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Taguchi and ANN approaches for predicting the FSW parameters to analyse the mechanical properties

Interactions 2024年第1期245卷 1-12页

作者： Manickam, Selvaraj Kavitha, N. Rao, N. Srinivasa Indira, K.P. Pydi, Hari Prasadarao Cheepurupalli, N. Rao Department of Automation and Robotics IMPACT College of Engineering and Applied Sciences Bangalore India Department of Physics NPR College of Engineering and Technology Tamilnadu Natham Dindigul624 401 India Department of Mechanical Engineering Shri Vishnu Engineering College for Women Bhimavaram India Department of Biomedical Engineering Saveetha School of Engineering SIMATS Chennai Kuthambakkam India Department of Mechanical Engineering College of Engineering and Technology Bule Hora University Bule Hora Ethiopia Department of Mineral Processing and Metallurgical Engineering Faculty of Mines Aksum University Aksum Ethiopia

Taguchi design utilized to execute mathematical analysis to assess friction stir welding factors on the mechanical properties like ultimate tensile strength (UTS) and Hardness (BHN). Tool rotational speed (TO), pin depth of tool (PI) and welding speed (WE) were selected. The collected experimental data were used to train ANN model using the LM backpropagation algorithm, aiming to achieve accurate predictions of the maximize the mechanical properties. The optimized ANN was structured as a multilayer perceptron with a feed-forward architecture, consisting of 3 input nodes, 10 neurons in the hidden layer, and 2 output node (3-10-3 structure). The developed model accurately which predicted UTS and BHN values, with an overall R of 0.99335 which indicates a high level of accuracy. The optimal settings for UTS at the highest and lowest levels in Exp. No 8 and Exp. No 3 are identified as TO3-WE2-PI1(1600 rpm, 200 mm/min, and 0.3 mm) and TO1-WE3-PI3 (1200 rpm, 250 mm/min, and 0.9 mm). © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.

关键词： Aluminum alloys

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Hydrogels for ameliorating osteoarthritis:Mechanical modulation,anti-inflammation,and regeneration

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BMEMat(biomedical engineering Materials) 2024年第2期2卷 34-60页

作者： Xuwei Jiang Yuxiang Sun Yuanning Lyu Heemin Kang Jianyang Zhao Kunyu Zhang Liming Bian School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouChina National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouChina Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhouChina Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhouChina Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea

Osteoarthritis(OA)is a chronic and degenerative disease with limited clinical options for effective ***,significant endeavors have been explored to reveal its pathogenesis and develop treatments against ***,designed with a striking resemblance to the extracellular matrix,offer a biomimetic interaction with biological tissues,presenting a promising avenue for OA *** a result,biocompatible hydrogels have been erected incorporating on-demand bioactivities to optimize the intra-articular microenvironment,thereby alleviating OA symptoms and fostering the eventual regeneration of articular *** review highlights the collaborative objectives underlying the establishment of this tissue microenvironment,encompassing mechanical modulation,anti-inflammation,and tissue ***,we consolidate recent advances in hydrogel-based biomaterials,serving as the tissue engineering scaffolds to replicate the lubrication properties of natural joints or the bioactive agent-loaded vehicles to combat localized ***,hydrogels function as cell scaffolds to facilitate the maintenance of cellular homeostasis and contribute to the advancement of cartilage ***,this review outlines the prospective directions for hydrogel-mediated OA therapies.

关键词： cargo-delivery cellular induction hydrogels lubrication osteoarthritis

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Three-dimensional ultrasound subwavelength arbitrary focusing with broadband sparse metalens

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Science China(Physics,Mechanics & Astronomy) 2022年第2期65卷 50-56页

作者： Xue Jiang JiaJie He ChuanXin Zhang HuaLiang Zhao WeiQi Wang DeAn Ta Cheng-Wei Qiu Center for Biomedical Engineering School of Information Science and TechnologyFudan UniversityShanghai 200433China Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore

Ultrasound focusing in three-dimensional(3 D)space is of crucial and enduring significance in a variety of biomedical and industrial *** ultrasound focusing based on active phase array or passive geometry of bulky size is unable to realize the 3 D arbitrary focusing with subwavelength *** metamaterial of complex deep-subwavelength microstructure has facilitated the advanced airborne-sound-focusing but is inevitably not applicable for underwater ultrasound,restricted by the law between the multi-modes coupling/thermal viscosity and the feature size of the ***,we aim to circumvent the restriction by increasing the feature size of the metamaterial while keeping the compact overall geometry,and realize the robust subwavelength ultrasound focusing with the sparse metalens of the wavelength-scale *** theoretically propose and demonstrate numerically and experimentally the broadband arbitrary ultrasound focusing in 3 D *** axial and off-axis ultrasound focusing with the subwavelength resolution(FWHM<0.58λ)are achieved by the spatially sparse and compact metalens within one-octave *** advantages of 3 D freewheeling focusing,subwavelength resolution,spatial sparsity,geometric simplicity,and broadband,the sparse metalens would offer more initiatives to advanced researches in ultrasound focusing and empower applications such as precise biomedical imaging and therapy,nondestructive evaluation,integrated and multiplexed ultrasound devices.

关键词： broadband ultrasound focusing sparse metalens subwavelength resolution three-dimensional focusing

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Test-retest Reliability of Neurovascular Coupling and Impairment in Epilepsy Measured by fNIRS and EEG 46

Test-retest Reliability of Neurovascular Coupling and Impair...

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46th Annual International Conference of the IEEE engineering in Medicine and Biology Society, EMBC 2024

作者： Smith, Quinn Limvaree, Intouch August Farrand, Jesse Edwards, Summer Stephens, Tressie Dunn, Ian F. Conner, Andrew Ding, Lei Yuan, Han Stephenson School of Biomedical University of Oklahoma NormanOK United States University of Oklahoma Health Sciences Center Department of Neurosurgery Oklahoma CityOK United States Institute for Biomedical Engineering Science and Technology University of Oklahoma Stephenson School of Biomedical Engineering NormanOK United States

ISBN: (纸本)9798350371499

Simultaneous fNIRS-EEG is a cost efficient, noninvasive, and adaptable multimodal imaging method that measures both the hemodynamics and electrical activity of the brain. Neurovascular coupling (NVC) is an important mechanism in the brain in which increased neuronal activity propels an increase in oxygenated hemoglobin as well as decrease in deoxygenated hemoglobin in the local cerebral blood flow to that specific area. Previous literature has suggested that NVC may be impaired in individuals with epilepsy. The unique approach to measure and quantify NVC via multimodal fNIRS-EEG imaging is an intriguing method to probe the NVC in clinical settings. Therefore, the purpose of the present study is to determine the reliability of NVC in a group of healthy subjects and investigate NVC in a pilot sample of epileptic patients to compare with healthy through a series of auditory tasks using simultaneous fNIRS-EEG. Results showed excellent test-retest reliability agreement in the fNIRS responses and NVC for the healthy control group. Meanwhile, abnormally lower fNIRS and NVC responses were observed in the epileptic patient group. These results provide important data for the reliability of fNIRS-EEG-based NVC testing and show promise that simultaneous fNIRS-EEG imaging can detect impaired NVC in epileptic individuals. © 2024 IEEE.

关键词： Neurons

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Tumor microenvironment-responsive self-assembly of barium titanate nanoparticles with enhanced piezoelectric catalysis capabilities for efficient tumor therapy

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Bioactive Materials 2024年第3期33卷 251-261页

作者： Zhuo Xiang Lingling Xu Yizhu Shan Xi Cui Bojing Shi Yuan Xi Panxing Ren Xuemei Zheng Chaochao Zhao Dan Luo Zhou Li Center on Nanoenergy Research School of Physical Science&TechnologyGuangxi UniversityNanning530004China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing100049China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing100190China School of Biological Science and Medical Engineering Beihang UniversityBeijing100191China Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing100191China College of Chemistry and Chemical Engineering Center on Nanoenergy ResearchGuangxi UniversityNanning530004China Department of Biomedical Engineering School of MedicineFoshan UniversityFoshan528225China

Catalytic therapy based on piezoelectric nanoparticles has become one of the effective strategies to eliminate ***,it is still a challenge to improve the tumor delivery efficiency of piezoelectric nanoparticles,so that they can penetrate normal tissues while specifically aggregating at tumor sites and subsequently generating large amounts of reactive oxygen species(ROS)to achieve precise and efficient tumor *** the present study,we successfully fabricated tumor microenvironment-responsive assembled barium titanate nanoparticles(tma-BTO NPs):in the neutral pH environment of normal tissues,tma-BTO NPs were monodisperse and possessed the ability to cross the intercellular space;whereas,the acidic environment of the tumor triggered the self-assembly of tma-BTO NPs to form submicron-scale aggregates,and deposited in the tumor *** self-assembled tma-BTO NPs not only caused mechanical damage to tumor cells;more interestingly,they also exhibited enhanced piezoelectric catalytic efficiency and produced more ROS than monodisperse nanoparticles under ultrasonic excitation,attributed to the mutual extrusion of neighboring particles within the confined space of the ***-BTO NPs exhibited differential cytotoxicity against tumor cells and normal cells,and the stronger piezoelectric catalysis and mechanical damage induced by the assemblies resulted in significant apoptosis of mouse breast cancer cells(4T1);while there was little damage to mouse embryo osteoblast precursor cells(MC3T3-E1)under the same treatment *** experiments confirmed that peritumoral injection of tma-BTO NPs combined with ultrasound therapy can effectively inhibit tumor progression *** tumor microenvironment-responsive self-assembly strategy opens up new perspectives for future precise piezoelectric-catalyzed tumor therapy.

关键词： Self-assembly Piezoelectric catalysis Tumor microenvironment response Sonodynamic therapy

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Computational assessment of airflow circuit in a double-acting solenoid-type non-invasive bi-level ventilator

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Research on biomedical engineering 2024年第1期40卷 25-41页

作者： Ige, Ebenezer Olubunmi Amudipe, Samuel Olufemi Zaccheus, Jesuloluwa Emmanuel Oyejide, Ayodele James Ekpo-Epkenyong, Otu Akintayo, Christopher Oloruntoba Dare, Ademola Adebukola Glucksberg, Matthew R. Department of Mechanical Engineering Rochester Institute of Technology RochesterNY14623 United States Department of Biomedical Engineering Afe Babalola University Ado-Ekiti360231 Nigeria Department of Mechanical and Mechatronic Engineering Afe Babalola University Ado-Ekiti360231 Nigeria Department of Physiology College of Medicine and Health Sciences Afe Babalola University Ado-Ekiti360231 Nigeria Department of Medicine and Surgery College of Health Sciences Obafemi Awolowo University Ile-Ife220282 Nigeria Department of Biomedical Engineering University of Ibadan Ibadan200005 Nigeria Department of Biomedical Engineering Center for Innovation in Global Health Technologies Northwestern University EvanstonIL60208 United States

Purpose: Bi-level ventilation is a lung-preserving strategy employed for clinical presentations of acute respiratory distress syndrome (ARDS). Although mechanical ventilation enjoyed significant patronage during the coronavirus pandemic era, certain pertinent challenges in the purview of automation of the bi-level ventilation process have limited its application in critical management decisions. Method: On an electro-pneumatic platform, computational studies of oxygenation were executed using a FluidSIM-enabled electro-pneumatic workbench configured to mimic a biphasic pressure–controlled ventilator. A double-acting cylinder equipped with 5/2-5/3-4/2-way solenoid-actuator arrangements, an on-delay timer, and a proportional integral derivative (PID) controller architecture is used to record the observations, which are made at the typical minute intervals of 10 s, 12 s, 14 s, and 16 s respectively. Results: Our observation revealed improved ventilation performance for 5/2-5/3-4/2-way solenoid-actuator double-acting cylinder electro-pneumatic circuit based on parameters consisting of tidal volume, exhaust time, and selected actuator valve configurations of exhalation valves. Conclusion: This report demonstrated the contribution of PID controllers in optimizing the delivery of bi-level-type oxygenation during the ventilation procedure. Premised on the configuration of the solenoid-actuators utilized, the concept underscores the role of controlled pressurization in achieving the requirement for oxygen delivery in an archetypal model of a ventilating system. © The Author(s), under exclusive licence to The Brazilian Society of biomedical engineering 2023.

关键词： Ventilation

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Biodegradable hafnium-doped CaCO₃ nanoparticles as a dual-modality radiosensitizer for cancer radiotherapy

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Nanomedicine 2024年第13期19卷 1133-1144页

作者： Chen, Min-Hua Zeng, Xiang-Hao Shu, Yi-Ting Liang, Hsiang-Kuang Chen, Ching-Yun Lin, Chun-Yu Lin, Cheng-An J. Chen, Jen-Kun Department of Biomedical Engineering Chung Yuan Christian University Taoyuan City 320314 Taiwan Institute of Biomedical Engineering & Nanomedicine National Health Research Institutes Miaoli County 35053 Taiwan Department of Materials & Textiles Asia Eastern University of Science & Technology New Taipei County 220303 Taiwan Department of Biomedical Engineering National Taiwan University Taipei City 10617 Taiwan Department of Biomedical Sciences & Engineering National Central University Taoyuan City 320317 Taiwan Center for Biomedical Engineering in Cancer Chung Yuan Christian University Taoyuan City 320314 Taiwan Biotechnology Center National Chung Hsing University Taichung City 40227 Taiwan Graduate Institute of Life Sciences National Defense Medical Center Taipei City 11490 Taiwan

Aim: Radiotherapy employs high-energy ionizing radiation to inflict DNA damage on cancer cells, thereby causing their demise. However, this procedure can inadvertently harm healthy tissue. Thus, this study aimed to develop biodegradable radiosensitizers that counteract these adverse effects by enhancing the radiation sensitivity of tumor cells and safeguarding normal cells. Materials & methods: A biodegradable radiosensitizer was engineered by incorporating hafnium ions (Hf) into calcium carbonate (CaCO₃) nanoparticles via a chemical precipitation technique, resulting in the formation of Hf:CaCO₃ nanoparticles. Results & conclusion: Our findings demonstrate that Hf:CaCO₃ nanoparticles exhibit pH-dependent solubility and can augment the efficacy of radiotherapy in treating cancer cells. This research underscores the potential of Hf:CaCO₃ nanoparticles as a dual-modality radiosensitizer in radiotherapy. © 2024 Expert Publishing Medicine Ltd trading as Taylor & Francis.

关键词： bioceramics cancer/oncology nanomaterials nanoparticles therapeutics

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Recent progress in three-terminal artificial synapses based on 2D materials:from mechanisms to applications

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Microsystems & Nanoengineering 2023年第1期9卷 73-89页

作者： Fanqing Zhang Chunyang Li Zhongyi Li Lixin Dong Jing Zhao School of Mechatronical Engineering Beijing Institute of Technology100081BeijingChina Beijing Advanced Innovation Center for Intelligent Robots and Systems Beijing Institute of Technology100081BeijingChina Department of Biomedical Engineering City University of Hong KongKowloon Tong999077Hong KongChina

Synapses are essential for the transmission of neural *** plasticity allows for changes in synaptic strength,enabling the brain to learn from *** the rapid development of neuromorphic electronics,tremendous efforts have been devoted to designing and fabricating electronic devices that can mimic synapse operating *** growing interest in the field will provide unprecedented opportunities for new hardware architectures for artificial *** this review,we focus on research of three-terminal artificial synapses based on two-dimensional(2D)materials regulated by electrical,optical and mechanical *** addition,we systematically summarize artificial synapse applications in various sensory systems,including bioplastic bionics,logical transformation,associative learning,image recognition,and multimodal pattern ***,the current challenges and future perspectives involving integration,power consumption and functionality are outlined.

关键词： artificial transformation devoted

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Adaptive Polynomial Predictive Filter: Solving Inconsistent and Interrupted Sensor Data Challenges

Adaptive Polynomial Predictive Filter: Solving Inconsistent ...

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IEEE International Conference on robotics and Biomimetics

作者： Dileep Sivaraman Branesh M. Pillai Songpol Ongwattanakul Jackrit Suthakorn Department of Biomedical Engineering Center for Biomedical and Robotics Technology (BART LAB) Faculty of Engineering Mahidol University Thailand

This article discusses the challenges faced by sensor fusion systems owing to inconsistent and interrupted sensor data and proposes an adaptive polynomial predictive filter-based sensor fusion approach to address this problem. This approach incorporates an adaptive polynomial filter based on polynomial extrapolation that can effectively capture the temporal dynamics of the sensor data and provide a robust estimate of the underlying signal. This paper provides a detailed analysis of the proposed approach, including its theoretical foundation, implementation, and performance evaluation using simulated sensor data. The simulation results demonstrate that the adaptive polynomial sensor fusion approach outperforms several state-of-the-art sensor fusion techniques, particularly in scenarios in which the sensor data are inconsistent or interrupted. The article concludes that the proposed approach offers an effective solution to the problem of inconsistent and interrupted sensor data in sensor fusion, with potential applications in various fields including robotics, autonomous vehicles, and healthcare.

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Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer

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Bioactive Materials 2023年第9期27卷 72-81页

作者： Qiongyu Qin Ming Yang Yu Shi Haijing Cui Chunshu Pan Wenzhi Ren Aiguo Wu Jianqing Hu School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou510640GuangdongPR China Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCAS1219 ZhongGuan West RoadNingbo315201PR China Advanced Energy Science and Technology Guangdong Laboratory Huizhou516000PR China Department of Radiology Ningbo No.2 HospitalNingbo315010PR China

Currently,precise ablation of tumors without damaging the surrounding normal tissue is still an urgent problem for clinical microwave therapy of liver ***,we synthesized Mn-doped Ti MOFs(Mn-Ti MOFs)nanosheets by in-situ doping method and applied them for microwave *** thermal imaging results indicate Mn-Ti MOFs can rapidly increase the temperature of normal saline,attributing to the porous structure improving microwave-induced ion collision ***,Mn-Ti MOFs show higher 1O2 output than Ti MOFs under 2 W of low-power microwave irradiation due to the narrower band-gap after Mn *** the same time,Mn endows the MOFs with a desirable T1 contrast of magnetic resonance imaging(r2/r1=2.315).Further,results on HepG2 tumor-bearing mice prove that microwave-triggered Mn-Ti MOFs nearly eradicate the tumors after 14 days of *** study offers a promising sensitizer for synergistic microwave thermal and microwave dynamic therapy of liver cancer.

关键词： Metal-organic framework Titanium-based nanomaterials Microwave dynamic therapy Microwave thermal therapy MR image

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