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Self-packaged stretchable printed circuits with ligand-bound liquid metal particles in elastomer

Nature communications 2025年第1期16卷 4944页

作者： Hyeonyeob Seo Gun-Hee Lee Jiwoo Park Dong-Yeong Kim Yeonzu Son Semin Kim Kum Seok Nam Congqi Yang Joonhee Won Jae-Young Bae Hyunjun Kim Seung-Kyun Kang Steve Park Jiheong Kang Seongjun Park Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea. Departments of Cogno-Mechatronics Engineering Pusan National University Busan Republic of Korea. Departments of Optics and Mechatronics Engineering Pusan National University Busan Republic of Korea. School of Electrical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea. Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon South Korea. Graduate School of Semiconductor Technology Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea. Medical Research Center Seoul National University Seoul Republic of Korea. Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea. Department of Materials Science and Engineering Seoul National University Seoul Republic of Korea. KAIST Institute for NanoCentury Daejeon Republic of Korea. Department of Chemistry Seoul National University Seoul Republic of Korea. jiheongkang@snu.ac.kr. Medical Research Center Seoul National University Seoul Republic of Korea. seongjunpark@snu.ac.kr. Department of Biomedical Sciences College of Medicine Seoul National University Seoul Republic of Korea. seongjunpark@snu.ac.kr. School of Transdisciplinary Innovations Seoul National University Seoul Republic of Korea. seongjunpark@snu.ac.kr. Interdisciplinary Program in Bioengineering College of Engineering Seoul National University Seoul Republic of Korea. seongjunpark@snu.ac.kr. Department of Transdisciplinary Medicine Seoul National University Hospital Seoul South Korea. seongjunpark@snu.ac.kr.

Packaging in stretchable electronics is crucial to protect components from environmental damage while preserving mechanical flexibility and providing electrical insulation. The conventional packaging process involves multiple steps that increase in complexity as the number of circuit layers multiply. In this study, we introduce a self-packaged stretchable printed circuit board enabled by the in situ phase separation of liquid metal particles (LMPs) within various polymer matrices during solution-based printing processes. The ligand-bound LMPs (LB-LMPs), engineered to inhibit oxide growth, undergo in situ sintering, prompting vertical phase separation. This synthesis strategy not only achieves high initial conductivity of the LMPs but also encapsulates them within the polymer matrix, preventing leakage and providing electrical insulation. Our method enables multi-layer circuit printing, eliminating the need for additional activation and packaging processes. Furthermore, by integrating conductive materials into packaging layers for selective electrical conductivity, vertical interconnect accesses and conductive pads can be formed, enabling large-scale, stretchable, and leakage-free multi-layer electrical circuits and bio-interfaces.

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Strong hydrogen trapping by tangled dislocations in cold-drawn pearlitic steels

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Acta Materialia 2025年

作者： Chao Huang Chuanjie Cui Ranming Niu Fenghua Lu Cheng-Yun Wu Xiaoxiong Zhu Hongzhou Lu Yongqing Zhang Pang-Yu Liu Bosheng Dong Yi-Hsuan Sun Hongjian Wang Wei Li Hung-Wei Yen Aimin Guo Julie M. Cairney Emilio Martínez-Pañeda Eason Yi-Sheng Chen Australian Centre for Microscopy and Microanalysis The University of Sydney Sydney NSW 2006 Australia School of Aerospace Mechanical and Mechatronic Engineering The University of Sydney Sydney NSW 2006 Australia Department of Engineering Science The University of Oxford Oxford OX1 3PJ United Kingdom School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China School of Biomedical Engineering The University of Sydney Sydney NSW 2006 Australia Jiangsu Tokyo Rope Co. Ltd. Jiangyin Jiangsu 214445 China CITIC Metal Co. Beijing 100004 China Department of Materials Science and Engineering National Taiwan University Taipei 10617 Taiwan Advanced Research Center for Green Materials Science and Technology National Taiwan University Taipei 10617 Taiwan School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore

The presence of diffusible hydrogen atoms can lead to hydrogen embrittlement in steels, compromising their structural integrity. A potential solution is incorporating strong hydrogen traps into the microstructures to immobilize hydrogen solute atoms and prevent their diffusion towards stress-prone areas where embrittlement is most likely to occur. However, creating materials with effective hydrogen traps usually involves adding expensive alloying elements, which increase the production costs, hindering the adoption of this strategy in the steel industry. Here we show that cold drawing of pearlitic steel rods introduces a high-density of dislocations that accumulate and tangle at cementite-ferrite interfaces; this strengthens the steel and make it less susceptible to embrittlement. We use atom probe tomography to confirm that these tangled dislocations firmly trap hydrogen in a steel that displays low embrittlement susceptibility. Our findings suggest a pathway for producing metallic materials that have an excellent combination of high strength and hydrogen embrittlement resistance, underscoring the potential of using structural defects as cost-effective hydrogen traps.

关键词： Hydrogen embrittlement hydrogen trapping steels atom probe tomography materials design

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Intelligent wireless theranostic contact lens for close-loop electrical sensing and regulation of glaucoma

Research Square

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Research Square 2021年

作者： Yang, Cheng Wu, Qianni Liu, Junqing Mo, Jingshan Li, Xiangling Yang, Chengduan Liu, Ziqi Yang, Jingbo Jiang, Lelun Chen, Weirong Chen, Hui-Jiuan Wang, Ji Xie, Xi State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat-Sen University Guangzhou510006 China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou510006 China The First Affiliated Hospital of Sun Yat-Sen University Sun Yat-Sen University Guangzhou510006 China Department of Cardiology The First Affiliated Hospital of Jinan University Guangzhou510630 China School of Biomedical Engineering Sun Yat-Sen University Guangzhou510006 China

Engineered closed-loop devices that can wirelessly track intraocular pressure (IOP) and offer feedback-medicine administrations are highly desirable for glaucoma treatments, yet remain difficult to develop. Integrated theranostic systems based on contact lens still confront several challenges, including size limits, requirements of wireless operations, and cross-coupling between multiple functional modulus. Here, for the first time to our knowledge, an integrated wireless theranostic contact lens (WTCL) for in situ electrical sensing and on-demand drug delivery of glaucoma was developed. The WTCL utilized a highly compact circuitry and structural design, which enabled highdegreed integration of IOP sensing and electrically controlled delivery modulus on the curved and limited surface of contact lens. The wireless IOP sensing modulus could ultra-sensitively detect IOP fluctuations, due to the unique cantilever configuration design of LCR circuit with ultra-soft air dielectric film sandwiched between each capacitive sensing plate. The drug delivery modulus employed a highly efficient wireless power transfer circuit, to trigger delivery of anti-glaucoma drug into aqueous chamber via iontophoresis to enhance drug permeation across cornea. The specialized design of frequency separation enabled individual operations of different modules without cross-coupling. The minimally invasive, smart, wireless and closed-loop theranostic features endowed the WTCL as a highly promising system for glaucoma treatments. © 2021, CC BY.

关键词： Closed loop systems

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Molecular level investigations on mussel inspired polymer thin films using nonlinear vibrational spectroscopy

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AIP Conference Proceedings 2021年第1期2352卷

作者： Shilpi Chaudhary Harpreet Kaur Kailash C. Jena 1Department of Applied Sciences Punjab Engineering College (Deemed to be University) Chandigarh-160012 India 2Department of Physics Indian Institute of Technology Ropar Rupnagar Punjab-140001 India 3Center for Biomedical Engineering Indian Institute of Technology Ropar Rupnagar Punjab-140001 India

The development of surface coatings demands a better understanding of surface/interface chemistry to design high-performance coating materials. We have studied the polymerization processes of mussel-inspired adhesive protein, Dopamine. Molecular level insight on the mechanism of thin film formation during the polymerization processes has been probed using sum frequency generation vibrational spectroscopy. The investigations of the polydopamine thin films with variation in polymerization time of dopamine at air-polymer interface reveal the molecular footprints and polymerization mechanism of dopamine. The polymerization intermediates were dependent on polymerization time, which can be used for immobilization strategies. Additionally, the morphological measurements show the formation of nanoparticles during the polymerization at the surfaces even when the vertical orientation of sample and/ or stirring of solution were followed to prevent macro/nanostructures. The acquired investigations can be applied in designing the deterministic surfaces and interfaces for coating, coupling, and sensing applications.

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Multi-channel masked autoencoder and comprehensive evaluations for reconstructing 12-lead ECG from arbitrary single-lead ECG

npj Cardiovascular Health

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npj Cardiovascular Health 2024年第1期1卷 1-13页

作者： Jiarong Chen Shenda Hong Wanqing Wu Tong Liu National Institute of Health Data Science Peking University Beijing China School of Biomedical Engineering Sun Yat-sen University Shenzhen Guangdong China Department of Micro/Nano Electronics and MoE Key Lab of Artificial Intelligence Shanghai Jiao Tong University Shanghai China Institute of Medical Technology Health Science Center of Peking University Beijing China Institute for Artificial Intelligence Peking University Beijing China Tianjin Key Laboratory of lonic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University Tianjin China

Electrocardiogram (ECG) has emerged as a widely accepted diagnostic instrument for cardiovascular diseases (CVD). The standard clinical 12-lead ECG configuration causes considerable inconvenience and discomfort, while wearable devices offers a more practical alternative. To reduce information gap between 12-lead ECG and single-lead ECG, this study proposes a multi-channel masked autoencoder (MCMA) for reconstructing 12-Lead ECG from arbitrary single-lead ECG, and a comprehensive evaluation benchmark, ECGGenEval, encompass the signal-level, feature-level, and diagnostic-level evaluations. MCMA can achieve the state-of-the-art performance. In the signal-level evaluation, the mean square errors of 0.0175 and 0.0654, Pearson correlation coefficients of 0.7772 and 0.7287. In the feature-level evaluation, the average standard deviation of the mean heart rate across the generated 12-lead ECG is 1.0481, the coefficient of variation is 1.58%, and the range is 3.2874. In the diagnostic-level evaluation, the average F1-score with two generated 12-lead ECG from different single-lead ECG are 0.8233 and 0.8410.

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NIMG-29. ASSOCIATION OF PARTIAL T2-FLAIR MISMATCH SIGN AND ISOCITRATE DEHYDROGENASE MUTATION IN WHO GRADE 4 GLIOMA/GLIOBLASTOMA: RESULTS FROM THE RESPOND CONSORTIUM

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Neuro-Oncology 2022年第SUPPLEMENT_7期24卷 vii168–vii169页

作者： Lee, Matthew Sako, Chiharu Patel, Sohil Mohan, Suyash Balana, Carmen Barnholtz-Sloan, Jill Sloan, Andrew Badve, Chaitra Poisson, Laila Griffith, Brent Booth, Thomas Palmer, Joshua Chakravarti, Arnab Bakas, Spyridon Nasrallah, MacLean Choi, Yoon Seong Dicker, Adam Flanders, Adam Shi, Wenyin Mahajan, Abhishek Colen, Rivka Marcus, Daniel Orringer, Daniel Davatzikos, Christos Jain, Rajan Department of Radiology NYU Grossman School of Medicine New York NY USA Center for Biomedical Image Computing and Analytics and Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia USA Department of Radiology University of Virginia School of Medicine Charlottesville USA Center for Biomedical Image Computing and Analytics Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Medical Oncology Department Catalan Institute of Oncology Barcelona Spain Center for Biomedical Informatics and Information Technology and Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD USA Department of Pathology and Department of Neurosurgery Case Western Reserve University and University Hospitals Cleveland Medical Center Seidman Cancer Center and Case Comprehensive Cancer Center Cleveland USA Department of Radiology Case Western Reserve University and University Hospitals Cleveland Medical Center Cleveland USA Department of Public Health Sciences Center for Bioinformatics Henry Ford Health System Detroit MI USA Department of Radiology Henry Ford Health System Detroit MI USA School of Biomedical Engineering and Imaging Sciences King’s College London United Kingdom The Department of Radiation Oncology The James Cancer Hospital Ohio State University Wexner Medical Center Columbus OH USA Department of Radiation Oncology Ohio State University Wexner Medical Center Columbus OH USA Center for Biomedical Image Computing and Analytics Department of Radiology and Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Department of Radiology Yonsei University College of Medicine Seoul Republic of Korea Department of Radiation Oncology Sidney Kimmel Cancer Center Thomas Jefferson

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The use of gross split contract scheme in economic analysis of shale gas field at meliat formation in Tarakan Basin

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IOP Conference Series: Earth and Environmental Science 2021年第1期673卷

作者： S Z Wahyunita A Ahmudi A Wijanarko S C Asih M Nasikin M Sahlan Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Depok West Java 16424 Indonesia Center for Energy Environment and Sustainable Development Studies Faculty of Science and Technology Binawan University Jakarta 13630 Indonesia Research Center for Biomedical Engineering Faculty of Engineering University of Indonesia Campus UI Depok 16424 West Java Indonesia

Due to the low supply and increasing demand for natural gas in Indonesia, the government has decided to develop other resources such as shale gas. The Meliat formation in the Tarakan Basin has a shale-gas potential for which 3.8 TCF is technically recoverable with 25.1 TCF risked in place. This study examines the economic impact of the gross split contract scheme on the development of this shale-gas field. Our model leverages three flow-rate profiles, comprising a low-production profile wells having an initial production (qi) of 50 mmcf/mo, a medium-production profile wells of qi = 125 mmcf/mo and a high-production profile wells of qi = 200 mmcf/mo. We used US models and the nearest field in the Tarakan Basin as a benchmark in making investment costs for development. Sensitivity analysis was conduct for the production profile, drilling costs and wellhead gas prices. Gross split contracts have a net present value (NPV) > 0 and an individual rate of return >10% on medium and high-production profile wells. The analysis showed that the production profile is the most substantial factor that is affected by the NPV increase. As a result, the indicator of NPV reaching positive is when the gas price sets at $9.24/MMBTU for medium-production profile wells and $6.43/MMBTU for high-production profile wells.

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Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice

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Journal of Sport and Health Science 2025年第3期 1-18页

作者： Marit Hjorth Casey L.Egan Guilherme D.Telles Martin Pal David Gallego-Ortega Oliver K.Fuller Emma D.Mc Lennan Ryan D.Gillis Tae Gyu Oh George E.O.Muscat Surafel Tegegne Michael S.M.Mah Joanna Skhinas Emma Estevez Timothy E.Adams Matthew J.Mc Kay Mark Molloy Kevin I.Watt Hongwei Qian Paul Gregorevic Thomas R.Cox Pernille Hojman Julie Midtgaard Jesper F.Christensen Martin Friedrichsen Renato V.Iozzo Erica K.Sloan Brian G.Drew Jùrgen F.P.Wojtaszewski Martin Whitham Mark A.Febbraio Department of Nutrition Institute of Basic Medical Sciences Faculty of Medicine University of Oslo Garvan Institute of Medical Research Drug Discovery Biology Monash Institute of Pharmaceutical Sciences Monash University Laboratory of Neuromuscular Adaptations to Strength Training School of Physical Education and Sport University of S?o Paulo (USP)S?o Paulo 05508-030 Brazil Center of Study in Exercise and Oncology (CEEO) School of Dentistry & Medical Sciences Charles Sturt University School of Biomedical Engineering University of Technology College of Medicine University of Oklahoma Institute of Molecular Biosciences University of Queensland CSIRO Manufacturing Australian Proteome Analysis Facility Macquarie University School of Medical Sciences University of Sydney Murdoch Children’s Research Institute The Royal Children’s Hospital Department of Physiology The University of Melbourne Copenhagen University Hospital Department of Nutrition Exercise and Sports University of Copenhagen Sidney Kimmel Medical College Thomas Jefferson University Baker Heart and Diabetes Institute School of Sport Exercise and Rehabilitation Sciences University of Birmingham

Purpose: Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully *** purpose of this study was to examine the mechanisms behind the protective effects of ***: We used a variety of rodent and human experimental model systems to determine whether exercise training can reduce tumor burden in breast cancer and to identify mechanism associated with any exercise training effects on tumor ***: We show that voluntary wheel running slows tumor development in the mammary specific polyomavirus middle T antigen overexpression(MMTV-Py MT) mouse model of breast cancer but only when mice are not housed alone. We identify the proteoglycan decorin as a contraction-induced secretory factor that systemically increases in patients with breast cancer immediately following exercise. Moreover, high expression of decorin in tumors is associated with improved prognosis in patients, while treatment of breast cancer cells in vitro with decorin reduces cell proliferation. Notwithstanding, when we overexpressed decorin in murine muscle or injected recombinant decorin systemically into mouse models of breast cancer, elevated plasma decorin concentrations did not result in higher tumor decorin levels and tumor burden was not ***: Exercise training is anti-tumorigenic in a mouse model of luminal breast cancer, but the effect is abrogated by social isolation. The proteoglycan decorin is an exercise-induced secretory protein, and tumor decorin levels are positively associated with improved prognosis in patients. The hypothesis that elevated plasma decorin is a mechanism by which exercise training improves breast cancer progression in humans is not, however, supported by our pre-clinical data since elevated circulating decorin did not increase tumor decorin levels in these models.

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Distance correlation based brain functional connectivity estimation and non-convex multi-task learning for developmental fMRI studies

arXiv

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arXiv 2020年

作者： Xiao, Li Cai, Biao Qu, Gang Stephen, Julia M. Wilson, Tony W. Calhoun, Vince D. Wang, Yu-Ping Department of Biomedical Engineering Tulane University New OrleansLA70118 United States Mind Research Network AlbuquerqueNM87106 United States Department of Neurological Sciences University of Nebraska Medical Center OmahaNE68198 United States Georgia State University Georgia Institute of Technology Emory University AtlantaGA30030 United States

Resting-state functional magnetic resonance imaging (rs-fMRI)-derived functional connectivity patterns have been extensively utilized to delineate global functional organization of the human brain in health, development, and neuropsychiatric disorders. In this paper, we investigate how functional connectivity in males and females differs in an age prediction framework. We first estimate functional connectivity between regions-of-interest (ROIs) using distance correlation instead of Pearson’s correlation. Distance correlation, as a multivariate statistical method, explores spatial relations of voxel-wise time courses within individual ROIs and measures both linear and nonlinear dependence, capturing more complex information of between-ROI interactions. Then, a novel non-convex multi-task learning (NC-MTL) model is proposed to study age-related gender differences in functional connectivity, where age prediction for each gender group is viewed as one task. Specifically, in the proposed NC-MTL model, we introduce a composite regularizer with a combination of non-convex 2,1−2 and 1−2 regularization terms for selecting both common and task-specific features. Finally, we validate the proposed NC-MTL model along with distance correlation based functional connectivity on rs-fMRI of the Philadelphia Neurodevelopmental Cohort for predicting ages of both genders. The experimental results demonstrate that the proposed NC-MTL model outperforms other competing MTL models in age prediction, as well as characterizing developmental gender differences in functional connectivity patterns. Copyright © 2020, The Authors. All rights reserved.

关键词： Learning systems

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The calculation of the impedance of biological tissue on the model of Yamamoto in the process of galvanic effects 5

The calculation of the impedance of biological tissue on the...

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5th International Scientific and Practical Conference on Virtual Simulation, Prototyping and Industrial Design 2018, VSPID 2018

作者： Gorbunov, A. Gromov, Y. Egorov, V. Department of Biomedical Engineering Tambov State Technical University 106 Sovetskaya Street Tambov392000 Russia Institute of Automation and Information Technology Tambov State Technical University 106 Sovetskaya Street Tambov392000 Russia Center for New Information Technologies Tambov State Technical University 106 Sovetskaya Street Tambov392000 Russia

The purpose of this work is to improve the accuracy of research related to the work in the field of modeling and measurement of galvanic processes in biological tissues under the influence of electric current. For this purpose, we propose a refined equivalent electrical model of biotissue and an algorithm for numerical determination of its components. © 2019 IOP Publishing Ltd. All rights reserved.

关键词： Tissue

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