检索结果-内蒙古大学图书馆

第十一届中国钢铁年会

作者： Gao Zhikai Wang Anding Chen Pingbo Li Fushan Chang Chuntao He Aina Wang Xinmin Liu Chain-Tsuan School of Materials Science and Engineering Zhengzhou University Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of Sciences Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center for Advanced Structural Materials Department of Mechanical and Biomedical Engineering College of Science and Engineering City University of Hong Kong

Annealing induced magnetic and mechanical property changes for the FeNbB bulk metallic glass were systematically *** is interesting that this ternary alloy can combinedly exhibit outstanding magnetic and mechanical properties, especially good ductility, after optimally annealing in structure relaxation stage for eliminating the internal stress and homogenizing the *** alloy exhibits low coercive force of 1.6 A/m, high effective permeability of 15×10, high fracture strength of 4.2 GPa and good plastic strain of 1.8%.It is also found that the responses of mechanical and magnetic properties to structure relaxation are *** glass transition and crystallization will greatly deteriorate the magnetic and mechanical *** we propose a physical picture and demonstrate that the primary structure factors determining magnetic and mechanical properties are *** work will bring a promising material for application and a new perspective to study the effect of annealing induced structure relaxation on mechanical and magnetic properties.

关键词： bulk metallic glass annealing mechanical property magnetic property structure relaxation

来源：评论

学校读者我要写书评

暂无评论

Imaging analysis of nanodomain components of cardiac calcium release units

Imaging analysis of nanodomain components of cardiac calcium...

引用

第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Tobias Kohl Eva Wagner Marcel Lauterbach Jan-Hendrik Streich Brian Hagen Volker Westphal Stefan W Hell W J Lederer Stephan E Lehnart Heart Research Center Gttingen Department of Cardiology & PulmonologyUniversity Medicine Gttingen Max Planck Institute for Biophysical Chemistry Department of NanoBiophotonicsGottingenGermany Center for Biomedical Engineering and Technology University of Maryland BaltimoreMDUSA Max Planck Institute for Biophysical Chemistry Department of NanoBiophotonicsGttingenGermany

Intracellular nanodomains are very small subcellular compartments containing membrane structures and specific *** intracellular Ca2+ release unit(CRU) nanodomain is sized 10-350 nm and specialized in spatiotemporal control of cardiac Ca2+ *** activated a single CRU produces elementary units of cardiac Ca2+ release,the Ca2+ *** individual CRU components have been studied in detail,the

关键词： Nanodomain Calcium T-tubule Ryanodine receptor Heart

来源：评论

学校读者我要写书评

暂无评论

Magnetic bioassembly platforms towards the generation of extracellular vesicles from human salivary gland functional organoids for epithelial repair

引用

Bioactive Materials 2022年第12期7卷 151-163页

作者： Ajjima Chansaenroj Christabella Adine Sawanya Charoenlappanit Sittiruk Roytrakul Ladawan Sariya Thanaphum Osathanon Sasitorn Rungarunlert Ganokon Urkasemsin Risa Chaisuparat Supansa Yodmuang Glauco R.Souza Joao N.Ferreira Avatar Biotechnologies for Oral Health and Healthy Longevity Research Unit Faculty of DentistryChulalongkorn UniversityBangkok10330Thailand Faculty of Dentistry National University of Singapore119077SingaporeSingapore Department of Biomedical Engineering Faculty of EngineeringNational University of Singapore119077SingaporeSingapore Functional Ingredients and Food Innovation Research Group National Center for Genetic Engineering and BiotechnologyNational Science and Technology Development AgencyPathum Thani12120Thailand The Monitoring and Surveillance Center for Zoonotic Diseases in Wildlife and Exotic Animals Faculty of Veterinary ScienceMahidol UniversityNakhon Pathom73170Thailand Department of Anatomy Faculty of DentistryChulalongkorn UniversityBangkok10330Thailand Department of Preclinical and Applied Animal Science Faculty of Veterinary ScienceMahidol UniversityNakhon Pathom73170Thailand Research Affairs Faculty of MedicineChulalongkorn UniversityBangkok10330Thailand University of Texas Health Sciences Center at Houston HoustonTX77030USA Nano3D Biosciences Inc. HoustonTX77030USA Greiner Bio-One North America Inc MonroeNC28110USA

Salivary glands(SG)are exocrine organs with secretory units commonly injured by ***-engineered organoids and extracellular vesicles(EV)are currently under investigation as potential strategies for SG ***,three-dimensional(3D)cultures of SG functional organoids(SGo)and human dental pulp stem cells(hDPSC)were generated by magnetic 3D bioassembly(M3DB)*** growth factor 10(FGF10)was used to enrich the SGo in secretory epithelial *** 11 culture days via M3DB,SGo displayed SG-specific acinar epithelial units with functional properties upon *** consistently develop 3D hDPSC in vitro,3 culture days were sufficient to maintain hDPSC undifferentiated genotype and phenotype for EV *** isolation was performed via sequential centrifugation of the conditioned media of hDPSC and SGo *** were characterized by nanoparticle tracking analysis,electron microscopy and *** were in the exosome range for hDPSC(diameter:88.03±15.60 nm)and for SGo(123.15±63.06 nm).Upon ex vivo administration,exosomes derived from SGo significantly stimulated epithelial growth(up to 60%),mitosis,epithelial progenitors and neuronal growth in injured SG;however,such biological effects were less distinctive with the ones derived from ***,these exosome biological effects were investigated by proteomic *** spectrometry profiling of SGo exosomes predicted that cellular growth,development and signaling was due to known and undocumented molecular targets downstream of *** were identified as one of the novel targets requiring further ***,M3DB platforms can generate exosomes with potential to ameliorate SG epithelial damage.

关键词： Salivary gland Hyposalivation Human dental pulp stem cells Magnetic bioassembly Organoids Exosome

来源：评论

学校读者我要写书评

暂无评论

An Exploration into the Design of Multi-Session Robot-Mediated Joint Attention Intervention for Young Children with Autism Spectrum Disorders

SSRN

引用

SSRN 2023年

作者： Nie, Guangtao Zheng, Zhi Swanson, Amy R. Weitlauf, Amy S. Warren, Zachary E. Sarkar, Nilanjan Vanderbilt University United States The Biomedical Engineering Department Rochester Institute of Technology RochesterNY14623 United States Vanderbilt University Medical Center NashvilleTN37212 United States Department of Pediatrics Vanderbilt University Medical Center NashvilleTN37212 United States The Mechanical Engineering Department Electrical Engineering and Computer Science Department Vanderbilt University NashvilleTN37212 United States

One in 44 children in the United States has Autism Spectrum Disorder (ASD). Numerous robotic intervention systems have been proposed for children with ASD. It is widely acknowledged that engagement with the robotic system is important for intervention success. Visual attention toward the robot can be used as a proxy for engagement. However, less is known about how to maintain and enhance visual attention within a robotic system, and how the variation of visual attention may influence adaptation of dynamic intervention protocols to improve outcomes. Therefore, in this work, we propose a new metric, System Capture Ratio (SCR), that can be automatically quantified in real-time, to measure a participant’s visual attention within a robotic system designed for joint attention intervention for children with ASD. Then, we demonstrate that compared to a static intervention protocol, a dynamic intervention protocol can help sustain visual attention and thus achieve a significant performance improvement. The results support the implementation of adaptive and dynamic robotic intervention protocols for children with ASD that are based on SCR, offering suggestions on designing effective multi-session studies for autism intervention. © 2023, The Authors. All rights reserved.

关键词： Human robot interaction

来源：评论

学校读者我要写书评

暂无评论

Genome-wide identification and spatiotemporal expression profiling of zinc finger SWIM domain-containing protein family genes

引用

Zoological Research 2023年第3期44卷 663-674页

作者： Imtiaz Ul Hassan Hafiz Mamoon Rehman Ziran Liu Liangji Zhou Muhammad Kaleem Samma Chengdong Wang Zixin Rong Xufeng Qi Dongqing Cai Hui Zhao Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Centre for Agricultural Biochemistry and Biotechnology(CABB) University of Agriculture FaisalabadFaisalabad 38000Pakistan Qingdao Municipal Center for Disease Control and Prevention QingdaoShandong 266034China Key Laboratory of Regenerative Medicine of Ministry of Education Department of Developmental&Regenerative BiologyJinan UniversityGuangzhou 511436China Department of Biology and Chemistry City University of Hong KongHong Kong SARChina Department of Gene Technology School of Engineering Sciences in ChemistryBiotechnology and Health(CBH)KTH Royal Institute of Technology10691 StockholmSweden Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics The Chinese University of Hong KongHong Kong SARChina

The biological function of the novel zinc-finger SWIM domain-containing protein family(ZSWIM)during embryonic development remains ***,we conducted a genome-wide analysis to explore the evolutionary processes of the ZSWIM gene family members in mice,Xenopus tropicalis,zebrafish,and *** identified nine putative ZSWIM genes in the human and mouse genome,eight in the Xenopus genome,and five in the zebrafish *** on multiple sequence alignment,three members,ZSWIM5,ZSWIM6,and ZSWIM8,demonstrated the highest homology across all four *** available RNA sequencing(RNAseq)data,ZSWIM genes were found to be widely expressed across different tissues,with distinct tissuespecific *** identify the functions of the ZSWIM protein family during embryogenesis,we examined temporal and spatial expression patterns of zswim family genes in Xenopus *** real-time polymerase chain reaction(qRT-PCR)revealed that each member had a distinct expression ***-mount in situ hybridization showed that both zswim1 and zswim3 were maternally expressed genes;zswim5 and zswim6were expressed throughout embryogenesis and displayed dynamic expression in the brain,eyes,somite,and bronchial arch at the late tailbud stages;zswim7 was detected in the eye area;zswim8 showed a dynamic expression pattern during the tailbud stages,with expression detected in the brain,eyes,and somite;zswim9 was faintly expressed throughout embryonic *** study provides a foundation for future research to delineate the functions of ZSWIM gene members.

关键词： ZSWIM gene family Xenopus Gene expression Phylogenetic analysis Bioinformatics

来源：评论

学校读者我要写书评

暂无评论

Biophysical and epigenetic regulation of cancer stemness, invasiveness and immune action

引用

Current tissue microenvironment reports 2020年第4期1卷 277-300页

作者： Praveen Krishna Veerasubramanian Annie Trinh Navied Akhtar Wendy F Liu Timothy L Downing Department of Biomedical Engineering University of California-Irvine Irvine CA USA. The Edwards Lifesciences Center for Advanced Cardiovascular Technology University of California-Irvine Irvine CA USA. Department of Microbiology and Molecular Genetics University of California-Irvine Irvine CA USA. Department of Chemical and Biomolecular Engineering University of California-Irvine Irvine CA USA. NSF-Simons Center for Multiscale Cell Fate Research University of California-Irvine Irvine CA USA.

PURPOSE OF REVIEW:The tumor microenvironment (TME) is an amalgam of multiple dysregulated biophysical cues that can alter cellular behavior through mechanotransductive signaling and epigenetic modifications. Through this review, we seek to characterize the extent of biophysical and epigenetic regulation of cancer stemness and tumor-associated immune cells in order to identify ideal targets for cancer therapy. RECENT FINDINGS:Recent studies have identified cancer stemness and immune action as significant contributors to neoplastic disease, due to their susceptibility to microenvironmental influences. Matrix stiffening, altered vasculature, and resultant hypoxia within the TME can influence cancer stem cell (CSC) and immune cell behavior, as well as alter the epigenetic landscapes involved in cancer development. SUMMARY:This review highlights the importance of aberrant biophysical cues in driving cancer progression through altered behavior of CSCs and immune cells, which in turn sustains further biophysical dysregulation. We examine current and potential therapeutic approaches that break this self-sustaining cycle of disease progression by targeting the presented biophysical and epigenetic signatures of cancer. We also summarize strategies including the normalization of the TME, targeted drug delivery, and inhibition of cancer-enabling epigenetic players.

关键词： biomechanics cancer stemness cancer therapeutics epigenetics immunoevasion mechanotransduction tumor heterogeneity

来源：评论

学校读者我要写书评

暂无评论

Size effect of hydroxyapatite nanoparticles on viability and functions to osteoblast-like cells

Size effect of hydroxyapatite nanoparticles on viability and...

引用

全球华人口腔医学大会暨2010中国国际口腔医学大会

作者： Xiaochen Liu Jie Wei Shicheng Wei Key Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and TechnologyShanghai 200237 P.R.China Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University 100871 Beijing P.R.China Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University 100871 Beijing P.R.China Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary Studies Peking University 100871 Beijing P.R.China Department of Oral and Maxillofacial Surgery School of Stomatology Peking University 100081 Beijing P.R.China

来源：评论

学校读者我要写书评

暂无评论

Statistical Dependency Guided Contrastive Learning for Multiple Labeling in Prenatal Ultrasound

arXiv

引用

arXiv 2021年

作者： He, Shuangchi Lin, Zehui Yang, Xin Chen, Chaoyu Wang, Jian Shuang, Xue Deng, Ziwei Liu, Qin Cao, Yan Lu, Xiduo Huang, Ruobing Ravikumar, Nishant Frangi, Alejandro Zhang, Yuanji Xiong, Yi Ni, Dong National-Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering Health Science Center Shenzhen University China Lab. Shenzhen University China Marshall Laboratory of Biomedical Engineering Shenzhen University China University of Leeds United Kingdom Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds United Kingdom KU Leuven Leuven Belgium Department of Ultrasound Luohu People’s Hospital Shenzhen China

Standard plane recognition plays an important role in prenatal ultrasound (US) screening. Automatically recognizing the standard plane along with the corresponding anatomical structures in US image can not only facilitate US image interpretation but also improve diagnostic efficiency. In this study, we build a novel multi-label learning (MLL) scheme to identify multiple standard planes and corresponding anatomical structures of fetus simultaneously. Our contribution is three-fold. First, we represent the class correlation by word embeddings to capture the fine-grained semantic and latent statistical concurrency. Second, we equip the MLL with a graph convolutional network to explore the inner and outer relationship among categories. Third, we propose a novel cluster relabel-based contrastive learning algorithm to encourage the divergence among ambiguous classes. Extensive validation was performed on our large in-house dataset. Our approach reports the highest accuracy as 90.25% for standard planes labeling, 85.59% for planes and structures labeling and mAP as 94.63%. The proposed MLL scheme provides a novel perspective for standard plane recognition and can be easily extended to other medical image classification tasks. Copyright © 2021, The Authors. All rights reserved.

关键词： Learning algorithms

来源：评论

学校读者我要写书评

暂无评论

Electropermeabilization of Mammalian Cells Visualized with Fluorescent Semiconductor Nanocrystals (Quantum Dots)

引用

MRS Online Proceedings Library 2006年第1期873卷 1-6页

作者： Yinghua Sun P. Thomas Vernier Jingjing Wang Andras Kuthi Laura Marcu Martin A. Gundersen Department of Materials Science University of Southern California Los Angeles USA Department of Electrical Engineering-Electrophysics University of Southern California Los Angeles USA MOSIS Information Sciences Institute University of Southern California Marina del Rey USA Department of Biomedical Engineering University of Southern California Los Angeles USA Biophotonics Research and Technology Development Cedars-Sinai Medical Center Los Angeles USA

Electroporation/electropermeabilization is a non-viral technique for gene transfection and drug delivery. Here, the transfer mechanisms were studied with fluorescent nanocrystals (quantum dots, QDs) in mammalian cells. Interactions of the cell membrane and nanoscale particles were visualized after electric pulse treatment. Responses of human multiple myeloma cells to nanocrystals were tracked for periods up to 7 days. Large particles do not cross the membrane directly after pulsing, even if the membrane is permeabilized to small molecules. Large QDs were trapped on the cell membrane for hours after electroporation and were gradually either excluded or internalized by cells. QD uptake efficiency depended on both particle size and membrane transport activity. These results, consistent with an electropermeabilization model, suggest that enhancing the interactions between the cell membrane and macromolecules may improve the transfer efficiency.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Application of time-fractional order bloch equation in magnetic resonance fingerprinting

arXiv

引用

arXiv 2019年

作者： Wang, Haifeng Zou, Lixian Ye, Huihui Su, Shi Chang, Yuchou Liu, Xin Liang, Dong Paul C. Lauterbur Research Center for Biomedical Imaging Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen College of Advanced Technology University of Chinese Academy of Sciences State Key Laboratory of Modern Optical Instrumentation College of Optical Science and Engineering Zhejiang University Department of of Computer Science and Engineering Technology University of Houston-Downtown

Magnetic resonance fingerprinting (MRF) is one novel fast quantitative imaging framework for simultaneous quantification of multiple parameters with pseudo - randomized acquisition patterns. The accuracy of the resulting multi-parameters is very important for clinical applications. In this paper, we derived signal evolutions from the anomalous relaxation using a fractional calculus. More specifically, we utilized time-fractional order extension of the Bloch equations to generate dictionary to provide more complex system descriptions for MRF applications. The representative results of phantom experiments demonstrated the good accuracy performance when applying the time-fractional order Bloch equations to generate dictionary entries in the MRF framework. The utility of the proposed method is also validated by in-vivo study. Copyright © 2019, The Authors. All rights reserved.

关键词： Magnetic resonance

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：