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Random Illumination Microscopy:faster,thicker,and aberration-insensitive

Light(Science & Applications) 2025年第1期14卷 15-17页

作者： Boya Jin Peng Xi Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing100871China National Biomedical Imaging Center Peking UniversityBeijing100871China

The Extended Depth of Field(EDF)approach has been combined with Random Illumination Microscopy(RIM)to realize aberration-insensitive,fast super-resolution imaging with extended depth,which is a promising tool for dyna... 详细信息

关键词： thick faster insensitive

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Optical sectioning methods in three-dimensional bioimaging

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Light(Science & Applications) 2025年第1期14卷 47-74页

作者： Jing Zhang Wei Qiao Rui Jin Hongjin Li Hui Gong Shih-Chi Chen Qingming Luo Jing Yuan Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhanChina MoE Key Laboratory for Biomedical Photonics Innovation InstituteHuazhong University of Science and TechnologyWuhanChina Hong Kong Center for Cerebro-Cardiovascular Health Engineering N.THong KongChina Department of Biomedical Engineering City University of Hong KongHong KongChina HUST-Suzhou Institute for Brainsmatics SuzhouChina Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatinN.T.Hong KongChina School of Biomedical Engineering Hainan UniversityHaikouChina

In recent advancements in life sciences,optical microscopy has played a crucial role in acquiring high-quality three-dimensional structural and functional ***,the quality of 3D images is often compromised due to the intense scattering effect in biological tissues,compounded by several issues such as limited spatiotemporal resolution,low signal-to-noise ratio,inadequate depth of penetration,and high *** various optical sectioning techniques have been developed to address these challenges,each method adheres to distinct imaging principles for specific *** a result,the effective selection of suitable optical sectioning techniques across diverse imaging scenarios has become crucial yet *** paper comprehensively overviews existing optical sectioning techniques and selection guidance under different imaging ***,we categorize the microscope design based on the spatial relationship between the illumination and detection axis,i.e.,on-axis and *** classification provides a unique perspective to compare the implementation and performances of various optical sectioning ***,we integrate selected optical sectioning methods on a custom-built off-axis imaging system and present a unique perspective for the future development of optical sectioning techniques.

关键词： illumination intense integrate

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MMP-9-responsive probe for fiuorescence-magnetic resonance dual-mode imaging of hepatocellular carcinoma models with different metastatic capacities

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Chinese Chemical Letters 2025年第4期36卷 351-356页

作者： Qiuye Wang Yabing Sun Liangxue Lai Haijing Cui Yonglong Ye Ming Yang Weihao Zhu Bo Yuan Quanliang Mao Wenzhi Ren Aiguo Wu Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Cixi Biomedical Research Institute Wenzhou Medical UniversityNingbo 315300China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Department of Radiology First Affiliated Hospital of Ningbo UniversityNingbo 315010China

Visual assessment of tumor metastatic capacity is crucial for predicting hepatocellular carcinoma(HCC)prognosis and guiding clinical therapeutic *** this study,we developed an enzyme-responsive probe based on the peptide GK10,which is selectively cleaved by matrix metalloproteinase-9(MMP-9),a critical marker for metastasis in *** GK10 peptide was conjugated with near-infrared fiuorescent molecule IR783,fiuorescent quencher black hole quencher 3(BHQ3),and magnetic resonance(MR)contrast agent DOTA-Gd,forming the IR783-GK10-BHQ3-Gd *** MMP-9 cleavage of GK10,BHQ3 is released from the probe,thereby amplifying the previously quenched IR783 fiuorescence *** vitro experiments demonstrate the probe's impressive detection limit for MMP-9,as low as 1.84 ng/m ***,in vivo imaging results reveal that the probe can differentiate liver cancers with varying metastatic *** fiuorescence and MR imaging signal intensity of high metastatic HCC are approximately1.2 times greater than that of low metastatic ***,this engineered probe holds promise as a valuable tool for evaluating HCC metastatic capacity through fiuorescence-MR dual-mode imaging.

关键词： Hepatocellular carcinoma Matrix metalloproteinase-9 Fluorescence imaging Magneticresonance imaging F?rster resonance energy transfer

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PD-L1 targeted iron oxide SERS bioprobe for accurately detecting circulating tumor cells and delineating tumor boundary

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Chinese Chemical Letters 2025年第1期36卷 408-414页

作者： Ting Pan Dinghu Zhang Guomei You Xiaoxia Wu Chenguang Zhang Xinyu Miao Wenzhi Ren Yiwei He Lulu He Yuanchuan Gong Jie Lin Aiguo Wu Guoliang Shao Department of Interventional Radiology Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Cixi Institute of Biomedical EngineeringInternational Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Early diagnosis and accurate boundary delineation are the key steps of tumor precision *** tumor cells(CTCs)detection of liquid biopsy can provide abundant information for early diagnosis of *** detection specificity and good enrichment features are two key factors for CTCs accurate identification in peripheral blood *** this purpose,iron oxide(IO)-based surface-enhanced Raman scattering(SERS)bioprobes with good biocompatibility,high detection sensitivity,remarkable detection specificity,and good enrichment efficiency,were developed for detecting different types of *** SERS bioprobes combined with programmed death ligand-1(PD-L1)antibody are regarded as an effective way to boost the targeting ability and detection specificity,benefiting for accurately capturing and identifying rare *** types of CTCs with different PD-L1 expression were accurately distinguished among white blood cells via high-resolution SERS mapping images and stable Raman ***,CTCs blood samples obtained from the triple negative breast cancer patients were also successfully recognized compared to that of health people,indicating IO@AR@PDA-a PD-L1 SERS bioprobe possessed great potential for CTCs detection in liquid ***,IO-based bioprobe exhibited excellent dual-modal imaging abilities of high-resolution SERS imaging mode and microimaging magnetic resonance imaging *** two highly complementary imaging modes endowed IO-based bioprobes unrivalled capacity in tumor boundary differentiation,supporting tumor accurate resection and precise *** our best knowledge,this is the first time that biocompatible IO-based SERS bioprobes without noble metal element were reported not only for CTCs accurate detection,but also for precise tumor boundary delineation,showing great advantages in tumor diagnosis and treatment.

关键词： Circulating tumor cells Surface-enhanced Raman scattering PD-L1 Iron oxide bioprobe Dual-modal imaging Tumor boundaries delineation

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Biomechanics-Informed Mechatronics Design of Comfort-centered Portable Hip Exoskeleton: Actuator, Wearable Interface, Controller

IEEE Transactions on Medical Robotics and Bionics

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IEEE Transactions on Medical robotics and Bionics 2025年第2期7卷 687-698页

作者： Rodriguez-Jorge, Daniel Zhang, Sainan Huang, Jin Sen Lopez-Sanchez, Ivan Srinivasan, Nitin Zhang, Qiang Zhou, Xianlian Su, Hao North Carolina State University Department of Mechanical and Aerospace Engineering RaleighNC27695 United States Tandon School of Engineering New York University Laboratory of Biomechatronics and Intelligent Robotics Department of Biomedical Engineering New YorkNY11201 United States The University of Alabama Department of Mechanical Engineering Department of Chemical & Biological Engineering TuscaloosaAL35401 United States New Jersey Institute of Technology Department of Biomedical Engineering NewarkNJ07102 United States

Exoskeletons can improve human mobility, but discomfort remains a significant barrier to their widespread adoption. This paper presents a comfort-centered mechatronics design of portable hip exoskeletons, comprising of three factors: (i) actuation, (ii) wearable interface, (iii) and assistive controller. We introduced an analytical multibody model to predict the human-exoskeleton contact forces during gait. Informed by this model, we designed a wearable interface that significantly improved the three considered objective metrics: (i) undesired contact forces at the wearable interface, (ii) wobbling, and (iii) metabolic reduction, and also the post-test evaluation via a System Usability Scale questionnaire as a subjective metric. Our experiments with two exoskeleton controllers (gait-based and reinforcement learning-based) demonstrated that the design of the wearable physical interface has a greater impact on reducing metabolic rate and minimizing wobbling than the choice of controller. Our actuation design method leads to highly backdrivable, lightweight quasi-direct drive actuators with high torque tracking performance. By leveraging this wearable design, we achieved up to 60% reduction in undesired contact forces, and a 74% reduction in exoskeleton wobbling in the frontal axis compared to a traditional configuration. Additionally, the net metabolic cost reduction was 18% compared to the no exoskeleton condition. © 2018 IEEE.

关键词： Exoskeleton (robotics)

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The Intersection of Genetics and Neuroimaging: A Systematic Review of Imaging Genetics in Neurological Disease for Personalized Treatment

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Journal of Molecular Neuroscience 2025年第2期75卷 1-26页

作者： Mashhour, Mahinaz A. Youssef, Ibrahim Wahed, Manal Abdel Mabrouk, Mai S. Biomedical Engineering Department Misr University for Science and Technology Giza Egypt Systems and Biomedical Engineering Department Cairo University Giza Egypt Center for Informatics Science (CIS) School of Information Technology and Computer Science Nile University Giza Egypt

Imaging genetics is one of the important keys to precision medicine that leads to personalized treatment based on a patient’s genetics, phenotype, or psychosocial characteristics. It deepens the understanding of the mechanisms through which genetic variations contribute to neurological and psychiatric disorders. This systematic review overviews the methods and applications of imaging genetics in the context of neurological diseases, mentioning its potential role in personalized medicine. Following PRISMA guidelines, this review systematically analyzes 28 studies integrating genetic and neuroimaging data to explore disease mechanisms and their implications for precision medicine. Selected research included multiple neurological disorders, including frontotemporal dementia, Alzheimer’s disease, bipolar disorder, schizophrenia, Parkinson’s disease, and others. Voxel-based morphometry was the most common imaging technique, while frequently examined genetic variants included APOE, C9orf72, MAPT, GRN, COMT, and BDNF. Associations between these variants and regional gray matter loss (e.g., frontal, temporal, or subcortical regions) suggest that genetic risk factors play a key role in disease pathophysiology. Integrating genetic and neuroimaging analyses enhances our understanding of disease mechanisms and supports advancements in precision medicine. © The Author(s) 2025.

关键词： Imaging genetics Neurological diseases Precision medicine Radiogenomics Voxel-based morphometry

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Quantitative fs-laser crystalline lens softening surgery towards presbyopia treatment based on optical coherence elastography

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biomedical Optics Express 2025年第5期16卷 2171-2183页

作者： Zhang, Zhuoyu Lv, Haijun Zhang, Hao Zhang, Ying Wang, Bingxi Liao, Yinan Zhou, Zimeng Deng, Jun Bian, Ruonan Chen, Shangbin Quan, Tingwei Liu, Xiuli Wang, Honghao Wang, Jing Li, Peng Lv, Xiaohua Zeng, Shaoqun Britton Chance Center for Biomedical Photonics MOE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Hubei Wuhan430074 China Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Hubei Wuhan430074 China State Key Lab of Modern Optical Instrumentation College of Optical Science and Engineering Zhejiang University Zhejiang Hangzhou310027 China

Presbyopia, a prevalent age-related vision disorder, is primarily characterized by the progressive loss of accommodative ability due to crystalline lens hardening, as described by the Helmholtz theory of accommodation. Among emerging presbyopia correction techniques, femtosecond laser lentotomy (fs-lento) has gained attention for its potential to restore accommodative function through the creation of intracapsular gliding planes via laser-induced optical breakdown (LIOB). This approach offers distinct advantages, including potential accommodative recovery, a non-invasive nature, minimal tissue disruption, and negligible bleeding risk. However, despite two decades of technical development, the clinical translation of fs-lento remains hindered by challenges in quality control and outcome heterogeneity, primarily due to the absence of precise quantitative methods for assessing the surgical effects on tissue mechanical properties. To address these limitations, we developed a femtosecond laser ocular research apparatus (FLORA) system for surgical investigations. Furthermore, we implemented a novel PZT-contact optical coherence elastography (OCE) system, modified from SD-OCT and validated through phantom experiments, for quantitative tissue mechanical characterization. Our experimental results using ex vivo porcine lenses demonstrated that the sequential creation of 16 flower-patterned gliding planes (2 × 3 mm2) with pulse energy of 4.1 µJ, generating cavitation bubbles © 2025 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： Femtosecond lasers

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Multierror learning enhanced fluorescence diffusion tomography in reflection geometry

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Optics Express 2025年第10期33卷 22062-22077页

作者： Chen, Haitao Liu, Kaixian Jiang, Yuxuan Dou, Yuxiang Deng, Yong School of Engineering Sciences School of Future Technology Huazhong University of Science and Technology Wuhan 430074 China Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China MoE Key Laboratory for Biomedical Photonics Department of Biomedical Engineering Huazhong University of Science and Technology Wuhan 430074 China

Accurate three-dimensional (3D) localization and sensing of intravital fluorescent probes are indispensable for elucidating neural circuit mechanisms and evaluating tumor dynamics. Fluorescence diffusion tomography in reflection geometry (rFDT) offers a powerful tool for circumventing object size limitations and enables volumetric functional imaging in deep tissues. However, due to its spatially nonuniform detection sensitivity in reflection geometry, imperfect photon transport models, and tissue heterogeneity, the photon diffusion paths are highly susceptible to unexpected perturbations. Here, we present multierror-learning-enhanced rFDT (MEL-rFDT) for precise 3D localization and sensing of intravital fluorescent probes at subcentimeter depths. By embedding physical priors derived from photon transport models and spatial attention into the deep network, MEL-rFDT adaptively compensates for various errors and depth-dependent detection sensitivity, thus enabling the high-fidelity reconstruction of intravital fluorescent probes trained with only hundreds of in silico samples. Ex vivo brain tumor and in vivo subcutaneous tumor imaging in mice demonstrated MEL-rFDT’s unprecedented 3D localization and sensing accuracy, as well as its volumetric and functional generalization across samples, facilitating intraoperative pathology, dynamic imaging, and reliable healthcare decision-making. © 2025 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.

关键词： biomedical imaging Deep learning Diffuse optical tomography Imaging techniques Optical coherence tomography Tissue optics

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The Effects of IABP on Central and Peripheral Organ Blood Flow in a Dog Model

Transactions of Japanese Society for Medical and Biological ...

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Transactions of Japanese Society for Medical and Biological engineering 2025年第1期63卷 47-52页

作者： Nakamoto, Kanata Morita, Hidetaka Matsushita, Hiroki Yoshida, Yuki Sato, Kei Nishikawa, Takuya Fujisato, Toshiya Saku, Keita Environmental and Biomedical Engineering Graduate School of Engineering Osaka Institute of Technology Japan Department of Cardiovascular Dynamics National Cerebral and Cardiovascular Center Japan Department of Research Promotion and Management National Cerebral and Cardiovascular Center Japan

Cardiogenic shock (CS) is a circulatory failure with a poor prognosis. The intra-aortic balloon pump (IABP), one of the mechanical circulatory support devices, is the most widely used for treating CS. However, clinical trials have not demonstrated its efficacy in treating CS with IABP. In this study, we systematically examined the effects of IABP on perfusion of the central and peripheral organs, including the brain and kidneys, in addition to the systemic and coronary circulation, and explored the optimization and maximization of IABP’s effects. Using a normal canine model (N＝1), we measured blood pressure, ventricular pressure, left and right atrial pressures, cardiac output, and blood flow in the coronary, carotid, and renal arteries, comparing the presence and absence of IABP. To fit the diameter of the dog’s aorta, we custom-made two balloons with diameters of 6mm and 8mm. Diastolic augmentation and systolic unloading by the IABP were observed in the aortic pressure waveform, and both balloons increased coronary flow and decreased left ventricular systolic pressure. Still, the 8mm balloon had a greater effect than the 6mm balloon. The impact on aortic pressure and cardiac output was minimal. However, distal aortic pressure decreased, and renal blood flow was reduced with both balloons. This study revealed that balloon diameter significantly affects the efficacy of IABP and suggested that this model and experimental system are useful for optimizing IABP. © 2025, Japan Soc. of Med. Electronics and Biol. engineering. All rights reserved.

关键词： Plasma (human)

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Coffee-derived self-anti-inflammatory polymer as drug nanocarrier for enhanced rheumatoid arthritis treatment

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Chinese Chemical Letters 2025年第3期36卷 371-378页

作者： Chunlei Dai Liying Wang Xinru You Yi Zhao Zhong Cao Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China RNA Biomedical Institute Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SARChina Shenzhen International Institute for Biomedical Research Shenzhen 518116China

Systemic administration of the anti-rheumatic drug methotrexate(MTX)for a long period of time may lead to therapeutic tolerance,various adverse effects,and potential harm to the immune *** nano-delivery carriers constructed based on biologically active phenols provide a promising approach to enhance the therapeutic effect of anti-rheumatic *** acid,a natural compound with anti-inflammatory properties,holds significant potential in the treatment of diverse inflammatory *** this paper,we first constructed a nano-delivery platform for MTX using caffeic acid-based polyphenol polymer Ph-CaA-OH(PCOH),and investigated the treatment of rheumatoid arthritis(RA)at low drug administration doses(2.5 mg/kg).PCOH nanoparticles(NPs)could inhibit lipopolysaccharidesstimulated macrophage inducible nitric oxide synthase(iNOS)expression and pro-inflammatory differentiation in *** vivo imaging revealed the rapid accumulation and sustained presence of PCOH NPs at inflamed joints in collagen induced-arthritis(CIA)*** evaluation of CIA mice demonstrated that MTX@PCOH NPs were superior to free MTX in reducing the progression of RA and decreasing the expression of multiple pro-inflammatory cytokines without significant toxic *** enhancing drug aggregation at inflammatory joints and capitalizing on the synergistic effects of active carriers,MTX@PCOH NPs effectively minimized the required drug dosage and mitigated toxic side effects in RA *** application of PCOH NPs to RA treatment provides a new strategy for the development of safer and more effective anti-RA nanomedicines.

关键词： Rheumatoid arthritis Caffeic acid Self-anti-inflammatory polymer Nanocarrier Methotrexate

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