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Corrigendum to “Dynamic scouring of multifunctional granular material enhances filtration performance in membrane bioreactor: Mechanism and modeling” [J. Membr. Sci. 663 (2022) 120979]

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Journal of Membrane Science 2024年 698卷

作者： Wenxiang Zhang Wenzhong Liang Zhien Zhang Biological and Environmental Science and Engineering Division Water Desalination and Reuse Research Center King Abdullah University of Science and Technology Thuwal Saudi Arabia State Environmental Protection Key Laboratory of Water Environmental Simulation and Pollution Control South China Institute of Environmental Sciences Ministry of Ecology and Environment of the People's Republic of China Guangzhou 510530 PR China Department of Chemical and Biomedical Engineering West Virginia University 40110 Evansdale Drive Morgantown WV 26506 USA

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Expression of concern: Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

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Nanoscale advances 2024年第20期6卷 2024 Sep 18页

作者： Mostafa Ghafori Gorab Hooman Aghamirza Moghim Aliabadi Amir Kashtiaray Mohammad Mahdavi Milad Salimi Bani Andisheh Etminan Nabi Salehpour Reza Eivazzadeh-Keihan Ali Maleki Catalysts and Organic Synthesis Research Laboratory Department of Chemistry Iran University of Science and Technology Tehran 16846-13114 Iran maleki@iust.ac.ir reza.tab_chemist@*** +98-21-73021584 +98-21-73228313. Advanced Chemical Studies Lab Department of Chemistry K. N. Toosi University of Technology Tehran Iran. Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute Tehran University of Medical Sciences Tehran Iran. Department of Biomedical Engineering Faculty of Engineering University of Isfahan Isfahan Iran. School of Mechanical Engineering Iran University of Science and Technology (IUST) Tehran Iran. Department of Medical Biotechnology Pasteur Institute of Iran Tehran Iran.

Expression of concern for 'Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications' by Mostafa Ghafori...

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Correction: Photothermal-responsive Prussian blue nanocages loaded with thrombin for tumor starvation therapy and photothermal therapy

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Biomaterials science 2025年第6期13卷 1593页

作者： Yang Liu Bingjie Yue Ranran Wang Hailin Cong Hao Hu Bing Yu Youqing Shen College of Chemistry and Chemical Engineering College of Materials Science and Engineering Institute of Biomedical Materials and Engineering Qingdao University Qingdao 266071 China. huhao@***. Institute of Rehabilitation Medicine School of Rehabilitation Medicine Binzhou Medical University Yantai 264003 PR China. School of Materials Science and Engineering Shandong University of Technology Zibo 255000 China. State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao University Qingdao 266071 China. Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineering and Department of Chemical and Biological Engineering Zhejiang University Hangzhou Zhejiang 310027 China.

Correction for 'Photothermal-responsive Prussian blue nanocages loaded with thrombin for tumor starvation therapy and photothermal therapy' by Yang Liu , , 2023, , 4938-4947, https://***/10.1039/D3BM00526G.

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Muscle Activation Patterns Estimation during Repeated Wrist Movements from MRI and sEMG*

Muscle Activation Patterns Estimation during Repeated Wrist ...

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IEEE/RAS-EMBS International Conference on biomedical robotics and Biomechatronics (BioRob)

作者： Enrico Piovanelli Davide Piovesan Shouhei Shirafuji Natsue Yoshimura Yousuke Ogata Jun Ota Department of Precision Engineering The University of Tokyo Bunkyo Hongo Japan Department of Biomedical Gannon University Erie PA USA Research Into Artifacts Center for Engineering (RACE) School of Engineering The University of Tokyo Tokyo Japan Integrative Brain Imaging Center National Center of Neurology and Psychiatry (NCNP) Kodaira Tokyo Japan Institute of Innovative Research Tokyo Institute of Technology Midori-ku Yokohama Japan Precursory Research for Embryonic Science and Technology (PRESTO) Japan Science and Technology Agency (JST) Kawaguchi Saitama Japan

ISBN: (数字)9781728159072

ISBN: (纸本)9781728159089

Functional electrical stimulation (FES) is a widely used method to bypass spinal chord damages and bring the neurological input to muscles. FES methods that allow the activation of both superficial and deep muscles were proposed in the literature. However, even if many studies using surface electromyography (sEMG) for the estimation of muscles' activation were presented, it still remains impossible to access information of deep muscles. Our group proposed a solution that exploits the morphological information of magnetic resonance imaging (MRI) and the sEMG for the estimation of the average muscles' activation pattern during isometric muscle contractions of forearm muscles. With this work we introduce the time dimension to study how the activation patterns changes while performing 3 simple wrist movements. The study involved data collected from a single row of electrodes wrapped around the forearm of a single healthy participant. Morphological information are extracted from the MRI to build a model that is then used to estimate the muscles' activation pattern. The results show that the method is able to provide an estimation of the muscles' activation patterns that explain more than 93% of the input sEMG information and that have a corresponding in anatomical information from the literature.

关键词： Muscles Electrodes Magnetic resonance imaging Estimation Electromyography Wrist Skin

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The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma

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Cellular oncology (Dordrecht, Netherlands) 2023年第4期46卷 933-951页

作者： Ti-Chun Chan Cheng-Tang Pan Hsin-Yu Hsieh Pichpisith Pierre Vejvisithsakul Ren-Jie Wei Bi-Wen Yeh Wen-Jeng Wu Lih-Ren Chen Meng-Shin Shiao Chien-Feng Li Yow-Ling Shiue Department of Medical Research Chi-Mei Medical Center Tainan 71004 Taiwan. National Institute of Cancer Research National Health Research Institutes Tainan 71004 Taiwan. Institute of Precision Medicine College of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Department of Mechanical and Electro-Mechanical Engineering National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Institute of Advanced Semiconductor Packaging and Testing College of Semiconductor and Advanced Technology Research National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Institute of Biomedical Sciences College of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Program in Translational Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand. Department of Pathology Kaohsiung Armed Forces General Hospital Kaohsiung 80284 Taiwan. Institute of Medical Science and Technology School of Medicine National Sun Yat-Sen University Kaohsiung 80424 Taiwan. Department of Medical Laboratory Sciences and Biotechnology Fooyin University Kaohsiung 83102 Taiwan. Department of Urology School of Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Department of Urology Kaohsiung Medical University Hospital Kaohsiung 80708 Taiwan. Graduate Institute of Clinical Medicine College of Medicine Kaohsiung Medical University Kaohsiung 80708 Taiwan. Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung 80708 Taiwan. Division of Physiology Livestock Research Institute Tainan 71246 Taiwan. Research Center Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 10400 Thailand. Department of Medical Research Chi-Mei Medical Center Tainan 71004 Taiwan. angelo.p@yahoo.com.tw. National Institute of Cancer Research National Health Research Institutes Tainan 71004 Taiwan. angelo.p@yahoo.com.tw. Institute of Precision Medicine College of Medicine Nat

PURPOSE:Urothelial carcinoma (UC) is a common disease in developed counties. This study aimed to identify autocrine roles and signaling pathways of gremlin 1, DAN family BMP antagonist (GREM1), which inhibits tumor growth and epithelial-mesenchymal transition (EMT) in UC. METHODS:Systematic in vitro and in vivo studies using genetic engineering, different urinary bladder urothelial carcinoma (UBUC)-derived cell lines, and mouse models were performed, respectively. Further, primary upper tract urothelial carcinoma (UTUC) and UBUC specimens were evaluated by immunohistochemistry. RESULTS:GREM1 protein levels conferred better disease-specific and metastasis-free survival rates and played an independent prognostic factor in UTUC and UBUC. Hypermethylation is the primary cause of low GREM1 levels. In different UBUC-derived cell lines, the autocrine/secreted and glycosylated GREM1 interacted with transforming growth factor beta 1 (TGFB1) and inhibited TGFβ/BMP/SMAD signaling and myosin light chain 9 (MYL9) transactivation, subsequently cell proliferation and epithelial-mesenchymal transition (EMT). Secreted and glycosylated GREM1 also suppressed tumor growth, metastasis, and MYL9 levels in the mouse model. Instead, cytosolic GREM1 promoted cell proliferation and EMT by activating the tumor necrosis factor (TNF)/AKT/nuclear factor kappa B (NFκB) axis. CONCLUSIONS:Clinical associations, animal models, and in vitro indications provided solid evidence to show that the epithelial autocrine GREM1 is a novel tumor suppressor in UCs. The glycosylated-GREM1 hampered cell proliferation, migration, invasion, and in vitro angiogenesis through interaction with TGFB1 to inactivate TGFβ/BMP/SMAD-mediated EMT in an autocrine manner.

关键词： Autocrine Epithelial-mesenchymal transition GREM1 TGFβ Urothelial carcinoma

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Post-synthetic modification and application of sulfhydryl-functionalized carbon quantum dots for label-free Ag + detection

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Process Safety and Environmental Protection 2025年

作者： Yanzhi He Pengyuan Yin Xiaopei Li Jinghang Li Jie Ma Hang Yu Wenrong Yang Lijun Luo Wei Tan Hongbin Wang School of Chemistry and Environment Yunnan Minzu University Key Laboratory of Resource Clean Conversion in Ethnic Regions Education Department of Yunnan Key Laboratory of Environmental Functional Materials of Yunnan Province Education Department Kunming 650500 PR China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology Wuhan 430070 China Centre for Chemistry and Biotechnology School of Life and Environmental Sciences Deakin University Waurn Ponds Victoria 3216 Australia

The potential toxicity of silver ions (Ag + ) to humans and the environment cannot be overlooked with their widespread application in modern life and industry. Inspired by the higher affinity between -SH and Ag + , a sulfhydryl-functionalized carbon quantum dots (SH-CQDs) was prepared by post-synthesis modification with L-cysteine (L-Cys) as a surface modifier through an amide reaction method. The as-prepared SH-CQDs exhibited a small particle size (6.629 ± 0.4132 nm) and uniform dispersion. The maximum excitation and emission wavelengths of SH-CQDs were 413 nm and 563 nm, respectively. The fluorescence (FL) of SH-CQDs can be quenched by Ag + through static quenching and electron transfer (ET). Hence, a fluorescence assay for Ag + detection with high selectivity and sensitivity was constructed. Significantly, a wide linear (5.00-300 μM) and low detection limit (LOD) (0.7679 μM) was obtained owing to the specific binding of SH-CQD to Ag + . Satisfactory recovery and relative standard deviation (RSD) were measured as 97.36-102.7% and 1.961-5.719% in practical water, respectively. In addition, cytotoxicity and bioimaging assays verified that SH-CQDs have good biocompatibility and low cytotoxicity, which suggested that it has excellent potential in bioimaging.

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Cortical thickness abnormalities in patients with first episode psychosis:a meta-analysis of psychoradiologic studies and replication in an independent sample

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Psychoradiology 2021年第4期1卷 185-198页

作者： Keren Wen Youjin Zhao Qiyong Gong Ziyu Zhu Qian Li Nanfang Pan Shiqin Fu Joaquim Radua Eduard Vieta Poornima Kumar Graham J.Kemp Bharat B.Biswal Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610041SichuanChina Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu 610041SichuanChina Functional and Molecular Imaging Key Laboratory of Sichuan Province Chengdu 610041SichuanChina Institut d’Investigacions Biom`ediques August Pi i Sunyer(IDIBAPS) Mental Health Research Networking Center(CIBERSAM)Barcelona 08036CataloniaSpain Centre for Psychiatric Research and Education Department of Clinical NeuroscienceKarolinska InstitutetSolna 171-77StockholmSweden Department of Psychosis Studies Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK Barcelona Bipolar Disorders and Depressive Unit Hospital ClinicInstitute of NeurosciencesUniversity of BarcelonaBarcelona 08036CataloniaSpain Center for Depression Anxiety and Stress ResearchMcLean HospitalBelmont 02478MAUSA Department of Psychiatry Harvard Medical SchoolBoston 02115MAUSA Liverpool Magnetic Resonance Imaging Centre(LiMRIC)and Institute of Life Course and Medical Sciences University of LiverpoolLiverpool L693GEUK Department of Biomedical Engineering New Jersey Institute of TechnologyNewark 07102NJUSA The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina

Background:Abnormalities of cortical thickness(CTh)in patients with their first episode psychosis(FEP)have been frequently reported,but findings are ***:To define the most consistent CTh changes in patients with FEP by meta-analysis of publishedwholebrain ***:The meta-analysis used seed-based dmapping(SDM)software to obtain the most prominent regional CTh changes in FEP,and meta-regression analyses to explore the effects of demographics and clinical *** meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age-and sex-matched healthy controls(HCs),using both a vertex-wise and a region of interest analysis,with multiple comparisons ***:The meta-analysis identified lower CTh in the rightmiddle temporal cortex(MTC)extending to superior temporal cortex(STC),insula,and anterior cingulate cortex(ACC)in FEP compared with *** significant correlations were identified between CTh alterations and demographic or clinical *** results were replicated in the independent dataset ***:This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.

关键词： psychoradiology first episode psychosis early psychosis cortical thickness meta-analysis seed-based d mapping

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Classification of glioma grade and Ki-67 level prediction in MRI data: A SHAP-driven interpretation

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Computerized Medical Imaging and Graphics 2025年

作者： E.H. Bhuiyan M.M. Khan S.A. Hossain R. Rahman Q. Luo M.F. Hossain K. Wang M.S.I. Sumon S. Khalid M. Karaman J. Zhang M.E.H. Chowdhury W. Zhu X.J. Zhou Center for Magnetic Resonance Research University of Illinois Chicago Chicago 60612 IL USA Department of Pathology and Biomedical Science University of Otago 2 Riccarton Ave Christchurch 8140 New Zealand Department of Biochemistry University of Regina 3737 Wascana Pkwy Regina S4S 0A2 SK Canada Spiced Academy Ritterstraße 12-14 Regina 10969 Berlin Germany Department of Radiology University of Illinois Chicago Chicago 60612 IL USA Department of Physics University of Virginia Charlottesville 22904-4714 VA USA Department of Electrical Engineering Qatar University Doha 213 Qatar Department of Neurology University of Illinois Chicago Chicago 60612 IL USA Department of Biomedical Engineering University of Illinois Chicago Chicago 60607 IL USA Department of Radiology Tongji Hospital Huazhong University of Science and Technology Charlottesville Wuhan China Departments of Radiology and Neurosurgery University of Illinois College of Medicine at Chicago Chicago 60612 IL USA

This study focuses on artificial intelligence-driven classification of glioma and Ki-67 leveling using T2w-FLAIR MRI, exploring the association of Ki-67 biomarkers with deep learning (DL) features through explainable artificial intelligence (XAI) and SHapley Additive exPlanations (SHAP). This IRB-approved study included 101 patients with glioma brain tumor acquired MR images with the T2W-FLAIR sequence. We extracted DL bottleneck features using ResNet50 from glioma MR images. Principal component analysis (PCA) was deployed for dimensionality reduction. XAI was used to identify potential features. The XGBosst classified the histologic grades of the glioma and the level of Ki-67. We integrated potential DL features with patient demographics (age and sex) and Ki-67 biomarkers, utilizing SHAP to determine the model’s essential features and interactions. Glioma grade classification and Ki-67 level predictions achieved overall accuracies of 0.94 and 0.91, respectively. It achieved precision scores of 0.92, 0.94, and 0.96 for glioma grades 2, 3, and 4, and 0.88, 0.94, and 0.97 for Ki-67 levels (low: 5 % ≤ K i − 67 < 10 % , moderate: 10 % ≤ K i − 67 ≤ 20 , and high: K i − 67 > 20 % ). Corresponding F1-scores were 0.95, 0.88, and 0.96 for glioma grades and 0.92, 0.93, and 0.87 for Ki-67 levels. SHAP analysis further highlighted a strong association between bottleneck DL features and Ki-67 biomarkers, demonstrating their potential to differentiate glioma grades and Ki-67 levels while offering valuable insights into glioma aggressiveness. This study demonstrates the precise classification of glioma grades and the prediction of Ki-67 levels to underscore the potential of AI-driven MRI analysis to enhance clinical decision-making in glioma management.

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The effect of acid hydrolysis treatment on the mechanical properties of oil palm empty fruit bunches (OPEFB) fibers/thermoplastic starch

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AIP Conference Proceedings 2024年第1期2883卷

作者： Sinar Arzuria Adnan Jayganapatay Di Sheng Lai Azlin Fazlina Osman Nur Hidayah Ahmad Zaidi Ismail Ibrahim Awad A. Alrashdi Husna Mat Salleh Faculty of Chemical Engineering & Technology Universiti Malaysia Perlis (UniMAP) 02600 Arau Perlis Malaysia. Biomedical and Nanotechnology Research Group Center of Excellence Geopolymer and Green Technology (CEGeoGTech) Universiti Malaysia Perlis (UniMAP) 02600 Arau Perlis Malaysia. Chemistry Department Umm Al-Qura University Al-Qunfudhah University College Al-Qunfudhah Center for Scientific Research (QCSR) Al Qunfudhah 21962 Saudi Arabia. Politeknik Sultan Abdul Halim Mu’adzam Shah 06000 Jitra Kedah Malaysia.

Oil Palm Empty Fruit Bunches (OPEFB) fiber is a byproduct of the palm oil industry, and have the potential as a reinforcement material in various polymer based products, resulting in remarkable improvements in mechanical properties. In recent years, researchers have focused on developing OPEFB fiber reinforced thermoplastic starch (TPS) films as a potential alternative to petroleum based plastic films. However, the mechanical properties of these films need to be improved for practical applications. One approach to improving the mechanical properties of OPEFB fibers/TPS films is acid hydrolysis (AH) treatment. TPS films were formed by the plasticization process, in which the structure of granule starch was devastated and reformed by water, and glycerin through the heating process. The OPEFB fiber were undergo AH treatment for reduced the size of particles, removed impurities, and enhanced the compatibility between the OPEFB cellulose, and the TPS matrix. The OPEFB cellulose was added to the TPS matrix to produce OPEFB(AH)/TPS bio composites by film casting. The TPS films with OPEFB(AH) fiber content in the range of 1wt% to 6wt% were prepared. The mechanical properties were studied by changing the content of OPEFB(AH) fiber added to the TPS matrix. Results show that the films achieved the highest tensile strength when 4wt% OPEFB(AH)/TPS were used to form bio composites films. This was due to the homogenous, and good distribution of OPEFB cellulose in the TPS matrix. The tensile strength reduces when the OPEFB(AH)/TPS fiber content was increased to 5wt%. The elongation at the break of films experienced a slightly reduced as the loading of OPEFB(AH) cellulose increased because the mobility of the starch chain was hindered by OPEFB(AH) cellulose. The morphology of different loading OPEFB(AH) cellulose with the TPS matrix was investigated using a scanning electron microscope (SEM).

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Original askiatic imaging used in Chinese medicine eye-feature diagnosis of visceral diseases

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 92-97页

作者： Ning Xue Kai Jiang Qi Li Lili Zhang Li Ma Ruliang Wang Rongxin Fu Xue Lin Ya Su Xiangyu Jin Rongzan Lin Guoliang Huang Department of Biomedical Engineering The School of Medicine Tsinghua UniversityBeijing 100084P.R.China National Engineering Research Center for Beijing Biochip Technology Beijing 102206 P.R.China

Eye-feature diagnosis is a time-homored met hod for studying many diseases in tradit ional Chinese *** is a dlose relationship between eye feature and viscera,and eye feature is a reflect ion of viscer al health *** used ophthalmology diagnosis instr uments have disadvantages and cannot satisfy the requirements of eye feature *** this paper,we proposed a novel askiatic imaging method that removes the interference of an ilumination source's reflection shadow and is free from image *** developed a novel imaging system to implement this method,and some eye feature characteristics to analyze visceral diseases were obtained.

关键词： In vivo eye feature diagnosis askiatic imaging image processing

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