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arXiv 2023年

作者： Xia, Wei Bai, Bo Chen, Xuejiao Yang, Yichen Zhang, Yang Yuan, Jian Li, Qiang Yang, Kunya Liu, Xiangqi Shi, Yang Ma, Haiyang Yang, Huali He, Mingquan Li, Lei Xi, Chuanying Pi, Li Lv, Xiaodong Wang, Xia Liu, Xuerong Li, Shiyan Zhou, Xiaodong Liu, Jianpeng Chen, Yulin Shen, Jian Shen, Dawei Zhong, Zhicheng Wang, Wenbo Guo, Yanfeng School of Physical Science and Technology ShanghaiTech University Shanghai201210 China CAS Key Laboratory of Magnetic Materials Devices Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo315201 China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai200050 China State Key Laboratory of Surface Physics Department of Physics Fudan University Shanghai200433 China Low Temperature Physics Lab College of Physics Center of Quantum Materials and Devices Chongqing University Chongqing401331 China Xi’an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University Xi’an710072 China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory of the Chinese Academy of Sciences Anhui Hefei230031 China ShanghaiTech Laboratory for Topological Physics ShanghaiTech University Shanghai201210 China College of Physics and Electronic Information Inner Mongolia Normal University 81 Zhaowuda Road Inner Mongolia Hohhot010022 China Analytical Instrumentation Center School of Physical Science and Technology ShanghaiTech University Shanghai201210 China Institute for Nanoelectronic Devices and Quantum Computing Fudan University Shanghai200433 China Clarendon Laboratory Department of Physics University of Oxford OxfordOX1 3PU United Kingdom National Synchrotron Radiation Laboratory University of Science and Technology of China 42 South Hezuohua Road Anhui Hefei230029 China

Generally, the dissipationless Hall effect in solids requires time-reversal symmetry breaking (TRSB), where TRSB induced by external magnetic field results in ordinary Hall effect, while TRSB caused by spontaneous magnetization gives rise to anomalous Hall effect (AHE) which scales with the net magnetization. The AHE is therefore not expected in antiferromagnets with vanishing small magnetization. However, large AHE was recently observed in certain antiferromagnets with noncolinear spin structure and nonvanishing Berry curvature. Here, we report another origin of AHE in a layered antiferromagnet EuAl2Si2, namely the domain wall (DW) skew scattering with Weyl points near the Fermi level, in experiments for the first time. Interestingly, the DWs form a unique periodic stripe structure with controllable periodicity by external magnetic field, which decreases nearly monotonically from 975 nm at 0 T to 232 nm at 4 T. Electrons incident on DW with topological bound states experience strong asymmetric scattering, leading to a giant AHE, with the DW Hall conductivity (DWHC) at 2 K and 1.2 T reaching a record value of ∼1.51×104 S cm-1 among bulk systems and being two orders of magnitude larger than the intrinsic anomalous Hall conductivity. The observation not only sets a new paradigm for exploration of large anomalous Hall effect, but also provides potential applications in spintronic devices. © 2023, CC BY.

关键词： Hall effect

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Learning an optimal PSF-pair for ultra-dense 3D localization microscopy

arXiv

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arXiv 2020年

作者： Nehme, Elias Ferdman, Boris Weiss, Lucien E. Naor, Tal Freedman, Daniel Michaeli, Tomer Shechtman, Yoav Erna and Andrew Viterbi Faculty of Electrical Engineering Technion - Israel Institute of Technology Haifa3200003 Israel Biomedical Engineering Department Lorry I. Lokey Center for Life Sciences and Engineering Technion - Israel Institute of Technology Haifa3200003 Israel Russel Berrie Nanotechnology Institute Technion - Israel Institute of Technology Haifa3200003 Israel Google Research Haifa Israel Equal Contribution

A long-standing challenge in multiple-particle-tracking is the accurate and precise 3D localization of individual particles at close proximity. One established approach for snapshot 3D imaging is point-spread-function (PSF) engineering, in which the PSF is modified to encode the axial information. However, engineered PSFs are challenging to localize at high densities due to lateral PSF overlaps. Here we suggest using multiple PSFs simultaneously to help overcome this challenge, and investigate the problem of engineering multiple PSFs for dense 3D localization. We implement our approach using a bifurcated optical system that modifies two separate PSFs, and design the PSFs using three different approaches including end-to-end learning. We demonstrate our approach experimentally by volumetric imaging of fluorescently labelled telomeres in cells. Copyright © 2020, The Authors. All rights reserved.

关键词： Optical transfer function

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Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution

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Asian Journal of Pharmaceutical Sciences 2018年第2期13卷 155-162页

作者： Haslet Eksi-Kocak Sibel Ilbasmis Tamer Sebnem Yilmaz Merve Eryilmaz Ismail Hakkl Boyaci Ugur Tamer Department of Biomedical Engineering Faculty of Engineering Istanbul Aydin University Department of Pharmaceutical Technology Faculty of Pharmacy Gazi University Department of Analytical Chemistry Faculty of Pharmacy Gazi University Food Research Center Hacettepe University

In this study, we proposed a rapid and sensitive method for quantification and spatial distribution of salicylic acid in film tablets using FT-Raman spectroscopy with multivariate curve resolution(MCR). For this purpose, the constituents of film tablets were identified by using FT-Raman spectroscopy, and then eight different concentrations of salicylic acid tablets were visualized by Raman mapping. MCR was applied to mapping data to expose the active pharmaceutical ingredients in the presence of other excipients by monitoring distribution maps and combination of FT-Raman mapping with MCR enabled the determination of lower salicylic acid concentrations. In addition, the distribution of major excipient, lactose, was examined in the tablet form. A calibration curve was obtained by plotting the intensity of the Raman signal at 1635 cm^(-1) versus the concentration of salicylic acid and the correlation was found to be linear within the range of 0.5%–3.9% with a correlation coefficient of 0.99. The limit of detection for the technique was determined 0.35%. The ability of the technique to quantify salicylic acid in tablet test samples was also investigated.

关键词： Raman mapping Multivariate curve resolution FT-Raman spectroscopy Salicylic acid

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Organic Cathode Electrolyte Interphase Achieving 4.8 V LiCoO2

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Angewandte Chemie 2024年第7期137卷

作者： Chaocang Weng Meijia Qiu Bingfang Wang Jiaqi Yang Wenjie Mai Likun Pan Sumei Huang Jinliang Li School of Physics and Electronic Science Shanghai Key Laboratory of Magnetic Resonance Engineering Research Center for Nanophotonics & Advanced Instrument Ministry of Education East China Normal University Shanghai 200241 China These authors contributed equally. Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy Materials Department of Physics College of Physics & Optoelectronic Engineering Jinan University Guangzhou 510632 China The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 China Institute of Magnetic Resonance and Molecular Imaging in Medicine East China Normal University Shanghai 200241 China

Developing high-voltage electrolytes to stabilize LiCoO 2 (LCO) cycling remains a challenge in lithium-ion batteries. Constructing a high-quality cathode electrolyte interphase (CEI) is essential to mitigate adverse reactions at high voltages. However, conventional inorganic CEIs dominated by LiF have shown limited performance for high-voltage LCO. Here, we propose an ionic liquid electrolyte (ILE) with a high donor number additive, enabling Li//LCO cells to achieve a high cut-off voltage of 4.7 V/4.8 V and a high-capacity retention of 86.9 %/74.2 % after 100 cycles at 0.5 C. During this process, a groundbreaking phenomenon was discovered: the construction of a stable organic CEI rich in C−F bonds by the high donor number additive under high voltage. These strong polar C−F bonds exhibit excellent electrochemical inertness and film-forming properties, resulting in optimal passivation of the cathode. This organic C−F bond-dominated CEI significantly suppresses phase transitions, cobalt dissolution, and gas evolution in LCO at high voltage. Additionally, the 4.8 V-class Li//LiNi 0.6 Co 0.2 Mn 0.2 O 2 and 4.95 V-class Li//LiNi 0.5 Mn 1.5 O 4 cells also demonstrate outstanding cycling stability. Even at 60 °C, the ILE-constructed organic CEI maintains superior performance. Our findings highlight the potential of organic CEI to enhance high-voltage cathode stability, paving the way for more efficient lithium-ion batteries.

关键词： High-voltage electrolyte LiCoO2 side reactions Donor number Organic cathode electrolyte interphase

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A Prospective Multi-centre Trial on Survival after Microwave Ablation VErsus Resection for Resectable Colorectal Liver Metastases (MAVERRIC)

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HPB 2023年 25卷 S243-S244页

作者： Tinguely, P. Ruiter, S.J.S. Engstrand, J. de Haas, R.J. Nilsson, H. Candinas, D. de Jong, K.P. Freedman, J. Karolinska Institutet at Danderyd Hospital Division of Surgery Department of Clinical Sciences Stockholm Sweden Inselspital University Hospital Bern Department of Visceral Surgery and Medicine Bern Switzerland University of Bern ARTORG Center for Biomedical Engineering Research Bern Switzerland University Medical Center Groningen University of Groningen Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation Groningen Netherlands Karolinska Institutet Karolinska University Hospital Division of Surgery Department of Clinical Science Intervention and Technology Stockholm Sweden University Medical Center Groningen University of Groningen Department of Radiology Groningen Netherlands

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Correction: Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients

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Journal of translational medicine 2023年第1期21卷 304页

作者： Jinho Kim Hyunjung Kim Min-Seok Lee Heetak Lee Yeon Jeong Kim Woo Yong Lee Seong Hyeon Yun Hee Cheol Kim Hye Kyung Hong Sridhar Hannenhalli Yong Beom Cho Donghyun Park Sun Shim Choi Precision Medicine Center Future Innovation Research Division Seoul National University Bundang Hospital Seongnam 13620 Korea. Division of Biomedical Convergence College of Biomedical Science Institute of Bioscience & Biotechnology Kangwon National University Chuncheon 24341 Korea. Center for Genome Engineering Institute for Basic Science 55 Expo‑ro Yuseng‑gu Daejeon 34126 Korea. Samsung Medical Center Samsung Genome Institute Seoul 06351 Korea. Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 06351 Korea. Samsung Medical Center Institute for Future Medicine Seoul 06351 Korea. Cancer Data Science Lab Center for Cancer Research National Cancer Institute Bethesda MD 20814 USA. Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 06351 Korea. yongbeom.cho@***. Department of Health Sciences and Technology SAIHST Sungkyunkwan University Seoul 06351 Korea. yongbeom.cho@***. Geninus Inc Seoul 05836 Korea. dh37.park@***. Division of Biomedical Convergence College of Biomedical Science Institute of Bioscience & Biotechnology Kangwon National University Chuncheon 24341 Korea. schoi@kangwon.ac.kr.

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Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer

Npj imaging

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Npj imaging 2024年第1期2卷 12页

作者： Yohana C Toner Geoffrey Prévot Mandy M T van Leent Jazz Munitz Roderick Oosterwijk Anna Vera D Verschuur Yuri van Elsas Vedran Peric Rianne J F Maas Anna Ranzenigo Judit Morla-Folch William Wang Martin Umali Anne de Dreu Jessica Chimene Fernandes Nathaniel A T Sullivan Alexander Maier Christian Mason Thomas Reiner Zahi A Fayad Willem J M Mulder Abraham J P Teunissen Carlos Pérez-Medina BioMedical Engineering and Imaging Institute Icahn School of Medicine at Mount Sinai New York NY USA. Department of Diagnostic Molecular and Interventional Radiology Icahn School of Medicine at Mount Sinai New York NY USA. Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Medical Center Nijmegen the Netherlands. Cardiovascular Research Institute Icahn School of Medicine at Mount Sinai New York NY USA. Laboratory of Chemical Biology Department of Biomedical Engineering Eindhoven University of Technology Eindhoven The Netherlands. Department of Cardiology and Angiology Heart Center Freiburg University Faculty of Medicine University of Freiburg Freiburg Germany. Department of Radiology Memorial Sloan Kettering Cancer Center New York NY USA. Department of Radiology Weill Cornell Medical College New York NY USA. Chemical Biology Program Memorial Sloan Kettering Cancer Center New York NY USA. Icahn Genomics Institute Icahn School of Medicine at Mount Sinai New York NY USA. Centro Nacional de Investigaciones Cardiovasculares (CNIC) Madrid Spain.

Macrophages are key inflammatory mediators in many pathological conditions, including cardiovascular disease (CVD) and cancer, the leading causes of morbidity and mortality worldwide. This makes macrophage burden a valuable diagnostic marker and several strategies to monitor these cells have been reported. However, such strategies are often high-priced, non-specific, invasive, and/or not quantitative. Here, we developed a positron emission tomography (PET) radiotracer based on apolipoprotein A1 (ApoA1), the main protein component of high-density lipoprotein (HDL), which has an inherent affinity for macrophages. We radiolabeled an ApoA1-mimetic peptide (mA1) with zirconium-89 (Zr) to generate a lipoprotein-avid PET probe (Zr-mA1). We first characterized Zr-mA1's affinity for lipoproteins in vitro by size exclusion chromatography. To study Zr-mA1's in vivo behavior and interaction with endogenous lipoproteins, we performed extensive studies in wildtype C57BL/6 and hypercholesterolemic mice. Subsequently, we used in vivo PET imaging to study macrophages in melanoma and myocardial infarction using mouse models. The tracer's cell specificity was assessed by histology and mass cytometry (CyTOF). Our data show that Zr-mA1 associates with lipoproteins in vitro. This is in line with our in vivo experiments, in which we observed longer Zr-mA1 circulation times in hypercholesterolemic mice compared to C57BL/6 controls. Zr-mA1 displayed a tissue distribution profile similar to ApoA1 and HDL, with high kidney and liver uptake as well as substantial signal in the bone marrow and spleen. The tracer also accumulated in tumors of melanoma-bearing mice and in the ischemic myocardium of infarcted animals. In these sites, CyTOF analyses revealed that Zr-mA1 was predominantly taken up by macrophages. Our results demonstrate that Zr-mA1 associates with lipoproteins and hence accumulates in macrophages in vivo. Zr-mA1's high uptake in these cells makes it a promising radiotracer for non-

关键词： biomedical engineering Imaging techniques and agents Positron-emission tomography

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Proanthocyanidin Capsules Remodel the ROS Microenvironment Via Regulating Mapk Signaling for Accelerating Diabetic Wound Healing

SSRN

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SSRN 2024年

作者： Wei, Shaoyin Yang, Dong Shou, Zeyu Zhang, Yipiao Zheng, Shengwu Zan, Xingjie Li, Lianxin Zhang, Chunwu School of Ophthalmology and Optometry Eye Hospital School of Biomedical Engineering Wenzhou Medical University Wenzhou325035 China Wenzhou Institute University of Chinese Academy of Sciences Zhejiang Wenzhou325001 China Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical Engineering Shandong University Shandong Jinan250100 China The First Affiliated Hospital of Wenzhou Medical University Zhejiang Wenzhou325000 China Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of Technology No. 18 Chaowang Road Gongshu District Zhejiang Hangzhou310014 China Zhejiang Provincial Key Laboratory of TCM for Innovative R&D and Digital Intelligent Manufacturing of TCM Great Health Products Huzhou313200 China Wenzhou Celecare Medical Instruments Co. Ltd Wenzhou325000 China Department of Orthopaedics Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Shandong Province Jinan City250021 China Wenzhou Medical University China

The complex nature of the healing deficits associated with diabetic wounds represents a significant clinical challenge. Hyperglycemia-induced excess reactive oxygen species (ROS) activate the MAPK signaling pathway (especially the p38 MAPK), which results in the sustained release of inflammatory factors, leading to cell damage and apoptosis. At present, agents that modulate p38 MAPK are ineffective due to their restricted regulatory capacity and side effects. Plant-derived polyphenols are regarded as highly effective ROS scavengers;however, their low bioavailability (easily degraded in vivo and low efficiency in endocytosis) significantly restricts their application in biomedicine. Herein, we developed a simple and efficient method to prepare proanthocyanidin (PC) capsules, which were constructed through hydrogen bonding and hydrophobic interactions between PC molecules. PC capsules exhibited long-lasting scavenging of multiple free radicals, sustained release of PC molecules, and efficient endocytosis by cells, which dramatically improved the bioavailability of PCs and enabled the healing of traumatic wounds of diabetic mice in just one administration. It was demonstrated that PC capsules markedly diminished the concentration of inflammatory mediators and impeded apoptosis by modulating the p38 MAPK signaling cascade, thereby remodeling the ROS microenvironment of diabetic wounds and accelerating the healing. This study has made an important contribution to the field of polyphenol bioavailability and provided insights into the potential of regulating the MAPK signaling pathway, with implications for the treatment of other inflammatory and oxidative stress-related disorders. © 2024, The Authors. All rights reserved.

关键词： Cell death

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High-performance hot-warm rolled Zn-0.8Li alloy with nano-sized metastable precipitates and sub-micron grains for biodegradable stents

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Journal of Materials Science & technology 2019年第11期35卷 2618-2624页

作者： Zhen Li Zhang-Zhi Shi Yuan Hao Hua-Fang Li Xue-Feng Liu Alex AVolinsky Hai-Jun Zhang Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083China Department of Mechanical Engineering University of South FloridaTampaFL33620USA Department of Interventional and Vascular Surgery The Tenth People’s Hospital of ShanghaiTongji UniversityShanghai200072China National United Engineering Laboratory for Biomedical Material Modification Branden Industrial ParkQihe Economic&Development ZoneDezhou251100China

Fabricated through a newly developed hot-warm rolling process,Zn-0.8 Li(wt%)alloy has ideal strength and ductility far beyond the mechanical benchmark of materials for biodegradable *** of needle-like Zn in primary p-LiZn4 phase is observed in Zn-Li alloy for the first *** relationship between them can be described as[1-213]β//[2-1-10](Zn),(10-10)βabout 4.5°from(0002)(Zn).Zn grains with an average size of 640 nm exhibit strong basal texture,detected by transmission electron back-scatter *** distribution is determined by three-dimensional atom probe,which reveals the formation of nano-sized metastableα-Li2Zn3 precipitates with a number density of 7.16×10^22 m^-*** fine lamellar Zn+β-LiZn4 structure,sub-micron grains and the nano-sized precipitates contribute to the superior mechanical properties.

关键词： Zn-Li alloy Mechanical properties Three-dimensional atom probe Precipitation Recrystallization

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Combined fluorescence lifetime imaging-optical coherence tomography for in vivo label-free assessment of high-risk atherosclerotic plaque 5

Combined fluorescence lifetime imaging-optical coherence tom...

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European Conference on biomedical Optics, ECBO_2019

作者： Nam, Hyeong Soo Kim, Sunwon Kang, Woo Jae Lee, Min Woo Han, Jeongmoo Song, Joon Woo Ahmed, Yosuf Syed Kim, Hyungil Oh, Wang-Yuhl Kim, Jin Won Yoo, Hongki Department of Biomedical Engineering Hanyang University Seoul Korea Republic of Department of Cardiology Korea University Ansan Hospital Ansan Korea Republic of Department of Mechanical Engineering Korea Advanced Institute of Science and Technology Daejeon Korea Republic of Cardiovascular Center Korea University Guro Hospital Seoul Korea Republic of Aurios Medical Incheon Korea Republic of

ISBN: (纸本)9781510628397

Multimodal optical coherence tomography (OCT) techniques are promising diagnostic tools to accurately assess high-risk atherosclerotic plaques. For rapid translation into clinical practice, the techniques should be performed through an intravascular imaging catheter without exogenous contrast agents under the same procedures as conventional imaging. In this study, we developed a label-free, multispectral, and catheter-based imaging system to simultaneously visualize the morphological and compositional information of coronary plaques by combining fluorescence lifetime imaging (FLIm) and OCT. Using a broadband hybrid optical rotary joint and a dual-modal imaging catheter, intravascular combined FLIm-OCT imaging was safely performed in an in vivo atherosclerotic coronary artery of atherosclerotic swine models without any imaging agent. Along with detailed coronary microstructure by OCT, the multispectral FLIm could accurately visualize fluorescence lifetime signature of key biochemical components of plaque in vivo (lipid, macrophage, and fibrous tissue) when comparing the corresponding histopathological stained-sections and ex vivo FLIm microscopy images. Especially, significant differences in fluorescence lifetime distribution were noted between lipid and macrophage (p © SPIE-OSA 2019

关键词： Optical tomography

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