检索结果-内蒙古大学图书馆

Enhanced electrochemical immunosensor utilizing pATA/AuNPs for sensitive detection of the leukemia-associated biomarker CD123 in bone marrow supernatant

引用

European Journal of Pharmaceutical Sciences 2025年 211卷 107124页

作者： Li, Xin Wang, Qing Qin, Chun-Rong Liu, Ai-Lin Chen, Yong Department of Hematology Fujian Provincial Key Laboratory on Hematology Fujian Institute of Hematology Fujian Medical University Union Hospital Fuzhou 350001 China Department of Blood Transfusion Medicine School of Medical Technology and Engineering Fujian Medical University Fuzhou 350122 China Department of Histology and Embryology School of Basic Medical Sciences Fujian Medical University Fuzhou 350122 China Sichuan Nursing Vocational College Chengdu 610100 China Center for Reproductive Medicine Shenzhen Maternity and Child Healthcare Hospital Southern Medical University Shenzhen 518000 China Department of Pharmaceutical Analysis Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province School of Pharmacy Fujian Medical University Fuzhou 350122 China

Background: Cluster of differentiation 123 (CD123) prominently overexpress in various hematological malignancies and plays a crucial role in diagnosis and prognosis of leukemia. Clinical studies have demonstrated that cell-free CD123 levels also significantly influence leukemia immunotherapy outcomes. The development of novel electrochemical immunosensors addresses the need for point-of-care detection tools, thereby facilitating advancements in clinical monitoring technologies. Methods: This study presented a practical electrochemical immunosensor constructed using sandwich strategy for CD123 detection based on the modification of gold nanoparticles and poly (2-aminoterephthalic acid). Common proteins and tumor-related biomarkers found in human were selected as interference factors to evaluate the detection specificity of the electrochemical immunosensor. Further, the electrochemical immunosensor was utilized to directly detect CD123 in bone marrow supernatant from leukemia patients. Results: The constructed electrochemical immunosensor exhibited good linearity for CD123 detection over a range of 0.02 to 2.5 µg/mL, with a detection limit of 12.8 ng/mL, alongside satisfactory specificity and repeatability. Furthermore, the immunosensor was successfully employed to detect CD123 levels in the bone marrow supernatant of leukemia patients, demonstrating results that were highly consistent with those obtained via ELISA. Conclusions: The developed approach is anticipated to provide robust technical support for the long-term monitoring of leukemia patients during their diagnosis and treatment. © 2025

关键词： Bone marrow supernatant CD123 Electrochemical immunosensor Leukemia Poly (2-aminoterephthalic acid)

来源：评论

学校读者我要写书评

暂无评论

Assessment of Graft Maturity After Anterior Cruciate Ligament Reconstruction Using Autografts: A Systematic Review of Biopsy and Magnetic Resonance Imaging studies

引用

Arthroscopy, Sports Medicine, and Rehabilitation 2020年第4期2卷 e377-e388页

作者： van Groningen, Bart van der Steen, M.C. Janssen, Daan M. van Rhijn, Lodewijk W. van der Linden, Antoine N. Janssen, Rob P.A. Orthopaedic Center Máxima Máxima Medical Center Eindhoven Netherlands Department of Orthopaedic Surgery Catharina Hospital Eindhoven Eindhoven Netherlands Department of Orthopaedic Surgery Maastricht University Medical Center Maastricht Netherlands Department of Radiology Máxima Medical Center Eindhoven Netherlands Fontys University of Applied Sciences Eindhoven Netherlands Orthopaedic Biomechanics Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands

Purpose: The purpose of this investigation was to evaluate systematically the literature concerning biopsy, MRI signal to noise quotient (SNQ) and clinical outcomes in graft-maturity assessment after autograft anterior cruciate ligament reconstruction (ACLR) and their possible relationships. Methods: The systematic review was reported and conducted according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. Studies through May 2019 evaluating methods of intra-articular ACL autograft maturity assessment were considered for inclusion. Eligible methods were histologic studies of biopsy specimens and conventional MRI studies reporting serial SNQ and/or correlation with clinical parameters. Results: Ten biopsy studies and 13 imaging studies, with a total of 706 patients, met the inclusion criteria. Biopsy studies show that graft remodeling undergoes an early healing phase, a phase of remodeling or proliferation and a ligamentization phase as an ongoing process even 1 year after surgery. Imaging studies showed an initial increase in SNQ, peaking at approximately 6 months, followed by a gradual decrease over time. There is no evident correlation between graft SNQ and knee stability outcome scores at the short- and long-term follow-up after ACLR. Conclusions: The remodeling of the graft is an ongoing process even 1 year after ACLR, based on human biopsy studies. MRI SNQ peaked at approximately 6 months, followed by a gradual decrease over time. Heterogeneity of the MRI methods and technical restrictions used in the current literature limit prediction of graft maturity and clinical and functional outcome measures by means of MRI graft SNQ after ACLR. Level of evidence: Level IV, systematic review, including level III and IV studies. © 2020 Arthroscopy Association of North America. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词：

来源：评论

学校读者我要写书评

暂无评论

Acute and Sustained Effects on Human Brain Induced by Different Modalities of Acupuncture: An fMRI Study

Acute and Sustained Effects on Human Brain Induced by Differ...

引用

2019 International Conference on Medical Imaging Physics and engineering, ICMIPE 2019

作者： Wei, Yarui Wang, Jingjun Wang, Yanyan Hu, Sheng Mei, Ling Diao, Yanjun Wang, Xiaoxiao Yu, Haibo Long, Xiaojing Qiu, Bensheng University of Science and Technology of China Centers for Biomedical Engineering Hefei China Jinan First People's Hospital Outpatient Department Jinan China Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Key Lab for MRI Shenzhen China Shenzhen International TCM Training Center Shenzhen Hospital of Traditional Chinese Medicine Shenzhen China

ISBN: (纸本)9781728148557

The aim of this study was to mainly investigate the acute and sustained effects of manual acupuncture (MA) and electroacupuncture (EA) on human whole-brain activity. Here, we employed functional magnetic resonance imaging (fMRI) to explore the human whole-brain activity during stimulation and post-stimulation periods for MA and EA at ST 36 (Zusanli) which is one of the most commonly used acupoint in acupuncture-related studies. 12 right-handed healthy controls participated in both MA and EA procedures in an interval of more than one week. Overall, similar significant signal decreases in the somatosensory area, limbic/paralimbic regions, prefrontal lobe and superior temporal gyrus were observed in both MA and EA during stimulation period. In general, MA produced more complicated brain activity than EA in the post-stimulation period. These results indicate that MA and EA at ST 36 produce similar acute effect, but different sustained effect during post-acupuncture period. The investigation of acupuncture-induced acute and sustained brain responses using neuroimaging techniques may facilitate the understanding of the mechanism and treatment for MA and EA in clinical practice. © 2019 IEEE.

关键词： Electroacupuncture

来源：评论

学校读者我要写书评

暂无评论

Global distribution of human chikungunya arbovirus infection: A review

引用

Journal of Acute Disease 2020年第4期9卷 145-151页

作者： Rouhullah Dehghani Hamid Kassiri Rozhin Kasiri Mousa Dehghani Maral Kasiri Social Determinants of Health Research Center and Department of Environment HealthKashan University of Medical SciencesKashanIran Department of Medical Entomology School of HealthAhvaz Jundishapur University of Medical SciencesAhvazIran School of Medicine Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of Environmental Science Faculty of Natural ResourcesIsfahan University of TechnologyIsfahanIran Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCaliforniaUnited States of America

The five main arbovirus families that cause diseases in humans and other animals are Bunya viridae,Togaviridae,Flaviviridae,Reoviridae,and Rhab *** arbovirus(Togaviridae:Alphavirus),an arbovirus transmitted byAedes spp.,is a well-known global health *** has been recognized in more than 60 countries in Asia,Africa,Europe,and the ***,the eastern neighborhood of Iran,is one of the endemic foci of this *** the largest province of Iran,Sistan-Baluchestan has always been threatened by infectious diseases from abroad due to its geographical location and neighborhood with Afghanistan and *** diseases are more likely to occur in the eastern borders of Iran arising from(1)lack or limited jobs due to deprivation of the area,the harsh weather conditions,unbearable conditions,traditional society,and lack of industry development;(2)Lack or limited facilities due to the distance from the center of the country and high percentage of illiteracy or low literacy,and traffic to neighboring countries to trade goods and get a ***,health authorities should pay more attention to trafficking of illegal aliens,traveling of people to high-risk countries,smuggling of livestock,and strengthening of quarantine posts across borders,especially in the eastern borders of *** first case of chikungunya disease was confirmed in Sistan-Baluchestan province in 2019,where most of the cases have been *** findings of the present study provide evidence of chikungunya virus in Iran and emphasize the urgency to increase the preventive standards and surveillance system.

关键词： Chikungunya Epidemiology Arbovirus Control Mosquito Aedes Geographical distribution Iran

来源：评论

学校读者我要写书评

暂无评论

Author Correction: The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions

Communications biology

引用

Communications biology 2023年第1期6卷 213页

作者： Mara Stellato Matthias Dewenter Michal Rudnik Amela Hukara Çagla Özsoy Florian Renoux Elena Pachera Felix Gantenbein Petra Seebeck Siim Uhtjaerv Elena Osto Daniel Razansky Karin Klingel Joerg Henes Oliver Distler Przemysław Błyszczuk Gabriela Kania Center of Experimental Rheumatology Department of Rheumatology University Hospital Zurich University of Zurich Zurich Switzerland. Institute of Experimental Cardiology University Hospital Heidelberg Germany. Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology Faculty of Medicine University of Zurich Zurich Switzerland. Institute for Biomedical Engineering Department of Information Technology and Electrical Engineering ETH Zurich Zurich Switzerland. Zurich integrative Rodent Physiology University of Zurich Zurich Switzerland. Institute of Clinical Chemistry University Hospital Zurich Zurich Switzerland. Cardiopathology Institute for Pathology and Neuropathology University Hospital Tubingen Tubingen Germany. Internal Medicine II Division of Rheumatology University Hospital Tubingen Tubingen Germany. Department of Clinical Immunology Jagiellonian University Medical College Krakow Poland. Center of Experimental Rheumatology Department of Rheumatology University Hospital Zurich University of Zurich Zurich Switzerland. gabriela.kania@uzh.ch.

来源：评论

学校读者我要写书评

暂无评论

Integrated Coding and Non-Coding Transcriptional Single-Cell Atlas of Multiple Myeloma: Unraveling the Effects of Myeloma Genotype on the Bone Marrow Microenvironment

引用

Blood 2024年 144卷 3258-3258页

作者： Marina E Michaud Sarthak Satpathy William Pilcher Edgar Gonzalez-Kozlova Dimitra Karagkouni Lijun Yao Yered Pita-Juarez Chaitanya Acharya Mark Hamilton Shivani Nanda Yizhe Song Julia T Wang Mojtaba Bakhtiari David Avigan Taxiarchis Kourelis Madhav V. Dhodapkar Sagar Lonial Swati Bhasin Immune Network Li Ding Manoj Bhasin Department of Pediatrics Emory University Atlanta GA Department of Biomedical Informatics Emory University Atlanta GA Department of Biomedical Engineering Georgia Institute of Technology Atlanta GA Icahn School of Medicine At Mount Sinai New York NY Department of Pathology Cancer Research Institute Harvard Medical School Beth Israel Deaconess Medical Center Boston MA WUSTL Saint Louis Department of Pathology Beth Israel Deaconess Medical Center Boston MA Multiple Myeloma Research Foundation Norwalk CT Broad Institute of Harvard and MIT Cambridge MA WUSTL St Louis MO McDonnell Genome Institute Washington University School of Medicine in St. Louis St. Louis MO Department of Medicine Beth Israel Deaconess Medical Center Boston MA Division of Hematology Mayo Clinic Rochester MN Winship Cancer Institute of Emory University Atlanta GA Winship Cancer Institute Atlanta GA Aflac Cancer and Blood Disorders Center Children's Healthcare of Atlanta Atlanta GA Immune Network Multiple Myeloma Research Foundation Norwalk CT Washington University St. Louis MO

Introduction: In recent years, multiple myeloma (MM) research has increasingly focused on unraveling the complex interactions between malignant plasma cells and their surrounding bone marrow microenvironment (BMME). To further elucidate these interactions, we developed a comprehensive single-cell atlas of the MM BMME, integrating both coding and noncoding (ncRNA) transcriptional profiles. By correlating these profiles with specific cytogenetic abnormalities in myeloma cells, we aim to uncover how ncRNAs regulate the phenotypic and functional states of myeloma cells and, consequently, shape the cellular landscape of the BMME. A detailed understanding of how the noncoding transcriptome affects the cellular components and immune landscape of the BMME is essential for advancing our knowledge of MM pathogenesis and identifying novel biomarkers and therapeutic targets. Methods: Our atlas was constructed using single-cell RNA sequencing data from 481 samples of CD138 neg cells sorted from bone marrow aspirates of MM patients enrolled in the MMRF CoMMpass study. This dataset includes accompanying whole-genome sequencing and survival data, enabling correlative analysis between transcriptional profiles, cytogenetic abnormalities, and patient outcomes. To generate a combined coding and non-coding transcriptome, we developed an expanded human reference genome by systematically merging mRNA and ncRNA transcripts from the LncBook2.0 and GENECODEv42 reference genomes. The sequencing data was aligned to this expanded genome, followed by quality control processing, batch correction, clustering, and supervised analysis. Results: The resulting coding and non-coding atlas comprises over 1.9 million cells, spanning immune, plasma, and stromal compartments. Remarkably, ncRNAs constituted 46% of the associated genes, including 22,102 long ncRNAs (lncRNAs) and 3,112 small ncRNAs. Subclustering analysis of the major immune compartments (B lymphoid, myeloid, and NK and T lymphoid) yielded 70

关键词：

来源：评论

学校读者我要写书评

暂无评论

Corrigendum to "Synergetic dual antibiotics-loaded chitosan/poly (vinyl alcohol) nanofibers with sustained antibacterial delivery for treatment of XDR bacteria-infected wounds" [Int. J. Biol. Macromol. 229 (2023) 22-34]

引用

International journal of biological macromolecules 2024年第PT 1期280卷 135540页

作者： Sanaz Alizadeh Paniz Farshi Navid Farahmandian Zahra Aliakbar Ahovan Ali Hashemi Mohammad Majidi Abdolnaser Azadbakht Mahsa Darestanifarahani Koushan Sineh Sepehr Subhas C Kundu Mazaher Gholipourmalekabadi Cellular and Molecular Research Center Iran University of Medical Sciences Tehran Iran Department of Tissue Engineering & Regenerative Medicine Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences Tehran Iran. Biomaterials Group Faculty of Biomedical Engineering Amirkabir University of Technology Tehran Iran. Department of Microbiology School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran. Department of Biomedical Engineering Central Tehran Branch Islamic Azad University Tehran Iran Stem Cells Research Center Tissue Engineering and Regenerative Medicine Institute Central Tehran Branch Islamic Azad University Tehran Iran. Department of Medical Biotechnology Faculty of Allied Medicine Iran University of Medical Sciences Tehran Iran. Laboratory Sciences Research Center Golestan University of Medical Sciences Gorgan Iran. Electronic address: k.sinehsepehr@goums.ac.ir. 3Bs Research Group I3Bs - Research Institute on Biomaterials Biodegradable and Biomimetics Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine University of Minho AvePark Guimaraes Portugal. Department of Tissue Engineering & Regenerative Medicine Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences Tehran Iran Department of Medical Biotechnology Faculty of Allied Medicine Iran University of Medical Sciences Tehran Iran. Electronic address: mazaher.gholipour@iums.ac.ir.

来源：评论

学校读者我要写书评

暂无评论

Evaluation of techniques for automated classification and artery quantification of the circle of Willis on TOF-MRA images: The CROWN challenge

引用

Medical Image Analysis 2025年

作者： Iris N. Vos Ynte M. Ruigrok Edwin Bennink Mireille R.E. Velthuis Barbara Paic Maud E.H. Ophelders Myrthe A.D. Buser Bas H.M. van der Velden Geng Chen Matthieu Coupet Félix Dumais Adrian Galdran Zhang Junyi Wei Liu Ting Ma Madhu S. Nair Mathieu Naudin Preena K.P. Keerthi A.S. Pillai Pengcheng Shi Hugo J. Kuijf Image Sciences Institute UMC Utrecht Utrecht The Netherlands Department of Neurology and Neurosurgery University Medical Center Utrecht Utrecht The Netherlands Department of Radiology University Medical Center Utrecht Utrecht The Netherlands Princess Máxima Center for Pediatric Oncology 3584 CS Utrecht The Netherlands Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou China Jinan Guoke Medical Technology Development Co. Ltd Jinan China XLIM Laboratory University of Poitiers UMR CNRS 7252 Poitiers France I3M Common Laboratory CNRS-Siemens University and Hospital of Poitiers Poitiers France Department of Computer Sciences Université de Sherbrooke Sherbrooke Canada Universitat Pompeu Fabra Barcelona Spain School of Electronic & Information Engineering Suzhou University of Science and Technology Suzhou China Electronic & Information Engineering School Harbin Institute of Technology (Shenzhen) Shenzhen China Artificial Intelligence & Computer Vision Lab Department of Computer Science Cochin University of Science and Technology (CUSAT) Kochi 682022 Kerala India University Hospital CHU Poitiers 86000 France DACTIM-MIS/LMA Laboratory University of Poitiers UMR CNRS 7348 Poitiers 86000 France

Assessing risk factors for intracranial aneurysm (IA) development on images is crucial for early detection of high-risk cases. IAs often form at bifurcations within the circle of Willis (CoW), but manual assessment of these arteries is both time-consuming and susceptible to inconsistencies. Previous studies on imaging markers for IA development lack sufficient evidence for clinical implications, highlighting the need for automated methods to assess CoW morphology. No systematic approach currently exists to identify the best methodological strategies. To address this, we organized a scientific challenge to compare various techniques against a clinical reference standard. Participants were tasked with (1) automated classification of CoW anatomical variants and (2) automated prediction of CoW artery diameters and bifurcation angles. We provided 300 TOF-MRA scans for training and another 300 for testing, all manually annotated. Submissions were evaluated using balanced accuracy, mean absolute error, and Pearson correlation coefficient metrics. This paper provides a detailed analysis of the results from six participating teams. The findings show that various methods may be suitable for automated CoW assessment, but that these need further improvement to meet clinical standards. The challenge remains open for future submissions, offering a benchmark for new techniques.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Premixing enables loading of long RNA in cubic phase lipid nanoparticles

引用

Nature communications 2025年第1期16卷 5054页

作者： Harin Jin Iji Seo Jongeon Park Yunhee Seo Jae Chul Park Seunghwan Bang Joonwoo Rhee Kwan Hyi Lee Jahyun Koo Youngdo Jeong Ji-Hoon Kim Hojun Kim Division of Bio-Medical Science and Technology KIST school University of Science and Technology (UST) Seoul Republic of Korea. Center for Advanced Biomolecular Recognition Korea Institute of Science and Technology (KIST) Seoul Republic of Korea. Department of Cancer Biology Seoul National University Cancer Research Institute Seoul Republic of Korea. School of Biomedical Engineering Korea University Seoul Republic of Korea. Advanced Analysis and Data Center Korea Institute of Science and Technology (KIST) Seoul Republic of Korea. KU-KIST Graduate School of Converging Science and Technology Korea University Seoul Republic of Korea. Department of HY-KIST Bio-convergence Hanyang University Seoul Republic of Korea. Center for Advanced Biomolecular Recognition Korea Institute of Science and Technology (KIST) Seoul Republic of Korea. jihoonkim@kist.re.kr. Department of KHU-KIST Convergence Science and Technology Kyung Hee University Seoul Republic of Korea. jihoonkim@kist.re.kr. Division of Bio-Medical Science and Technology KIST school University of Science and Technology (UST) Seoul Republic of Korea. cuboplex@kist.re.kr. Center for Advanced Biomolecular Recognition Korea Institute of Science and Technology (KIST) Seoul Republic of Korea. cuboplex@kist.re.kr.

Cubic phase lipid nanoparticles (cubosomes) show promise as carriers for nucleic acids due to their outstanding delivery performance and physical stability. However, both theoretical analysis and experimental results have shown that encapsulating long RNA is almost impossible while maintaining a cubic structure. Here we show successful encapsulation of long RNA (up to 4000 bases) in cubosomes by premixing RNA and lipids before self-assembly. Surprisingly, we discovered that long RNA within cubosomes folded into an isotropic phase, similar to other lipid self-assembly structures encapsulating nucleic acids. The cubosome-long RNA complex maintained excellent delivery efficiency even after 24 days at room temperature, underpinning its exceptional stability. Our premixing strategy not only demonstrates the feasibility of developing cold chain-free mRNA vaccines, but also offers insights for incorporating large cargo into other liquid crystals, such as peptides and/or polymer materials.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Progressive Volume Atrophy in Hippocampal Subfields and the Correlation with Cognition in Alzheimer’s Disease and Mild Cognitive Impairment

Research Square

引用

Research Square 2021年

作者： Kang, Guixia Luo, Peiqi Xu, Xin Han, Ying Li, Xuemei Ling, Zhipei Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing100876 China Chinese PLA General Hospital China Wuxi BUPT Sensory Technology and Industry Institute CO. LTD Wuxi214001 China Biomedical Engineering Institute Hainan University Haikou570228 China Department of Neurology XuanWu Hospital of Capital Medical University Beijing100053 China Center of Alzheimer’s Disease Beijing Institute for Brain Disorders Beijing100053 China National Clinical Research Center for Geriatric Disorders Beijing100053 China

Objective: To assess the progression of volume changes in hippocampus and its subfields of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), and to explore the association of the hippocampus and its subfields volumes with cognitive function. Methods: Five groups of participants including 35 normal controls (NC) persons, 30 MCI patients, 30 Mild AD patients, 30 Moderate AD patients and 8 Severe AD patients received structural MRI brain scans. Freesurfer6.0 was used for automatically segmentation of MRI, and the left and right hippocampus were respectively divided into 12 subfields. By statistical analysis, the volumes of hippocampus and its subfields were compared between the five groups, and the correlation of the volumes with Mini-mental State Examination (MMSE) score was analyzed. Result & Conclusion: In the disease, each hippocampal subfield shows an uneven atrophy trajectory;The volumes of the subiculum and presubiculum are significantly different between Mild AD and MCI, which can contribute to the early diagnosis of AD;Parasubiculum is the least sensitive subfield for volume atrophy of AD, while subiculum, presubiculum, CA1, molecular_layer_HP and fimbria show much more significant volume changes. Meanwhile the volumes of these five subfields are positively correlated with MMSE, which may help in stage division of AD;Compared with the right hippocampus, the volume atrophy on the left side is more significantly, and the volumes are more significantly correlated with MMSE, So the left hippocampus and its subfields may provide a higher reference value for the clinical evaluation of AD than the right side. © 2021, CC BY.

关键词： Diagnosis

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：