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Bisphosphonate-based hydrogel mediates biomimetic negative feedback regulation of osteoclastic activity to promote bone regeneration

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Bioactive materials 2022年第7期7卷 9-22页

作者： Zhuo Li Haixing Wang Kunyu Zhang Boguang Yang Xian Xie Zhengmeng Yang Lingchi Kong Peng Shi Yuan Zhang Yi-Ping Ho Zhi-Yong Zhang Gang Li Liming Bian Department of Biomedical Engineering The Chinese University of Hong KongSha TinNew Territories999077Hong KongChina Department of Orthopaedic and Traumatology The Chinese University of Hong KongSha TinNew Territories999077Hong KongChina Department of Materials Science and Engineering Johns Hopkins UniversityBaltimoreMD21218USA Department of Orthopaedic Surgery Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai200233China School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou510006China Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong Province510150China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006China

The intricate dynamic feedback mechanisms involved in bone homeostasis provide valuable inspiration for the design of smart biomaterial scaffolds to enhance in situ bone *** this work,we assembled a biomimetic hyaluronic acid nanocomposite hydrogel(HA-BP hydrogel)by coordination bonds with bisphosphonates(BPs),which are antiosteoclastic *** HA-BP hydrogel exhibited expedited release of the loaded BP in response to an acidic *** in vitro studies showed that the HA-BP hydrogel inhibits mature osteoclastic differentiation of macrophage-like RAW264.7 cells via the released ***,the HA-BP hydrogel can support the initial differentiation of primary macrophages to preosteoclasts,which are considered essential during bone regeneration,whereas further differentiation to mature osteoclasts is effectively inhibited by the HA-BP hydrogel via the released *** in vivo evaluation showed that the HA-BP hydrogel can enhance the in situ regeneration of *** work demonstrates a promising strategy to design biomimetic biomaterial scaffolds capable of regulating bone homeostasis to promote bone regeneration.

关键词： Bisphosphonate Hydrogel Tissue engineering Bone regeneration

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Injury and obesity differentially and synergistically induce dysregulation of synovial immune cells in osteoarthritis

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Annals of the Rheumatic Diseases 2025年第6期84卷 1033-1044页

作者： Harasymowicz, Natalia S. Harissa, Zainab Rashidi, Neda Lenz, Kristin Tang, Ruhang Guilak, Farshid Department of Orthopaedic Surgery Washington University St. Louis MO United States Shriners Hospitals for Children St. Louis MO United States Center of Regenerative Medicine Washington University St. Louis MO United States Department of Orthopaedic Surgery Operations University of Utah Salt Lake City UT United States Molecular Medicine Program University of Utah Salt Lake City UT United States Department of Biomedical Engineering Washington University in Saint Louis St. Louis MO United States Department of Mechanical Engineering & Materials Science Washington University St. Louis MO United States

Objectives: The heterogeneity and phenotype of immune cells orchestrate many physiologic and pathologic processes. Recent evidence suggests that immune cells play critical roles in the progression of osteoarthritis (OA). We hypothesised that injury and obesity, two major risk factors for OA, affect the immunophenotype of the synovium, the primary reservoir of immune cells in the joint. Methods: Using single-cell transcriptomics, immunoprofiling, transgenic mouse models, and genetic fate mapping methods, we characterised the presence and fate of multiple populations of immune cells found in the knee joint capsule. Results: We found that joint injury and obesity differentially and synergistically alter the architectural, cellular, and molecular profiles of the synovial capsule. We observed fewer patrolling monocytes in obese animals and found a significantly higher influx of proinflammatory monocyte-derived macrophages in the first 3 days after joint injury in obese compared with that in control animals. We also showed a significant loss of barrier-forming synovial lining macrophages 3 days after destabilisation of medial meniscus surgery, with a significant restoration of their numbers in normal weight but not in obese mice in advanced stages of OA. Finally, we characterised the presence and changes of other immune cell subtypes, including T, B, and mast cells and neutrophils, as well as local synovial fluid cytokines associated with injury and obesity. Conclusions: Our data revealed that injury and obesity independently and synergistically contribute to the dysregulation of the synovial immune landscape, providing new insight into their role in the pathogenesis of OA. © 2025 The Authors

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Brownian motion of poly(divinylbenzene) nanoparticles in water

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Journal of Applied Physics 2023年第11期133卷 114303-114303页

作者： Lin, Ching-Bin Lee, Chia-Wei Ouyang, Hao Yang, Fuqian Lee, Sanboh Mechanical and Electro-Mechanical Engineering Tamkang University New Taipei City251301 Taiwan Department of Materials Science and Engineering National Tsing Hua University Hsinchu300 Taiwan Materials Program Department of Chemical and Materials Engineering University of Kentucky LexingtonKY40506 United States

Understanding the motion of nanoparticles in liquid is of practical importance for drug delivery and fluid flow in nanofluidic systems. In this work, we use a nanoparticle tracking analyzer to investigate the Brownian motion of polydivinylbenzene (PDVB) nanoparticles in water and a video camera to record the aggregation of PDVB aggregates on the water surface. Using water as the liquid medium precludes the possible complex interaction between the liquid medium and the PDVB nanoparticles, which can possibly alter the random characteristics of the motion of the PDVB nanoparticles. The diffusivity of the PDVB nanoparticles determined from the mean square displacements of the PDVB nanoparticles has the same activation energy as that for the intrinsic viscosity of the corresponding aqueous suspension of the PDVB nanoparticles. The correlation between the diffusivity for the motion of the PDVB nanoparticles in water and the intrinsic viscosity of the corresponding aqueous suspension follows the Stokes-Einstein relation. The capillary effect and the interaction between PDVB aggregates and the liquid media enable the aggregation of the PDVB aggregates on the water surface, which follows the first-order reaction with activation energy larger than that for the random motion of the PDVB nanoparticles in water. © 2023 Author(s).

关键词： Nanoparticles

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Study on adhesion mechanism of fouling organisms on marine steel surface based on inverted microscope

Study on adhesion mechanism of fouling organisms on marine s...

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第六届环境预防和污染控制技术国际学术会议

作者： Kai Shen Yi Li Xia Wu Hyun-Do Jung Weirong Li Zhihui Liu Nuriddinov Khusniddin Zafariddin Abdujabbarova Umida Mashrukovna Yanfang Li Zhaoyang Lv Shukhrat Giyasov Di Tie Engineering Research Center of Continuous Extrusion Ministry of Education Dalian Jiaotong University School of Materials Science and Engineering Jilin Jianzhu University Department of Biomedical-Chemical Engineering The Catholic University of Korea Dongguan Eontec Co. Ltd State Key Laboratory of Tribology in Advanced Equipment Tsinghua University Department of urology Tashkent medical academy School of Materials Science and Engineering Northeastern University School of Materials Science and Engineering Guangdong Ocean University

Marine stainless steel is immersed in seawater for a long time, and its surface will inevitably adhere layer by layer to form biofilm, which will lead to microbial corrosion of the material. Therefore, it is necessary to master the microbial adhesion mechanism to better control the occurrence of fouling. However, at present,the observation method is to dye by fluorescence microscope or fix the fouling organisms and then observe them by scanning electron microscope(SEM). These methods all damage the cell activity of algae, and only the results of algae attachment can be observed, which is not conducive to further study of algae attachment mechanism. Based on the inverted microscope platform, the observation of algae attached to the metal surface found that the thinner the substrate of the sample liquid, the clearer the image of algae attached to the metal surface, and further found that the dominant algae in the liquid could complete the attachment and aggregation behavior on the metal surface within 1 hour to 2 hours. The conclusions obtained in this paper will guide the study on the attachment mechanism of fouling organisms on metal surfaces and provide a preliminary basis for the design of prevention and control strategies and time points of fouling organisms.

关键词： Study on adhesion mechanism of fouling organisms on marine steel surface based on inverted microscope

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Meta-optic accelerators for object classifier

Meta-optic accelerators for object classifier

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2023 Conference on Lasers and Electro-Optics, CLEO 2023

作者： Zheng, Hanyu Liu, Quan Zhou, You Kravchenko, Ivan I. Huo, Yuankai Valentine, Jason Department of Electrical and Computer Engineering Vanderbilt University NashvilleTN37212 United States Department of Computer Science Vanderbilt University NashvilleTN37212 United States Department of Mechanical Engineering Vanderbilt University NashvilleTN37212 United States Interdisciplinary Materials Science Program Vanderbilt University NashvilleTN37212 United States Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak RidgeTN37830 United States

A meta-optic platform for accelerating object classification is demonstrated. End-to-end design is used to co-optimize the optical and digital systems resulting in a high-speed and robust classifier with 93.1% accurac...

ISBN: (纸本)9781957171258

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Intraoperative bioprinting of human adipose-derived stem cells and extra-cellular matrix induces hair follicle-like downgrowths and adipose tissue formation during full-thickness craniomaxillofacial skin reconstruction

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Bioactive materials 2024年第3期33卷 114-128页

作者： Youngnam Kang Miji Yeo Irem Deniz Derman Dino JRavnic Yogendra Pratap Singh Mecit Altan Alioglu Yang Wu Jasson Makkar Ryan R.Driskell Ibrahim T.Ozbolat Engineering Science and Mechanics Department Penn State UniversityUniversity ParkPA16802USA The Huck Institutes of the Life Sciences Penn State UniversityUniversity ParkPA16802USA Department of Surgery College of MedicinePenn State UniversityHersheyPA17033USA School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen518055China School of Molecular Biosciences College of Veterinary MedicineWashington State UniversityPullmanWA99164USA Department of Biomedical Engineering Penn State UniversityUniversity ParkPA16802USA Materials Research Institute Penn State UniversityUniversity ParkPA16802USA Department of Neurosurgery Pennsylvania State College of MedicineHersheyPA17033USA Penn State Cancer Institute Penn State UniversityHersheyPA17033USA Department of Medical Oncology Cukurova UniversityAdan101130Turkey

Craniomaxillofacial(CMF)reconstruction is a challenging clinical *** often necessitates skin replacement in the form of autologous graft or flap surgery,which differ from one another based on hypodermal/dermal ***,both approaches are plagued by scarring,poor cosmesis,inadequate restoration of native anatomy and hair,alopecia,donor site morbidity,and potential for ***,new reconstructive approaches are warranted,and tissue engineered skin represents an exciting *** this study,we demonstrated the reconstruction of CMF full-thickness skin defects using intraoperative bioprinting(IOB),which enabled the repair of defects via direct bioprinting of multiple layers of skin on immunodeficient rats in a surgical *** a newly formulated patient-sourced allogenic bioink consisting of both human adipose-derived extracellular matrix(adECM)and stem cells(ADSCs),skin loss was reconstructed by precise deposition of the hypodermal and dermal components under three different sets of animal ***,even at a very low concentration such as 2%or less,has shown to be bioprintable via droplet-based bioprinting and exhibited de novo adipogenic capabilities both in vitro and in *** findings demonstrate that the combinatorial delivery of adECM and ADSCs facilitated the reconstruction of three full-thickness skin defects,accomplishing near-complete wound closure within two *** importantly,both hypodermal adipogenesis and downgrowth of hair follicle-like structures were achieved in this two-week time *** approach illustrates the translational potential of using human-derived materials and IOB technologies for full-thickness skin loss.

关键词： Intraoperative bioprinting Adipose-derived extracellular matrix Adipose-derived stem cells Skin tissue engineering

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Nonlinear optical characterization of Ag2Se and PbSe colloidal quantum dots using 1030 nm femtosecond pulses

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Optical and Quantum Electronics 2024年第12期56卷 1-17页

作者： Ganeev, Rashid A. Bejoy, Namitha Brijit Piatkowski, Piotr A. Boltaev, Ganjaboy S. Aslanov, Sergey V. Zvyagin, Andrey I. Smirnov, Mikhail S. Ovchinnikov, Oleg V. Alnaser, Ali S. Materials Research Center College of Arts and Science American University of Sharjah Sharjah26666 United Arab Emirates Department of Optics and Spectroscopy Voronezh State University Voronezh394018 Russia TIIAME National Research University Tashkent100000 Uzbekistan Department of Sciences Western Caspian University BakuAZ1001 Azerbaijan Department of Physics College of Arts and Sciences American University of Sharjah Sharjah26666 United Arab Emirates Materials Science and Engineering Program College of Arts and Sciences American University of Sharjah Sharjah26666 United Arab Emirates

Nonlinear optical characteristics of chemically prepared silver selenide (Ag2Se, 3.7 nm) and lead selenide (PbSe, 6.3 nm) colloidal quantum dots (QDs) are investigated using the 1030 nm femtosecond pulses. Ag2Se QDs demonstrated two-photon absorption followed by saturable absorption. PbSe QDs initially showed the saturable absorption at small intensities of 1030 nm probe pulses, followed by reverse saturable absorption at stronger excitation. The difference in the positive nonlinear optical absorption mechanisms in these two QD colloids is attributed to their different bandgaps. The studied QD colloids exhibited the Kerr-induced positive nonlinear refraction. Transient absorption studies of the QDs showed that photoexcitation creates a hot exciton that forms band-edge exciton within 1.2 ps after excitation. Most of the electron-hole pairs further recombine through band-to-band recombination with a time constant of 1490 ps. Furthermore, the results from the transient absorption studies indicate the contribution of trap-assisted recombination occurs on a time scale exceeding that of the experimental time window. © The Author(s), under exclusive licence to Springer science+Business Media, LLC, part of Springer Nature 2024.

关键词： Semiconductor quantum dots

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Mass transport in a highly immiscible alloy on extended shear deformation

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Journal of materials science & Technology 2023年第3期134卷 197-208页

作者： Miao Song Jia Liu Xiaolong Ma Qin Pang Matthew J.Olszta Joshua Silverstein Madhusudhan R.Pallaka Peter V.Sushko Suveen N.Mathaudhu Cynthia Powell Arun Devaraj Bharat Gwalani Physical and Computational Sciences Directorate Pacific Northwest National Laboratory902 Battelle BoulevardRichlandWA 99354USA Energy and Environmental Directorate Pacific Northwest National Laboratory902 Battelle BoulevardRichlandWA 99354USA Material Science and Engineering Program University of CaliforniaRiversideCA92521USA Colorado School of Mines 1500 Illinois St.GoldenCO 8040USA Department of Materials Science and Engineering North Carolina State UniversityRaleighNC27695-7907USA State Key Laboratory of Powder Metallurgy Central South Uni-versityChangsha 410083China

Forced mixing to a single-phase or supersaturated solid solution(SSS)and its prerequisite microstructure evolution in immiscible systems has been a focus of research for fundamental science and practical *** the formation of SSS by shear deformation could enable a material design beyond conventional equilibrium microstructure in immiscible ***,a highly immiscible Cu-50 at.%Cr binary alloy(mixing enthalpy of∼20 kJ mol^(−1))was employed to investigate the microstructure evolution and localized tendencies of SSS during severe shear *** results demonstrate the dislocation mediated microstructural refinement process in each phase of the binary alloy and the mechanisms associated with localized solute supersaturation as a function of shear *** grain refinement in the softer Cu phase occurs owing to the strain localization driving the preferential dynamic *** grain refinement of the Cr phase,however,is enabled by the progressive evolution of grain lamination,splitting,and fragmentation as a function of shear *** solute supersaturation is found to be strongly dependent on the local environments that affect the dislocation activity,including the level of microstructure refinement,the interfacial orientation relationship,the mechanical incompatibility,and the localized preferential phase *** initio simulations confirm that it is more favorable to oxidize Cr than Cu at incoherent Cu/Cr interfaces,limiting the mass transport on an incoherent *** results unveil the mechanism underpinning the non-equilibrium mass transport in immiscible systems upon severe deformation that can be applied to produce immiscible alloys with superior mechanical properties.

关键词： Tribology Immiscible alloys Nanostructures Shear deformation Forced mixing Atom probe

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Effects of Y and Hf addition on soft magnetic property and ductility improvement of Fe–6.9 wt% Si alloy

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Journal of materials Research and Technology 2025年 37卷 1362-1378页

作者： Guojun Cai Yanru Huang Yongquan Qing R.D.K. Misra School of Mechanical Engineering Liaoning Petrochemical University Fushun 113001 China College of Sciences Liaoning Petrochemical University Fushun 113001 China School of Materials Science and Engineering Northeastern University Shenyang 110819 China Laboratory for Excellence in Advanced Steel Research Department of Metallurgical Materials and Biomedical Engineering University of Texas at El Paso El Paso TX 79968 USA

Fe–6.9 wt% Si alloy is superior to conventional electrical steels containing 3 wt%Si in terms of soft magnetic performance at high frequencies but its lack of ductility resulting in large restriction on workability and shaping. In present investigation, an excellent ductile behavior was observed in the Fe–6.9 wt% Si alloy containing Y and Hf, together with high magnetic induction B 8 of 1.385 T and B 50 of 1.661 T, as well as low core loss P 10/1000 of 32.168 W/kg. Smaller-sized Y 2 O 3 oxides were diffusely distributed in 6.9Si–0.03Y alloy, while the irregular larger-sized Y 2 Hf 2 O 7 oxides were distribute randomly in grains and at grain boundaries of 6.9Si–0.03Y–0.2Hf alloy. Y-Hf-containing oxides caused the preferential nucleation advantage of λ oriented grains in the nucleation process and hindered the development of γ-fiber recrystallization textures during final annealing, leading to an excellent soft magnetic property of 6.9Si–0.03Y–0.2Hf alloy. Benefiting from the suppression of brittle ordered phases and the change of dislocation configuration, the fracture strain of alloy increased from 6.7 % to 9.0 % in 6.9Si–0.03Y sheet and showed an excellent ductility value of 11.4 % duo to Hf addition. Y and Hf complex oxides doped in alloy provided an effective approach for improving the ductility without deterioration of soft magnetic property of high silicon steels.

关键词： Fe–6.9 wt% Si alloy Y Hf Texture Ductility

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A new approach to predict the performance of objective response detectors from Monte Carlo simulations

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Research on biomedical engineering 2022年第4期38卷 1113-1119页

作者： Passos, Marcos Aurelio Freire Ferraz de Sá, Antônio Maurício Ferreira Leite Miranda Antunes, Felipe Felix, Leonardo Bonato Axis of Control and Industrial Processes Federal Institute Sul Rio Grandense RS Santana do Livramento Brazil Biomedical Engineering Program Federal University of Rio de Janeiro RJ Rio de Janeiro Brazil Department of Electrical Engineering Federal Institute of Education Science and Technology of Minas Gerais—Ipatinga Campus MG Ipatinga Brazil Department of Electrical Engineering Federal University of Viçosa MG Viçosa Brazil

Purpose: Objective response detection (ORD) techniques assess if evoked potentials are embedded in the background electroencephalogram (EEG). If each technique gives its result, then it is necessary to check which test performs it better. Therefore, a methodology derived from Monte Carlo (MC) simulation was proposed to compare five ORD techniques. Methods: It was based on estimating the probability of detection (PD) of the tests for the different number of data segments (windows) and with a signal-to-noise ratio (SNR) ranging from − 40 to 0 dB. Moreover, an EEG database of subjects under auditory stimulation was used in order to validate the proposed methodology. Results: The simulation results showed that the detectors that used the neighboring frequency-band to the interest frequency, as the local spectral F test and Hotelling’s T2, have a better PD when the number of windows used is less than about 20. Conversely, when they are compared in cases with a greater number of windows, magnitude squared coherence, and modified Rayleigh test tend to have a higher PD value. These predictions were validated with the EEG signals. Conclusion: Therefore, this work predicted the performance of detectors only by means of MC simulation, as a function of the number of windows and tuned to an SNR range consistent with the EEG. © 2022, The Author(s), under exclusive licence to The Brazilian Society of biomedical engineering.

关键词： Signal to noise ratio

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