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ECG Signal-Based Feature Identification of Obstructive Sleep Apnea Using Dual-Tree Complex Wavelet Transform and Adaptive Neuro-Fuzzy Inference System 2

ECG Signal-Based Feature Identification of Obstructive Sleep...

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2nd Jordanian International biomedical engineering Conference, JIBEC 2024

作者： Bassam, Al-Naami Al-Zaben, Awad Visconti, Paolo De Fazio, Roberto Rawash, Yahia The Hashemite University Engineering Faculty Biomedical Engineering Department Zarqa Jordan Yarmouk University Hijjawi Faculty For Engineering Technology Biomedical Systems and Medical Informatics Department Jordan University of Salento Lecce Italy University of Salento Dept. of Innovation Engineering Lecce Italy Hashimaite University Engineering Faculty Biomedical Engineering Department Jordan Center for Biomolecular Nanotech. IIT Dept. of Innovation Engineering Arnesano Italy

ISBN: (纸本)9798331539542

Obstructive sleep apnea (OSA) is a common disease that affects a large number of people around the world. It could be prevented if diagnosed early, but many cases go undetected due to the cost and limitations of home overnight polysomnography (PSG) systems. In this research, we propose a new diagnostic method for detecting the OSA disease using a feature extraction and classification approach from the electrocardiograph (ECG) signal only. The ECG can be easily extracted at home in a comfortable and minimally invasive way by anyone;then, the Dual-Tree Complex Wavelet Transform (DTCWT) is used to denoise the ECG signal. Five features were extracted, and the classification process was performed using the Adaptive Neuro Fuzzy Inference System (ANFIS). © 2024 IEEE.

关键词： Sleep research

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Novel Adjustable 3D Electrokinetic Microelectrode for Blood-Formed Elements Separation 6

Novel Adjustable 3D Electrokinetic Microelectrode for Blood-...

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6th IEEE Novel Intelligent and Leading Emerging Sciences Conference, NILES 2024

作者： Abdelbaset, Reda Ismail, Yehea Helwan University Faculty of Engineering Biomedical Engineering Department Cairo Egypt Zewail City of Science and Technology Center of Nanoelectronics and Devices Cairo Egypt Cairo Egypt

ISBN: (纸本)9798350378511

Many medical applications now require manipulating biological cells in order to separate and trap them for further operations. The invention of a method for simultaneously separating and trapping living cells has several advantages, including lower costs, smaller sample sizes, and a lower risk of sample infection. Researchers may investigate cell population activity more appropriately and avoid erroneous conclusions by separating blood cells from a complete blood sample. A distinct array of three-dimensional (3D) cubic microelectrodes is modified to allow or block a certain kind of biological cell according to the applied voltage. Unlike the previous work, the proposed design is developed to trap cells after separation using triple arrays of dielectrophoretic-based microelectrode which is vital for many applications such as cell culture. The designed microfluidic is simulated using the finite element approach by COMSOL Multiphysics 5.5. The results supported the developed square microelectrode' ability to simultaneously, rapidly, and efficiently separate and trap two types of blood cells: red blood cells (RBCs) and platelets. © 2024 IEEE.

关键词： Platelets

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pH-sensitive quantum dots-based fluorescent array for detection of biogenic amines 4

pH-sensitive quantum dots-based fluorescent array for detect...

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4th International Conference on Biomedicine and Bioinformatics engineering, ICBBE 2024

作者： Deng, Chenliang Zhong, Xianhua Jiang, Ling Yang, Jia Chongqing Engineering Research Center of Medical Electronics and Information Technology Department of Biomedical Engineering School of Bioinformatics Chongqing University of Posts and Telecommunications Chongqing400065 China

ISBN: (纸本)9781510682443

A fluorescence array based on quantum dots was built for the detection of biogenic amines, including spermine, spermidine, and putrescine. A one-step synthetic strategy is adopted for the fabrication of carbon quantum dots using N-Acetyl-Lcysteine and citric acid. The carbon quantum dots show pH sensitivity. The carbon quantum dots were combined with fluorescamine and fluorescein to form a fluorescent array sensor. On the strength of the distinct fluorescence responses between the fluorescence sensing units and biogenic amines, fluorescence spectra were collected to build a fluorescence spectral dataset. The fluorescence spectra data were utilized as features for the three amine substances. To accurately evaluate the different amines, principal component analysis (PCA) and hierarchical cluster analysis (HCA) were employed to process the spectral data. Qualitative and quantitative analysis of the three amines was successfully achieved. The quantitative range was 0.125 - 12.5 μM, with an extremely low detection limit of 0.125 μM. Furthermore, several supervised classification algorithms were applied to classify the spectral data. Some of the classification algorithms achieved accuracy rates of up to 100%. Focusing on spectral data analysis, this study provides an accurate, simple, and fast approach to amine detection. © 2024 SPIE.

关键词： Fluorescence spectroscopy

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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok Kim Bruno Rigo Gabriella Wong Yoon Jae Lee Woon‑Hong Yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

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Enhanced light-driven photoelectrochemical catalysis of water splitting by TiO2 nanotubes grown on acid-etched titanium foils

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International Journal of Hydrogen Energy 2024年第PartA期51卷 1483-1493页

作者： Hsiao, Yu-Cheng Lai, Jhih-Hong Fan, Yu-Min Chen, Hung-Ming Yougbaré, Sibidou Saukani, Muhammad Chen, Chih-Yu Wu, Yung-Fu Lin, Lu-Yin International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan /Nanoro 03 B.P 7192 Ouagadougou03 Burkina Faso Department of Mechanical Engineering Faculty of Engineering Universitas Islam Kalimantan MAB Jl. Adhyaksa No. 2 Banjarmasin70124 Indonesia Department of Orthopedics Shuang Ho Hospital Taipei Medical University New Taipei City23561 Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan

Titanium dioxide with suitable band edges is one of promising photocatalysts for water splitting. Nanotubes with one-dimensional structure can induce efficient charge transfers and hollow centers can provide large surface area for surface reactions. Modifying Ti foils for anodization can enhance light utilization of TiO2 nanotube photoelectrodes. In this work, it is firstly to fabricate TiO2 nanotube photoelectrodes on acid-etched Ti foils by anodization (MNT) for photoelectrochemical catalyzing water splitting. Different acid-etching durations are applied on Ti foils to induce various rugged surfaces. The resulting photoelectrodes present largely enhanced light utilization than that fabricated by the pristine Ti foil. The anodization duration is also optimized to find suitable lengths of MNT. The smallest overpotential of 524.7 mV at 10 mA/cm2 and Tafel slope of 167 mV/dec are obtained for the optimal MNT photoelectrode. The TiO2 nanotubes grown on the pristine Ti foil shows the overpotential of 679.3 mV at 10 mA/cm2 and Tafel slope of 285 mV/dec. This result opens a blueprint for raising the photocatalytic ability by simply modifying the surface property of the conductive substrate. Other modifications may be applicable to enhance the roughness of Ti foils for growing more efficient MNT array as photocatalysis of water splitting. © 2023 Hydrogen Energy Publications LLC

关键词： Titanium dioxide

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D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-Ⅱ fluorescence imaging-guided through-skull photodynamic therapy of gliomas

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Aggregate 2024年第1期5卷 185-195页

作者： Xuelu He Yuan Luo Yanying Li Yuanbo Pan Ryan T.K.Kwok Lulu He Xiaolin Duan Pengfei Zhang Aiguo Wu Ben Zhong Tang Juan Li Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboP.R.China Guangdong Key Laboratory of Nanomedicine Shenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS-HK Joint Lab for BiomaterialsResearch Laboratory for Biomedical Optics and Molecular ImagingShenzhen Key Laboratory for Molecular ImagingCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenP.R.China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced StudyThe Hong Kong University of Science and Technology(HKUST)KowloonP.R.China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenP.R.China

Glioma is one of the most common malignant tumors of the central nervous system,leading high mortality rates in ***-induced emission(AIE)photosensitizers-based photodynamic therapy(PDT)has emerged as a promising therapeutic strategy for least-invasive treatment of glioma,which involves local irradiation of the tumor using an external near-infrared(NIR)***,most AIE photosensitizers suffered from poorly penetration of the visible light excitation,bad spatiotemporal resolution in deep tissues and low efficient blood-brain barrier(BBB)crossing ability,which greatly limited the clinical practice of AIE photosensitizers for especially deep-seated brain tumor *** this work,we developed a multifunctional NIR-driven theranostic agent through hybrid of AIE photosensitizers TIND with rare-earth doping nanoparticles(RENPs)NaGdF4:Nd/Yb/Tm with up/down dual-mode conversion *** theranostic agent was further decorated with D-type neuropeptide DNPY for crossing BBB and targeting *** the 808-nm light irradiation,the down-conversion NIR-II luminescence could indicate the position glioma and the upconversion NIR-I luminescence could trigger the AIE photosensitizers producing reactive oxygen species to inhibit orthotopic glioma tumor growth in *** results demonstrate that the integration of Dtype neuropeptide,AIE photosensitizers and RENPs could be promising candidates for in vivo NIR-II fluorescence image-guided through-skull PDT treatments of brain tumors.

关键词： aggregation-induced emission D-type neuropeptide glioma photodynamic therapy rare-earth doping nanoparticles

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One-step co-doping of ZnO and Zn^(2+)in osteoinductive calcium phosphate ceramics with synergistic antibacterial activity for regenerative repair of infected bone defect

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Journal of Materials Science & technology 2023年第32期163卷 168-181页

作者： Tinghan He Hongxu Chen Puxin Liu Hao Shi Xiujuan Xu Cong Feng Yuyi Wang Xiangfeng Li Ning Lei Yumei Xiao Xiangdong Zhu Jianguo Xu Xingdong Zhang National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China

How to endow bone grafts with long-term antibacterial activity and good bone regenerative ability to achieve the regenerative repair of infected bone defects has been the focus of the clinical treatment of *** present study introduced a novel one-step route to realizing the co-doping of zinc oxide(ZnO)and zinc ion(Zn^(2+))in biphasic calcium phosphate(BCP)ceramics to utilize their synergistic *** with the conventional BCP ceramics(BCP-Ca),the ZnO/Zn^(2+)co-doping ones(BCP-Zn)possessed strong antibacterial ability on *** and *** as well as stimulated the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)*** synergistic antibacterial mechanism of ZnO and Zn^(2+)was also ***-Zn showed excellent osteoinductivity and angiogenesis at three months postoperatively in the canine intramuscular implantation ***,BCP-Zn exhibited excellent anti-infective ability and bone regenerative repair compared to BCP-Ca and control groups in the infected bone defect model of rat ***,these findings suggest that the simultaneous introduction of ZnO/Zn^(2+)could have immense potential to expand the application of osteoinductive BCP ceramics in the regenerative repair of infected bone defects.

关键词： Biphasic calcium phosphate ceramics Zinc oxide Zinc ion Antibacterial ability Osteoinductivity

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Quantifying Joint Movement Variability in Healthy and Hemiplegic Gait using OpenSim 2

Quantifying Joint Movement Variability in Healthy and Hemipl...

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2nd IEEE International Conference on Interdisciplinary Approaches in technology and Management for Social Innovation, IATMSI 2024

作者： Rafiq, Tabassum Younis, Sadia Narayan, Jyotindra Institute of Information Management and Technology Department of Biotechnology Uttar Pradesh Aligarh202001 India Government College of Engineering and Technology Department of Biomedical Engineering Jammu and Kashmir Ganderbal193504 India Indian Institute of Technology Guwahati Mechatronics and Robotics Laboratory Department of Mechanical Engineering Assam Guwahati781039 India

ISBN: (纸本)9798350360523

This study delves into the scaling capabilities of OpenSim, a biomechanical modeling tool, to scrutinize musculoskeletal alterations accompanying the hemiplegic condition compared to a healthy model. Contralateral hemiplegia (CH), characterized by unilateral paralysis, induces profound changes in bone size and significantly influences an individual's gait. Motivated by understanding the biomechanical repercussions of CH on human movement, we conducted a comprehensive investigation involving ten patients with CH, with a median age of 46 years (range: 39 to 52.0 years and height: 1.75 0.6 m). Ten healthy controls with similar body attributes were±also recruited. We assessed musculoskeletal changes post-CH using bone length data from MRI reports obtained from a hospital. Inverse kinematics in OpenSim are facilitated for a detailed comparison of joint angles between unhealthy and healthy individuals. The gait data is visualized and analyzed using statistical metrics such as mean absolute deviation, box plots, and a two-sample t-test. The results revealed significant differences in hip and ankle joint angles between healthy and hemiplegic individuals, underscored by low p-values. Interestingly, no significant difference was observed in knee joint angles (p-value = 0.9126). These findings contribute to a valuable understanding of hemiplegia-related musculoskeletal changes, offering potential avenues for tailored interventions to improve mobility and quality of life. © 2024 IEEE.

关键词： Inverse kinematics

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Computer Simulation of Gene Knockout in Bacteria Accelerated by AI 16

Computer Simulation of Gene Knockout in Bacteria Accelerated...

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16th International Congress on Image and Signal Processing, biomedical engineering and Informatics, CISP-BMEI 2023

作者： Geng, Peter X. Hou, Jiaheng Zhu, Huaiqiu Peking University College of Future Technology Center for Quantitative Biology Department of Biomedical Engineering Beijing100871 China

ISBN: (纸本)9798350330755

Using genome-scale metabolic models (GEMs) to perform flux balance analysis (FBA) has been a powerful tool to simulate the microbial phenotypes after gene knockout. Time of one-gene knockout by such a strategy can be acceptable. However, screening multi-gene knockout candidates via computational simulation is largely time-consuming and provides a challenge in metabolic engineering. Here taking the case of two-gene combinations, we propose an artificial neural network (ANN) model to predict knockout candidates which can enhance ethanol yield in Escherichia coli K-12 MG1655. Our deep learning model not only achieves the performance with average area under the curve (AUC) of 0.999, precision of 1.00, and recall of 0.85, but also outperforms FBA with a speed that is approximately 30,000 times faster. The results therefore implied the potential of deep learning in screening multi-gene knockout candidates. Our work demonstrated the advantage of AI that solves the challenge of predicting the complex cellular metabolic networks from the one-dimension genomic sequences, indicating its significant promise in future synthetic biology applications. © 2023 IEEE.

关键词： Metabolic engineering

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Supercritical CO2 mediated construction of aluminium waste recovered γ-Al2O3 impregnated Dracaena trifasciata biomass-derived carbon composite: A robust electrocatalyst for mutagenic pollutant detection

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Journal of Colloid and Interface Science 2024年 659卷 71-81页

作者： Pandiyarajan, Sabarison Manickaraj, Shobana Sebastin Mary Liao, Ai-Ho Baskaran, Gopinath Selvaraj, Manickam Assiri, Mohammed A. Zhou, Hong Chuang, Ho-Chiao Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei106344 Taiwan Department of Mechanical Engineering National Taipei University of Technology Taipei106344 Taiwan Graduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei106335 Taiwan Department of Biomedical Engineering National Defense Medical Center Taipei114201 Taiwan Global Calcium Pvt. Ltd. Karnataka Banglore India Department of Chemistry Faculty of Science King Khalid University Abha61413 Saudi Arabia Department of Electronics Information and Communication Engineering Osaka Institute of Technology 5-16-1 Omiya Osaka Asahi-ku535-8585 Japan

Inspired by the waste-to-wealth concept, we have recovered the gamma phase aluminium oxide nanoparticles (γ-Al2O3 NPs) from waste aluminium (Al) foils and fabricated a composite with Dracaena trifasciata biomass-derived activated carbon matrix (DT-AC) using supercritical carbon-di-oxide (SC-CO2) pathway. The prepared samples are characterized altogether by various micro- and spectroscopic analyses. Based on the results, the recovered γ-Al2O3 NPs are well impregnated in the DT-AC surface by the action of the microbubble effect from the SC-CO2. The higher D-band and ID/IG value of 1.07 in the Al2O3/DT-AC nanocomposite indicate increased defects and the amorphous nature of the carbon materials. The effect of scan rate (ν) demonstrated greater linearity in ν1/2 vs peak current in the electrochemical detection study of the mutagenic pollutant 4-(methylamino) phenol hemi sulfate, showing a quasi-reversible electron transfer process undergoing diffusion-controlled kinetics. Furthermore, the limit of detection is determined to be 3.2 nM L–1 with an extensive linear range, spanning from 0.05 to 618.25 µM/L. The incredible sensitivity of 2.117 μA μM−1 cm−2, along with excellent selectivity, repeatability, and stability, is observed. Further, the respectable recovery percentage of 98.61 % in the environmental water sample is perceived. The observed outcomes suggest that the prepared Al2O3/DT-AC composite performs as an excellent electrocatalyst material, and the processing techniques used are thought to be sustainable in nature. © 2023 Elsevier Inc.

关键词： Aluminum oxide

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