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Microscopy Histopathology and Analytics, Microscopy 2024 - Part of Optica Biophotonics Congress: biomedical Optics

作者： Kim, Byungchan Cheng, Tom Y. Zimmermann, Bernhard B. Robinson, Mitchell B. Renna, Marco Carp, Stefan A. Franceschini, Maria Angela Boas, David A. Cheng, Xiaojun Neurophotonics Center Department of Biomedical Engineering Boston University BostonMA02215 United States Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Harvard Medical School CharlestownMA02129 United States Lincoln Laboratory Massachusetts Institute of Technology LexingtonMA02421 United States

We have developed the fiber-based speckle contrast optical spectroscopy (SCOS) system to measure human cerebral blood flow (CBF) and brain functions, and demonstrated that SCOS outperforms traditional diffuse correlat... 详细信息

ISBN: (纸本)9781957171340

关键词： Plasma (human)

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Electrospun Textile Strategies in Tendon to Bone Junction Reconstruction

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Advanced Fiber Materials 2023年第3期5卷 764-790页

作者： Xiaoyun Xu Yifan Si Yi Zhao Qinfei Ke Jinlian Hu Department of Biomedical Engineering City University of Hong KongHong Kong S.A.R 999077China Shanghai Frontiers Science Center of Advanced Textiles Donghua UniversityShanghai 201620China Shanghai Institute of Technology Shanghai 200235China

The repair of tendon to bone junction(TBJ)remains a tremendous challenge in tissue engineering due to the complicated structure,components,mechanical properties,and cell *** order to reconstruct the tissue and restore its functionality,biomedical scaffolds with hierarchical and gradient structures have been fabricated by various *** recent decades,electrospinning has become one of the most popular methods in fabricating TBJ scaffolds due to easy fabrication,high porosity,and ECM-like nano-scale ***,mechanical properties are the pain point of electrospun biomedical *** textile technology can be exploited to compensate for this weakness,which will be deeply discussed *** review will start with a brief introduction to the structure and function of the native TBJ tissue and a short overview of electrospinning ***,different electrospun biomedical scaffolds for TBJ repair will be summarized and ***,some advanced technologies and modification methods in fabricating functionalized electrospun TBJ scaffolds are *** the end,current challenges and solutions are being proposed,which would provide instruction for the research of electrospun textile TBJ scaffolds.

关键词： Electrospun Textile Tendon to bone Tissue engineering Biomimetic

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Single-molecule techniques in studying the molecular mechanisms of DNA synapsis in non-homologous end-joining repair

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Biophysics Reports 2025年第1期11卷 46-55页

作者： Yuhao Jiang Chao Zhao Chenyang Zhang Weilin Li Di Liu Bailin Zhao Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University Institute of Molecular and Translational Medicine (IMTM) and Department of Biochemistry and Molecular Biology Xi'an Jiaotong University Health Science Center Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences

DNA double-strand breaks(DSBs) are the most severe form of DNA damage, primarily repaired by the non-homologous end joining(NHEJ) pathway. A critical step in this process is DNA synapsis, where the two broken ends are brought together to facilitate timely repair. Deficiencies in NHEJ synapsis can lead to improper DNA end configurations, potentially resulting in chromosomal translocations. NHEJ synapsis is a highly dynamic, multi-protein mediated assembly process. Recent advances in single-molecule techniques have led to significant progress in understanding the molecular mechanisms driving NHEJ synapsis. In this review, we summarize single-molecule methods developed for studying NHEJ synapsis, with a particular focus on the single-molecule fluorescence resonance energy transfer(sm FRET)technique. We discuss the various molecular mechanisms of NHEJ synapsis uncovered through these studies and explore the coupling between synapsis and other steps in NHEJ. Additionally, we highlight the strategies, limitations, and future directions for single-molecule studies of NHEJ synapsis.

关键词： Single-molecule techniques smFRET Magnetic tweezers Non-homologous end joining (NHEJ) DNA Synapsis

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Multiple stimuli-responsive nanosystem for potent,ROS-amplifying,chemo-sonodynamic antitumor therapy

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Bioactive Materials 2022年第9期7卷 355-371页

作者： JunJie Tang Xiaoge Zhang Lili Cheng Yadong Liu You Chen Zhaozhong Jiang Jie Liu School of Biomedical Engineering Sun Yat-sen UniversityGuangzhouGuangdong510006China Faculty of Arts and Sciences Department of Biomedical EngineeringIntegrated Science and Technology CenterYale University600 West Campus DriveWest HavenCT06516United States

Although sonodynamic therapy(SDT)is a promising non-invasive tumor treatment strategy due to its safety,tissue penetration depth and low cost,the hypoxic tumor microenvironment limits its therapeutic ***,we have designed and developed an oxygen-independent,ROS-amplifying chemo-sonodynamic antitumor therapy based on novel pH/GSH/ROS triple-responsive PEG-PPMDT *** formulated artemether(ART)/Fe_(3)O_(4)-loaded PEG-PPMDT NPs can rapidly release drug under the synergistic effect of acidic endoplasmic pH and high intracellular GSH/ROS levels to inhibit cancer cell ***,the ROS level in the NPs-treated tumor cells is magnified by ART via interactions with both Fe^(2+)ions formed in situ at acidic pH and external ultrasound irradiation,which is not affected by hypoxia tumor ***,the enriched intracellular ROS level can cause direct necrosis of ROS-stressed tumor cells and further accelerate the drug release from the ROS-responsive PEG-PPMDT NPs,achieving an incredible antitumor ***,upon the chemo-sonodynamic therapy by ART/Fe_(3)O_(4)-loaded PEG-PPMDT NPs,all xenotransplants of human hepatocellular carcinoma(HepG2)in nude mice shrank significantly,and 40% of the tumors were completely ***,the Fe3O4 encapsulated in the NPs is an efficient MRI contrast agent and can be used to guide the therapeutic ***,biosafety analyses show that the PEG-PPMDT NPs possess minimal toxicity to main ***,our combined chemo-sonodynamic therapeutic method is promising for potent antitumor treatment by controlled release of drug and facile exogenous generation of abundant ROS at target tumor sites.

关键词： Nanoparticle pH/GSH/ROS triple-Responsive MRI imaging Chemodynamic therapy Sonodynamic therapy

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Facile synthesis and in vivo bioimaging applications of porphyrin derivative-encapsulated polymer nanoparticles

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Chinese Chemical Letters 2022年第8期33卷 4101-4106页

作者： Mengfei Hou Wandi Chen Junkai Zhao Deshen Dai Mo Yang Changqing Yi Guangdong Provincial Engineering and Technology Center of Advanced and Portable Medical Devices School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South China Collaborative Innovation Center For Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Fluorescence(FL)imaging guided photodynamic therapy(PDT)is becoming highly desirable for personalized therapy and precision *** this study,fluorescent polymer nanoparticles TCPP@PEI/PGA were facilely synthesized through electrostatic interaction-mediated self-assembly of porphyrins tetra(4-carboxyphenyl)porphine(TCPP)and polyethylenimine(PEI),and subsequent surface modification withγ-poly(glutamic acid)(γ-PGA).TCPP served a dual function as the FL imaging probe and the *** as-prepared TCPP@PEI/PGA nanoparticles showed excellent water-solubility and biocompatibility,while having outstanding capabilities of in vivo bioimaging and~1 O_(2) *** bioimaging of mice and effective killing of CT 26 cells as well as CT 26 tumor-bearing mice upon laser irradiation were successfully demonstrated when using TCPP@PEI/PGA as theranostic *** study provides a simple but robust method to design and synthesize porphyrin-based polymer nanoparticles for theranostics.

关键词： Porphyrins Fluorescence imaging Photodynamic therapy Theranostics

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A Rigid-Soft Switchable Lower Body Exosuit for Lifting

A Rigid-Soft Switchable Lower Body Exosuit for Lifting

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2024 International Conference on Advanced robotics and Intelligent Systems, ARIS 2024

作者： Liu, Nai-Yu Erpenback, Pablo Manuel Ramos Arriagada, Sofia Ormazabal Su, Pin-Hsuan Tuan, Pham Anh Yu, Cheng-Hao Chang, Biing-Shwen National Taiwan University of Science and Technology Department of Mechanical Engineering Taipei10617 Taiwan Research Center for Information Technology Innovation National Taiwan University Taipei10617 Taiwan National Taiwan University Department of Biomedical Engineering Taipei10617 Taiwan

ISBN: (纸本)9798350362572

Lower-limb assistive wearable exosuits can reduce occupational injuries of manual workers by assisting strenuous and repetitive lifting tasks. This study aims to develop a lower-limb assistive wearable exosuit using a mechanism called SwitchSpring to assist users during lifting. The base structure of the SwitchSpring functions as a spring rod and can switch between rigid and soft states by adjusting the cable tension on the rod. When the SwitchSpring is switched to its rigid state, the energy is harvested and released as the user squats down and stands up. The lower limb joint angles and muscle activations of a female subject lifting a 5 kg box with and without the device were measured. The results show that the SwitchSpring wearable robot manages to reduce the muscle activation level by up to 30% on the rectus femoris (RF), 35% on the biceps femoris (BF), and 37% on the tibialis anterior (TA), showing the potential of lower limb power assistance in lifting. © 2024 IEEE.

关键词： Joints (anatomy)

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Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes

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Science China(Life Sciences) 2024年第5期67卷 1051-1060页

作者： Yaomeng Yuan Xihao Liao Shuang Li Xin-Hui Xing Chong Zhang MOE Key Laboratory for Industrial Biocatalysis Institute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Base editing,the targeted introduction of point mutations into cellular DNA,holds promise for improving genome-scale functional genome screening to single-nucleotide *** efforts in prokaryotes,however,remain confined to loss-of-function screens using the premature stop codons-mediated gene inactivation library,which falls far short of fully releasing the potential of base ***,we developed a base editor-mediated functional single nucleotide variant screening pipeline in Escherichia *** constructed a library with 31,123 sgRNAs targeting 462 stress response-related genes in ***,and screened for adaptive mutations under isobutanol and furfural selective *** by the screening results,we successfully identified several known and novel functional *** pipeline might be expanded to the optimization of other phenotypes or the strain engineering in other microorganisms.

关键词： base editor high-throughput large-scale screening Escherichia coli functional mutation

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Preparing lipid nanoparticles with tunable drug loading capacity and morphology via improved sequential nanoprecipitation

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Science China Chemistry 2024年第5期67卷 1373-1374页

作者： Haoran Wang Ben Zhong Tang Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemistry.Institute of Molecular Functional MaterialsState Key Laboratory of NeuroscienceDivision of Biomedical Engineering and Division of Life ScienceThe Hong Kong University of Science and TechnologyHong Kong 999077China School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Nanotechnology hailed as a revolutionary new technology of the 21st century, has ignited a wave of innovation across diverse fields spanning chemistry, physics, materials science,medicine, engineering, and electronics. In 2016, Nature published an article titled “The nanolight revolution is coming”, underscoring that “virus-sized particles that emit light in every color could transform applications ranging from television displays to cancer treatment”.

关键词： sized loading treatment

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A biomimetic upconversion nanoreactors for near-infrared driven H2 release to inhibit tauopathy in Alzheimer’s disease therapy

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Bioactive Materials 2024年第12期42卷 165-177页

作者： Qin Zhang Chuanqi Li Bohan Yin Jiaxiang Yan Yutian Gu Yingying Huang Jiareng Chen Xinyue Lao Jianhua Hao Changqing Yi Yi Zhou James Chung Wai Cheung Siu Hong Dexter Wong Mo Yang School of Medicine and Pharmacy Ocean University of ChinaQingdao266003ChinaLaboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao266237China Department of Biomedical Engineering The Hong Kong Polytechnic University999077Hong KongChina The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen518000China Research Center for Nanoscience and Nanotechnology The Hong Kong Polytechnic UniversityKowloon999077Hong KongChina Joint Research Center of Biosensing and Precision Theranostics The Hong Kong Polytechnic UniversityKowloon999077Hong KongChina Department of Applied Physics The Hong Kong Polytechnic University999077Hong KongChina Key Laboratory of Sensing Technology and Biomedical Instruments(Guangdong Province) School of Biomedical EngineeringSun Yat-Sen UniversityGuangzhou510000China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou510080China

Abnormal hyperphosphorylation of tau protein is a principal pathological hallmark in the onset of neurodegenerative disorders,such as Alzheimer’s disease(AD),which can be induced by an excess of reactive oxygen species(ROS).As an antioxidant,hydrogen gas(H_(2))has the potential to mitigate AD by scavenging highly harmful ROS such as·***,conventional administration methods of H_(2) face significant challenges in controlling H_(2) release on demand and fail to achieve effective accumulation at lesion ***,we report artificial nanoreactors that mimic natural photosynthesis to realize near-infrared(NIR)light-driven photocatalytic H_(2) evolution in *** nanoreactors are constructed by biocompatible crosslinked vesicles(CVs)encapsulating ascorbic acid and two photosensitizers,chlorophyll a(Chla)and indoline dye(Ind).In addition,platinum nanoparticles(Pt NPs)serve as photocatalysts and upconversion nanoparticles(UCNP)act as light-harvesting antennas in the nanoreacting system,and both attach to the surface of *** NIR irradiation,the nanoreactors release H_(2) in situ to scavenge local excess ROS and attenuate tau hyperphosphorylation in the AD mice *** NIR-triggered nanoreactors provide a proof-of-concept design for the great potential of hydrogen therapy against AD.

关键词： Artificial photosynthesis Hydrogen therapy Oxidative stress Tau hyperphosphorylation Alzheimer’s disease

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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei Chen Zhitong Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

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