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New unexpected role for Wolfram Syndrome protein WFS1:a novel therapeutic target for Alzheimer’s disease?

Neural Regeneration Research 2023年第7期18卷 1501-1502页

作者： Shuo Chen Diana Acosta Hongjun Fu Department of Neuroscience Biomedical Sciences Graduate ProgramThe Ohio State UniversityColumbusOHUSA Department of Neuroscience The Ohio State UniversityColumbusOHUSA

Selective vulnerability of excitatory neurons in Alzheimer’s disease(AD):AD is the most common form of dementia;however,the pathogenesis of AD is largely *** of the characteristic features of AD is the formation of intracellular neurofibrillary tangles(NFTs).NFTs are abnormal accumulates of misfolded tau protein,which may eventually cause neuronal death and neurodegeneration(Jack et al.,2018).In the early stages of AD progression,not all neurons are equally vulnerable to tau *** studies have shown that large pyramidal neurons in the entorhinal cortex(EC)are specifically vulnerable to pathological tau accumulation(Fu et al.,2017).This selective vulnerability of excitatory neurons to tau pathology is one of the fundamental questions needed to be answered in AD research.

关键词： Alzheimer tau cortex

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Characterization of retinal ganglion cell damage at single axon bundle level in mice by visible-light optical coherence tomography fibergraphy

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Neural Regeneration Research 2023年第1期18卷 135-136页

作者： Xiaorong Liu Hao F.Zhang Department of Biology Department of PsychologyProgram in Fundamental NeuroscienceUniversity of VirginiaCharlottesvilleVAUSA Department of Biomedical Engineering Northwestern UniversityEvanstonILUSA

Retinal ganglion cells(RGCs)receive synaptic inputs through their dendritic trees in the inner plexiform layer(IPL)and convey the visual information via their axons which form the optic nerve to the brain(Sanes and Masland,2015).In glaucoma,RGCs and their axons degenerate and die,leading to irreversible vision loss and eventually blindness if left untreated(Quigley,2016).

关键词： bundle visible eventually

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Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the brain

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Neural Regeneration Research 2024年第5期19卷 969-970页

作者： Anne-Eva van der Wijk Ed VanBavel Amsterdam UMC location University of Amsterdam Department of Biomedical Engineering and PhysicsAmsterdamThe Netherlands Amsterdam Neuroscience Neurovascular Disorders ProgramAmsterdamThe Netherlands Amsterdam Cardiovascular Sciences Microcirculation ProgramAmsterdamThe Netherlands

Development of therapeutics for brain diseases has remained challenging,in particular due to the difficulty of passing the blood-brain *** a result,the current arsenal of therapeutics targeting the brain is limited to small,lipid-soluble drugs and there is a lack of options for treating neuroblastomas,Alzheimer’s disease,and many other devastating *** the advances in strategies for crossing the blood-brain barrier such as the use of nanoparticles(Hersh et al.,2022;Duan et al.,2023),such delivery systems have not yet reached clinical ***,novel platforms for the transport of therapeutics across the blood-brain barrier remain highly *** specifically holds for large molecules such as monoclonal antibodies and recombinant proteins,as well as nucleotide-based therapeutics and cell *** efforts in this field are increasing exponentially,with thousands of publications in the last few years.

关键词： therapeutics holds spite

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Three-color single-molecule localization microscopy in chromatin

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光：科学与应用（英文版） 2025年第5期14卷 1265-1277页

作者： Nicolas Acosta Ruyi Gong Yuanzhe Su Jane Frederick Karla I.Medina Wing Shun Li Kiana Mohammadian Luay Almassalha Geng Wang Vadim Backman Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Center for Physical Genomics and Engineering Northwestern UniversityEvanstonIL 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Center for Physical Genomics and Engineering Northwestern UniversityEvanstonIL 60208USA IBIS Interdisciplinary Biological Sciences Graduate Program Northwestern UniversityEvanstonIL 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Center for Physical Genomics and Engineering Northwestern UniversityEvanstonIL 60208USA Applied Physics Program Northwestern UniversityEvanstonIL 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Center for Physical Genomics and Engineering Northwestern UniversityEvanstonIL 60208USA Department of Gastroenterology and Hepatology Northwestern Memorial HospitalChicagoIL 60611USA

Super-resolution microscopy has revolutionized our ability to visualize structures below the diffraction limit of conventional optical microscopy and is particularly useful for investigating complex biological targets like *** exhibits a hierarchical organization with structural compartments and domains at different length scales,from nanometers to *** molecule localization microscopy(SMLM)methods,such as STORM,are essential for studying chromatin at the supra-nucleosome level due to their ability to target epigenetic marks that determine chromatin ***-label imaging of chromatin is necessary to unpack its structural ***,these efforts are challenged by the high-density nuclear environment,which can affect antibody binding affinities,diffusivity and non-specific *** buffer conditions,fluorophore stability,and antibody specificity is crucial for achieving effective antibody ***,we demonstrate a sequential immunolabeling protocol that reliably enables three-color studies within the dense nuclear *** protocol couples multiplexed localization datasets with a robust analysis algorithm,which utilizes localizations from one target as seed points for distance,density and multi-label joint affinity measurements to explore complex organization of all three *** this multiplexed algorithm to analyze distance and joint density reveals that heterochromatin and euchromatin are not-distinct territories,but that localization of transcription and euchromatin couple with the periphery of heterochromatic *** work is a crucial step in molecular imaging of the dense nuclear environment as multi-label capacity enables for investigation of complex multi-component systems like chromatin with enhanced accuracy.

关键词： localization chromatin microscopy single-molecule three-color

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Interfering with sleep apnea

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Bioelectronic Medicine 2024年第1期10卷 1-3页

作者： Pedersen, Nigel Paul Astorga, Raul Castillo Department of Neurology School of Medicine and Center for Neuroscience University of California Davis 1515 Newton Court DavisCA95618 United States Graduate Program in Biomedical Engineering University of California DavisCA95618 United States

The effects of electromagnetic interference have been hiding in plain sight for millennia and are now being applied to the non-invasive stimulation of deep tissues. In the article by Missey et al., the effect of non-invasive stimulation of the hypoglossal nerve by an interference envelope of interfering carrier waves is examined in mice and participants with sleep apnea. This stimulation is capable of activating the nerve and reducing apnea-hypopnea events. Temporally interfering electric fields have potential applications far beyond hypoglossal stimulation and may represent a revolutionary new approach to treating illness and understanding the functional organization of the nervous system. © 2024, The Author(s).

关键词： Electric fields

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Modeling gut neuro-epithelial connections in a novel microfluidic device

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Microsystems & Nanoengineering 2023年第6期9卷 235-246页

作者： Jose M.de Hoyos-Vega Xi Yu Alan M.Gonzalez-Suarez Sisi Chen Arnaldo Mercado-Perez Eugene Krueger Jeric Hernandez Yaroslav Fedyshyn Brooke R.Druliner David R.Linden Arthur Beyder Alexander Revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMNUSA Enteric Neuroscience Program(ENSP) Mayo ClinicRochesterMNUSA Division of Gastroenterology and Hepatology Department of MedicineMayo ClinicRochesterMNUSA

The intestinal lumen is filled with diverse chemical and physical *** epithelial cells sense these stimuli and signal to enteric neurons which coordinate a range of physiologic processes required for normal digestive tract ***,the neuro-epithelial connections remain poorly resolved,in part because the tools for orchestrating interactions between these cellular compartments are *** describe the development of a two-compartment microfluidic device for co-culturing enteric neurons with intestinal epithelial *** device contains epithelial and neuronal compartments connected by *** epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human intestinal *** demonstrated that organoids planarized effectively and retained epithelial phenotype for over a *** the second chamber we dissociated and cultured intestinal myenteric neurons including intrinsic primary afferent neurons(IPANs)from transgenic mice that expressed the fluorescent protein *** extended projections into microgrooves,surrounded and frequently made contacts with epithelial *** density and directionality of neuronal projections were enhanced by the presence of epithelial cells in the adjacent *** microfluidic device represents a platform that may,in the future,be used to dissect structure and function of neuro-epithelial connections in the gut and other organs(skin,lung,bladder,and others)in health and disease.

关键词： fluid bladder organs

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Boosting corticospinal system synaptic plasticity to recover motor functions

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Neural Regeneration Research 2023年第10期18卷 2182-2183页

作者： Weiguo Song John H.Martin Feinstein Institutes for Medical Research ManhassetNYUSA Department of Molecular Cellularand Biomedical SciencesCenter for Discovery and Innovation Neuroscience Program Graduate Center of the City University of New YorkNew YorkNYUSA

An importa nt strategy to promote voluntary movements after motor system injury is to strengthen the connections between the motor cortex and muscles by taking advantage of the plasticity of the corticospinal motor *** neuromodulation approaches are directed to activate the spinal cord and peripheral axons to strengthen muscle *** discuss in this perspective that,the cortex and spinal cord should be ta rgeted together to enhance cortex-to-musclefunction(Amer and Martin,2022).

关键词： plasticity system activation

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A Novel SERS Substrate Containing Silver Nanoparticle-Deposited Photoresist Microcone Array for Sensitive Biosensing

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IEEE Sensors Journal 2024年第2期24卷 1398-1404页

作者： Lin, Ying-Ting Wang, Sheng-Hsiang Tseng, Yu-Hsin Lin, Ze-Cheng Chen, Jyun-Tu Chang, Cheng-Chung Wang, Gou-Jen National Chung Hsing University Program in Tissue Engineering and Regenerative Medicine Taichung40227 Taiwan National Chung Hsing University Department of Mechanical Engineering Taichung40227 Taiwan Graduate Institute of Biomedical Engineering National Chung Hsing University Taichung40227 Taiwan

In this study, we developed a novel surface-enhanced Raman scattering (SERS) substrate formed by depositing silver nanoparticles (AgNPs) on a silver thin film-coated photoresist (PR) microcone array. The semiconductor photolithographic process was adopted for fabricating the PR microcone array. The hotspot enhancement effect of the SERS substrates was optimized by adjusting the concentration of the trisodium citrate, which was used as a reducing agent and a stabilizing agent for the synthesis of AgNPs. Experimental results showed that the proposed SERS substrate could detect the indicating peaks of Rhodamine 6G (R6G) at a relatively low concentration of 10-12 M. A standard detection curve for HbA1c detection with a linear detection range of 5000-20000 ng/mL with good linearity of 0.994 and a limit of detection (LOD) of 850.2 ng/mL was further established by adding HbA1c agent to artificial blood to simulate a real environmental condition. Recovery rate detection experiments confirmed the reproducibility of the established standard detection curve. © 2001-2012 IEEE.

关键词： Silver nanoparticles

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BLOCKCHAIN TECHNOLOGY IMPLEMENTATION FOR HEALTHCARE PRIVACY DATA SYSTEMS IN THE UAE 50

BLOCKCHAIN TECHNOLOGY IMPLEMENTATION FOR HEALTHCARE PRIVACY ...

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50th International Conference on Computers and Industrial engineering: Sustainable Digital Transformation, CIE 2023

作者： Alshamsi, Hessa Marei, Fatemaal Marwan, Tasnim Shamayleh, Abdulrahim Department of Industrial Engineering American University of Sharjah Sharjah United Arab Emirates Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates Department of Industrial Engineering Biomedical Engineering Graduate Program American University of Sharjah Sharjah United Arab Emirates

ISBN: (纸本)9781713886952

Blockchain technology is being recognized as a significant solution to technical issues across various industries, including healthcare. In the healthcare sector, Blockchain has the potential to revolutionize processes such as transferring patient medical records, managing the medicine supply chain, and aiding healthcare researchers in unlocking genetic code. The United Arab Emirates (UAE) has emerged as a developed country actively exploring blockchain technology to enhance its healthcare sector. Despite efforts to improve healthcare in the UAE, integrating new technologies has been limited. The focus has primarily been on improving equipment and procedures rather than adopting innovative solutions. The growing population and increasing emphasis on medical tourism have also amplified the demand for advanced healthcare services. Therefore, immediate action is required to initiate significant developments in the healthcare sector. This research aims to highlight the importance and role of blockchain technology, specifically in the UAE healthcare sector. It seeks to improve the competence and privacy of healthcare data systems while addressing concerns related to centralization. The study presents recent findings concerning the initiatives and vision of the UAE government to establish a globally outstanding healthcare sector. It defines blockchain technology and emphasizes its positive impact on enhancing healthcare data systems. Furthermore, the research showcases various applications of blockchain technology that can be implemented in the healthcare sector. By demonstrating blockchain technology's benefits and potential applications, this research endeavors to encourage the strategic adoption of blockchain solutions in the healthcare sector. Such initiatives can pave the way for advancements in patient data systems and privacy. © 2023 Computers and Industrial engineering. All rights reserved.

关键词： Blockchain

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Downsizing and soft X-ray tomography for cellular uptake of interpenetrated metal-organic frameworks

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Journal of Materials Chemistry B 2024年第25期12卷 6079-6090页

作者： Yu, Yu-Sheng Liang, Yung-Yi Hsieh, Chia-Chun Lin, Zi-Jing Cheng, Po-Hsiu Cheng, Chih-Chan Chen, Shu-Ping Lai, Lee-Jene Wu, Kevin C.-W. National Taiwan University Department of Chemical Engineering Taipei Taiwan National Health Research Institute Institute of Biomedical Engineering and Nanomedicine Miaoli Taiwan Hsinchu Taiwan International Graduate Program of Molecular Science and Technology Taiwan International Graduate Program Academia Sinica Taipei Taiwan National Taiwan University Taipei Taiwan

Metal-organic frameworks (MOFs) are porous materials with potential in biomedical applications such as sensing, drug delivery, and radiosensitization. However, how to tune the properties of the MOFs for such applications remains challenging. Herein, we synthesized two MOFs, Zr-PEB and Hf-PEB. Zr-PEB can be classified as porous interpenetrated zirconium frameworks (PIZOFs) and Hf-PEB is its analogue. We controlled their sizes while maintaining their crystal structure by employing a coordination modulation strategy. They were designed to serve as sensitizer for X-ray therapy and as potential drug carriers. Comprehensive characterizations of the MOFs' properties have been conducted, and the in vitro biological impacts have been studied. Since viability assay showed that Hf-PEB was more biocompatible compared to Zr-PEB, the cellular uptake of Hf-PEB by cells was evaluated using both fluorescence microscopy and soft X-ray tomography (SXT), and the three-dimensional structure of Hf-PEB in cells was observed. The results revealed the potential of Zr-PEB and Hf-PEB as nanomaterials for biomedical applications and demonstrated that SXT is an effective tool to assist the development of such materials. © 2024 The Royal Society of Chemistry.

关键词： Organometallics

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