoTX76798USA

Fragile X Messenger Ribonucleoprotein 1(FMR1)gene mutations lead to fragile X syndrome,cognitive disorders,and,in some individuals,scoliosis and craniofacial ***-month-old(mo)male mice with deletion of the FMR1 gene exhibit a mild increase in cortical and cancellous femoral bone ***,consequences of absence of FMR1 in bone of young/aged male/female mice and the cellular basis of the skeletal phenotype remain *** found that absence of FMR1 results in improved bone properties with higher bone mineral density in both sexes and in 2-and 9-mo *** cancellous bone mass is higher only in females,whereas,cortical bone mass is higher in 2-and 9-mo males,but higher in 2-and lower in 9-mo female FMR1-knockout ***,male bones show higher biomechanical properties at 2mo,and females at both *** of FMR1 increases osteoblast/mineralization/bone formation and osteocyte dendricity/gene expression in vivo/ex vivo/in vitro,without affecting osteoclasts in vivo/ex ***,FMR1 is a novel osteoblast/osteocyte differentiation inhibitor,and its absence leads to age-,site-and sex-dependent higher bone mass/strength.

关键词： female Messenger agile

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Smart Nanopipette Technology for Studying 2D and 3D Cancer Models

Smart Nanopipette Technology for Studying 2D and 3D Cancer M...

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2024 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2024

作者： Vaneev, Alexander Timoshenko, Roman Kolmogorov, Vasilii Akasov, Roman Karshieva, Saida Koudan, Elizaveta Majouga, Alexander Gorelkin, Peter Erofeev, Alexander National University of Science and Technology ''MISIS Laboratory of Biophysics Moscow Russia I.M. Sechenov First Moscow State Medical University Laboratory of Molecular Pharmacology Moscow Russia National University of Science and Technology ''MISIS Center for Biomedical Engineering Moscow Russia National University of Science and Technology ''MISIS Department of Physical Materials Science Moscow Russia

ISBN: (纸本)9798350362107

This study presents a novel approach for studying 3D spheroids using glass nanopipettes and nanoelectrodes. The innovative application of these tools allows the investigation of spheroids from multiple perspectives. The first demonstration of this approach involved the use of scanning ion conductance microscopy (SICM), which enabled the spheroidal surface topography of U87MG (human glioblastoma) to be obtained for the first time. This was complemented by the mapping of Young's module. Furthermore, the electrochemical approach enabled the internal oxygen, reactive oxygen species(ROS) profiles to be obtained within the spheroids formed from primary cortical neurons and U87MG spheroids, representing a novel advancement in this field. The principal advantage of nanocapillary-based electrodes is their ability to perform minimally invasive measurements in the interior regions of spheroids, thereby facilitating precise electrochemical detection of oxygen and ROS levels at a given spheroid depth. This technological advance represents a significant step forward, opening up new opportunities for minimally invasive, high-resolution spheroid studies that can improve the development of therapies for tumor and neurodegenerative diseases. © 2024 IEEE.

关键词： Neurodegenerative diseases

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Robust adaptive estimator based on a novel objective function—Using the L1-norm and L0-norm

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Journal of Automation and Intelligence 2023年第2期2卷 105-117页

作者： Sihai Guan Chuanwu Zhang Guofu Wang Bharat Biswal Key Laboratory of Electronic and Information Engineering State Ethnic Affairs CommissionChengdu610041China College of Electronic and Information Southwest Minzu UniversityChengdu610041China Center for Materials Science and Engineering School of Electrical and Information EngineeringGuangxi University of Science and TechnologyLiuzhou545006China Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ07102USA The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationCenter for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731China

To fully take advantage of LMS,LMAT,and SELMS,a novel adaptive estimator using the L1-norm and L0-norm of the estimated error is proposed in this *** based on minimizing the mean-square deviation at the current time,the optimal step-size,parameters𝛿and𝜃of the proposed adaptive estimator are ***,the stability and computational complexity of the mean estimation error is analyzed *** results(both simulation and real mechanical system datasets)show that the proposed adaptive estimator is more robust to input signals and a variety of measurement noises(Gaussian and non-Gaussian noises).In addition,it is superior to LMS,LMAT,SELMS,the convex combination of LMS and LMAT algorithm,the convex combination of LMS and SELMS algorithm,and the convex combination of SELMS and LMAT *** theoretical analysis is consistent with the Monte-Carlo *** of them show that the adaptive estimator has an excellent performance in the estimation of unknown linear systems under various measurement noises.

关键词： Adaptive filter LMS LMAT SELMS Multiple types of noises

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Measurement of peripheral nerve magnetostimulation thresholds of a head solenoid coil between 200 Hz and 88.1 kHz

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IEEE Journal of Translational engineering in Health and Medicine 2025年 13卷 275-285页

作者： Barksdale, Alex C. Ferris, Natalie G. Mattingly, Eli Sliwiak, Monika Guerin, Bastien Wald, Lawrence L. Davids, Mathias Klein, Valerie MIT Department of Electrical Engineering and Computer Science CambridgeMA United States Martinos Center for Biomedical Imaging CharlestownMA United States Harvard University Harvard Graduate Program in Biophysics CambridgeMA United States Harvard-MIT Division of Health Sciences and Technology BostonMA United States Harvard Medical School BostonMA United States

Objective: Magnetic fields switching at kilohertz frequencies induce electric fields in the body, which can cause peripheral nerve stimulation (PNS). Although magnetostimulation has been extensively studied below 10 kHz, the behavior of PNS at higher frequencies remains poorly understood. This study aims to investigate PNS thresholds at frequencies up to 88.1 kHz and to explore deviations from the widely accepted hyperbolic strength-duration curve (SDC). Methods and procedures: PNS thresholds were measured in the head of 8 human volunteers using a solenoidal coil at 16 distinct frequencies, ranging from 200 Hz to 88.1 kHz. A hyperbolic SDC was used as a reference to compare the frequency-dependent behavior of PNS thresholds. Results: Contrary to the predictions of the hyperbolic SDC, PNS thresholds did not decrease monotonically with frequency. Instead, thresholds reached a minimum near 25 kHz, after which they increased by an average of 39% from 25 kHz to 88.1 kHz across subjects. This pattern indicates a significant deviation from previously observed behavior at lower frequencies. Conclusion: Our results suggest that PNS thresholds exhibit a non-monotonic frequency dependence at higher frequencies, diverging from the traditional hyperbolic SDC. These findings offer critical data for refining neurodynamic models and provide insights for setting PNS safety limits in applications like MRI gradient coils and magnetic particle imaging (MPI). Further investigation is needed to understand the biological mechanisms driving these deviations beyond 25 kHz. Clinical impact: These findings call for further basic research into biological mechanisms underlying high frequency PNS threshold trends, and supports refinement of safety guidelines for MRI and MPI systems for clinical implementation. © 2013 IEEE.

关键词： Neuroimaging

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Prediction of Weather Patterns Using Linear Angstrom Model

Prediction of Weather Patterns Using Linear Angstrom Model

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2022 Advances in science and engineering Technology International Conferences, ASET 2022

作者： Aljaghoub, Haya Alashkar, Adnan Alami, Abdul Hai Tawalbeh, Muhammad University of Sharjah Department of Industrail Engineering and Engineering Management Sharjah United Arab Emirates American University of Sharjah Materials Science and Engineering PhD Program Sharjah United Arab Emirates University of Sharjah Department of Sustainable and Renewable Energy Engineering Sharjah United Arab Emirates

ISBN: (纸本)9781665418010

The paper investigates the correlation between solar irradiance and sunlit hours for the city of Sharjah, United Arab Emirates. This correlation is a strong function of the weather conditions, and is vital for the design and operation of solar energy systems. The Angstrom Model is a straightforward tool that establishes a linear relationship where the model parameters b and a (slope and y-intercept, respectively) are evaluated through plotting of experimental measurements. Wind speed and relative humidity are collected to interpret their effect on the quality of incident solar radiation. The model takes into consideration winter and summer months of the year 2021, hence it provides a complete weather pattern for the year. With continuous data logging, the model will be developed to predict the weather patterns of the city of Sharjah. © 2022 IEEE.

关键词： Solar energy

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Birds of a Feather Self-Regulate Together: The Intersection of Peer Networks and Self-Regulated Learning in biomedical engineering

Biomedical Engineering Education

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biomedical engineering Education 2025年 1-22页

作者： Luo, Linlin Tise, Joseph C. Patterson, Megan S. Alge, Daniel L. Hernandez, Paul R. Department of Teaching Learning & Culture Texas A&M University College Station USA Department of Health Behavior Texas A&M University College Station USA Department of Biomedical Engineering & Department of Materials Science and Engineering Texas A&M University College Station USA

The present study explored relationships between social network position, SRL, and academic achievement among biomedical engineering (BME) students. A cohort of undergraduate students (n = 107) entering their first year in the BME major participated in an online survey that asked about their demographic information, mentorship-based social capital, SRL strategies and motivational beliefs, and academic achievement. Participants were asked to nominate their friends and academic collaborators within the cohort. To determine how students’ positions within the peer social networks correlated with SRL and achievement, quadratic assignment procedures (QAPs) were conducted at the bivariate and multivariate levels. Centrality within academic collaboration and friendship networks was related to greater use of peer-learning strategies, higher regulation of cognition, and higher GPAs. Centrality within the friendship network was also associated with higher BME self-efficacy. In line with social-cognitive views of SRL, this exploratory study showed that students’ positions in their peer networks (social/contextual factors) were related to SRL and GPA (personal and behavioral factors). Specifically, on average, students positioned more centrally within their networks had higher GPAs and SRL strategy use.

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Optimized Silicon Nitride-Based Passive Components for 850 nm OCT on Photonic Chips

Optimized Silicon Nitride-Based Passive Components for 850 n...

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2024 Laser science, LS 2024

作者： Meng, Jiawei Hao, Senyue Adkins, Aaron J. Zhou, Weiyan Zhou, Chao Department of Biomedical Engineering Washington University in St. Louis St. LouisMO63130 United States Department of Electrical & Systems Engineering Washington University in St. Louis St. LouisMO63130 United States Imaging Science PhD Program Washington University in St. Louis St. LouisMO63130 United States

For optical coherence tomography (OCT) on photonic chips, we designed and validated optimized silicon nitride-based passive components for photonic integrated circuits. Centered at 850 nm, these components offer high ... 详细信息

关键词： Silicon nitride

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