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Clinical and biomarker analyses of SHR-1701 combined with famitinib in patients with previously treated advanced biliary tract cancer or pancreatic ductal adenocarcinoma:a phase II trial

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Signal Transduction and Targeted Therapy 2025年第1期10卷 328-339页

作者： Lixia Yi Haoqi Pan Zhouyu Ning Litao Xu Hena Zhang Longfei Peng Yaowu Liu Yifan Yang Waimei Si Ying Wang Xiaoyan Zhu Shenglin Huang Zhiqiang Meng Jing Xie Department of Integrative Oncology Fudan University Shanghai Cancer CenterShanghaiChina Department of Minimally Invasive Therapy Center Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Shanghai Key Laboratory of Medical Epigenetics Institutes of Biomedical SciencesFudan UniversityShanghaiChina Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of SciencesSuzhouChina Clinical Research&Development Jiangsu Hengrui Pharmaceuticals Co.Ltd.ShanghaiChina

Advanced biliary tract cancer(BTC)and pancreatic ductal adenocarcinoma(PDAC)have poor prognoses and limited treatment ***,we conducted thisfirst-in-class phase II study to evaluate the efficacy and safety of SHR-1701,a bifunctional fusion protein targeting programmed death-ligand 1(PD-L1)and transforming growth factor-beta(TGF-β),combined with famitinib,a multi-targeted receptor tyrosine kinase inhibitor,in patients with advanced BTC or PDAC who failed previous standard treatment(trial registration:ChiCTR2000037927).Among 51 enrolled patients,the BTC cohort showed an objective response rate(ORR)of 28%(including 2 complete responses)and a disease control rate(DCR)of 80%,with a median progression-free survival(mPFS)of 5.1 months and a median overall survival(mOS)of 16.0 *** the PDAC cohort,the ORR was 15%(2 complete responses),with a DCR of 60%,and the mPFS and mOS were 2.1 months and 5.3 months,*** 3 or 4 treatment-related adverse events(TRAEs)occurred in 29.4%of patients,with no grade 5 TRAEs *** analyses revealed that primary tumor resection history,peripheral blood immunophenotype changes,and distinct immune-metabolic profiles were associated with treatment *** immune/metabolism score integrating the features of six genes was developed as a predictive biomarker for immunotherapy response in multiple cohorts,allowing for the selection of patients most likely to experience positive outcomes from this therapy *** conclusion,our study provides proof-of-concept data supporting the potential of SHR-1701 plus famitinib as an effective and safe subsequent-line therapy for refractory BTC and PDAC,highlighting the promise of targeting PDL1,TGF-β,and angiogenesis pathways simultaneously.

关键词： patients adenocarcinoma metabolism

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Microfluidics for High Throughput Screening of Biological Agents and Therapeutics

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biomedical Materials and Devices 2025年第1期3卷 93-107页

作者： Bhusal, Anant Yogeshwaran, Swaprakash Goodarzi Hosseinabadi, Hossein Cecen, Berivan Miri, Amir K. Department of Mechanical Engineering Rowan University Glassboro 08028 NJ United States Department of Biomedical Engineering University of Massachusetts Amherst Amherst 01003 MA United States Department of Biomedical Engineering New Jersey Institute of Technology Newark 07901 NJ United States Institute of Pharmacology and Toxicology University Medical Center Göttingen Robert-Koch-Str. 40 Göttingen 37075 Germany Department of Biomedical Engineering Rowan University Glassboro 08028 NJ United States

Microfluidic devices have been widely used for gene analysis, immunoassays, organ-on-chip technology, cell engineering, and disease modeling. Their integration into high throughput screening (HTS) platforms has led to large-scale testing of various biological and chemical agents. This brief review discusses existing microfluidic HTS modalities, including the droplet mode, the perfusion mode, and the array-based platforms in active or passive designs, by exploring their fabrication methods and key design features. The main compartments are discussed, and the future trajectories of microfluidic HTS platforms, particularly in drug screening, are explained in detail. This review aims to serve as a guide for bioengineers and clinicians, offering insights to advance the development of the microfluidic toolboxes utilized in drug screening efforts. © The Author(s) 2024.

关键词： 3D printing High throughput screening Hydrogels Microfluidics

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Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration

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Bioactive Materials 2023年第3期21卷 267-283页

作者： Peihao Cai Shunyi Lu Jieqin Yu Lan Xiao Jiayi Wang Haifeng Liang Lei Huang Guanjie Han Mengxuan Bian Shihao Zhang Jian Zhang Changsheng Liu Libo Jiang Yulin Li The Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai200032China Centre for Biomedical Technologies School of MechanicalMedical and Process EngineeringQueensland University of TechnologyBrisbane4059Australia

Injectable materials show their special merits in regeneration of damaged/degenerated bones in minimally-invasive *** calcium phosphate bone cement(CPC)has attracted broad attention for its bioactivity,as compared to non-degradable polymethyl methacrylate ***,its brittleness,poor anti-washout property and uncontrollable biodegradability are the main challenges to limit its further clinical application mainly because of its stone-like dense structure and fragile inorganic-salt ***,we developed a kind of injectable CPC bone cement with porous structure and improved robustness by incorporating poly(lactide-co-glycolic acid)(PLGA)nanofiber into CPC,with carboxymethyl cellulose(CMC)to offer good injectability as well as anti-wash-out ***,the introduction of PLGA and CMC also enabled a formation of initial porous structure in the cements,where PLGA nanofiber endowed the cement with a dynamically controllable biodegradability which provided room for cell movement and bone ***-estingly,the reinforced biodegradable cement afforded a sustainable provision of Ca^(2+)bioactive components,together with its porous structure,to improve synergistically new bone formation and osteo-integration in vivo by using a rat model of femur condyle *** study on regenerative mechanisms indicated that the good minimally-invasive bone regeneration may come from the synergistic enhanced osteogenic effect of calcium ion enrichment and the improved revascularization capacity contributed from the porosity as well as the lactic acid released from PLGA *** results indicate the injectable bone cement with high strength,anti-washout property and controllable biodegradability is a promising candidate for bone regeneration in a minimally-invasive approach.

关键词： Injectable calcium phosphate cement Biodegradable PLGA nanofiber Angiogenesis Osseointegration Minimally-invasive bone regeneration

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Infection-responsive long-term antibacterial bone plates for open fracture therapy

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Bioactive Materials 2023年第7期25卷 1-12页

作者： Lujiao Zhang Yurun Yang Yan-Hua Xiong Yu-Qing Zhao Zongpeng Xiu Hui-Min Ren Kai Zhang Shun Duan Ying Chen Fu-Jian Xu State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology)Ministry of EducationBeijing Laboratory of Biomedical MaterialsBeijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing100029China Department of Orthopaedic Surgery China-Japan Friendship HospitalBeijing100029China

The infections in open fracture induce high morbidity ***,developing efficient anti-infective orthopedic devices is of great *** this work,we designed a kind of infection-responsive long-term antibacterial bone *** a facile and flexible volatilization method,a multi-aldehyde polysaccharide derivative,oxidized sodium alginate,was crosslinked with multi-amino compounds,gentamycin and gelatin,to fabricate a uniform coating on Ti bone plates via Schiff base reaction,which was followed by a secondary crosslinking process by *** double-crosslinked coating was stable under normal condition,and could responsively release gentamycin by the triggering of the acidic microenvironment caused by bacterial metabolism,owning to the pH-responsiveness of imine *** thickness of the coating was ranging from 22.0μm to 63.6μ*** coated bone plates(Ti-GOGs)showed infection-triggered antibacterial properties(>99%)and high *** being soaked for five months,it still possessed efficient antibacterial ability,showing its sustainable antibacterial *** in vivo anti-infection ability was demonstrated by an animal model of infection after fracture fixation(IAFF).At the early stage of IAFF,Ti-GOGs could inhibit the bacterial infection(>99%).Subsequently,Ti-GOGs could promote recovery of fracture of *** work provides a convenient and universal strategy for fabrication of various antibacterial orthopedic devices,which is promising to prevent and treat IAFF.

关键词： Antibacterial Open fracture Infection-responsive Coating Orthopedic medical device

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Catalytic activation of peroxodisulfate using shape-controlled cerium-manganese composite oxide for phenol degradation:Kinetics and degradation pathway investigation

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Journal of Rare Earths 2024年第8期42卷 1514-1523,I0004页

作者： Yanxia Zheng Lixi Yang Chuxin Huang Yuchao Li Cuncun Zuo Tingting Ge Haofei Huang Jiutao An Ming Wang Yansong Zhao Institute of Clean Chemical Technology School of Chemistry and Chemical EngineeringShandong University of TechnologyZibo255000China Shandong Collegial Engineering Research Center of Novel Rare Earth Catalysis Materials Shandong University of TechnologyZibo255000 China College of Resources and Environment Engineering Shandong University of TechnologyZibo255000China Department of Safety Chemistry and Biomedical Laboratory SciencesFaculty of Engineering and ScienceWestern Norway University of Applied Sciences(HVL)5063BergenNorway

Phenol-containing wastewater is typical organic wastewater,and its treatment is *** advanced method to treat this type of wastewater is persulfate *** friendly ceriummanganese composite oxide materials were synthesized by hydrothermal method and applied to the phenol degradation *** ratios of cerium and manganese,as well as the amount of sodium hydroxide,were *** solid solutions of cerium and manganese were formed and confirmed by X-ray diffraction(XRD) and transmission electron microscopy(TEM).H_(2)-temperature programmed reduction(H_(2)-TPR) and X-ray photoelectron spectroscopy(XPS) were utilized to analyze the synergistic effect of cerium and *** is found that there is a transformation between Ce^(4+)/Ce^(3+) and Mn^(2+)/Mn^(3+),which makes the material more trivalent manganese and thereby increases the catalytic *** effect of materials in catalyzing phenol degradation by peroxodisulfate(PDS) under various preparation conditions is discussed and high-effciency removal of phenol can be achieved and the removal rate at 180 min is close to 100%.The kinetic of this process was investigated and activation energy of phenol degradation is 62,35 kJ/*** degradation pathway of phenol was studied and it is found that PDS can be activated by low metal ions and the OH and SO_(4·)^(-)radicals play crucial roles according to the quenching experiments.

关键词： Advanced oxidation process Persulfate Mn-Ce solid solution Phenol degradation Rare earths

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A combined protocol for isolation, culture, and patch-clamp recording of dorsal root ganglion neurons

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Biophysics Reports 2025年第2期11卷 87-95页

作者： Ruolin Wang Yu Lu Jianbo Zhao Xueting Duan Yang Chen Zhuoyu Zhang Rong Huang Neuroscience Research Center Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and Technology Xi'an Jiaotong University Neurological Department of Tongji Hospital School of Medicine Tongji University

The dorsal root ganglion(DRG) neurons are crucial in transmitting sensory information from the peripheral nervous system to the central nervous system, including touch, pain, temperature, and proprioception. Understanding the functions and mechanisms of DRG neurons is essential for studying sensory processing and developing efficient treatments for sensory disorders. In addition, electrophysiological patch-clamp recording is a powerful and classical tool to study the functions and mechanisms of the nervous system. Building upon the strategies outlined in published works and our group's abundant research experience in DRG neurons' functions by patch-clamp, we have summarized and put forward a comprehensive step-by-step protocol combining juvenile rat DRG neuron isolation and culture,and patch-clamp recording. This protocol would be a powerful guidance document for neuroscience researchers to study sensory DRG neurons' physiological and pathological functions using electrophysiological tools.

关键词： Sensory dorsal root ganglion neurons Isolation Culture Patch-clamp recording

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The fabrication of hydroxyapatite mineralized hydrogels for bone tissue engineering

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biomedical engineering Communications 2023年第2期2卷 18-27页

作者： Xiu-Mei Zhang Jin-Qiao Jia Yu Cao Yan Wei Yin-Chun Hu Xiao-Jie Lian Zi-Wei Liang Di Huang Department of Biomedical Engineering Research Center for Nano-Biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Research Center for Biomaterials Shanxi-Zheda Institute of Advanced Materials and Chemical EngineeringTaiyuan 030032China.

Bone is a complex but orderly mineralized tissue with hydroxyapatite(HA)as the inorganic phase and collagen as the organic *** by natural bone tissues,HA-mineralized hydrogels have been widely designed and used in bone tissue *** is majorly utilized for the treatment of bone defects because of its excellent osteoconduction and bone *** is a three-dimensional hydrophilic network structure with similar properties to the extracellular matrix(ECM).The combination of HA and hydrogels produces a new hybrid material that could effectively promote osteointegration and accelerate the healing of bone *** this review,the structure and growth of bone and the common strategies used to prepare HA were briefly ***,we discussed the fabrication of HA mineralized hydrogels from simple blending to in situ *** hope this review can provide a reference for the development of bone repair hydrogels.

关键词： hydroxyapatite hydrogel mineralization bone tissue engineering

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Modification of gelatin and photocured 3D-printed resin to prepare biomimetic phantoms for ultrasound-guided minimally invasive surgeries

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Polymer engineering and Science 2023年第2期63卷 413-425页

作者： Chen, Chien-Hua Huang, Yi-Fan Chen, Po-Hao Hsu, Yu-Tung Jaw, Fu-Shan Ho, Ming-Hua Department of Biomedical Engineering National Taiwan University Taipei City Taiwan Department of Chemical Engineering National Taiwan University of Science and Technology Taipei City Taiwan R&D Center for Membrane Technology National Taiwan University of Science and Technology Taipei Taiwan

The main challenge of ultrasound-guided minimally invasive surgeries is to carry out treatments through small boreholes in the patient's body surface with sub-millimetric accuracy and facility offered by ultrasound instruments. Thus, the phantoms' biomimetic appearances, acoustic characteristics, and mechanical properties are essential for healthcare professionals. In this study, gelatin and 3D-printed photo-resin phantoms were developed for hard and soft tissues, respectively. Using glutaraldehyde (GA) and formaldehyde (FA) to crosslink gelatin phantoms, the mechanical strength, ultrasound velocity, acoustic impedance, needle insertion forces, and antiseptic periods were improved, and the addition of silica nanoparticles raised the acoustic impedance. For 3D-printed phantoms, the acoustic impedance ascended with hydrophilic polyethylene glycol diacrylate (PEGDA) oligomers. The additives applied in this study successfully made the gelatin and photo-resin phantoms more mimetic to muscle and bone tissues, allowing their application in preoperative preparations. © 2023 The Authors. Polymer engineering & Science published by Wiley Periodicals LLC on behalf of Society of Plastics Engineers.

关键词： 3D printers

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Signal acquisition of brain-computer interfaces:A medical-engineering crossover perspective review

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Fundamental Research 2025年第1期5卷 3-16页

作者： Yike Sun Xiaogang Chen Bingchuan Liu Liyan Liang Yijun Wang Shangkai Gao Xiaorong Gao Department of Biomedical Engineering Tsinghua UniversityBeijing 100084China Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China Center for Intellectual Property and Innovation Development China Academy of Information and Communications TechnologyBeijing 100161China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China

Brain-computer interface(BCI)technology represents a burgeoning interdisciplinary domain that facilitates direct communication between individuals and external *** efficacy of BCI systems is largely contingent upon the progress in signal acquisition *** paper endeavors to provide an exhaustive synopsis of signal acquisition technologies within the realm of BCI by scrutinizing research publications from the last ten *** review synthesizes insights from both clinical and engineering viewpoints,delineating a comprehensive two-dimensional framework for understanding signal acquisition in *** delineate nine discrete categories of technologies,furnishing exemplars for each and delineating the salient challenges pertinent to these *** review furnishes researchers and practitioners with a broad-spectrum comprehension of the signal acquisition landscape in BCI,and deliberates on the paramount issues presently confronting the *** enhancements in BCI signal acquisition should focus on harmonizing a multitude of disciplinary *** equilibrium between signal fidelity,invasiveness,biocompatibility,and other pivotal considerations is *** doing so,we can propel BCI technology forward,bolstering its effectiveness,safety,and depend-ability,thereby contributing to an auspicious future for human-technology integration.

关键词： Brain-computer interface Signal acquisition technologies Surgery Detection Human computer interaction

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Complex coacervate-derived hydrogel with asymmetric and reversible wet bioadhesion for preventing UV light-induced morbidities

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Bioactive Materials 2023年第12期30卷 62-72页

作者： Xin Peng Yuan Li Menghui Liu Zhuo Li Xuemei Wang Kunyu Zhang Xin Zhao Gang Li Liming Bian Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai519000China Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University ofHong KongPrince of Wales HospitalShatin999077Hong Kong Special Administrative Region School of Biomedical Sciences and Engineering Guangzhou International CampusNational Engineering Research Center for Tissue Restoration and ReconstructionGuangdong Provincial Key Laboratory of Biomedical EngineeringKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth ChinaUniversity of TechnologyGuangzhou510006PR China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong

Protecting the skin from UV light irradiation in wet and underwater environments is challenging due to the weak adhesion of existing sunscreen materials but highly *** we report a polyethyleneimine/thioctic acid/titanium dioxide(PEI/TA/TiO_(2))coacervate-derived hydrogel with robust,asymmetric,and reversible wet bioadhesion and effective UV-light-shielding *** PEI/TA/TiO_(2)complex coacervate can be easily obtained by mixing a PEI solution and TA/TiO_(2)*** fluid PEI/TA/TiO_(2)coacervate deposited on wet skin can spread into surface irregularities and subsequently transform into a hydrogel with increased cohesion,thereby establishing interdigitated contact and adhesion between the bottom surface and ***,the functional groups between the skin and hydrogel can form physical interactions to further enhance bioadhesion,whereas the limited movement of amine and carboxyl groups on the top hydrogel surface leads to low ***,the coacervate-derived hydrogel exhibits asymmetric adhesiveness on the bottom and top ***,the PEI/TA/TiO_(2)hydrogel formed on the skin could be easily removed using a NaHCO3 aqueous solution without inflicting *** importantly,the PEI/TA/TiO_(2)hydrogel can function as an effective sunscreen to block UV light and prevent UV-induced MMP-9 overexpression,inflammation,and DNA damage in animal *** advantages of PEI/TA/TiO_(2)coacervate-derived hydrogels include robust,asymmetric,and reversible wet bioadhesion,effective UV light-shielding ability,excellent biocompatibility,and easy preparation and usage,making them a promising bioadhesive to protect the skin from UV light-associated damage in wet and underwater environments.

关键词： Adhesive hydrogel Coacervate Asymmetric adhesion Reversible adhesion

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