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检索条件"机构=Department of Biomedical Engineering and Program in Bioinformatics"
183 条 记 录,以下是31-40 订阅
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KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection
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Science (New York, N.Y.) 2025年 第6735期387卷 eadn2337页
作者: Fagerberg, Eric Attanasio, John Dien, Christine Singh, Jaiveer Kessler, Emily A. Abdullah, Leena Shen, Jian Hunt, Brian G. Connolly, Kelli A. De Brouwer, Edward He, Jiaming Iyer, Nivedita R. Buck, Jessica Borr, Emily R. Damo, Martina Foster, Gena G. Giles, Josephine R. Huang, Yina H. Tsang, John S. Krishnaswamy, Smita Cui, Weiguo Joshi, Nikhil S. Department of Immunobiology Yale University School of Medicine New Haven CT United States Program in Computational Biology & Bioinformatics Yale University New Haven CT United States Department of Microbiology and Immunology Geisel School of Medicine at Dartmouth NH United States Department of Pathology Feinberg School of Medicine at Northwestern University Chicago IL United States Department of Genetics and Computer Science Yale University School of Medicine New Haven CT United States Department of Medicine University of Chicago Chicago IL United States Section of Hematology Department of Internal Medicine Yale University School of Medicine New Haven CT United States Department of Systems Pharmacology and Translational Therapeutics University of Pennsylvania Philadelphia PA United States Institute for Immunology Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Parker Institute for Cancer Immunotherapy Perelman School of Medicine University of Pennsylvania Philadelphia PA United States Yale Center for Systems and Engineering Immunology Yale University School of Medicine New Haven CT United States New Haven CT United States Department of Biomedical Engineering Yale University New Haven CT United States Computational Biology and Bioinformatics Program Yale University CT USA New Haven United States Applied Math Program Yale University New Haven CT United States
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiati...
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BPS2025 - Cross-scale conundrum: Slow masticatory myosin in jaw muscles that are both fast and strong
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Biophysical Journal 2025年 第3期124卷 516a-516a页
作者: Varun V. Dhorajia Nicholas LaFave Brandon Reder Robert Brocklehurst Nicolai Konow Sam Walcott Jeffrey R. Moore Biomedical Engineering and Biotechnology Program University of Massachusetts Lowell Lowell MA USA Department of Biological Sciences University of Massachusetts Lowell Lowell MA USA Department of Mathematical Sciences Worcester Polytechnic Institute Worcester MA USA Department of Bioinformatics and Computational Biology Worcester Polytechnic Institute Worcester MA USA
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Caco-2 Cell-Derived Biomimetic Electrochemical Biosensor for Cholera Toxin Detection
SSRN
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SSRN 2022年
作者: Kim, Yonghwan Lee, Dongtak Seo, Youngjun Jung, Hyo Gi Jang, Jae Won Park, Dongsung Kim, Insu Lee, Gyudo Hwang, Kyo Seon Kim, Seung-Hyun Lee, Sang Won Lee, Jeong Hoon Yoon, Dae Sung School of Biomedical Engineering Korea University Seoul02841 Korea Republic of Interdisciplinary Program in Precision Public Health Korea University Seoul02841 Korea Republic of Department of Clinical Pharmacology and Therapeutics College of Medicine Kyung Hee University Seoul02447 Korea Republic of Department of Biotechnology and Bioinformatics Korea University Sejong30019 Korea Republic of Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology Korea University Sejong30019 Korea Republic of School of Engineering Brown University ProvidenceRI02912 United States Department of Electrical Engineering and Computer Science University of California IrvineCA92697 United States Department of Electrical Engineering Kwangwoon University Seoul01897 Korea Republic of Astrion Inc Seoul02841 Korea Republic of
Cholera is a highly contagious and lethal waterborne disease induced by an infection with Vibrio cholerae (V. cholerae) secreting cholera toxin (CTx). Cholera toxin subunit B (CTxB) from the CTx specifically binds wit... 详细信息
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Functional neuroplasticity of facilitation and interference effects on inhibitory control following 3-month physical exercise in aging
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Scientific Reports 2024年 第1期14卷 1-13页
作者: Wu, Hong-Yi Huang, Chih-Mao Hsu, Ai-Ling Chen, Chiao-Nan Wu, Changwei W. Chen, Jyh-Horng Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan Bachelor Program in Artificial Intelligence Chang Gung University Taoyuan Taiwan Department of Psychiatry Chang Gung Memorial Hospital at Linkou Taoyuan Taiwan Department of Physical Therapy and Assistive Technology National Yang Ming Chiao Tung University Taipei Taiwan Graduate Institute of Mind Brain and Consciousness Taipei Medical University New Taipei Taiwan Research Center of Sleep Medicine Taipei Medical University Hospital Taipei Taiwan Department of Electrical Engineering National Taiwan University Taipei Taiwan
Preservation of executive function, like inhibition, closely links to the quality of life in senior adults. Although neuroimaging literature has shown enhanced inhibitory function followed by aerobic exercise, current...
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Gene knockout inference with variational graph autoencoder learning single-cell gene regulatory networks
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Nucleic acids research 2023年 第13期51卷 6578-6592页
作者: Yongjian Yang Guanxun Li Yan Zhong Qian Xu Bo-Jia Chen Yu-Te Lin Robert S Chapkin James J Cai Department of Electrical and Computer Engineering Texas A&M University College Station TX 77843 USA. Department of Statistics Texas A&M University College Station TX 77843 USA. Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of Statistics East China Normal University 3663 North Zhongshan Road Shanghai 200062 China. Department of Veterinary Integrative Biosciences Texas A&M University College Station TX 77843 USA. Graduate Institute of Microbiology and Public Health College of Veterinary Medicine National Chung Hsing University Taichung 402 Taiwan. Graduate Institute of Biomedical Electronics and Bioinformatics National Taiwan University Taipei Taiwan. Program in Integrative & Complex Diseases Department of Nutrition Texas A&M University College Station TX 77843 USA. Interdisciplinary Program of Genetics Texas A&M University College Station TX 77843 USA.
In this paper, we introduce Gene Knockout Inference (GenKI), a virtual knockout (KO) tool for gene function prediction using single-cell RNA sequencing (scRNA-seq) data in the absence of KO samples when only wild-type...
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Measurement and models accounting for cell death capture hidden variation in compound response (vol 82, pg 631, 2020)
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CELL DEATH & DISEASE 2020年 第8期11卷 1-9页
作者: Bae, Song Yi Guan, Ning Yan, Rui Warner, Katrina Taylor, Scott D. Meyer, Aaron S. Department of Pharmacology University of Minnesota-Twin Cities Minneapolis MN USA Department of Biological Engineering Massachusetts Institute of Technology Cambridge MA USA Institute for Computational and Mathematical Engineering Stanford University Stanford CA USA Biological and Biomedical Sciences Program Harvard University Cambridge MA USA Department of Bioengineering University of California Los Angeles CA USA Department of Bioinformatics University of California Los Angeles CA USA Jonsson Comprehensive Cancer Center University of California Los Angeles CA USA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research University of California Los Angeles CA USA
Cancer cell sensitivity or resistance is almost universally quantified through a direct or surrogate measure of cell number. However, compound responses can occur through many distinct phenotypic outcomes, including c... 详细信息
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Comparative analysis of gene regulation in single cells using Compass
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Cell Reports Methods 2025年 第5期5卷 101035页
作者: Wan, Changxin Qu, Yilong Ye, Zhiyou Zhang, Tianbei Ma, Huifang Chen, Ming Hou, Wenpin Ji, Zhicheng Department of Biostatistics and Bioinformatics Duke University School of Medicine Durham NC United States Program of Computational Biology and Bioinformatics Duke University School of Medicine Durham NC United States Department of Biomedical Engineering Pratt School of Engineering Duke University Durham NC United States Department of Pathology Duke University School of Medicine Durham NC United States Duke Cancer Institute Duke University Durham NC United States Department of Biostatistics Columbia University Mailman School of Public Health New York City NY United States
Single-cell multi-omics is a transformative technology that measures both gene expression and chromatin accessibility in individual cells. However, most studies concentrate on a single tissue and are unable to determi... 详细信息
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WARMING EFFECT of BLANKETS with HIGH FAR-INFRARED EMISSIVITY on SKIN MICROCIRCULATION in TYPE 2 DIABETIC PATIENTS
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biomedical engineering - Applications, Basis and Communications 2020年 第6期32卷
作者: Bau, Jian-Guo Yang, Chun-Pai Huang, Bo-Wen Lin, Yung-Sheng Wu, Ming-Feng Hungkuang University Department of Biomedical of Engineering Taichung Taiwan Department of Neurology Kuang Tien General Hospital Taichung Taiwan Department of Nutrition Hungkuang University Taichung Taiwan Feng Chia University Master's Program of Bioinformatics and Biomedical Engineering Taichung Taiwan National United University Department of Chemical Engineering Miaoli Taiwan Department of Medical Intensive Care Unit Kuang Tien General Hospital Taichung Taiwan
Vascular complications are responsible for most of the morbidity and mortality in diabetic patients. Effective strategies to improve circulation appear to be another important issue in addition to the interventions of... 详细信息
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Artificial intelligence for modelling infectious disease epidemics
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Nature 2025年 第8051期638卷 623-635页
作者: Kraemer, Moritz U. G. Tsui, Joseph L.-H. Chang, Serina Y. Lytras, Spyros Khurana, Mark P. Vanderslott, Samantha Bajaj, Sumali Scheidwasser, Neil Curran-Sebastian, Jacob Liam Semenova, Elizaveta Zhang, Mengyan Unwin, H. Juliette T. Watson, Oliver J. Mills, Cathal Dasgupta, Abhishek Ferretti, Luca Scarpino, Samuel V. Koua, Etien Morgan, Oliver Tegally, Houriiyah Paquet, Ulrich Moutsianas, Loukas Fraser, Christophe Ferguson, Neil M. Topol, Eric J. Duchêne, David A. Stadler, Tanja Kingori, Patricia Parker, Michael J. Dominici, Francesca Shadbolt, Nigel Suchard, Marc A. Ratmann, Oliver Flaxman, Seth Holmes, Edward C. Gomez-Rodriguez, Manuel Schölkopf, Bernhard Donnelly, Christl A. Pybus, Oliver G. Cauchemez, Simon Bhatt, Samir Pandemic Sciences Institute University of Oxford Oxford United Kingdom Department of Biology University of Oxford Oxford United Kingdom Department of Electrical Engineering and Computer Science University of California Berkeley Berkeley CA United States UCSF UC Berkeley Joint Program in Computational Precision Health Berkeley CA United States Division of Systems Virology Department of Microbiology and Immunology The Institute of Medical Science The University of Tokyo Tokyo Japan Section of Epidemiology Department of Public Health University of Copenhagen Copenhagen Denmark Oxford Vaccine Group University of Oxford and NIHR Oxford Biomedical Research Centre Oxford United Kingdom Department of Epidemiology and Biostatistics Imperial College London London United Kingdom Department of Computer Science University of Oxford Oxford United Kingdom School of Mathematics University of Bristol Bristol United Kingdom MRC Centre for Global Infectious Disease Analysis School of Public Health Imperial College London London United Kingdom Department of Statistics University of Oxford Oxford United Kingdom Doctoral Training Centre University of Oxford Oxford United Kingdom Institute for Experiential AI Northeastern University MA Boston Thailand Santa Fe Institute Santa Fe NM United States World Health Organization Regional Office for Africa Brazzaville Congo WHO Hub for Pandemic and Epidemic Intelligence Health Emergencies Programme World Health Organization Berlin Germany Centre for Epidemic Response and Innovation (CERI) School for Data Science and Computational Thinking Stellenbosch University Stellenbosch South Africa African Institute for Mathematical Sciences (AIMS) South Africa Muizenberg Cape Town South Africa Genomics England London United Kingdom Scripps Research La Jolla CA United States Department of Biosystems Science and Engineering ETH Zürich Basel Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland The Ethox Centre Nuffield
Infectious disease threats to individual and public health are numerous, varied and frequently unexpected. Artificial intelligence (AI) and related technologies, which are already supporting human decision making in e...
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Chemoresistance in acute myeloid leukemia: An alternative single-cell RNA sequencing approach
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Hematological oncology 2023年 第3期41卷 499-509页
作者: Po-Liang Cheng Tzu-Hung Hsiao Chung-Hsing Chen Miao-Neng Hung Pei-Pei Jhan Li-Wen Lee Ting-Shuan Wu Jia-Rung Tsai Chieh-Lin Jerry Teng Department of Medical Research Taichung Veterans General Hospital Taichung Taiwan. Research Center for Biomedical Science and Engineering National Tsing Hua University Hsinchu Taiwan. Department of Public Health Fu Jen Catholic University New Taipei City Taiwan. Institute of Genomics and Bioinformatics National Chung Hsing University Taichung Taiwan. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung Taiwan. Division of Hematology/Medical Oncology Department of Medicine Taichung Veterans General Hospital Taichung Taiwan. Department of Life Science Tunghai University Taichung Taiwan. School of Medicine Chung Shan Medical University Taichung Taiwan. Ph.D. Program in Translational Medicine National Chung Hsing University Taichung Taiwan. Rong Hsing Research Center for Translational Medicine National Chung Hsing University Taichung Taiwan.
Our previous study demonstrated that myc, mitochondrial oxidative phosphorylation, mTOR, and stemness are independently responsible for chemoresistance in acute myeloid leukemia (AML) cells. This study aimed to identi... 详细信息
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