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Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy(PAR-SIM)

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Light(science & Applications) 2024年第6期13卷 1140-1158页

作者： Xinzhu Xu Wenyi Wang Liang Qiao Yunzhe Fu Xichuan Ge Kun Zhao Karl Zhanghao Meiling Guan Xin Chen Meiqi Li Dayong Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China Wallace H.Coulter Dept.of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlanta30332GAUSA National Biomedical Imaging Center Peking UniversityBeijing100871China Department of Biomedical Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055GuangdongChina Airy Technologies Co. Ltd.Beijing100086China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315200China School of Life Science Peking UniversityBeijing100871China Institute for Biomedical Materials and Devices(IBMD) Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia

Structured illumination microscopy(SIM)has emerged as a promising super-resolution fluorescence imaging technique,offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological *** efforts to enhance system frame rates have concentrated on processing algorithms,like rolling reconstruction or reduced frame reconstruction,or on investments in costly sCMOS cameras with accelerated row readout *** this article,we introduce an approach to elevate SIM frame rates and region of interest(ROI)coverage at the hardware level,without necessitating an upsurge in camera expenses or intricate ***,parallel acquisition-readout SIM(PAR-SIM)achieves the highest imaging speed for fluorescence imaging at currently available detector *** using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process,we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels·s^(−1),9.6-fold that of the latest techniques,with the lowest SNR of−2.11 dB and 100 nm ***-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations,even under conditions of low signal due to ultra-short exposure ***,mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell,recorded with PAR-SIM at an impressive 408 *** posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

关键词： hardware illumination resolution

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Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration

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Regenerative Biomaterials 2024年第5期3卷 49-58页

作者： Kui Wang Yongmei Ge Yongshuai Yang Zhenjian Li Jiayi Liu Yizebang Xue Yuanjun Zhang Xiangchao Pang A.H.W.Ngan Bin Tang Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering University of Hong KongHong Kong 999077China Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research Shenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China College of Materials Science and Engineering Central South University of Forestry and TechnologyChangsha 410004China

Diabetes is one of the most prevalent diseases *** tissue regeneration of diabetes patients is known to be rather tricky as the result of vascular dysfunction,and this leads to various clinical complications including diabetic foot *** vascular endothelial cells,which compactly line the inner surface of blood vessels,are responsible for the growth and maintenance of blood vessels and play an essential role in tissue *** the mechanical properties of cells are generally known to be regulated by physiological/pathological conditions,few studies have been performed to investigate vascular endothelial cellular mechanics under hyperglycemia and the biological functions related to tissue *** this study,we conduct a systematic investigation of this *** results suggested that the stiffness of human umbilical vein endothelial cells(HUVECs)can be significantly regulated by the glucose concentration,subsequently,leading to significant alterations in cell migration and proliferation capabilities that are closely related to tissue *** rearrangement of the cytoskeleton induced by hyperglycemia through Cdc42 was found to be one of the pathways for the alteration of the cell stiffness and the subsequent cell ***,we suggested that the inhibition of Cdc42 might be a promising strategy to facilitate various tissue regeneration for diabetes patients.

关键词： endothelial cell hyperglycemia stiffness migration Cdc42

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Displacement-pressure biparametrically regulated softness sensory system for intraocular pressure monitoring

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National science Review 2024年第6期11卷 159-168页

作者： Yu Cheng Yifei Zhan Fangyi Guan Junli Shi Jingxiao Wang Yi Sun Muhammad Zubair Cunjiang Yu Chuan Fei Guo Department of Materials Science and Engineering Southern University of Science and Technology Department of Engineering Science and Mechanics Pennsylvania State University Department of Biomedical Engineering Pennsylvania State University Department of Materials Science and Engineering Materials Research Institute Pennsylvania State University

High intraocular pressure(IOP) is one of the high-risk pathogenic factors of glaucoma. Existing methods of IOP measurement are based on the direct interaction with the cornea. Commercial ophthalmic tonometers based on snapshot measurements are expensive, bulky, and their operation requires trained *** contact lenses are easy to use, but they may block vision and cause infection. Here, we report a sensory system for IOP assessment that uses a soft indentor with two asymmetrically deployed iontronic flexible pressure sensors to interact with the eyelid-eyeball in an eye-closed situation. Inspired by human fingertip assessment of softness, the sensory system extracts displacement-pressure information for soft evaluation, achieving high accuracy IOP monitoring(>96%). We further design and custom-make a portable and wearable ophthalmic tonometer based on the sensory system and demonstrate its high efficacy in IOP screening. This sensory system paves a way towards cost-effective, robust, and reliable IOP monitoring.

关键词： intraocular pressure tonometer deep learning softness iontronic sensor

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High-fidelity and clean nanotransfer lithography using structure-embedded and electrostatic-adhesive carriers

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Microsystems & Nanoengineering 2023年第1期9卷 253-261页

作者： Zhuofei Gan Jingxuan Cai Zhao Sun Liyang Chen Chuying Sun Junyi Yu Zeyu Liang Siyi Min Fei Han Yu Liu Xing Cheng Shuhui Yu Dehu Cui Wen-Di Li Department of Mechanical Engineering University of Hong KongHong KongChina School of Microelectronics Southern University of Science and TechnologyShenzhenChina School of Biomedical Engineering Sun Yat-sen UniversityGuangzhouChina The Shenzhen Institute of Advanced Electronic Materials Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenChina Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhenChina

Metallic nanostructures are becoming increasingly important for both fundamental research and practical *** emerging applications employing metallic nanostructures often involve unconventional substrates that are flexible or nonplanar,making direct lithographic fabrication very *** alternative approach is to transfer prefabricated structures from a conventional substrate;however,it is still challenging to maintain high fidelity and a high yield in the transfer *** this paper,we propose a high-fidelity,clean nanotransfer lithography method that addresses the above challenges by employing a polyvinyl acetate(PVA)film as the transferring carrier and promoting electrostatic adhesion through triboelectric *** PVA film embeds the transferred metallic nanostructures and maintains their spacing with a remarkably low variation of<1%.When separating the PVA film from the donor substrate,electrostatic charges are generated due to triboelectric charging and facilitate adhesion to the receiver substrate,resulting in a high large-area transfer yield of up to 99.93%.We successfully transferred the metallic structures of a variety of materials(Au,Cu,Pd,etc.)with different geometries with a<50-nm spacing,high aspect ratio(>2),and complex 3D ***,the thin and flexible carrier film enables transfer on highly curved surfaces,such as a single-mode optical fiber with a curvature radius of 62.5μ*** this strategy,we demonstrate the transfer of metallic nanostructures for a compact spectrometer with Cu nanogratings transferred on a convex lens and for surface-enhanced Raman spectroscopy(SERS)characterization on graphene with reliable responsiveness.

关键词： transfer transferred film

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Rechargeable Multivalent-Ion Batteries

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Energy Material Advances 2024年第1期5卷 283-284页

作者： Juchen Guo Jennifer LSchaefer Yuyan Shao Department of Chemical and Environmental Engineering Materials Science and Engineering ProgramUniversity of CaliforniaRiversideRiversideCA 92521USA Department of Chemical and Biomolecular Engineering University of Notre DameNotre DameIN 46556USA Pacific Northwest National Laboratory RichlandWA 99352USA

Rechargeable batteries based on multivalent metal anodes including earth-abundant magnesium(Mg),calcium(Ca),zinc(Zn),and aluminum(Al)are potential new“beyond lithium(Li)”electrochemical energy storage technologies for large-scale energy storage *** multivalent elements are more earth abundant,and therefore promising candidates for reducing global dependence on Li for our growing energy storage *** the seminal work by Aurbach and coworkers[1]demonstrating the first prototype rechargeable Mg batteries,tremendous efforts have been made to the research and development of rechargeable multivalent-ion batteries.

关键词： energy storage calcium batteries rechargeable batteries multivalent elements multivalent metal anodes energy storage technologies magnesium batteries

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Engineered Janus hydrogels: biomimetic surface engineering and biomedical applications

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National science Review 2024年第10期11卷 350-367页

作者： Mingfei Pan Tao Shui Ziqian Zhao Li Xiang Bin Yan Ning Gu Hongbo Zeng Department of Chemical and Materials Engineering University of Alberta Changzhou Second People's Hospital Changzhou Medical Center Nanjing Medical University School of Materials Science and Engineering Southeast University School of Mechanical Engineering Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments Southeast University National Engineering Laboratory for Clean Technology of Leather Manufacture College of Biomass Science and Engineering Sichuan University Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Institute of Clinical Medicine Nanjing Drum Tower Hospital Medical School Nanjing University

Hydrogel bioadhesives, when applied to dysfunctional tissues substituting the epidermis or endothelium,exhibit compelling characteristics that enable revolutionary diagnostic and therapeutic procedures. Despite their demonstrated efficacy, these hydrogels as soft implants are still limited by improper symmetric surface functions, leading to postoperative complications and disorders. Janus hydrogel bioadhesives with unique asymmetric surface designs have thus been proposed as a reliable and biocompatible hydrogel interface,mimicking the structural characteristics of natural biological barriers. In this comprehensive review, we provide guidelines for the rational design of Janus hydrogel bioadhesives, covering methods for hydrogel surface chemistry and microstructure engineering. The engineering of Janus hydrogels is highlighted,specifically in tuning the basal surface to facilitate instant and robust hydrogel-tissue integration and modulating the apical surface as the anti-adhesion, anti-fouling, and anti-wear barrier. These asymmetric designs hold great potential in clinical translation, supporting applications including hemostasis/tissue sealing, chronic wound management, and regenerative medicine. By shedding light on the potential of Janus hydrogels as bioactive interfaces, this review paper aims to inspire further research and overcome current obstacles for advancing soft matter in next-generation healthcare.

关键词： interfacial science bionics hydrogel bioadhesives asymmetric surfaces

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Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction

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Bioactive materials 2025年第3期45卷 71-87页

作者： Shuang Wang Chao Xu Yuanman Yu Jie Li Tianwu Chen Jing Wang Changsheng Liu Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of the Ministry of EducationEast China University of Science and TechnologyShanghai200237PR China Key Laboratory for Ultrafine Materials of Ministry of Education The State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai200237PR China Sports Medicine Department Huashan HospitalFudan UniversityShanghai200040PR China College of Materials Science and Engineering Wuhan Textile UniversityWuhan430200PR China

Polyethylene terephthalate(PET)artificial ligaments are widely used in anterior cruciate ligament(ACL)reconstruction due to their high tensile ***,bone tunnel enlargement around PET ligaments poses a risk for surgical ***’s inert surface,lower bioactivity,and mechanical abrasion trigger an M1 macrophage-mediated inflammatory response,leading to excessive,disorganized scar *** scar tissue creates a space-occupying effect at the interface,obstructing graft-bone integration and contributing to bone tunnel *** address this issue,we developed a multi-layered immune-regulating hydrogel coating for scar-free PET-bone *** gelatin methacrylate(GelMA),polyethyleneglycol diacrylate(PEGDA),and sulfated polysaccharide(SCS),the hydrogel forms a hydrogen-bonded lubricating layer to reduce *** sustained release of SCS also down-regulates M1 macrophage polarization,inhibiting early scar *** eliminating the space-occupying effect of scar tissue,SCS subsequently promotes M2 macrophage *** shift releases endogenous factors that enhance blood vessel formation and new bone growth,ultimately achieving high-quality graft-bone *** application of this multi-layered,inflammation-modulating hydrogel coating not only removes scar tissue barriers but also improves graft-bone integration through enhanced angiogenesis and ***,it avoids the overuse of exogenous growth factors and potential complications,offering a more convenient and feasible therapeutic strategy.

关键词： Anterior cruciate ligament Scar tissue Macrophages Angiogenesis Osteogenesis

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Wearable bioelectronics fabricated in situ on skins

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npj Flexible Electronics 2023年第1期7卷 229-243页

作者： Faheem Ershad Shubham Patel Cunjiang Yu Department of Biomedical Engineering Pennsylvania State UniversityUniversity ParkPA 16801USA Department of Engineering Science and Mechanics Pennsylvania State UniversityUniversity ParkPA 16801USA Department of Materials Science and Engineering Materials Research InstitutePennsylvania State UniversityUniversity ParkPA 16801USA

In recent years,wearable bioelectronics has rapidly expanded for diagnosing,monitoring,and treating various pathological conditions from the skin *** the devices are typically prefabricated as soft patches for general usage,there is a growing need for devices that are customized in situ to provide accurate data and precise *** this perspective,the stateof-the-art in situ fabricated wearable bioelectronics are summarized,focusing primarily on Drawn-on-Skin(DoS)bioelectronics and other in situ fabrication *** advantages and limitations of these technologies are evaluated and potential future directions are suggested for the widespread adoption of these technologies in everyday life.

关键词： everyday electronics typically

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Ceramicized NASICON-based solid-state electrolytes for lithium metal batteries

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Journal of Solid State Electrochemistry 2024年第7期28卷 2047-2057页

作者： Tsai, Yung-Chun Ku, Meng-Chiao Hsieh, Chien-Te Sung, Po-Yu Chen, Pin-Shuan Mohanty, Debabrata Gandomi, Yasser Ashraf Hung, I-Ming Patra, Jagabandhu Chang, Jeng-Kuei Department of Chemical Engineering and Materials Science Yuan Ze University Taoyuan32003 Taiwan Department of Mechanical Biomedical Engineering University of Tennessee KnoxvilleTN37996 United States Department of Chemical Engineering Massachusetts Institute of Technology CambridgeMA02142 United States Research Center National Cheng Kung University Tainan70101 Taiwan Department of Materials Science and Engineering National Yang Ming Chiao Tung University Hsinchu30010 Taiwan

In this work, we have developed ceramicized hybrid solid state electrolytes (SSEs), which consisted of poly (vinylidene fluoride-hexafluoro propylene) (PVDF-HFP), lithium bis (trifluoromethanesulfonyl)imide (LiTFSI) salt, and sodium superionic conductor (NASICON)-type Li1+xAlxTi2‒x(PO4)3 (LATP) powders for lithium-ion batteries (LIBs) utilizing lithium metal anode. Adopting the sol–gel synthesis technique followed by a thermal calcination at 850 °C, we synthesized round-like LATP powders with an average particle size of ~ 30 μm. engineering the LATP content (~ 45 wt.%) within the hybrid SSEs, we were able to achieve thermal stability along with superior ionic conductivity (i.e., 1.40 × 10−4 S cm−1 at 30 °C). Employing the Arrhenius plot in the temperature range of 30‒70 °C, the activation energy for the ionic conduction was lowered significantly (i.e., 0.21 eV) compared to prior efforts reported in the literature (i.e., 0.27 − 0.35 eV). The application of highly optimized SSE within a LIB with lithium metal anode resulted in the maximal capacity of ~ 162 mAh g−1 at 0.1 C. The cyclic performance of the battery utilizing such an optimized SSE configuration was very robust with a highly stable coulombic efficiency (~ 96.7%) after 100 cycles. Indeed, the ceramicized LATP-based SSEs developed in this work, can be employed for boosting the ionic conductivity, specific capacity, and cycle life while mitigating the interfacial resistance of the electrolyte/electrode layer for LIBs with lithium metal anode. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023.

关键词： Activation energy

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Distance Learning at the MS and PhD Levels in the Nuclear and Radiation engineering program, Nuclear and Applied Robotics, materials science and engineering and Walker department of Mechanical engineering at the University of Texas at Austin

Distance Learning at the MS and PhD Levels in the Nuclear an...

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2023 Transactions of the American Nuclear Society Winter Conference and Expo, ANS 2023

作者： Landsberger1, Sheldon Charlton, William Clamo, Kevin Ezekoye, Ofodike Kovar, Desiderio Haas, Derek Pryor, Mitchell University of Texas at Austin Nuclear and Radiation Engineering Program Nuclear Engineering Teaching Lab 10100 Burnet Road Pickle Research Campus R-9000 AustinTX United States Walker Department of Mechanical Engineering University of Texas at Austin 204.Dean Keeton ETC II 5.160 AustinTX United States The University of Texas at Austin Materials Science and Engineering Walker Department of Mechanical Engineering 204 Dean Keeton ETC II 5.100 AustinTX United States

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