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The mechanism of dentine hypersensitivity:Stimuli-induced directional cation transport through dentinal tubules

Nano Research 2023年第1期16卷 991-998页

作者： Nuo Chen Jingjing Deng Shengjie Jiang Xiang-Yu Kong Teng Zhou Kai Zhao Zuohui Xiao Huimin Zheng Weipeng Chen Congcong Zhu Xinyu Liu Liping Wen Yan Wei Xuliang Deng Lei Jiang Beijing Laboratory of Biomedical Materials Department of Geriatric DentistryPeking University School and Hospital of StomatologyBeijing 100081China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Mechanical and Electrical Engineering College Hainan UniversityHainan 570228China School of Future Technology University of Chinese Academy of Sciences Beijing 100049China

Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains *** long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain ***,no experimental evidence supports the ***,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine *** in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine ***,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine ***,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical *** proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure.

关键词： dentine hypersensitivity cation transport dentinal tubules Ionic-current-rectification

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Electro-Mechanical Finite Element Model of Left Ventricular Hypertrophy 6th

Electro-Mechanical Finite Element Model of Left Ventricular ...

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6th Kuala Lumpur International Conference on biomedical engineering, BioMed 2021

作者： Hew, Zhi Chin Chan, Bee Ting Wan Ab Naim, Wan Naimah Dokos, Socrates Tey, Wah Yen Liew, Yih Miin Department of Mechanical Engineering Faculty of Engineering UCSI University Kuala Lumpur Malaysia Department of Mechanical Materials and Manufacturing Engineering Faculty of Science and Engineering University of Nottingham Malaysia Selangor Malaysia Faculty of Mechanical and Automotive Engineering Technology Universiti Malaysia Pahang Pahang Malaysia Graduate School of Biomedical Engineering UNSW Sydney Sydney Australia Malaysia-Japan International Institute of Technology University Teknologi Malaysia Skudai Malaysia Department of Biomedical Engineering Faculty of Engineering Universiti Malaya Kuala Lumpur Malaysia

ISBN: (纸本)9783030907235

Left ventricular hypertrophy (LVH) is one of the common heart diseases that contribute to global morbidity and mortality. LVH can be further classified into concentric LVH (cLVH), eccentric LVH (eLVH) and concentric left ventricular remodeling (cLVR) based on the changes in wall structure and cardiac function. This study simulated LVH cases by using an electro-mechanical left ventricular (LV) model. The simulation was performed on three LVH cases, with a healthy model used for baseline reference. The pressure–volume loops, LV wall thickening index (TI), shortening strain (SS) and thickening strain (TS) were evaluated. Although all LV models had a preserved ejection fraction, differences in TI, SS and TS were noted. The cLVH (TI: 24.4%, SS: −20.2%, TS: −52.5%) and eLVH (TI: 10.3%, SS: −81.2%, TS: 9.4%) models showed remarkable difference compared to the healthy model, whereas less significant discrepancy was noted in cLVR (TI: 5.1%, SS: −0.6%, TS: −7.3%). Distinct geometric features of increased wall thickness and chamber enlargement were observed to affect the operative chamber stiffness in cLVH and eLVH. The TI, SS and TS results indicate wall mechanics impairment in cLVH and eLVH patients. © 2022, Springer Nature Switzerland AG.

关键词： Strain

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Comparison of Coherent and Incoherent Donut Beams for Deep Tissue STED Microscopy

Comparison of Coherent and Incoherent Donut Beams for Deep T...

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Shanavas, Thariq McLeod, Robert R. Siemens, Mark E. Gopinath, Juliet T. Department of Physics University of Colorado BoulderCO80309 United States Department of Electrical Computer and Energy Engineering University of Colorado BoulderCO80309 United States Department of Physics University of Denver DenverCO80204 United States Materials Science Engineering Program University of Colorado BoulderCO80309 United States

We numerically compare the null quality for STED microscopy generated by Laguerre-Gaussian beams with orbital angular momentum and donut beams generated by incoherent addition of orthogonal Hermite Gaussian beams when... 详细信息

ISBN: (纸本)9781957171258

关键词： Tissue

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Multifunctional Devices Based on 3D Hybrid Networks of ZnO and 3D Carbon Nanomaterials 13

Multifunctional Devices Based on 3D Hybrid Networks of ZnO a...

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13th IEEE International Conference on Nanomaterials: Applications and Properties, NAP 2023

作者： Reimers, Armin Postica, Vasile Mishra, Yogendra Kumar Birnaz, Adrian Nia, Ali Shaygan Feng, Xinliang Adelung, Rainer Schutt, Fabian Lupan, Oleg Christian-Albrechts Universität zu Kiel Chair for Functional Nanomaterials Faculty of Engineering Department of Materials Science Kiel Germany Technical University of Moldova Center for Nanotechnology and Nanosensors Department of Microelectronics and Biomedical Engineering Chisinau Moldova Mads Clausen Institute NanoSYD University of Southern Denmark Sonderborg Denmark Department of Chemistry and Food Chemistry Dresden Germany

ISBN: (纸本)9798350329087

In this work, the room temperature UV and gas sensing properties of the three-dimensional (3D) networks based on zinc oxide (ZnO) tetrapods coated with carbon-based two-dimensional (2D) nanomaterials were investigated. Therefore, highly porous (~94%) cylindrical pellets of ZnO tetrapods were infiltrated with dispersions of graphene oxide (GO), electrochemically exfoliated graphene (EG) and reduced graphene oxide (rGO), resulting in the formation of nano-porous few-layer membranes on the surfaces of the individual tetrapods, that affect both, their gas and UV sensing properties. It was found, that by coating ZnO with rather insulating materials such as GO, the UV response of ZnO networks can be improved from ~ 5 to ~ 17 at an applied bias voltage of 10 V. On the other hand, the addition of conductive carbon-based nanomaterials, such as EG and rGO, results in a decrease in UV response compared to the pristine ZnO networks. The decrease is associated with the formation of percolating pathes through the ZnO network, that shunt the effect of potential barrier modulation between the ZnO tetrapods under UV illumination. However, while decreasing the UV response, EG enabled gas sensing. The EG based 3D networks were capable of detecting NH3 at room temperature, showing a gas response of ~ 1.15. The gas response could even be slightly increased by removing the underlying ZnO template, creating ultra-lightweight NH3 sensors. This study illustrates, that creating 3D hybrid networks based on ZnO and carbon based 2D nanomaterials has huge potential for synergistic effects that achieve new unique sensing properties at room temperature. © 2023 IEEE.

关键词： Zinc oxide

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Accuracy of DFT computed oxygen-vacancy formation energies and high-throughput search of solar thermochemical water-splitting compounds

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Physical Review materials 2023年第6期7卷 065403-065403页

作者： Bianca Baldassarri Jiangang He Xin Qian Emanuela Mastronardo Sean Griesemer Sossina M. Haile Christopher Wolverton Graduate Program in Applied Physics Northwestern University Evanston Illinois USA Department of Materials Science and Engineering Northwestern University Evanston Illinois USA

The enthalpy change involved in metal oxide reduction is a key quantity in various processes related to energy conversion and storage and is of particular interest for computational prediction. Often this prediction involves the simulation of a high-temperature reduction process with a 0-K methodology like density functional theory (DFT), and it is not infrequent for the high temperature and 0-K stable crystal structures to differ. This introduces a conundrum with regard to the choice of crystal structure to utilize in the computation, with approaches in the literature varying and experimental validation remaining scarce. In this work, we address both the crystal structure conundrum and the experimental validation, and then apply the insights we gain to guide a high-throughput search for new materials for solar thermochemical water-splitting applications. By computing the DFT+U oxygen-vacancy formation energy (ΔEvf) of a selection of ABO3 compounds and comparing different crystal structures for each composition, we highlight the issues that arise when the structure utilized in the computation is dynamically unstable at 0 K, namely the presence of an artificial lowering of ΔEvf, and the lack of convergence of ΔEvf with cell size. We solve these limitations by identifying and employing a suitable surrogate dynamically stable structure. We then validate the predictive power of our calculations against appositely generated experimental measurements of reduction enthalpy for a series of Hubbard U values, finding an accuracy ranging between 0.2–0.6 eV/O. In light of such conclusions, we revise and expand a previous a high-throughput DFT study on ABO3 perovskite oxides. We provide a list of candidate STCH materials, highlight trends with redox-active cation and structural distortion, and identify Mn4+, Mn3+, and Co3+ as the most promising redox-active cations.

关键词： Energy applications First-principles calculations Hydrogen energy

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Thermodynamic and Environmental Assessment of Low-GWP Alternative Refrigerants for Domestic Cooling

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Journal of The Institution of Engineers (India): Series C 2023年第2期104卷 377-383页

作者： Islam, Md. Amirul Rupam, Tahmid Hasan Hosan, Shahadat Saha, Bidyut Baran Institute for Materials Chemistry and Engineering Kyushu University Kasuga-Koen 6-1 Kasuga-Shi Fukuoka816-8580 Japan Department of Electrical and Electronics Engineering Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj8100 Bangladesh Kyushu University 744 Motooka Nishi-Ku Fukuoka819-0395 Japan Kyushu University Program for Leading Graduate School Green Asia Education Center Kyushu University Fukuoka Japan Department of Mechanical Engineering Kyushu University 744 Motooka Nishi-Ku Fukuoka819-0395 Japan

Nearly two billion air-conditioning (AC) units are currently being used for space cooling worldwide. The majority of these ACs use R134a as the working fluid, a greenhouse gas (GHG) with a global warming potential (GWP) of 1300 kg-CO2-eq. According to the rules set by the world environment safety organizations, the GWP of domestic air-conditioning systems must not exceed 750 kg-CO2-eq. Hence, the R134a must be phased out by 2025, and an alternative refrigerant with similar thermodynamic properties yet low GWP is required. Therefore, the authors have investigated several potential binary/ternary refrigerant blends in this study. Among the studied refrigerants, R445A, R30A, and NPB2 (newly proposed blend: 8% R152a + 92% R1234yf) can reduce 90–99% global warming impact (more than 200 million tonnes of CO2 emission equivalent) caused by the domestic air-conditioning systems every year. © 2023, The Institution of Engineers (India).

关键词： Refrigerants

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Correction to: Primary Creep Characterization in Porcine Lumbar Spine Subject to Repeated Loading (Annals of biomedical engineering, (2024), 10.1007/s10439-024-03557-2)

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Annals of biomedical engineering 2024年 1-1页

作者： Morino, Concetta Middleton, Shea Op’t Eynde, Joost Dimbath, Elizabeth Kait, Jason Luck, Jason Bass, Cameron Department of Mechanical Engineering and Materials Science Duke University DurhamNC United States Department of Biomedical Engineering Duke University DurhamNC United States Department of Biomedical Engineering Wayne State University DetroitMI United States Engineering Systems Inc. CharlotteNC United States

Authors Shea Middleton, Joost Op't Eynde, Elizabeth Dimbath, Jason Kait, and Jason Luck should have affiliation #2: department of biomedical engineering, Duke University, Durham, NC, USA. © The Author(s) unde...

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Self-Healable Sandfish Scale-Inspired Scalable Triboelectric Layer for Hybrid Energy Harvesting in Desert Environment

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Small 2024年第4期21卷 e2404637页

作者： Chen, An-Rong Parashar, Parag Sharma, Manish Kumar Shih, Jing-Siang Yeh, Hsuan-Yu Lin, Yen-Jui Kaswan, Kuldeep Fan, Kai-Po Chen, Po-Yu Lin, Zong-Hong Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Department of Biomedical Engineering National Taiwan University Taipei10617 Taiwan Institute of Biomedical Engineering National Tsing Hua University Hsinchu30013 Taiwan International Intercollegiate Ph.D. Program National Tsing Hua University Hsinchu30013 Taiwan

In deserts, sedimentation from frequent dust activities on solar cells poses a substantial technical challenge, reducing efficiency and necessitating advanced cost-inefficient cleaning mechanisms. Herein, a novel sandfish scale-inspired self-healing fluorinated copolymer-based triboelectric layer is directly incorporated on top of the polysilicon solar cell for sustained hybrid energy harvesting. The transparent biomimetic layer, with distinctive saw-tooth microstructured morphology, exhibits ultra-low sand adhesion and high abrasion-resistant properties, inhibits sedimentation deposition on solar cells, and concurrently harvests kinetic energy from wind-driven sand particles through triboelectric nanogenerator (TENG). The film exhibits a low friction coefficient (0.149), minimal sand adhesion force (27 nN), and a small wear area (327 µm2). In addition, over 2 months, a solar cell with the sandfish scale-inspired structure demonstrates only a 16% decline in maximum power output compared to the bare solar cell, which experiences a 60% decline. Further, the sandfish scale-based TENG device's electrical output is fully restored to its original value after a 6-h self-healing cycle and maintains consistent stable outputs. These results highlight the exceptional advantages of employing biomimetic self-healing materials as robust triboelectric layers, showcasing sustained device stability and durability for prolonged use in harsh desert environments, ultimately contributing to a low cost-of-electricity generation paradigm. © 2024 Wiley-VCH GmbH.

关键词： Nanogenerators

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Bioresource Upgrade for Sustainable Energy,Environment,and Biomedicine

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Nano-Micro Letters 2023年第3期15卷 48-97页

作者： Fanghua Li Yiwei Li KSNovoselov Feng Liang Jiashen Meng Shih‑Hsin Ho Tong Zhao Hui Zhou Awais Ahmad Yinlong Zhu Liangxing Hu Dongxiao Ji Litao Jia Rui Liu Seeram Ramakrishna Xingcai Zhang Center for Nanofibers and Nanotechnology National University of SingaporeSingapore 119260Singapore State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150090People’s Republic of China School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA The Key Laboratory for Biomedical Photonics of MOE at Wuhan National Laboratory for Optoelectronics–Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei 430074People’s Republic of China Centre for Advanced 2D Materials National University of SingaporeSingapore 117546Singapore School of Physics and Astronomy The University of ManchesterManchester M139PLUK Department of Anesthesia Critical Care and Pain MedicineMassachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA Department of Energy and Power Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Departamento de Quimica Organica Universidad de CordobaEdificio Marie Curie(C‑3)Ctra Nnal IV‑AKm 39614014 CordobaSpain Department of Chemical Engineering Monash UniversityClaytonVIC 3800Australia School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

We conceptualize bioresource upgrade for sustainable energy,environment,and biomedicine with a focus on circular economy,sustainability,and carbon neutrality using high availability and low utilization biomass(HALUB).We acme energy-efficient technologies for sustainable energy and material recovery and *** technologies of thermochemical conversion(TC),biochemical conversion(BC),electrochemical conversion(EC),and photochemical conversion(PTC)are summarized for *** biomass could contribute to a biofuel HHV of 35.72 MJ Kg^(-1)and total benefit of 749$/ton biomass via *** surface area of biochar reached 3000 m^(2)g^(-1)via pyrolytic carbonization of waste bean *** biomass can be effectively converted into bio-stimulants and biofertilizers via BC with a high conversion efficiency of more than 90%.Besides,lignocellulosic biomass can contribute to a current density of 672 mA m^(-2)via *** can be 100%selectively synthesized via electrocatalysis through EC and *** learning,techno-economic analysis,and life cycle analysis are essential to various upgrading approaches of *** biomaterials,sustainable living materials and technologies for biomedical and multifunctional applications like nano-catalysis,microfluidic and micro/nanomotors beyond are also *** techniques and systems for the complete conversion and utilization of HALUB for new energy and materials are further discussed.

关键词： High availability low utilization biomass(HALUB) Circular economy Machine learning Energy-efficient conversion Nano-catalysis

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Reciprocal folding dynamics in cellular networks at the stroma-basement membrane interface

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Acta Biomaterialia 2025年

作者： Jo, Youngmin Yim, Donghyun Park, Chan E Yong, Insung Lee, Jongbeom Ahn, Kwang Ho Yang, Chanhee Chang, Jae-Byum Kim, Taek-Soo Shin, Jennifer Hyunjong Kim, Taeyoon Kim, Pilnam Department of Bio and Brain Engineering KAIST Daejeon34141 Korea Republic of Weldon School of Biomedical Engineering Purdue University West LafayetteIN United States Department of Materials Science and Engineering KAIST Daejeon305-701 Korea Republic of Department of Mechanical Engineering KAIST Daejeon305-701 Korea Republic of Faculty of Science and Technology Keio University Kohoku Ward Yokohama Japan

Epithelium layer stands on a membrane, called basement membrane (BM) which serves as a boundary with the underlying stroma. While most studies on morphogenesis have focused on the epithelium-BM complex, the role of the BM-stroma interface remains poorly understood. In this study, we demonstrate how forces originating from the stromal layer contribute to tissue morphogenesis. Folds focalization at the BM-stroma interface is driven by mechanical instability, which arises from the fluidity of the stroma and the polarized tractional forces acting on the rigid membrane of stromal cell condensates. Stromal cells move towards the folded region by topographic guidance, while the concentration of forces intensifies. Through this process, stromal cells and folds engage in recursive interactions, resulting in the formation of a cellular network. Our observation provides a rational mechanism for pattern formation in a multi-layered living tissue. Statement of significance: This study addresses a crucial gap in understanding how stromal cells interact with the basement membrane to lead tissue surface morphogenesis. By developing a collagen-based, nanometer-thick engineered basement membrane, we demonstrate that the stromal cells exert traction forces on the basement membrane to fold. The folding process guides stromal cell migration, which in turn induces further folding in a recursive manner. The direction of folding, invagination or evagination, is determined by the stiffness difference between the stroma and the basement membrane. This model offers better understanding about how the basement membrane interacts with stromal cells to make evaginated network structures on tissue surface. © 2025 Acta Materialia Inc.

关键词： Tissue engineering

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