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Bioresource Upgrade for Sustainable Energy,Environment,and Biomedicine

Nano-Micro Letters 2023年第3期15卷 48-97页

作者： Fanghua Li Yiwei Li KSNovoselov Feng Liang Jiashen Meng Shih‑Hsin Ho Tong Zhao Hui Zhou Awais Ahmad Yinlong Zhu Liangxing Hu Dongxiao Ji Litao Jia Rui Liu Seeram Ramakrishna Xingcai Zhang Center for Nanofibers and Nanotechnology National University of SingaporeSingapore 119260Singapore State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090People’s Republic of China School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics–Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei 430074People’s Republic of China Centre for Advanced 2D Materials National University of SingaporeSingapore 117546Singapore School of Physics and Astronomy The University of ManchesterManchester M139PLUK Department of Anesthesia Critical Care and Pain MedicineMassachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Departamento de Quimica Organica Universidad de CordobaEdificio Marie Curie(C‑3)Ctra Nnal IV‑AKm 39614014 CordobaSpain Department of Chemical Engineering Monash UniversityClaytonVIC 3800Australia School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

We conceptualize bioresource upgrade for sustainable energy,environment,and biomedicine with a focus on circular economy,sustainability,and carbon neutrality using high availability and low utilization biomass(HALUB).We acme energy-efficient technologies for sustainable energy and material recovery and *** technologies of thermochemical conversion(TC),biochemical conversion(BC),electrochemical conversion(EC),and photochemical conversion(PTC)are summarized for *** biomass could contribute to a biofuel HHV of 35.72 MJ Kg^(-1)and total benefit of 749$/ton biomass via *** surface area of biochar reached 3000 m^(2)g^(-1)via pyrolytic carbonization of waste bean *** biomass can be effectively converted into bio-stimulants and biofertilizers via BC with a high conversion efficiency of more than 90%.Besides,lignocellulosic biomass can contribute to a current density of 672 mA m^(-2)via *** can be 100%selectively synthesized via electrocatalysis through EC and *** learning,techno-economic analysis,and life cycle analysis are essential to various upgrading approaches of *** biomaterials,sustainable living materials and technologies for biomedical and multifunctional applications like nano-catalysis,microfluidic and micro/nanomotors beyond are also *** techniques and systems for the complete conversion and utilization of HALUB for new energy and materials are further discussed.

关键词： High availability low utilization biomass(HALUB) Circular economy Machine learning Energy-efficient conversion Nano-catalysis

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Identifying Prognostic Markers of Non-small Cell Lung Carcinoma Using Bioinformatics

Identifying Prognostic Markers of Non-small Cell Lung Carcin...

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International Conference on Industrial Instrumentation and Control,ICI2C 2021

作者： Khan, Siladitya Chakraborty, Debamitra Department of Biomedical Engineering University of Rochester RochesterNY14627 United States Goergen Institute for Data Science University of Rochester RochesterNY14627 United States Materials Science Graduate Program University of Rochester RochesterNY14627 United States

ISBN: (纸本)9789811670107

We present a transcriptomics pipeline for performing the functional analysis of array expression profiling data of normal and adenocarcinoma lung tissue. Our aims are twofold, firstly to elucidate molecular processes that transform normal tissue, to a lung adenocarcinoma. Following this, we perform functional analysis to screen potential hub genes and demonstrate their value in cancer prognosis. Analysis was performed on a total of 500 differentially expressed genes (DEG), screened for their regulation and transcriptional modulation in a female population carrying non–small cell lung carcinoma (NSCLC). Key pathways like cytokine-cytokine receptors, ECM receptor interactions, and TNF signaling were identified suggesting a potential role in lung tumorigenesis. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

关键词： Bioinformatics

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Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-Sung Jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

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肝纤维化治疗:从传统方法到纳米材料递送系统

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science Bulletin 2024年第12期69卷 1829-1832页

作者：陈琳段禹姜婷婷毛春朱新华万密密 National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China Department of Hepatobiliary Surgery Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210093China

Liver diseases seriously affect human *** dysfunction-associated steatohepatitis(MASH)is a highly prevalent chronic liver disease that has a global prevalence of 32.4%,but this is increasing at an alarming rate[1].Cirrhosis is the 11th most common cause of death worldwide,and there was a 47%increase in mortality between 2010 and 2021[2].

关键词：递送系统 mortality Liver

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Neuro-Regenerative Behavior of Adipose-Derived Stem Cells in Aligned Collagen I Hydrogels

SSRN

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SSRN 2023年

作者： Lewis, Mackenzie David, Gabriel Jacobs, Danielle Woessner, Alan E. Kuczwara, Patrick Kim, Jin-Woo Quinn, Kyle P. Song, Younghye Department of Biomedical Engineering University of Arkansas FayettevilleAR United States Department of Biological & Agricultural Engineering University of Arkansas FayettevilleAR United States Materials Science & Engineering Program University of Arkansas FayettevilleAR United States

Peripheral nerve injuries persist as a major clinical issue facing the US population and can be caused by stretch, laceration, or crush injuries. Small nerve gaps are simple to treat, and the nerve stumps can be reattached with sutures. In longer nerve gaps, traditional treatment options consist of autografts, hollow nerve guidance conduits, and, more recently, manufactured fibrous scaffolds. These manufactured scaffolds often incorporate stem cells, growth factors, and/or extracellular matrix (ECM) proteins to better mimic the native environment but can have issues with homogenous cell distribution or uniformly oriented neurite outgrowth in scaffolds without fibrous alignment. Here, we utilize a custom device to fabricate collagen I hydrogels with aligned fibers and encapsulated adipose-derived mesenchymal stem cells (ASCs) for potential use as a peripheral nerve repair graft. Analysis of these scaffolds in vitro revealed heightened therapeutic secretome from ASCs, ECM deposition, and dorsal root ganglia (DRG) neurite outgrowth along the axis of fiber alignment. Our platform serves as an in vitro testbed platform to assess neuro-regenerative potential of ASCs in aligned collagen fiber scaffolds and may provide guidance on next-generation nerve repair scaffold design. © 2023, The Authors. All rights reserved.

关键词： Collagen

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Mo-terminated edges in two-dimensional molybdenum disulfide for site-specific hydrolysis and DNA cleavage

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materials Today 2025年 86卷 162-171页

作者： Wang, Cong Wu, Menghan Li, Muqing Zhao, Yingcan Zhao, Mingchuang Zhang, Yunhao Bai, Yichao Gao, Jianxiang Wang, Xiaoxia Tian, Xilin Zhang, Han Chang, Liang Zou, Xiaolong Liu, Bilu Kang, Feiyu Terrones, Mauricio Lei, Yu Institute of Materials Research Shenzhen Key Laboratory of Advanced Layered Materials for Value-added Applications Guangdong Provincial Key Laboratory of Thermal Management Engineering and Materials & Center of Double Helix Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Institute of Materials Research & Shenzhen Geim Graphene Center Shenzhen Key Laboratory of Advanced Layered Materials for Value-added Applications Tsinghua-Berkeley Shenzhen Institute and Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Environmental Science Program Department of Life Sciences Beijing Normal University-Hong Kong Baptist University United International College Guangdong519087 China Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen518055 China Department of Physics Department of Chemistry Department of Materials Sciences Center for 2-Dimensional and Layered Materials The Pennsylvania State University University ParkPA16802 United States International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale Optoelectronics Shenzhen University Shenzhen518060 China

The hydrolysis of DNA serves as the foundational principle for gene engineering that enable precise gene cleavage at the molecular level. This process typically occurs in biological nucleases, which exhibit nucleobase-selective and catalytic hydrolysis capabilities rarely replicated in abiotic nanomaterials. Here, we demonstrate that molybdenum-terminated (Mo-terminated) edges of molybdenum disulfide (MoS2) possess the unique ability to abstract a proton (H+) from water molecules, thereby facilitating catalytic hydrolysis reactions that cleave the phosphodiester bonds in DNA through the action of hydroxide ions. The enhanced proton absorption at Mo-terminated edges of MoS2 significantly reduces the activation energy required for the DNA hydrolysis reaction. Furthermore, the favorable interaction between the Mo-terminated edges and thymine nucleobases promotes both charge transfer and P-O bond cleavage, enabling targeted DNA hydrolysis at 'TTTTTTT' sequences under dark conditions. This discovery underscores the potential of MoS2 as a stable, efficient nanosystem for precise genetic editing, heralding advanced applications in the field of gene engineering. © 2025 The Author(s)

关键词： Activation energy

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Atomistic modeling and rational design of optothermal tweezers for targeted applications

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Nano Research 2021年第1期14卷 295-303页

作者： Hongru Ding Pavana Siddhartha Kollipara Linhan Lin Yuebing Zheng Walker Department of Mechanical Engineering The University of Texas at AustinAustinTX 78712USA State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China Materials Science&Engineering Program and Texas Materials Institute The University of Texas at AustinAustinTX 78712USA

Optical manipulation of micro/nanoscale objects is of importance in life sciences,colloidal science,and *** tweezers exhibit superior manipulation capability at low optical ***,our implicit understanding of the working mechanism has limited the further applications and innovations of optothermal ***,we present an atomistic view of opto-thermo-electro-mechanic coupling in optothermal tweezers,which enables us to rationally design the tweezers for optimum performance in targeted ***,we have revealed that the non-uniform temperature distribution induces water polarization and charge separation,which creates the thermoelectric field dominating the optothermal *** further design experiments to systematically verify our atomistic *** by our new model,we develop new types of optothermal tweezers of high performance using low-concentrated ***,we demonstrate the use of new tweezers in opto-thermophoretic separation of colloidal particles of the same size based on the difference in their surface charge,which has been challenging for conventional optical *** the atomistic understanding that enables the performance optimization and function expansion,optothermal tweezers will further their impacts.

关键词： optothermal tweezers optical tweezers optical manipulation thermophoresis molecular dynamics simulation

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Undulating Seal Whiskers Evolved Optimal Wavelength-to-Diameter Ratio for Efficient Reduction in Vortex-Induced Vibrations (Adv. Sci. 2/2024)

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ADVANCED science 2024年第2期11卷 e2304304页

作者： Kamat, Amar M. Zheng, Xingwen Bos, Julian Cao, Ming Triantafyllou, Michael S. Kottapalli, Ajay Giri Prakash Bioinspired MEMS and Biomedical Devices Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands Discrete Technology and Production Automation Group Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands Department of Mechanical Engineering Massachusetts Institute of Technology (MIT) Cambridge MA USA MIT Sea Grant College Program Massachusetts Institute of Technology (MIT) Cambridge MA USA Bioinspired MEMS and Biomedical Devices Engineering and Technology Institute Groningen Faculty of Science and Engineering University of Groningen Groningen The Netherlands MIT Sea Grant College Program Massachusetts Institute of Technology (MIT) Cambridge MA USA

Seals are well-known for their remarkable hydrodynamic trail-following capabilities made possible by undulating flow-sensing whiskers that enable the seals to detect fish swimming as far as 180 m away. In this work, the form-function relationship in the undulating whiskers of two different phocid seal species, viz. harbor and gray seals, is studied. The geometry and material properties of excised harbor and grey seal whiskers are systematically characterized using blue light 3D scanning, optical and scanning electron microscopy, and nanoindentation. The effect of the undulating geometry on the whiskers’ vibration in uniform water flow is studied using both experimental (piezoelectric MEMS and 3D-printed piezoresistive sensors developed in-house) and numerical (finite element method) techniques. The results indicate that the dimensionless ratio of undulation wavelength to mean whisker diameter (λ/Dm) in phocid seals may have evolved to be in the optimal range of 4.4–4.6, enabling an order-of-magnitude reduction in vortex-induced vibrations (compared to a similarly-shaped circular cylinder) and, consequently, an enhanced flow sensing capability with minimal self-induced noise. The results highlight the importance of the dimensionless λ/Dm ratio in the biomimetic design of seal whisker-inspired vibration-resistant structures, such as marine risers and wake detection sensors for submarines.

关键词： 3D printing biological fluid dynamics biomimetics microelectromechanical systems (MEMS) seal whiskers vortex-induced vibrations

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Study Of The Influence Of Milling Time On The Synthesis Temperature Of Monoclinic And Orthorhombic Nanostructured Cunb2o6 Via High-Energy Milling

Study Of The Influence Of Milling Time On The Synthesis Temp...

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Euro Powder Metallurgy 2023 Congress and Exhibition, PM 2023

作者： Gomes, Uilame Umbelino de Araújo, Kívia Fabiana Galvão José, Maria Lima, Santos De Souza, Vitor Manoel Silva Fernandes da Silva Lourenço, Cléber Raimundo, Rafael Alexandre Materials Science and Engineering Postgraduate Program Federal University of Rio Grande do Norte Natal59078-970 Brazil Department of Physics Federal University of Paraíba João Pessoa58051-900 Brazil

Copper niobate (CuNb2O6) has been studied for technological and environmental applications, such as in solar cells and photocatalysts, for example. And to make the application of CuNb2O6 even more feasible, in this study, therefore, high-energy milling was applied in its synthesis process with variation in the milling time, from the precursor powders Nb2O5 and CuO. The calcination occurred in a muffle with temperatures in the range of 500 °C to 1000 °C, for 3 h and heating rate of 5 °/min. Then, the powders were characterized by XRD, SEM, EDS and Raman. The powders showed crystallite sizes smaller than 80 nm, good homogeneity and high purity. The particle morphologies and the Raman spectrum are coherent with the literature. It was also verified that the increase in milling time reduced the initial formation temperature of the monoclinic phase and the calcination time for the complete formation of the orthorhombic phase. © European Powder Metallurgy Association (EPMA)

关键词： Mechanical alloying

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Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

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npj Flexible Electronics 2023年第1期7卷 119-130页

作者： Kiho Kim In Sik Min Tae Hee Kim Do Hyeon Kim Seungwon Hwang Kyowon Kang Kyubeen Kim Sangun Park Jongmin Lee Young Uk Cho Jung Woo Lee Woon-Hong Yeo Young Min Song Youngmee Jung Ki Jun Yu Functional Bio-integrated Electronics and Energy Management Lab School of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and Collaboration Biomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and Computer Science(EECS) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1 Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D Center DNA Lab PharmaresearchSeongnam 13486Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 136-705Republic of Korea School of Materials Science and Engineering Energy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

关键词： optoelectronic enable battery

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