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Macrophage-mediated control of implant-associated biofilms in a three-dimensional human oral mucosa model

Materialia 2025年 41卷

作者： Shuli Chen Muhammad Imran Rahim Carina Mikolai Daniela Paasch Andreas Winkel Katharina Doll-Nikutta Nico Lachmann Henning Menzel Dagmar Wirth Hansjörg Hauser Meike Stiesch Department of Prosthetic Dentistry and Biomedical Materials Science Hannover Medical School Carl-Neuberg-Str. 1 30625 Hannover Germany Lower Saxony Centre for Biomedical Engineering Implant Research and Development (NIFE) Stadtfelddamm 34 30625 Hannover Germany Department of Pediatric Pneumology Allergology and Neonatology Hannover Medical School 30625 Hannover Germany RESIST Cluster of Excellence Hannover Medical School 30625 Hannover Germany Biomedical Research in End Stage and Obstructive Lung Disease Hannover (BREATH) German Center for Lung Research (DZL) Hannover Germany Center of Translational Regenerative Medicine Hannover Medical School Hannover Germany Fraunhofer Institute for Toxicology and Experimental Medicine ITEM 30625 Hannover Germany Department of Macromolecular Chemistry Institute for Technical Chemistry Braunschweig University of Technology 38106 Braunschweig Germany Model Systems for Infection and Immunity Helmholtz Centre for Infection Research Braunschweig Germany Department of Experimental Hematology Hannover Medical School Carl-Neuberg-Str. 1 30625 Hannover Germany iBET-Instituto de Biologia Experimental e Tecnologica Apartado 12 2781-901 Oeiras Portugal

Macrophages are pivotal in regulating inflammation and facilitating pathogen clearance, particularly in peri-implant environments prone to biofilm infections. For a better understanding of the role of these immune cells in host-biofilm-implant interactions, we developed a complex three-dimensional (3D) implant-tissue-oral-bacterial-biofilm model (INTER b ACT) with integrated macrophages to mimic the intricate triangular interactions between implant materials, biofilms, and the host, in conditions simulating the in vivo environment. The INTER b ACT model includes a peri-implant mucosa with collagen-embedded fibroblasts and macrophages, overlaid with a multi-layered oral epithelium, as well as a multi-species biofilm. Histological analysis demonstrated a preserved peri-implant architecture with high cell viability. Co-cultivation with multi-species biofilms provided valuable insights into macrophage roles in pathogen defence and inflammation regulation. In tissues lacking macrophages, biofilm exposure led to compromised epithelial integrity, whereas macrophage-containing tissues maintained their epithelial structure. Macrophages significantly reduced the biofilm biomass while promoting bacterial death. Inflammatory cytokine levels elevated under sterile conditions decreased upon biofilm exposure, suggesting a biofilm-mediated immune suppression. Cytokine expression levels differentially reacted to biofilm exposure and macrophage concentration, with IL-1β and IL-17 levels notably elevated in biofilm-exposed tissues, aligning with clinical observations of peri-implant inflammation. Our findings demonstrate that the INTER b ACT model, after incorporation of macrophages, serves as a physiologically relevant platform for studying host-pathogen dynamics and allows to identify key inflammatory markers associated with biofilm-related complications. Furthermore, this model holds significant potential for evaluating novel therapeutic strategies, such as sensor-actuator systems

关键词： 3D peri-implant mucosa model Macrophages Human gingival fibroblasts Epithelial cells Biomaterial-associated infections Multi-species biofilms Inflammatory cytokines

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An integrated transcriptomic cell atlas of human neural organoids (vol 635, pg 690, 2024)

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NATURE 2025年第8045期637卷 E21-E21页

作者： He, Zhisong Dony, Leander Fleck, Jonas Simon Szalata, Artur Li, Katelyn X. Sliskovic, Irena Lin, Hsiu-Chuan Santel, Malgorzata Atamian, Alexander Quadrato, Giorgia Sun, Jieran Pasca, Sergiu P. Camp, J. Gray Theis, Fabian J. Treutlein, Barbara Department of Biosystems Science and Engineering ETH Zürich Basel Switzerland Institute of Computational Biology Computational Health Center Helmholtz Munich Neuherberg Germany Department Genes and Environment Max Planck Institute of Psychiatry Munich Germany International Max Planck Research School for Translational Psychiatry (IMPRS-TP) Munich Germany TUM School of Life Sciences Weihenstephan Technical University of Munich Freising Germany School of Computation Information and Technology Technical University of Munich Munich Germany Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden Institute of Human Biology (IHB) Roche Pharma Research and Early Development Roche Innovation Center Basel Basel Switzerland Biozentrum University of Basel Basel Switzerland Department of Stem Cell Biology and Regenerative Medicine Keck School of Medicine University of Southern California Los Angeles CA USA Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC Keck School of Medicine University of Southern California Los Angeles CA USA Department of Psychiatry and Behavioral Sciences Stanford University Stanford CA USA Stanford Brain Organogenesis Program Wu Tsai Neurosciences Institute and Bio-X Stanford CA USA Neural Stem Cell Institute Albany NY USA UK Dementia Research Institute at the University of Edinburgh Edinburgh Bioquarter Edinburgh UK Centre for Discovery Brain Sciences School of Biomedical Sciences College of Medicine and Veterinary Medicine The University of Edinburgh Edinburgh UK Human Technopole Milan Italy Department of Oncology and Hemato-Oncology University of Milan Milan Italy

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Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status-a brief report

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Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2024年第4期20卷 521-530页

作者： Batel Blechter Chao Agnes Hsiung Xiaoyu Wang Haoyu Zhang Wei Jie Seow Jianxin Shi Nilanjan Chatterjee Hee Nam Kim Maria Pik Wong Yun-Chul Hong Jason Yy Wong Juncheng Dai H Dean Hosgood Zhaoming Wang I-Shou Chang Jiyeon Choi Jiucun Wang Minsun Song Wei Hu Wei Zheng Jin Hee Kim Baosen Zhou Demetrius Albanes Min-Ho Shin Lap Ping Chung She-Juan An Hong Zheng Yasushi Yatabe Xu-Chao Zhang Young Tae Kim Xiao-Ou Shu Young-Chul Kim Roel C H Vermeulen Bryan A Bassig Jiang Chang James Chung Man Ho Bu-Tian Ji Michiaki Kubo Yataro Daigo Yukihide Momozawa Yoichiro Kamatani Takayuki Honda Hideo Kunitoh Shun-Ichi Watanabe Yohei Miyagi Haruhiko Nakayama Shingo Matsumoto Masahiro Tsuboi Koichi Goto Zhihua Yin Atsushi Takahashi Akiteru Goto Yoshihiro Minamiya Kimihiro Shimizu Kazumi Tanaka Tangchun Wu Fusheng Wei Jian Su Yeul Hong Kim In-Jae Oh Victor Ho Fun Lee Wu-Chou Su Yuh-Min Chen Gee-Chen Chang Kuan-Yu Chen Ming-Shyan Huang Hsien-Chih Lin Adeline Seow Jae Yong Park Sun-Seog Kweon Chien-Jen Chen Yu-Tang Gao Chen Wu Biyun Qian Daru Lu Jianjun Liu Hyo-Sung Jeon Chin-Fu Hsiao Jae Sook Sung Ying-Huang Tsai Yoo Jin Jung Huan Guo Zhibin Hu Tzu-Yu Chen Laurie Burdett Meredith Yeager Amy Hutchinson Sonja I Berndt Wei Wu Junwen Wang Jin Eun Choi Kyong Hwa Park Sook Whan Sung Li Liu Chang Hyun Kang Chung-Hsing Chen Jun Xu Peng Guan Wen Tan Chih-Liang Wang Alan Dart Loon Sihoe Ying Chen Yi Young Choi Jun Suk Kim Ho-Il Yoon Qiuyin Cai In Kyu Park Ping Xu Qincheng He Chih-Yi Chen Junjie Wu Wei-Yen Lim Kun-Chieh Chen John K C Chan Jihua Li Hongyan Chen Chong-Jen Yu Li Jin Joseph F Fraumeni Jie Liu Maria Teresa Landi Taiki Yamaji Yang Yang Belynda Hicks Kathleen Wyatt Shengchao A Li Hongxia Ma Bao Song Zhehai Wang Sensen Cheng Xuelian Li Yangwu Ren Motoki Iwasaki Junjie Zhu Gening Jiang Ke Fei Guoping Wu Li-Hsin Chien Fang-Yu Tsai Jinming Yu Victoria L Stevens Pan-Chyr Yang Dongxin Lin Kexin Chen Yi-Long Wu Keitaro Matsuo Nathaniel Rothman Kouya Shiraishi Hongbing Shen Stephen J Chanock Takashi Kohno Qing Lan Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA. Institute of Population Health Sciences National Health Research Institutes Zhunan Taiwan. Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville MD USA Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore. Department of Oncology School of Medicine Johns Hopkins University Baltimore MD USA Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore MD USA. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea. Department of Pathology Queen Mary Hospital Hong Kong Hong Kong. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea. Epidemiology and Community Health Branch National Heart Lung and Blood Institute Bethesda MD USA. Department of Epidemiology School of Public Health Nanjing Medical University Nanjing China. Department of Epidemiology and Population Health Albert Einstein College of Medicine New York USA. Department of Computational Biology St. Jude Children's Research Hospital Memphis TN USA. National Institute of Cancer Research National Health Research Institutes Zhunan Taiwan. Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai China. Department of Statistics & Research Institute of Natural Sciences Sookmyung Women's University Seoul 04310 Korea. Division of Epidemiology Department of Medicine Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center Nashville TN USA. Department of Environmental Health

We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the epidermal growth factor receptor (EGFR) gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4,544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared to EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (OR=8.63, 95% CI:5.67, 13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (OR=3.50, 95% CI: 2.44, 5.00) (p-heterogeneity=3.66x10). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.

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Range-max enhanced ultra-wideband micro-doppler signatures of behind wall indoor human activities

arXiv

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arXiv 2020年

作者： An, Qiang Wang, Shuoguang Hoorfar, Ahmad Zhang, Wenji Lv, Hao Li, Shiyong Wang, Jianqi Department of Biomedical Engineering Fourth Military Medical University Xi'an710032 China Beijing Key Laboratory of Millimeter Wave and Terahertz Technology Beijing Institute of Technology Beijing100081 China Antenna Research Laboratory Center for Advanced Communications Villanova University VillanovaPA19085 United States

Penetrating detection and recognition of behind wall indoor human activities has drawn great attentions from social security and emergency service department in recent years since intelligent surveillance aforehand could avail the proper decision making before operations being carried out. However, due to the influence of the wall effects, the obtained micro-Doppler signatures would be severely degenerated by strong near zero-frequency DC components, which would inevitably smear the detailed characteristic features of different behind wall motions in spectrograms and further hinder the motion recognition and classification. In this paper, an ultra-wideband (UWB) radar system is first employed to probe through the opaque wall media to detect the behind wall motions, which often span a certain number of range bins. By employing such a system, a high-resolution range map can be obtained, in which the embedded rich range information is expected to be fully exploited to improve the subsequent recognition and classification performance. Secondly, a high-pass filter is applied to remove the wall's effects in the raw range map. Then, with the aim of enhancing the characteristic features of different behind wall motions in spectrograms, a novel range-max enhancement strategy is proposed to extract the most significant micro-Doppler feature of each time-frequency cell along all range bins for a specific motion. Lastly, the effectiveness of the proposed micro-Doppler signature enhancement strategy is investigated by means of onsite experiments and comparative classification. Both the feature enhanced spectrograms and classification results show that the proposed approach outperforms other state-of-art time-frequency analysis based feature extraction methods. The paper thus suggests the usage of an UWB radar system accompanied with the proposed range-max time-frequency representation (R-max TFR) approach for motion recognition and classification tasks in complex penetration sce

关键词： Decision making

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再生医学中器官生物打印的进展（英文）

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engineering 2024年第11期 121-142页

作者：王象张迪 Yogendra Pratap Singh Miji Yeo 邓国滔赖嘉琪陈飞 Ibrahim T.Ozbolat 于寅 Center for Materials Synthetic Biology Chinese Academy of Sciences Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic Biology Shenzhen Institute of Advanced Technology Chinese Academy of Sciences The Huck Institutes of the Life Sciences Pennsylvania State University University Park Engineering Science and Mechanics Department Pennsylvania State University University Park Department of Biomedical Engineering Pennsylvania State University University Park Materials Research Institute Pennsylvania State University University Park Department of Neurosurgery Pennsylvania State College of Medicine Pennsylvania State Cancer Institute Pennsylvania State University University Park Biotechnology Research and Application Center Cukurova University

Organ damage or failure arising from injury, disease, and aging poses challenges due to the body's limited regenerative capabilities. Organ transplantation presents the issues of donor shortages and immune rejection risks, necessitating innovative solutions. The three-dimensional(3D) bioprinting of organs on demand offers promise in tissue engineering and regenerative medicine. In this review, we explore the state-of-the-art bioprinting technologies, with a focus on bioink and cell type selections. We follow with discussions on advances in the bioprinting of solid organs, such as the heart, liver, kidney, and pancreas,highlighting the importance of vascularization and cell integration. Finally, we provide insights into key challenges and future directions in the context of the clinical translation of bioprinted organs and their large-scale production.

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Tumor-Microenvironment-Responsive Cascade Reactions by a Cobalt-Single-Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy

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Angewandte Chemie 2022年第48期134卷

作者： Dr. Shuangfei Cai Dr. Jiaming Liu Jianwei Ding Zhao Fu Haolin Li Youlin Xiong Zheng Lian Prof. Rong Yang Prof. Chunying Chen CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety Center of Materials Science and Optoelectronics Engineering CAS center for Excellence in Nanoscience National Center for Nanoscience and Technology University of Chinese Academy of Sciences Beijing 100190 China Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University Raleigh NC 27607 USA Sino-Danish College Sino-Danish Center for Education and Research University of Chinese Academy of Sciences Beijing 100049 China GBA National Institute for Nanotechnology Innovation Guangzhou 510700 Guangdong China

Nanocatalytic therapy, involving the nanozyme-triggered production of reactive oxygen species (ROS) in the tumor microenvironment (TME), has demonstrated potential in tumor therapy, but nanozymes still face challenges of activity and specificity that compromise the therapeutic efficacy. Herein, we report a strategy based on a single-atom nanozyme to initiate cascade enzymatic reactions in the TME for tumor-specific treatment. The cobalt-single-atom nanozyme, with Co−N coordination on N-doped porous carbon (Co-SAs@NC), displays catalase-like activity that decomposes cellular endogenous H 2 O 2 to produce O 2 , and subsequent oxidase-like activity that converts O 2 into cytotoxic superoxide radicals to efficiently kill tumor cells. By incorporation with doxorubicin, the therapy achieves a significantly enhanced antitumor effect in vivo. Our findings show that cascade TME-specific catalytic therapy combined with chemotherapy is a promising strategy for efficient tumor therapy.

关键词： Cascade Catalysis Nanozyme ROS Single-Atom Material Tumor Therapy

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Electrochemical sensing of flunitrazepam based on MXene and cucurbituril supramolecular host-guest interaction

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Mikrochimica acta 2025年第7期192卷 396页

作者： Liang Zhou Siyu Chen Yunliang Qiu Huifang Wang Gengzhi Sun Jinming Kong Xueji Zhang School of Environmental and Biological Engineering Nanjing University of Science and Technology Nanjing 210094 Jiangsu China. Department of Criminal Science and Technology Nanjing Police College Nanjing 210023 China. Institute of Advanced Materials (IAM) Nanjing Tech University 30 South Puzhu Road Nanjing 211816 China. Institute of Advanced Materials (IAM) Nanjing Tech University 30 South Puzhu Road Nanjing 211816 China. iamgzsun@***. School of Environmental and Biological Engineering Nanjing University of Science and Technology Nanjing 210094 Jiangsu China. j.kong@***. School of Biomedical Engineering Shenzhen University Health Science Center Shenzhen 518060 China.

Flunitrazepam is a new psychoactive substance and belongs to the third generation of drugs with strong sedative and hypnotic effects, capable of causing "paraphilic amnesia." In recent years, flunitrazepam has been smuggled and trafficked in the form of disguised imported pills and has been strongly linked to cases of drug-facilitated sexual assault, presenting a significant threat to public safety and social stability. However, the lack of sensitivity and timeliness in existing detection methods makes it challenging to combat flunitrazepam effectively in judicial practice. To address this issue, this study presents an ITO/MXene/CB[8] electrochemical sensor platform that employs a host-guest strategy to achieve highly sensitive detection of flunitrazepam. The sensor leverages the high conductivity of MXene-TiCT nanomaterials to enhance detection sensitivity, while the highly selective capture of flunitrazepam by cucurbit[8] macrocyclic molecules ensures precise target detection. Demonstrating good linearity (R = 0.996) over the concentration range 20 nM to 80 µM, the platform exhibited a LOD of 1.27 nM and a sensitivity value of 14.948 µA·µM·cm, outperforming most existing electrochemical detection methods. Additionally, its practical applicability was validated through the detection of artificial urine samples. These results suggest that the sensor holds substantial promise for flunitrazepam detection and could be valuable in forensic applications.

关键词： CB[8] Electrochemical sensor Flunitrazepam Host–guest interaction MXene-Ti3C2Tx New psychoactive substance

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Heterogeneous Integration of 5G and Millimeter-Wave Diplexers with 3D Glass Substrates

Heterogeneous Integration of 5G and Millimeter-Wave Diplexer...

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Electronic Components and technology Conference (ECTC)

作者： Muhammad Ali Atom Watanabe Takenori Kakutani Pulugurtha M. Raj Rao. R. Tummala Madhavan Swaminathan 3D Systems Packaging Research Center Georgia Institute of Technology Atlanta GA USA Taiyo Ink Mfg. Co. Ltd. Saitama Japan Department of Biomedical Engineering Florida International University Miami FL USA

ISBN: (数字)9781728161808

ISBN: (纸本)9781728161815

Package-integrated implementation of highly- miniaturized diplexers is presented for the first time on ultra-thin laminated glass substrates for millimeter-wave (mm-wave) applications in emerging RF front-end modules (FEM). The diplexers are designed using miniaturized, doubly- terminated bandpass filters which cover the 5G new radio (NR) mm-wave bands: n257, n258 and n260. Two different types of filters: hairpin and edge-coupled are modeled, designed and optimized for this non-contiguous diplexer demonstration. Since diplexer is a three-port device, the considerations for optimum RF performance as well as characterization are included in the modeling phase. From the fabrication standpoint, unlike conventional etching processes, panel-scale semi-additive patterning (SAP) process is utilized to form high-precision, fine-feature redistribution layers (RDL) on ultra-thin glass substrates to accurately realize the aforementioned passive components. These diplexers can be integrated with antennas on the top layer of a multilayered 5G module or they can be utilized as integrated passive devices (IPDs). An appropriately sized ground plane is sufficient to isolate the rest of the system from these diplexers, making them ideal for applications such as heterogeneously-integrated packages. The demonstrated diplexers, comprising of 5G NR band filters, exhibit low insertion loss, high stopband rejection, high selectivity, ease-of-integration in packages as well as small footprint. The simulated response of the fabricated diplexers is in excellent agreement with the measured results.

关键词： Glass Fabrication 5G mobile communication Resonant frequency Substrates Broadband antennas Radio frequency

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Asian diversity in human immune cells

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Cell 2025年第8期188卷 2288-2306.e24页

作者： Kock, Kian Hong Tan, Le Min Han, Kyung Yeon Ando, Yoshinari Jevapatarakul, Damita Chatterjee, Ankita Lin, Quy Xiao Xuan Buyamin, Eliora Violain Sonthalia, Radhika Rajagopalan, Deepa Tomofuji, Yoshihiko Sankaran, Shvetha Park, Mi-So Abe, Mai Chantaraamporn, Juthamard Furukawa, Seiko Ghosh, Supratim Inoue, Gyo Kojima, Miki Kouno, Tsukasa Lim, Jinyeong Myouzen, Keiko Nguantad, Sarintip Oh, Jin-Mi Rayan, Nirmala Arul Sarkar, Sumanta Suzuki, Akari Thungsatianpun, Narita Venkatesh, Prasanna Nori Moody, Jonathan Nakano, Masahiro Chen, Ziyue Tian, Chi Zhang, Yuntian Tong, Yihan Tan, Crystal T.Y. Tizazu, Anteneh Mehari Loh, Marie Hwang, You Yi Ho, Roger C. Larbi, Anis Ng, Tze Pin Won, Hong-Hee Wright, Fred A. Villani, Alexandra-Chloé Park, Jong-Eun Choi, Murim Liu, Boxiang Maitra, Arindam Pithukpakorn, Manop Suktitipat, Bhoom Ishigaki, Kazuyoshi Okada, Yukinori Yamamoto, Kazuhiko Carninci, Piero Chambers, John C. Hon, Chung-Chau Matangkasombut, Ponpan Charoensawan, Varodom Majumder, Partha P. Shin, Jay W. Park, Woong-Yang Prabhakar, Shyam Genome Institute of Singapore (GIS) Agency for Science STAR) 60 Biopolis Street Genome Singapore 138672 Singapore Samsung Genome Institute Samsung Medical Center Seoul 06351 South Korea Laboratory for Advanced Genomics Circuit RIKEN Center for Integrative Medical Sciences (IMS) 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Laboratory for Transcriptome Technology RIKEN Center for IMS 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Single-cell omics and Systems Biology of Diseases (scSyBiD) Research Unit Faculty of Science Mahidol University Bangkok 10400 Thailand Department of Microbiology Faculty of Science Mahidol University Bangkok 10400 Thailand John C. Martin Centre for Liver Research and Innovations Sonarpur Kolkata 700150 India Laboratory for Systems Genetics RIKEN Center for IMS 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Department of Statistical Genetics of Medicine Osaka University 2-2 Yamadaoka Osaka Suita 565-0871 Japan Integrated Frontier Research for Medical Science Division Institute for Open and Transdisciplinary Research Initiatives Osaka University 2-2 Yamadaoka Osaka Suita 565-0871 Japan Samsung Advanced Institute for Health Sciences & Technology Sungkyunkwan University Seoul 06351 South Korea Laboratory for Autoimmune Diseases RIKEN Center for IMS 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Department of Biochemistry Faculty of Science Mahidol University Bangkok 10400 Thailand Integrative Computational BioScience Center Mahidol University Nakhon Pathom 73170 Thailand Biotechnology Research and Innovation Council National Institute of Biomedical Genomics West Bengal Kalyani 741251 India Laboratory for Genome Information Analysis RIKEN Center for IMS 1-7-22 Suehiro-cho Tsurumi-ku Kanagawa Yokohama 230-0045 Japan Department of Allergy and Rheumatology of Medicine The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8654 Japan D

The relationships of human diversity with biomedical phenotypes are pervasive yet remain understudied, particularly in a single-cell genomics context. Here, we present the Asian Immune Diversity Atlas (AIDA), a multi-national single-cell RNA sequencing (scRNA-seq) healthy reference atlas of human immune cells. AIDA comprises 1,265,624 circulating immune cells from 619 donors, spanning 7 population groups across 5 Asian countries, and 6 controls. Though population groups are frequently compared at the continental level, we found that sub-continental diversity, age, and sex pervasively impacted cellular and molecular properties of immune cells. These included differential abundance of cell neighborhoods as well as cell populations and genes relevant to disease risk, pathogenesis, and diagnostics. We discovered functional genetic variants influencing cell-type-specific gene expression, which were under-represented in non-Asian populations, and helped contextualize disease-associated variants. AIDA enables analyses of multi-ancestry disease datasets and facilitates the development of precision medicine efforts in Asia and beyond. © 2025 The Authors

关键词： eQTL genetic diversity genetics genomics healthy baseline human diversity immune cells precision medicine single-cell RNA sequencing sub-continental diversity

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A study of the initial adhesive force of cells on silk fibroin-based materials using micropipette aspiration

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Regenerative Biomaterials 2018年第3期5卷 151-157页

作者： Xiaojie Lian Shichao Liu Liming Liu Rui Xu Miaomiao Du Song Wang Hesun Zhu Qiang Lu Quanyou Zhang Yali Wu Di Huang Yan Wei Department of Biomedical Engineering Research Center for Nano-Biomaterials and Regenerative MedicineCollege of MechanicsTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength and Structural Impact Institute of Applied Mechanics and Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Research Center of Materials Science School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China National Engineering Laboratory for Modern Silk College of Textile and Clothing EngineeringSoochow UniversitySuzhou 215123China

With the development of biomaterials,more attention is paid to the adhesion characteristics between cells and *** is necessary to study the adhesive force with a suitable *** fibroin(SF)is widely investigated in biomedical application due to its novel biocompatibility and mechanical *** this article,the micropipette aspiration method and measurement pattern of uniform cells in round shape(UCR)was used to study the initial adhesive force of three types of cells on pure silk fibroin films(SFFs).We also compared the adhesive forces of modified SFFs with that of pure *** results of adhesive force in the initial adhesive stage were in concordance with the results of MTT assay andmicroscope observation,which were confirmed by the above three cell lines and four kinds of *** results indicated UCR was an efficient and quantitative measurement pattern in initial adhesion *** article also provides a useful method in identifying initial cell-materials interactions.

关键词： silk-based materials cell initial adhesion micropipette uniform cells in round shape

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