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Toward separation and purification of chlorogenic acid from Lonicerae Japonicae Flo (honeysuckle) using melamine–formaldehyde aerogel: A green and efficient approach

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Chemical engineering Journal 2024年 500卷

作者： Yong Zhu Bingmin Wu Songyan Xia Guangzhen Zheng Juanjuan Cheng Song Huang Qingping Xiong Jing Chen Hailun Li Hajime Hirao Yisheng He Jihang Chen Shenzhen Key Laboratory of Steroid Drug Discovery and Development School of Medicine The Chinese University of Hong Kong Shenzhen Guangdong 518172 China Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province Huaiyin Institute of Technology Huai’an Jiangsu 223003 China Shenzhen Futian Biomedical Innovation R&D Center The Chinese University of Hong Kong Shenzhen Guangdong 518000 China National Engineering Research Center for Modernization of Traditional Chinese Medicine Guangzhou University of Chinese Medicine Guangzhou Guangdong 510006 China Warshel Institute for Computational Biology School of Medicine The Chinese University of Hong Kong Shenzhen Guangdong 518172 China Department of Nephrology Affiliated Huai’an Hospital of Xuzhou Medical University Huai’an Jiangsu 223002 China

The separation and purification of chlorogenic acid (CA) from honeysuckle is a challenging yet significant task in the food industry. Traditional methods, such as precipitation and chromatography methods, often suffer from secondary pollution or low efficiency. This paper proposes a green and efficient adsorption method for separating CA from honeysuckle using melamine–formaldehyde aerogel (MFa) nanomaterial. The synthesis of MFa adsorbent with developed mesoporous material is crucial for achieving high efficiency. The optimal conditions for CA adsorption were determined to be an MFa dose of 0.03 g, a pH value of 3.72, and an adsorption temperature of 18.89 ℃. Under these conditions, a CA adsorption capacity of 151.84 mg/g and an adsorption ratio of 69.58 % were achieved, demonstrating the superior performance of the MFa method. Most notably, the purity of CA improved significantly from 10.50 % to 60.50 %, a marked enhancement improvement over traditional sorption resins. Additionally, the superior antioxidant effect of CA treated with the MFa method was confirmed at both the chemical assay and cytological levels. Affinity analysis and MD simulations revealed that CA adsorption is primarily driven by electrostatic interaction. This study not only addresses current limitations of honeysuckle but also broadens the application pontential of aerogel in food and medicine industries.

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Assymetry of coupling between the P3 and P4 electroencephalographic leads during the motions 3

Assymetry of coupling between the P3 and P4 electroencephalo...

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3rd School on Dynamics of Complex Networks and their Application in Intellectual robotics, DCNAIR 2019

作者： Khorev, Vladimir Zhuravlev, Maksim Borovkova, Ekaterina Ishbulatov, Yuri Gridnev, Vladimir Karavaev, Anatoly Center for Technologies in Robotics and Mechatronics Components Innopolis University Russia Department of Open Systems Physics Saratov State University Russia Department of Dynamic Modeling and Biomedical Engineering Saratov State University Saratov Russia Saratov State University Saratov Branch Institute of RadioEngineering and Electronics Russian Academy of Sciences Saratov State Medical University Named after V. I. Razumovsky Saratov Russia Department of Innovative Cardiological Information Technology Institute of Cardiological Research Saratov State Medical University Saratov Russia Saratov Branch Institute of RadioEngineering and Elecrronics Russian Academy of Sciences Russia

Based on the coupling analysis we analyze electroencephalograms (EEGs) acquired in untrained humans (operators) during real and imaginary movements, and show a difference between the related EEG signals and the record... 详细信息

ISBN: (纸本)9781728124704

关键词： Electroencephalography

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The Cooperative Effects of the Rh-M Dual-Metal Atomic Pairs in Formic Acid Oxidation

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Angewandte Chemie 2025年

作者： Runze Ma Jin Zhang Jiaxin Gong Yunxiang Lin Jialin Zhang Zheng-Qing Huang Chun-Ran Chang Shoujie Liu Wei Zhu Yuxin Wang Ke Zeng Yu Tao Jinhua Hu Zedong Zhang Xiao Liang Yunhu Han Junjie Mao Zechao Zhuang Jun Yan Dingsheng Wang Yu Xiong Department of Chemistry and Chemical Engineering Central South University Changsha 410083 P.R. China Beijing Key Laboratory of Bioinspired Materials and Devices & School of Energy and Power Engineering Beihang University Beijing 100191 P.R. China Institutes of Physical Science and Information Technology School of Materials Science and Engineering Anhui Key Laboratory of Information Materials and Device Key Laboratory of Structure and Functional Regulation of Hybrid Materials Anhui University Hefei Anhui 230601 P.R. China Shaanxi Key Laboratory of Energy Chemical Process Intensification School of Chemical Engineering and Technology Xi'an Jiaotong University Xi'an 710049 P.R. China State Key Lab of Organic–Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P.R. China Department of Chemistry Tsinghua University Beijing 100029 P.R. China Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University Xi'an 710072 P.R. China Key Laboratory of Functional Molecular Solids Ministry of Education College of Chemistry and Materials Science Anhui Normal University Wuhu 241002 P.R. China

The continuously increasing mass activity of precious metal in formic acid oxidation reaction (FAOR) is the key to achieving the practical application of direct formic acid fuel cells (DFAFCs). Herein, Rh-based dual-metal atomic pairs supported on nitrogen-doped carbon catalysts [DAP-(M, Rh)/CN] with adjacent interatomic Rh-M (M = V, Cr, Mn, Fe, Co, Ni, Cu) have been synthesized by a “host-guest” strategy. It is discovered that DAP-(Cr, Rh)/CN shows the highest mass activity of 64.1 A mg −1 , which is 3.8 times higher than that of the single atom Rh catalyst (17.0 A mg −1 ) and two orders of magnitude higher than Pd/C (0.58 A mg −1 ). Interestingly, the mass activity of DAP-(M, Rh)/CN first increases from 11.7 A mg −1 (Rh-V) to 64.1 A mg −1 (Rh-Cr) and then decreases to 21.8 A mg −1 (Rh-Cu), forming a volcano curve of the reaction activity. Density functional theory calculations combined with in situ Fourier transform infrared spectrometer (FTIR) spectra reveal that formic acid oxidized on a series of DAP-(M, Rh)/CN catalysts through the formate route with the subsidiary M metal atoms binding the HCOO species and the Rh atom accepting the H atoms. The most suitable adsorption strength of HCOO on the Cr sites luckily contributes to two spontaneous elementary steps and thus accelerates the FAOR rates.

关键词： Dual-metal atomic pairs Formic acid oxidation Synergistic effect Synthetic strategy

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Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions

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Current Directions in biomedical engineering 2020年第3期6卷

作者： Dierke, Ariane Borowski, Finja Großmann, Swen Brandt-Wunderlich, Christoph Matschegewski, Claudia Rosam, Paula Stiehm, Michael Bock, Andrea Schmitz, Klaus-Peter Siewert, Stefan Pilz, Nico Reister, Paul Schümann, Kerstin Grabow, Niels Einenkel, Rebekka Zygmunt, Marek Hinze, Ulf Chichkov, Boris Keiler, Jonas Wree, Andreas Institute for ImplantTechnology and Biomaterials E.V. Friedrich-Barnewitz-Str. 4 Rostock-Warnemünde 18119 Germany Institute for Implant Technology and Biomaterials E.V. Rostock-Warnemünde 18119 Germany Institute for Biomedical Engineering Rostock University Medical Center Rostock-Warnemünde 18119 Germany Department of Obstetrics and Gynecology University Medicine Greifswald Greifswald 17475 Germany Institute of Quantum Optics Leibniz University Hannover Hannover 30167 Germany Department of Anatomy Rostock University Medical Center Rostock 18057 Germany

Obstructions of the Fallopian tube represent one of the most common reasons for an unfulfilled desire to have children. Microstent technology opens up new therapeutic possibilities to restore the natural lumen of the Fallopian tube within a single treatment. Within the current work we developed a self-expandable biodegradable microstent for gynecological applications. Based on a novel microstent design, prototypes were manufactured from poly-L-lactide tubing by means of fs-laser cutting. Microstent prototypes were characterized morphologically by means of scanning electron microscopy and biaxial laser scanning. As manufactured, a microstents outside diameter of about 2.3 mm and a strut thickness/width of about 114 μm/103 μm was measured. Mechanical characterization of microstents included bending as well as crimping and release behavior. After crimping to a minimum diameter of 0.8 mm and consecutive release, a microstent recovery to a diameter of 1.8 mm was found. Therefore, proof-of-concept for the self-expandable microstent could be successfully provided. © 2020 by Walter de Gruyter Berlin/Boston 2020.

关键词： Scanning electron microscopy

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A Novel Big Data-Enabled Approach, Individualizing and Optimizing Brain Disorder Rehabilitation

Studies in Big Data

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Studies in Big Data 2019年 42卷 101-127页

作者： Janatova, Marketa Uller, Miroslav Stepankova, Olga Brezany, Peter Lenart, Marek Prague Czech Republic Robotics and Machine Perception Department CIIRC CTU Prague Czech Republic Biomedical Engineering and Assistive Technologies Department CIIRC CTU Prague Czech Republic Faculty of Computer Science University of Vienna Vienna Austria SIX Research Group Brno University of Technology Brno Czech Republic

Brain disorders occur when our brain is damaged or negatively influenced by injury, surgery, or health conditions. This chapter shows how the combination of novel biofeedback-based treatments producing large data sets with Big Data and Cloud-Dew Computing paradigms can contribute to the greater good of patients in the context of rehabilitation of balance disorders, a significant category of brain damage impairments. The underlying hypothesis of the presented original research approach is that detailed monitoring and continuous analysis of patient´s physiological data integrated with data captured from other sources helps to optimize the therapy w.r.t. the current needs of the patient, improves the efficiency of the therapeutic process, and prevents patient overstressing during the therapy. In the proposed application model, training built upon two systems, Homebalance—a system enabling balance training and Scope—a system collecting physiological data, is provided both in collaborating rehabilitation centers and at patient homes. The preliminary results are documented using a case study confirming that the approach offers a viable way towards the greater good of a patient. © Springer International Publishing AG, part of Springer Nature 2019.

关键词： Patient rehabilitation

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Chemically Patterning Lithiophilic Interphase to Harmonize Spatial Electrons and Thermal Catalysis Dynamics for Safe Lithium Metal Batteries

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Angewandte Chemie 2025年

作者： Yisha Wang Feng Xu Edison Huixiang Ang Liu Yang Tianyang Cui Haoteng Sun Mingtong Zhang Tianxiang Yang Hanqi Zhang Jixin Zhu Yuan Hu State Key Laboratory of Fire Science University of Science and Technology of China Jin Zhai Road 96 Hefei Anhui 230026 P. R. China Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) Xi'an Institute of Biomedical Materials & Engineering Northwestern Polytechnical University (NPU) 127 West Youyi Road Xi'an 710072 P. R. China Natural Sciences and Science Education National Institute of Education Nanyang Technological University Singapore 637616 Singapore Department of Chemistry Brown University RI 02912 United States

Lithium metal batteries have garnered significant attention as promising energy storage solutions. However, their performance is often compromised by the risks associated with highly active metallic lithium, unrestricted electrode expansion, and excessive dendrites growth. Here we introduce an advanced lithiophilic anode substrate designed by chemically patterning technology for multiple security enhancements. The innovative lithiophilic array harmonizes spatial Li + to prepare compact and reversible electrodes. The composite electrodes feature an enhanced C−F component in the solid-electrolyte interface, which protects the deposited lithium metal from unwanted side reactions, thereby stabilizing electrochemical cycling. Notably, the thermal safety can be revealed through the substrate‘s excellent catalytic ability to convert smoke and toxic gases during extreme thermal runaway. This work demonstrates a novel approach to integrating battery cycling stability with thermal safety, paving the way for more reliable and secure energy storage systems.

关键词： chemically patterning lithiophilic interphase spatial electrons dynamics thermal catalysis dynamics safety lithium metal batteries

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Red-emitting salicylaldehyde Schiff base with AIE behaviour and large Stokes shift

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Chinese Chemical Letters 2018年第10期29卷 1493-1496页

作者： Junyi Gong Peifa Wei Yuanan Su Ying Li Xing Feng Jacky W.Y.Lam Dongzhou Zhang Xiangzhi Song Ben Zhong Tang College of Chemistry and Chemical Engineering Central South University Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionDivision of Life Science and Division of Biomedical EngineeringThe Hong Kong University of Science and Technology Partnership for Extreme Crystallography Hawaii Institute of Geophysiscs and PlanetologyUniversity of Hawaii at Manoa

Three salicylaldehyde Schiff base（SSB）, iso-PBP, PBP and EPB, were facilely synthesized and exhibited aggregation-induced emission. The introduction of C= N-N = C moiety in these SSB dyes largely extend the conjugation system and push their emission to yellow to red spectral region. These SSB dyes were negligibly fluorescent in dilute THF solution. In THF/water mixtures with high water fractions, they displayed strong yellow to red fluorescence（up to 617nm） and large Stokes shifts（up to 152 nm）. Single crystal analysis on EBP showed the longer emission of in aggregated state was attributed to the molecular packing effect as compared with that in dilute solution. The bio-imaging application indicated EBP could specifically accumulate in lipid droplets in living cells.

关键词： Aggregation-induced emission Salicylaldehyde Schiff base Red-emitting ESIPT Aldehyde-amine condensation

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A High-Throughput, Multi-Index Isothermal Amplification Platform for Rapid Detection of 19 Types of Common Respiratory Viruses Including SARS-CoV-2

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engineering 2020年第10期6卷 1275-1286页

作者： Wanli Xing Yingying Liu Huili Wang Shanglin Li Yongping Lin Lei Chen Yan Zhao Shuang Chao Xiaolan Huang Shaolin Ge Tao Deng Tian Zhao Baolian Li Hanbo Wang Lei Wang Yunpeng Song Ronghua Jin Jianxing He Xiuying Zhao Peng Liu Weimin Li Jing Cheng Department of Biomedical Engineering School of MedicineTsinghua UniversityBeijing 100084China National Engineering Research Center for Beijing Biochip Technology Beijing 102206China CapitalBio Technology Beijing 101111China CapitalBio Corporation Beijing 102206China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China Department of Laboratory Medicine First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Neurology West China HospitalSichuan UniversityChengdu 610041China Clinical Laboratory Center Beijing Youan Hospital Capital Medical UniversityBeijing 100069China Department of Pediatrics Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Experiment Center Capital Institute of PediatricsBeijing 100020China President's Office Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department of Cardiothoracic Surgery State Key Laboratory of Respiratory DiseaseChina Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Clinical Laboratory Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

快速、准确地诊断以及及时对感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的患者进行隔离被认为是抗击新冠病毒肺炎(COVID-19)大流行的最有效的措施。本文介绍了一款高通量、多指标的等温扩增检测平台(RTisochip^TM-W),该平台使用离心... 详细信息

快速、准确地诊断以及及时对感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的患者进行隔离被认为是抗击新冠病毒肺炎(COVID-19)大流行的最有效的措施。本文介绍了一款高通量、多指标的等温扩增检测平台(RTisochip^TM-W),该平台使用离心式微流控芯片,在90min内即可完成一次运行,从16个样本中检测出包括SARS-CoV-2在内的19种常见呼吸道病毒。通过RTisochip^TM-W系统检测的所有病毒的检出限均等于或小于50拷贝·μL^-1,与常规逆转录聚合酶链反应(RT-PCR)灵敏度相当。该系统具有重复性好、鲁棒性强和特异性高的优点。最后,使用RTisochip^TM-W系统对201例临床前样本、14例COVID-19阳性临床样本、25例临床确诊样本以及614例来自呼吸道感染或疑似感染的患者的临床样本进行了测试。测试结果与临床诊断结果吻合良好,也反映出呼吸道传染病的流行特征。在对SARS-CoV-2的诊断上,RTisochip^TM-W系统与参考试剂盒的一致性达到98.15%。基于大量的测试结果,我们相信RTisochip^TM-W系统是一款抗击COV ID-19大流行的强有力工具。

关键词： COVID-19 SARS-CoV-2 微流控核酸检测等温扩增

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Author Correction: A comprehensive human embryo reference tool using single-cell RNA-sequencing data

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Nature methods 2025年第3期22卷 636页

作者： Cheng Zhao Alvaro Plaza Reyes John Paul Schell Jere Weltner Nicolás M Ortega Yi Zheng Åsa K Björklund Laura Baqué-Vidal Joonas Sokka Ras Trokovic Brian Cox Janet Rossant Jianping Fu Sophie Petropoulos Fredrik Lanner Department of Clinical Science Intervention and Technology Karolinska Institutet and Division of Obstetrics and Gynecology Karolinska Universitetssjukhuset Stockholm Sweden. Department of Integrative Pathophysiology and Therapy Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER) Seville Spain. Stem Cells and Metabolism Research Program University of Helsinki Helsinki Finland. Folkhälsan Research Center Helsinki Finland. Department of Mechanical Engineering University of Michigan Ann Arbor MI USA. Department of Biomedical and Chemical Engineering Syracuse University Syracuse NY USA. Department of Cell and Molecular Biology National Bioinformatics Infrastructure Sweden Science for Life Laboratory Uppsala University Uppsala Sweden. Department of Physiology Faculty of Medicine University of Toronto Toronto Ontario Canada. Program in Developmental and Stem Cell Biology Hospital for Sick Children Toronto Ontario Canada. Department of Cell and Developmental Biology University of Michigan Medical School Ann Arbor MI USA. Department of Biomedical Engineering University of Michigan Ann Arbor MI USA. Department of Clinical Science Intervention and Technology Karolinska Institutet and Division of Obstetrics and Gynecology Karolinska Universitetssjukhuset Stockholm Sweden. sophie.petropoulos@ki.se. Département de Médecine Université de Montréal Montreal Quebec Canada. sophie.petropoulos@ki.se. Centre de Recherche du Centre Hospitalier de l'Université de Montréal Axe Immunopathologie Montreal Quebec Canada. sophie.petropoulos@ki.se. Department of Clinical Science Intervention and Technology Karolinska Institutet and Division of Obstetrics and Gynecology Karolinska Universitetssjukhuset Stockholm Sweden. fredrik.lanner@ki.se. Ming Wai Lau Center for Reparative Medicine Stockholm Node Karolinska Institutet Stockholm Sweden. fredrik.lanner@ki.se.

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Highly Uniform DNA Monolayers Generated by Freezing-Directed Assembly on Gold Surfaces Enable Robust Electrochemical Sensing in Whole Blood

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Angewandte Chemie 2023年第45期135卷

作者： Zhenglian Li Yanguan Lv Xiaoman Duan Prof. Dr. Biwu Liu Prof. Dr. Yongxi Zhao Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an Shaanxi 710049 P. R. China Department of Clinical Medical Laboratory Affiliated Hospital of Yang Zhou University Medical College Huai'an Maternal and Child Health Care Center Huai'an Jiangsu 223002 P. R. China Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an Shaanxi 710049 P. R. China

Assembling DNA on solid surfaces is fundamental to surface-based DNA technology. However, precise control over DNA conformation and organization at solid–liquid interfaces remains a challenge, resulting in limited stability and sensitivity in biosensing applications. We herein communicate a simple and robust method for creating highly uniform DNA monolayers on gold surfaces by a freeze-thawing process. Using Raman spectroscopy, fluorescent imaging, and square wave voltammetry, we demonstrate that thiolated DNA is concentrated and immobilized on gold surfaces with an upright conformation. Moreover, our results reveal that the freezing-induced DNA surfaces are more uniform, leading to improved DNA stability and target recognition. Lastly, we demonstrate the successful detection of a model drug in undiluted whole blood while mitigating the effects of biofouling. Our work not only provides a simple approach to tailor the DNA-gold surface for biosensors but also sheds light on the unique behavior of DNA oligonucleotides upon freezing on the liquid-solid interface.

关键词： Antifouling Backfilling DNA Aptamer Self-Assembly Biosensors

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