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Mesenchymal stromal cell-derived small extracellular vesicles modulate macrophage polarization and enhance angio-osteogenesis to promote bone healing

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Genes & Diseases 2022年第4期9卷 841-844页

作者： Shang Jiunn Chuah Chee Weng Yong Kristeen Ye Wen Teo Jacob Ren Jie Chew Yi Ann Cheow Shipin Zhang Raymond Chung Wen Wong Asher Ah Tong Lim Sai Kiang Lim Wei Seong Toh Faculty of Dentistry National University of Singapore119085Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research138648Singapore Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119288Singapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore117583Singapore Tissue Engineering Program Life Sciences InstituteNational University of Singapore117456Singapore Integrative Sciences and Engineering Program NUS Graduate SchoolNational University of Singapore119077Singapore

Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical *** MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.

关键词： healing clinical macrophage

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Impact of Electrical Current Stressing on ?'-Cu6Sn5 in Electronics Packaging 19

Impact of Electrical Current Stressing on ?'-Cu6Sn5 in Elect...

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19th International Microsystems, Packaging, Assembly and Circuits Technology Conference, IMPACT 2024

作者： Mukherjee, Shubhayan Lin, Shih-Kang National Cheng Kung University Department of Materials Science and Engineering Tainan70101 Taiwan Research Center Tainan70101 Taiwan Academy of Innovative Semiconductor and Sustainable Manufacturing National Cheng Kung University Program on Smart and Sustainable Manufacturing Tainan70101 Taiwan

ISBN: (纸本)9798331532246

In advanced electronic packaging, the stability of intermetallic compounds (IMCs) under high electric current density is crucial for the reliability of solder joints. Cu6Sn5, a predominant IMC formed between Sn-based solders and Cu substrates, exists in two allotropes: the high-temperature hexagonal phase and the low-temperature monoclinic ?' phase, with a transition temperature of 186°C. This study investigates the effects of electric current on ?'-Cu6Sn5 phase, focusing on structural characterization and mechanical properties. Various electric current densities were applied to thermally aged ?'-Cu6Sn5. Synchrotron radiation-based X-ray diffraction (SR-XRD) was used to examine crystallographic changes, while nanoindentation tests assessed mechanical property alterations. These observations contribute to understanding the impact of electric current density on the structural and mechanical behavior of the monoclinic ?'-Cu6Sn5 phase. © 2024 IEEE.

关键词： Synchrotron radiation

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Degradation of differently processed Mg-based implants leads to distinct foreign body reactions(FBRs)through dissimilar signaling pathways

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Journal of Magnesium and Alloys 2023年第6期11卷 2106-2124页

作者： Xiaosong Liu Guoqiang Chen Xiongxiong Zhong Tianfang Wang Xiaohong He Weipeng Yuan Pingping Zhang Ying Liu Dongming Cao Shu Chen Ken-ichi Manabe Zhengyi Jiang Tsuyoshi Furushima Damon Kent Yang Chen Guoying Ni Mingyong Gao Hejie Li Cancer Research Institute First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Rheumatology First People’s Hospital of FoshanFoshanGuangdong 528000China The Second Clinical Medical College of Jinan University Shenzhen People’s HospitalShenzhenGuangdong 510632China Genecology Research Centre University of the Sunshine CoastMaroochydore BCQLD 4558Australia Department of Medical Imaging First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Surgery First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Mechanical Engineering Graduate School of Science and EngineeringTokyo Metropolitan University1-1 Minami-osawaHachiojiTokyo 192-0397Japan School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering and Information SciencesUniversity of WollongongNorthfields AveWollongong NSW 2522Australia Institute of Industrial Science Department of Mechanical and Biofunctional Systemsthe University of Tokyo4-6-1KomabaMeguroTokyo 153-8505Japan School of Science Technology and EngineeringUniversity of the Sunshine CoastMaroochydore BCQLD 4558Australia

Mg alloys have mechanical properties compatible with human ***,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human *** this study,three differently processed Mg alloys,pure Mg(PM),cold extruded Mg alloy AZ31(CE AZ31),and fully annealed AZ31 Mg alloy(FA AZ31)were comparatively investigated for their potential as implants using a rat *** three implanted Mg alloys do not show any impact on hepato-and renal function,nor any signs of observable changes to vital *** analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways;while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array ***,FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured ***,EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated(10–11){10–1–2}grain texture with a value of 0.25,while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17,*** is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in *** conclusion,the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.

关键词： Toxicity test Proteomics analysis Signaling pathway Biocompatibility and corrosion resistance First-order pyramidal slip system Recovery and recrystallization Foreign body reactions(FBRs)

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Enhancing wound healing and adhesion through dopamine-assisted gelatin-silica hybrid dressings

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International Journal of Biological Macromolecules 2024年第Part2期258卷 128845页

作者： Lin, Yu-Chien Wang, Huey-Yuan Tang, Yao-Chun Lin, Wan-Rong Tseng, Ching-Li Hu, Chih-Chien Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei10608 Taiwan School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore639798 Singapore Department of Stomatology MacKay Memorial Hospital Taipei104217 Taiwan Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Research Center of Biomedical Device College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan International Ph. D. Program in Cell Therapy and Regenerative Medicine College of Medicine Taipei Medical University Taipei11031 Taiwan Bone and Joint Research Center Chang Gung Memorial Hospital Linkou33305 Taiwan Taipei10608 Taiwan

Gelatin, widely employed in hydrogel dressings, faces limitations when used in high fluid environments, hindering effective material adhesion to wound sites and subsequently reducing treatment efficacy. The rapid degradation of conventional hydrogels often results in breakdown before complete wound healing. Thus, there is a pressing need for the development of durable adhesive wound dressings. In this study, 3-glycidoxypropyltrimethoxysilane (GPTMS) was utilized as a coupling agent to create gelatin-silica hybrid (G-H) dressings through the sol-gel method. The coupling reaction established covalent bonds between gelatin and silica networks, enhancing structural stability. Dopamine (DP) was introduced to this hybrid (G-H-D) dressing to further boost adhesiveness. The efficacy of the dressings for wound management was assessed through in-vitro and in-vivo tests, along with ex-vivo bioadhesion testing on pig skin. Tensile bioadhesion tests demonstrated that the G-H-D material exhibited approximately 2.5 times greater adhesion to soft tissue in wet conditions compared to pure gelatin. Moreover, in-vitro and in-vivo wound healing experiments revealed a significant increase in wound healing rates. Consequently, this material shows promise as a viable option for use as a moist wound dressing. © 2023

关键词： Adhesion

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SiO2-reinforced Poly (methyl methacrylate): Tribology Performance as Service Life Sensor

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Sensors and materials 2023年第8-2期35卷 2845-2854页

作者： Shi, Shih-Chen Zeng, Xin-Xing Chen, Tao-Hsing Wang, Chih-Chia Lin, Yue-Feng Department of Mechanical Engineering National Cheng Kung University No. 1 University Road Tainan City70101 Taiwan Department of Mechanical Engineering National Kaohsiung University of Science and Technology No. 415 Jiangong Rd. Sanmin Dist. Kaohsiung City807618 Taiwan Department of Chemical and Materials Engineering Chung Cheng Institute of Technology National Defense University No. 75 Shiyuan Road Taoyuan335009 Taiwan System Engineering and Technology Program National Yang Ming Chiao Tung University No. 1001 University Road Hsinchu300093 Taiwan Department of Mechanical Engineering National Chin-Yi University of Technology No. 57 Sec. 2 Zhongshan Rd. Taiping Dist. Taichung411030 Taiwan

Poly (methyl methacrylate) (PMMA), which is suitable for use in the human body owing to its biocompatibility, is commonly used in medical applications such as bone nails, bone cement, and dentures. However, owing to its hard and brittle nature, PMMA can cause damage when it is subjected to excessive stress and can also cause severe wear. In this study, three different sizes of silica particles were used as reinforcing additives to enhance the wear resistance of PMMA composites. A pin-on-disk wear test was conducted to record the coefficient of friction and wear volume, and the wear volume was measured using a 3D laser scanning microscope. In the wear test, the transfer film of micron and submicron particles produced a plowing effect, resulting in wide grooved wear scars and a higher wear rate than the raw material. The nanoparticle transfer film reduced direct material wear, the wear scars were fine and flat, and the wear rate was decreased, reducing the wear of SiO2-reinforced PMMA composites by 40%. The experimental results revealed that the wear volume is proportional to the wear time. In addition, the observed area of the transfer film on the wear counterpart can be used as a service life sensor of the coating material. © MYU K.K.

关键词： Tribology

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Optics‑guided Robotic System for Dental Implant Surgery

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Chinese Journal of Mechanical engineering 2022年第3期35卷 135-147页

作者： Biao Yan Wenlong Zhang Lijing Cai Lingxiang Zheng Kaiyang Bao Yuming Rao Lin Yang Weitao Ye Peifeng Guan Wei Yang Jiang Li Rongqian Yang School of Materials Science and Engineering South China University of TechnologyGuangzhouChina RD Department Shenzhen SONTU Medical Imaging Equipment Co.LtdShenzhenChina Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Aimooe Technology Co. LtdGuangzhouChina School of Biomedical Engineering Southern Medical UniversityGuangzhouChina Department Prosthodontics School of StomatologyGuangzhou Medical UniversityGuangzhouChina

At present,dental implant surgery mainly relies on the clinical experience of the doctor and the assistance of preoperative medical ***,there are some problems in dental implant surgery,such as narrow space,sight obstruction,inaccurate positioning,and high requirements of doctors’***,a dental implant robot system(DIRS)guided by optical navigation is developed in this study,with an x-shaped tool and an irregular pentagonal tracer are designed for spatial registration and needle tip positioning strategy *** coordinate system of each unit in DIRS is unified through system calibration,spatial registration,and needle tip positioning *** the surgical path is planned on the computed tomography(CT)images in the navigation software before *** automatic positioning method and the auxiliary positioning method can be used in the operation to achieve accurate positioning and assist doctors to complete the *** errors of spatial registration,needle tip positioning strategy,and the overall accuracy of the system were evaluated respectively,and the results showed that they all met the needs of clinical *** study preliminarily verified the feasibility of the precise positioning method for dental surgery robots and provided certain ideas for subsequent related research.

关键词： Dental implant surgery Robot system Calibration Registration

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Subsurface intercalation activating basal plane of black phosphorus for nitrogen reduction

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Journal of Energy Chemistry 2021年第9期30卷 293-299页

作者： Xue Zhang Haitao Zhao Paul K.Chu Jiahong Wang Xue-Feng Yu Shenzhen Engineering Center for the Fabrication of Two-Dimensional Atomic Crystals Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina

Ammonia(NH3)is not only an important chemical in many fields,but also provides a promising intermediate for energy stor-age[1,2].To produce NH3 from naturally abundant N2,the strong N≡N bond in the inert N2 molecules... 详细信息

关键词： Subsuface intercalation Nitrogen reduction reaction Basal surface sites Intrinsic activity Selectivity

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Analysis of a Casimir-driven parametric amplifier with resilience to Casimir pull-in for MEMS single-point magnetic gradiometry

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Microsystems & Nanoengineering 2021年第5期7卷 183-193页

作者： Josh Javor Zhancheng Yao Matthias Imboden David K.Campbell David J.Bishop Department of Mechanical Engineering Boston UniversityBostonMA 02215USA Division of Materials Science and Engineering Boston UniversityBostonMA 02215USA K-MEMS St.BlaiseSwitzerland Department of Electrical Engineering Boston UniversityBostonMA 02215USA Department of Physics Boston UniversityBostonMA 02215USA Department of Biomedical Engineering Boston UniversityBostonMA 02215USA

The Casimir force,a quantum mechanical effect,has been observed in several microelectromechanical system(MEMS)*** to its extreme sensitivity to the separation of two objects,the Casimir force has been proposed as an excellent avenue for quantum *** application,however,is challenging due to attractive forces leading to stiction and device failure,called Casimir *** this work,we design and simulate a Casimir-driven metrology platform,where a time-delay-based parametric amplification technique is developed to achieve a steady-state and avoid *** apply the design to the detection of weak,low-frequency,gradient magnetic fields similar to those emanating from ionic currents in the heart and *** parameters are selected from recent experimental platforms developed for Casimir metrology and magnetic gradiometry,both on MEMS *** a MEMS offers many advantages to such an application,the detected signal must typically be at the resonant frequency of the device,with diminished sensitivity in the low frequency regime of biomagnetic *** a Casimir-driven parametric amplifier,we report a 10,000-fold improvement in the best-case resolution of MEMS single-point gradiometers,with a maximum sensitivity of 6 Hz/(pT/cm)at 1 *** development of the proposed design has the potential to revolutionize metrology and may specifically enable the unshielded monitoring of biomagnetic fields in ambient conditions.

关键词： parametric Casimir apply

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Characterization of Anisotropic Lattice Structured Phantoms Using 3D-Rotational Shear Wave Elasticity Imaging (3D-RSWEI)

Characterization of Anisotropic Lattice Structured Phantoms ...

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IEEE International Symposium on Applications of Ferroelectrics (ISAF)

作者： Shruthi Srinivasan Daniel Yoon Margrethe Ruding Kevin Eckstein Ned C. Rouze Wren E. Wightman Mark L. Palmeri David P. Bradway Derek Y. Chan Kaden D. Bock Philip V. Bayly Kathryn R. Nightingale Department of Biomedical Engineering Duke University Durham NC United States Mechanical Engineering and Materials Science Washington University St. Louis MO United States

ISBN: (数字)9798350371901

ISBN: (纸本)9798350371918

We present a 3D-RSWEI characterization of anisotropic lattice phantoms. Shear wave speeds versus rotational angle were measured while the lattices were submerged in water and after embedding in a softer, isotropic polyvinyl alcohol cryogel. In both cases, shear wave propagation was anisotropic and fit to an ellipse, with faster wave speeds observed along the material symmetry direction. Measured shear wave speeds and shear anisotropy decreased between lattices in water versus embedded in PVA. Linear wave dispersion slopes were higher along versus across the material symmetry direction. Measured speed of sound was higher and acoustic attenuation was lower than that of biological tissue. These results showcase applicability of 3D-RSWEI to characterize novel anisotropic lattice phantoms.

关键词： Fabrication Protocols Anisotropic magnetoresistance Lattices Phantoms Anisotropic NIST Imaging phantoms Acoustics Dispersion

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An Investigation of Cu/Ni/Ga Interfacial Reaction with Different Ni/Ga Ratio 23

An Investigation of Cu/Ni/Ga Interfacial Reaction with Diffe...

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23rd International Conference on Electronics Packaging, ICEP 2024

作者： Huang, Tzu-Hsuan Huang, Jian-Wei Lin, Zhih-Feng Lin, Shih-Kang National Cheng Kung University Department Of Materials Science And Engineering Tainan70101 Taiwan Research Center Tainan70101 Taiwan National Cheng Kung University Program On Smart And Sustainable Manufacturing Academy Of Innovative Semiconductor And Sustainable Manufacturing Tainan70101 Taiwan

ISBN: (纸本)9784991191176

In this article, we utilized electroplating method forming Cu/Ni/Ga structure. Interfacial reaction was investigated with different ratio of Ni: Ga 7:3 and 1:20. The result showed that Ga reacted with the substrates immediately as plated forming NiGas and CuGa2 compound respectively in different ratio of Ni: Ga. IMCs transformed into Ni2Ga3and Cu31.3Ga16.3 respectively after 300°C heat treatment. This research explored a new optimizing idea in developing Ga TLP bonding technology. © 2024 Japan Institute of Electronics Packaging.

关键词： Electroplating

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