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3D printed fiber-optic nanomechanical bioprobe

International Journal of Extreme Manufacturing 2023年第1期5卷 222-234页

作者： Mengqiang Zou Changrui Liao Yanping Chen Lei Xu Shuo Tang Gaixia Xu Ke Ma Jiangtao Zhou Zhihao Cai Bozhe Li Cong Zhao Zhourui Xu Yuanyuan Shen Shen Liu Ying Wang Zongsong Gan Hao Wang Xuming Zhang Sandor Kasas Yiping Wang Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China School of Electronic and Communication Engineering Shenzhen PolytechnicShenzhen 518000People’s Republic of China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhen 518055People’s Republic of China Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Laboratory of Food and Soft Materials Department of Health Sciences and TechnologyETH Zurich8092 ZurichSwitzerland Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and Technology(HUST)Wuhan 430074People’s Republic of China Department of Applied Physics The HongKong Polytechnic UniversityHong KongPeople’s Republic of China Laboratory of Biological Electron Microscopy Ecole Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland UnitéFacultaire d’Anatomie et de Morphologie(UFAM) CUMRLUniversity of Lausanne1005 LausanneSwitzerland

Ultrasensitive nanomechanical instruments,*** force microscopy(AFM),can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological ***,these instruments are limited because of their size and complex feedback *** this study,we demonstrate a miniature fiber optical nanomechanical probe(FONP)that can be used to detect the mechanical properties of single cells and in vivo tissue measurements.A FONP that can operate in air and in liquids was developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser two-photon polymerization *** realize stiffness matching of the FONP and sample,a strategy of customizing the microcantilever’s spring constant according to the sample was proposed based on structure-correlated *** a proof-of concept,three FONPs with spring constants varying from 0.421 N m^(−1)to 52.6 N m^(−1)by more than two orders of magnitude were *** highest microforce sensitivity was 54.5 nmμN^(−1)and the detection limit was 2.1 *** Young’s modulus of heterogeneous soft materials,such as polydimethylsiloxane,muscle tissue of living mice,onion cells,and MCF-7 cells,were successfully measured,which validating the broad applicability of this *** strategy provides a universal protocol for directly programming fiber-optic ***,this method has no special requirements for the size and shape of living biological samples,which is infeasible when using commercial *** has made substantial progress in realizing basic biological discoveries,which may create new biomedical applications that cannot be realized by current AFMs.

关键词： two-photon polymerization nanolithography optical fiber sensor nanomechanical probe stiffness tunable microcantilever biosensor

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Interfacial delivery of carbon monoxide via smart titanium implant coating for enhanced soft tissue integration with switchable antibacterial and immunomodulatory properties

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Bioactive materials 2024年第10期40卷 318-333页

作者： Minghao Zhou Gangfeng Li Jingwei Yu Qian Zhou Kun Wang Jiaxin Kang Tengjiao Wang Peng Li Hongbo Wei State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of Oral ImplantsSchool of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiPR China Frontiers Science Center for Flexible Electronics(FSCFE) Institute of Flexible Electronics(IFE)&Institute of Biomedical Materials and Engineering(IBME)Northwestern Polytechnical University(NPU)Xi’anShaanxiPR China School of Flexible Electronics Henan Institute of Flexible Electronics(HIFE)Henan University379 Mingli RoadZhengzhou450046PR China Chongqing Innovation Center Northwestern Polytechnical UniversityChongqing401135PR China

Soft tissue integration around titanium(Ti)implants is weaker than that around natural teeth,compromising long-term success of Ti *** monoxide(CO)possesses distinctive therapeutic properties,rendering it as a highly promising candidate for enhancing ***,achieving controlled CO generation at the STI interface remains ***,a controlled CO-releasing dual-function coating was constructed on Ti *** near-infrared(NIR)irradiation,the designed surface could actively accelerate CO generation for antibiosis against both aerobic and anaerobic *** importantly,in the absence of NIR,the slow release of CO induces macrophage polarization from pro-inflammatory phenotype towards pro-regenerative *** a rat implantation model with induced infection,the designed surface effectively controlled the bacterial infection,alleviates accompanying inflammation and modulated immune microenvironment,leading to enhanced ***-cell sequencing revealed that the coating alters the cytokine profile within the soft tissue,thereby influencing cellular *** expressed genes in macrophages are highly enriched in the PIK3-Akt ***,the cellular communication between fibroblasts and macrophages was significantly enhanced through the CXCL12/CXCL14/CXCR4 and CSF1-CSF1R ligand-receptor *** findings indicate that our coating showed an appealing prospect for enhancing STI around Ti implants,which would ultimately contribute to the improved long-term success of Ti implants.

关键词： Gastrotransmitters Soft tissue integration Immune microenvironment Ti implants Antibacterial

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An Assessment of Patent Scoring Using Natural Language programming

An Assessment of Patent Scoring Using Natural Language Progr...

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2022 Portland International Conference on Management of engineering and Technology, PICMET 2022

作者： Khongamnuaisak, Lertchai Pentrakoon, Duanghathai Sinthupinyo, Sukree Suanpong, Kwanrat Chulalongkorn University Technopreneurship and Innovation Management Program Graduate School Bangkok Thailand Chulalongkorn University Faculty of Science Department of Materials Science Bangkok Thailand Faculty of Engineering Chulalongkorn University Department of Computer Engineering Bangkok Thailand Chulalongkorn Business School Commerce Department Bangkok Thailand

ISBN: (数字)9781890843410

ISBN: (纸本)9781890843410

Patent has been an increasingly important role in the world because it is not only significant to protect the invention of the company's business but also to generate revenue from the commercialization. WIPO (2018) reports that the repository has many patents so, to assess patent, it consumes time and requires various expertise. Generally, several models have been developed to address this matter, which to assess using a questionnaire tool for portfolios by human. Perhaps, there is not precise because it is assessed base on personal bias or previous experience of expertise. So that, occurs bias any limitation exists that our research will address by artificial intelligence. Thus, this research applies a Natural Language programming to assess for commercial of the patent. Then, the obtained data is used to assigned factors and calculate the model for assessing the commercialization of patent. This finding should deliver an alternative effective patent assessment, which is tool addresses, some current deficiency patent assessment for commercialization. © 2022 PICMET.

关键词： Patents and inventions

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Oil/Water Separation for Isolating Microplastic Particles Dispersed in Water

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SSRN 2024年

作者： Diddams, Amanda Burke, Nathan J. Love, Brian J. The University of Michigan United States Department of Materials Science and Engineering Department of Biomedical Engineering 2300 Hayward St Ann Arbor48109 United States California Polytechnic State University United States

With the wealth of published work documenting where microplastic particulates can be found, it is also worth considering how to isolate and sequester microplastics at scale. Here, different colored microplastics of polypropylene, PP, polyethylene, PE, polyethylene terephthalate, PET, and turf rubber particulates, either ground from macroplastics or used as received, were dispersed in tap water into separatory funnels for isolation and collection efficiency assessments. Canola oil was added to the dispersions and mixed, after which the aqueous and oil-rich phases separated based on density, in minutes. Complete transfer of the olefin particulates was observed while collections of PET and the rubber particles were >80% transferred into the oil phase at 20oC. The collection rate was slightly higher for PET when the water was chilled to 0.6° C and the collection rate was invariant with temperature for the rubber. It is noted that particles denser than water when mixed with a digestible oil could still be drawn into the more buoyant, oil rich phase. The notion of degradable oil-water separation for plumes that can be skimmed seems achievable on a technical level and is worth further investigation and feasibility assessment. © 2024, The Authors. All rights reserved.

关键词： Rubber

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Computational study of the role of counterions and solvent dielectric in determining the conductance of B-DNA

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Physical Review E 2023年第4期107卷 044404-044404页

作者： Yiren Wang Busra Demir Hashem Mohammad Ersin Emre Oren M. P. Anantram Deparment of Electrical and Computer Engineering University of Washington Seattle Washington 98105 USA Bionanodesign Laboratory Department of Biomedical Engineering and Department of Materials Science & Nanotechnology Engineering TOBB University of Economics and Technology Ankara 06510 Turkey Department of Electrical Engineering Kuwait University P.O. Box 5969 Safat 13060 Kuwait

DNA naturally exists in a solvent environment, comprising water and salt molecules such as sodium, potassium, magnesium, etc. Along with the sequence, the solvent conditions become a vital factor determining DNA structure and thus its conductance. Over the last two decades, researchers have measured DNA conductivity both in hydrated and almost dry (dehydrated) conditions. However, due to experimental limitations (the precise control of the environment), it is very difficult to analyze the conductance results in terms of individual contributions of the environment. Therefore, modeling studies can help us to gain a valuable understanding of various factors playing a role in charge transport phenomena. DNA naturally has negative charges located at the phosphate groups in the backbone, which provides both the connections between the base pairs and the structural support for the double helix. Positively charged ions such as the sodium ion (Na+), one of the most commonly used counterions, balance the negative charges at the backbone. This modeling study investigates the role of counterions both with and without the solvent (water) environment in charge transport through double-stranded DNA. Our computational experiments show that in dry DNA, the presence of counterions affects electron transmission at the lowest unoccupied molecular orbital energies. However, in solution, the counterions have a negligible role in transmission. Using the polarizable continuum model calculations, we demonstrate that the transmission is significantly higher at both the highest occupied and lowest unoccupied molecular orbital energies in a water environment as opposed to in a dry one. Moreover, calculations also show that the energy levels of neighboring bases are more closely aligned to ease electron flow in the solution.

关键词： Electrical conductivity Electronic structure of atoms & molecules Quantum transport DNA Nucleic acids Density functional theory Methods in transport Nonequilibrium Green's function

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Urchin-like Ni[sbnd]Co hydroxide@ tamarind seed biochar for high performance supercapacitor

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Journal of Energy Storage 2024年 84卷

作者： Khedulkar, Akhil Pradiprao Pandit, Bidhan Yu, Wan-Ju Doong, Ruey-an Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan Department of Materials Science and Engineering and Chemical Engineering Universidad Carlos III de Madrid Avenida de la Universidad 30 Madrid Leganés28911 Spain Department of Materials Science and Engineering National Tsing Hua University Hsinchu30013 Taiwan Institute of Analytical and Environmental Sciences National Tsing Hua University Hsinchu30013 Taiwan

This study introduces a novel composite material, U-NiCo-OH@TTBC, comprised of tamarind seed biochar (TTBC) and nickel-cobalt hydroxide, designed for high-performance supercapacitors. This composite exhibits a unique urchin-like structure with a specific surface area of 610 m2 g−1, facilitating efficient electron-ion transport and electrolyte diffusion. U-NiCo-OH@TTBC demonstrates an impressive storage capacity of 759 F g−1 at 1 A g−1, along with a specific capacitance of 158 F g−1. The symmetric device built with U-NiCo-OH@TTBC boasts power densities ranging from 787 to 7183 W kg−1 and energy densities between 16 and 54 Wh kg−1. Most notably, the device exhibits exceptional long-term cyclic stability, retaining 92 % of its performance after 10,000 charge-discharge cycles. This work highlights the potential of agricultural waste as sustainable carbon sources and their compatibility with metal hydroxides to create eco-friendly and durable supercapacitor electrodes. © 2024 Elsevier Ltd

关键词： Agricultural wastes

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Open-System Force-Elongation Relationship of Collagen in Chemo-Mechanical Equilibrium with Water: Effect of Molecular Coiling

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SSRN 2023年

作者： Deymier, Alix C. Deymier, Pierre Alix Department of Biomedical Engineering UConn Health FarmingtonCT United States Department of Materials Science and Engineering University of Arizona TucsonAZ85721 United States

The primary deformation mechanism of collagen at low loads is dominated by molecular uncoiling. Although the effect of hydration and cross-linking has been investigated at larger loads when collagen undergoes molecular sliding, their effects on collagen uncoiling remain unclear. Here we develop two thermodynamic models that use the notion of open-system elasticity to elucidate the effect of swelling due to water uptake during deformation of collagen under low and high cross-linking conditions. With low crosslinking, entropic contributions dominate resulting in rejection of solvent from the polymer network leading to reduced collagen stiffness with increased loads. Contrarily, high cross-linking inhibits initial coiling and the mechanical behavior is dominated by elastic energy. In this configuration, the solvent content depends on the sign of the applied load resulting in a non-linear open-system stress-strain relationship. The models provide insight on the parameters that impact the stress-strain relationships of hydrated collagen and can inform the way collagenous tissues such as tendons are treated both in medical and laboratory settings. © 2023, The Authors. All rights reserved.

关键词： Collagen

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Electrochemical aptasensor based on black phosphorus-porous graphene nanocomposites for high-performance detection of Hg^(2+)

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Chinese Chemical Letters 2024年第11期35卷 372-377页

作者： Jie Zhou Chuanxiang Zhang Changchun Hu Shuo Li Yuan Liu Zhu Chen Song Li Hui Chen Rokayya Sami Yan Deng Hengyang Medical School University of South ChinaHengyang 421001China Institute for Future Sciences University of South ChinaChangsha 410000China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China College of Packing and Materials Engineering Hunan University of TechnologyZhuzhou 412007China Department of Food Science and Nutrition College of SciencesTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

A novel approach was developed to fabricate a label-free electrochemical aptasensor for specific detection of mercury ions(Hg^(2+)).This involved modifying polylysine(PLL)-coated black phosphorus-porous graphene(BP-PG)nanocomposites(PLL/BP-PG)onto the surface of glassy carbon electrodes(GCE),which were further modified with gold nanoparticles(AuNPs)to combine with a thiolated aptamer(Apt)capable of specifically recognizing Hg^(2+).BP-PG was synthesized using the solvothermal method and covalently bonded to form BP-PG nanosheets,resulting in significant enhanced electrochemical properties of the PLL/BP-PG ***,the PLL/BP-PG composite was improved environmental stability of BP and provided a considerable quantity of-NH_(2)for bonding to Au NPs firmly by *** physical properties and electrochemical behavior of the substrate materials were investigated using various characterization techniques,and analytical parameters were *** is shown that,the Apt/AuNPs/PLL/BP-PG/GCE had a linear response(R~2=0.999)with good selectivity and high sensitivity over the Hg^(2+)range of 1-10,000 nmol/*** proposed sensor has a detection limit of 0.045 nmol/L and can be employed for detecting of Hg^(2+).It also obtained satisfying results in river water,soil and vegetable samples.

关键词： Hg^(2+) Electrochemical sensor Black phosphorus-porous graphene Aptamer AuNPs

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Analgesic nanomedicines for the treatment of chronic pain

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BMEMat(biomedical engineering materials) 2024年第1期2卷 76-87页

作者： Hao Liu Hongjun Zhuang Ya Wang Yuen Yee Cheng Feixiang Chen Jian Chen Xinglei Song Run Zhang Yanyan Liu Wenbo Bu State Key Laboratory of Molecular Engineering of Polymers Department of Materials ScienceFudan UniversityShanghaiChina Department of Rehabilitation Zhongshan HospitalFudan UniversityShanghaiChina Central Laboratory The First Affiliated Hospital of Xiamen UniversityXiamenChina Institute for Biomedical Materials&Devices(IBMD) Faculty of ScienceThe University of Technology SydneySydneyNew South WalesAustralia Department of Anatomy and Physiology Shanghai Jiao Tong University School of MedicineShanghaiChina Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueenslandAustralia

Chronic pain is a major cause of suffering that often accompanies diseases and therapies,affecting approximately 20%of individuals at some point in their ***,current treatment modalities,such as anesthetic and antipyretic analgesics,have limitations in terms of efficacy and side *** technology offers a promising avenue to overcome these challenges and introduce new therapeutic *** article reviews the recent research on nanomedicine analgesics,integrating analyses of neuroplasticity changes in neurons and pathways related to the transition from acute to chronic ***,it explores potential future strategies using nanomaterials,aiming to provide a roadmap for new analgesic development and improved clinical pain *** leveraging nanotechnology,these approaches hold the potential to revolutionize pain treatment by delivering targeted and effective relief while minimizing side effects.

关键词： analgesics chronic pain local anesthetics nanomedicine neuroplasticity

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3D Image Generation from X-Ray Projections Using Generative Adversarial Networks

3D Image Generation from X-Ray Projections Using Generative ...

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IEEE Symposium on Bioinformatics and Bioengineering (BIBE)

作者： Mohammad AlShurbaji Salam Dhou Biomedical Engineering Graduate Program American University of Sharjah Sharjah UAE Department of Computer Science and Engineering American University of Sharjah Sharjah UAE

The human brain can effortlessly imagine a 3D image from only 2D images with a little expertise and imagination, but for machines, this is not a trivial task. Because of this, reconstructing 3D images from 2D ones is a hot topic and has many applications. In this paper, we propose a Generative Adversarial Network (GAN)-based approach that generates CT-like images using pairs of orthogonal X-ray projections taken from different angles. In this work, a variety of orthogonal pairs from different angles, ranging from 0°&90° to 60°&150°, were considered as input to the 3D image generation model. The effectiveness of the proposed method was assessed by measuring the Structural Similarity Index (SSIM) and Peak Signal-to-Noise Ratio (PSNR), which resulted in values of 0.641 and 29.21, respectively. Furthermore, the model's ability to capture the respiratory motion in the input projections and reflect it in the generated images was also assessed. This work demonstrated the feasibility of generating CT-like images from X-ray projections captured from different orthogonal angles taking into consideration the respiratory motion exhibited in these projections.

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