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Quantifying Head Impact Exposure, Mechanisms and Kinematics Using an Instrumented Mouthguard in Female High School Lacrosse

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Orthopaedic Journal of Sports Medicine 2022年第5_suppl2期10卷

作者： Colin M Huber Declan A Patton Susan S Margulies Christina L Master Kristy B Arbogast Department of Bioengineering University of Pennsylvania PA USA Center for Injury Research and Prevention Children’s Hospital of Philadelphia PA USA Department of Biomedical Engineering Georgia Institute of Technology and Emory University GA USA Sports Medicine and Performance Center Children’s Hospital of Philadelphia PA USA Perelman School of Medicine University of Pennsylvania PA USA

Background: There is growing concern for the neurological effects of repetitive head impacts in sports, and girls’ lacrosse represents a popular but understudied sport regarding head impact exposure. Current debate exists over the need for enhanced protective equipment, and it is important to quantify head impact exposure and biomechanics to inform policy discussions and rule changes for improved protection.

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Correction: Direct laser writing-enabled 3D printing strategies for microfluidic applications

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Lab on a chip 2024年第9期24卷 2590页

作者： Olivia M Young Xin Xu Sunandita Sarker Ryan D Sochol Department of Mechanical Engineering University of Maryland College Park 2147 Glenn L. Martin Hall College Park MD 20742 USA. rsochol@umd.edu. Maryland Robotics Center University of Maryland College Park MD 20742 USA. Institute for Systems Research University of Maryland College Park MD 20742 USA. Department of Mechanical and Industrial Engineering University of Massachusetts Amherst MA 01003 USA. Fischell Department of Bioengineering University of Maryland College Park MD 20742 USA. Robert E. Fischell Institute for Biomedical Devices University of Maryland College Park MD 20742 USA.

Correction for 'Direct laser writing-enabled 3D printing strategies for microfluidic applications' by Olivia M. Young , , 2024, DOI: https://***/10.1039/D3LC00743J.

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Sensitive Data Transmission System for Biopotential Measurements in Wearable Application

Sensitive Data Transmission System for Biopotential Measurem...

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International Conference on Perspective Technologies and Methods in MEMS Design (MEMSTECH)

作者： Dominik Grochala Marcin Kajor Michał Grochala Paweł Smoleń Marek Iwaniec Justyna Lemejda Faculty of Electrical Engineering Automatics Computer Science and Biomedical Engineering AGH University of Science and Technology Kraków Poland sp. z o.o Nordic Semiconductor Poland Kraków Poland Smart Nanotechnologies S.A. Alwernia Poland Faculty of Mechanical Engineering and Robotics AGH University of Science and Technology Kraków Poland Department of Prosthodontics Jagiellonian University Medical College Jagiellonian University Kraków Poland

ISBN: (数字)9781728171807

ISBN: (纸本)9781728171814

In this paper we present a wearable biopotential measurement system with expanded data safety feature. The proposed solution combines dry electrodes as a biopotential interface and Bluetooth Low Energy (BLE) transmission which together with a pairing feature based on NFC aim to provide reliable yet safe data transfer. Electrodes were prepared as conductive pads made of composite with Multiwall Carbon Nanotubes (MWCNT) filler. Such a material is convenient for integration with textiles and provides required electrical properties. The main module of the system's electronic part is based on nRF52832 microcontroller with embedded BLE radio supporting Near Field Communication (NFC). The main focus of this paper is the development and testing of safety mechanisms in a short distance communication that can be implemented in medical data transfer.

关键词： sensitive data transfer wearables NFC dry electrodes Wearable negative feedback circuits short-range communication Wheat Sensitive data data transmission Electrodes Transmission systems

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Developmental patterns of white matter functional networks in neonates

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NeuroImage 2025年 314卷 121252-121252页

作者： Wang, Yuhan Pan, Ningning Li, Zhuoshuo Wang, Yating Chen, Ruoqing Fang, Zhicong Pan, Minmin Li, Hongzhuang Fang, Ke Wu, Xiaorui Liu, Mengting Ge, Xinting School of Biomedical Engineering Sun Yat-sen University Shenzhen 518107 China School of Information Science and Engineering Shandong Normal University No.1 Daxue Road Shandong Jinan 250358 China Department of Epidemiology School of Public Health (Shenzhen) Sun Yat-sen University Guangdong Shenzhen 518107 China Guangdong Engineering Technology Research Center of Nutrition Transformation Sun Yat-sen University Guangdong Shenzhen 518107 China Institute of Environmental Medicine Karolinska Institutet Stockholm 17177 Sweden School of Medical Imaging Xuzhou Medical University Jiangsu Xuzhou China

In recent years, the development of neonatal brain networks has become a research focus, with traditional studies primarily emphasizing gray matter (GM) functional networks. This study systematically explores the developmental characteristics of white matter (WM) functional networks in neonates. Utilizing data from the third release of the Developing Human Connectome Project (dHCP), we analyzed resting-state functional magnetic resonance imaging (rs-fMRI) data from 730 full-term and 157 preterm neonates. We successfully identified ten large-scale WM functional networks and validated their correspondence with established WM fiber tracts using diffusion tensor imaging (DTI). We examined WM functional networks from two dimensions: network functional connectivity and spontaneous activity, incorporating four factors: preterm birth status, age, sex, and hemispheric differences. The results indicate that WM network functional connectivity significantly increases with age, with preterm infants exhibiting lower connectivity than full-term infants, whereas no significant differences were observed between sexes or hemispheres. Regarding spontaneous activity, preterm infants showed lower amplitude in the low-frequency range, whereas in the high-frequency range, their amplitude distribution was more unstable and dispersed. Additionally, certain differences in spontaneous activity were observed between hemispheres and sexes. These findings provide novel insights into the early development of neonatal brain networks and hold significant implications for clinical interventions and treatment strategies for preterm infants. © 2025

关键词： Neonates Network correlations rs-fMRI Spontaneous activity White matter functional network

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A contrast-adaptive method for simultaneous whole-brain and lesion segmentation in multiple sclerosis

arXiv

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arXiv 2020年

作者： Cerri, Stefano Puonti, Oula Meier, Dominik S. Wuerfel, Jens Mühlau, Mark Siebner, Hartwig R. van Leemput, Koen Department of Health Technology Technical University of Denmark Denmark Danish Research Centre for Magnetic Resonance Copenhagen University Hospital Hvidovre Denmark Department of Biomedical Engineering University Basel Switzerland Department of Neurology TUM-Neuroimaging Center School of Medicine Technical University of Munich Germany Department of Neurology Copenhagen University Hospital Bispebjerg Denmark Institute for Clinical Medicine Faculty of Medical and Health Sciences University of Copenhagen Denmark Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Harvard Medical School United States

Here we present a method for the simultaneous segmentation of white matter lesions and normal-appearing neuroanatomical structures from multi-contrast brain MRI scans of multiple sclerosis patients. The method integrates a novel model for white matter lesions into a previously validated generative model for whole-brain segmentation. By using separate models for the shape of anatomical structures and their appearance in MRI, the algorithm can adapt to data acquired with different scanners and imaging protocols without retraining. We validate the method using three disparate datasets, showing state-of-the-art performance in white matter lesion segmentation while simultaneously segmenting dozens of other brain structures. We further demonstrate that the contrast-adaptive method can also be applied robustly to MRI scans of healthy controls, and replicate previously documented atrophy patterns in deep gray matter structures in MS. The algorithm is publicly available as part of the open-source neuroimaging package FreeSurfer. Copyright © 2020, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

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A simple and label-free dual-modal aptazyme for fluorescent/colorimetric sensitive on-site detection of small molecules in real samples

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Sensors and Actuators B: Chemical 2025年 442卷

作者： Yingping Luo Guohua Wu Qinrui Lu Tongtong Lai Linhui Xie Jingyan Zhang Shiwen Niu Jiancai Tang Haixiang Yu Department of Pharmacology North Sichuan Medical College Nanchong 637100 PR China Henan Key Laboratory of Rare Diseases Endocrinology and Metabolism Center The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Luoyang 471003 PR China Department of Biomedical Engineering Sichuan University Chengdu 610065 PR China School of Basic Medical Sciences Tianjin Medical University Tianjin 300070 PR China Department of Basic Medical Sciences North Sichuan Medical College Nanchong 637100 PR China School of Life Science and Technology China Pharmaceutical University Nanjing 211198 PR China

Dual-modal biosensors integrating colorimetric and fluorescent signal reporters have demonstrated high robustness and accuracy for onsite small-molecule detection. However, the development of such assays is limited by the lack of a universal reporter for both detection modes. In this study, we leverage the activity of G-quadruplex DNAzyme to catalyze both fluorescent and chromogenic substrates, presenting a generalizable strategy to engineer label-free dual-mode aptazyme (LDAzyme), for the naked-eye detection of small molecules. An LDAzyme consists of two strands that self-assemble to form an active G-quadruplex DNAzyme in the absence of the target. Upon target binding, a conformational change dissociates the LDAzyme and inactivates the DNAzyme motif. This target-induced change in aptazyme activity enables the reporting of target concentrations fluorescently and colorimetrically using fluorescent (rhodamine B) and chromogenic (2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid, ABTS) substrates, respectively. As a demonstration, we develope aflatoxin B1- and lactate-activated LDAzymes, which achieved sensitive and specific detection of their targets in both fluorescence and colorimetry modes. The similar dynamic ranges of the two modes facilitate the robust quantitation of the analyte in complex matrices, including herbal and food extracts and serum. Notably, the high activity of LDAzymes allows for the visual detection of targets in real samples within 15 min in both modes. Given the favorable sensing characteristics of LDAzymes, we believe that such a design strategy could be widely applied to various analytes by substituting the corresponding aptamer sequence in the construct, which should accelerate the development of on-site or mix-and-measure assays.

关键词： Colorimetry

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A metal-free bionic nanozyme for efficient inhibition of cancer recurrence and metastasis following photothermal therapy

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Chinese Chemical Letters 2025年

作者： Lingdan Kong Pingping Huang Feng Yuan Yue Zhang Xiaoqian Shi Kang Han Keke Liu Qing Xu Wenjing Zhang Tom Lawson Xiaoru Xia Yong Liu Yuepeng Jin Laboratory of Novel Optoelectronic Technology for Ophthalmic Devices (NOTOD) School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou 325027 China National Engineering Research Center of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University Wenzhou 325027 China School of Chemical Engineering University of New South Wales Sydney NSW 2052 Australia Rheumatology Department the First Affiliated Hospital of Wenzhou Medical University Wenzhou 325005 China National Key Clinical Specialty (General Surgery) the First Affiliated Hospital of Wenzhou Medical University Wenzhou 325005 China

Tumor heterogeneity and diversity significantly undermine the effectiveness of monotherapy. Collaborative therapy emerges as a promising approach to mitigate tumor recurrence resulting from monotherapy. Combining chemodynamic therapy (CDT) with photothermal therapy (PTT) offers a compelling solution for eradicating residual tumor cells post-PTT. In this study, we harness the Fenton-like response facilitated by glucose oxidase (GOD) and the mild hyperthermia induced by polyethyleneimine (PEI) functionalized nitrogen-containing graphene oxide to enhance tumor therapy through a metal-free bionic nanozyme. GOD catalyzes a substantial amount of hydrogen peroxide, and, with the carrier's involvement, triggers a Fenton-like reaction, yielding a wealth of hydroxyl radicals. These hydroxyl radicals effectively target tumor cells following photothermal action, bolstering CDT and culminating in a bidirectional amplification treatment that effectively prevents tumor recurrence and metastasis. This research amalgamates the physical and chemical attributes of nanomaterials with the unique characteristics of the tumor microenvironment, presenting a compelling and efficacious alternative for tumor treatment.

关键词： Metal-free bionic nanozyme Nitrogen-doped graphene Chemodynamic therapy (CDT) Photothermal therapy (PTT) Tumor recurrence and metastasis

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MobiCardio: A clinical-grade mobile health system for cardiovascular disease management 7

MobiCardio: A clinical-grade mobile health system for cardio...

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7th IEEE International Conference on Healthcare Informatics, ICHI 2019

作者： Li, Peiyao Cao, Desen Zhang, Zhengbo Yang, Zhicheng Yan, Wei Yan, Muyang He, Maoqing Yuan, Qian Lan, Ke Zheng, Jiewen Liu, Tongbo Chinese PLA General Hospital Dept. of Biomedical Engineering Beijing China University of California Dept. of Computer Science DavisCA United States Chinese PLA General Hospital Dept. of Hyperbaric Oxygen Therapy Beijing China Beijing SensEcho Science Technology Co. Ltd. Beijing China Chinese PLA General Hospital Dept. of Information Technology Beijing China Department of Biomedical Engineering and Medical Device Research and Development Evaluation Center China

ISBN: (纸本)9781538691380

Cardiovascular disease (CVD) is the leading death factor in China. Mobile Health (mHealth) has been proven as a promising solution for CVD management. However, mHealth for CVD management in Chinese healthcare system has not been widely adopted. In this paper, we introduce our holistic CVD management mHealth system, MobiCardio, which enables the efficient management of CVD patients specialized for clinical scenarios, by the integration of multi-sensor wearable technologies, machine-learning-based sleep analytics, and electronic health records (EHRs) information. Several ongoing featured clinical validation projects are described. © 2019 IEEE.

关键词： mHealth

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The performance evaluation of online training of children caregiver with special needs-cerebral palsy (CSN-CP) using friendly brain-hearth education method (RORI)

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AIP Conference Proceedings 2021年第1期2344卷

作者： Ayi Adikanyaa Paramesthi Basari Tri Arief Sardjono 1Biomedical Engineering Programs Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 2Research Center of Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia 3Department of Biomedical Engineering Faculty of Electrical Engineering and Intelligent Information Technology (Eclectics) Institut Teknologi Sepuluh Nopember Sukolilo Campus Surabaya East Java 60111 Indonesia

Children with Special need education-Cerebral palsy (CSN-CP) based The Indonesian Ministry of Education and Culture in 2019, predicted that 70% of CSN had not been served. The extent of the Republic of Indonesia and pandemic COVID-19 nowadays and the Government’s policy of learning from home to remain fulfilled by children’s rights and maintain the quality of life of CSN-CP, so the needs of caregiver trained very urgent. Training with online learning is the best solution in the expansion and equitable service in Indonesia. Cerebral Palsy (CP) in children is a disorder in development that can affect the motor ability and balance the body with its severity. The material in this study caregiver CSN especially CP, gadgets, application of teleconference with the digital learning materials in the form of video and slides. Data taken with an observation assessment of the companion performance and experts do the accuracy. This study uses a qualitative descriptive method to evaluate the performance of training results for caregiver CSN-CP online. Based on the non-parametric correlation test method Spearmen, the value of <0.05 is found in the achievement evaluation, the repetition process, and the respondent’s profession, indicating a significant correlation. Workshop at home with online learning can provide services on CSN-CP according to specific needs characteristics by a caregiver trained with friendly Brain-Hearth Education Method (RORI).

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Outside Front Cover: Volume 3 Issue 3

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SmartMat 2022年第3期3卷

作者： Yang Luo Donghai Wu Zehui Li Xiao-Yan Li Yinghong Wu Shien-Ping Feng Carlo Menon Houyang Chen Paul K. Chu Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Hong Kong China Empa Swiss Federal Laboratories for Materials Science and Technology ETH Domain Dübendorf Switzerland Centre for Water Technology and Policy Department of Civil Engineering The University of Hong Kong Hong Kong China Henan Key Laboratory of Nanocomposites and Applications Institute of Nanostructured Functional Materials Huanghe S & T University Zhengzhou China State Key Laboratory for Mesoscopic Physics Collaborative Innovation Center of Quantum Matter School of Physics Peking University Beijing China Biomedical and Mobile Health Technology Lab Department of Health Sciences and Technology ETH Zürich Zürich Switzerland Department of Mechanical Engineering The University of Hong Kong Hong Kong China Houyang Chen Department of Chemical and Biological Engineering State University of New York at Buffalo New York 14260-4200 NY USA. Paul K. Chu Department of Physics Department of Materials Science and Engineering and Department of Biomedical Engineering City University of Hong Kong Hong Kong 999077 China. Department of Chemical and Biological Engineering State University of New York at Buffalo New York USA

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