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Altered Resting-State Signals in Patients with Acute Stroke In or Under the Thalamus

Neuroscience Bulletin 2016年第6期32卷 585-590页

作者： Lijun Chen Chuanfu Li Jian Zhai Anqin Wang Qin Song Ying Liu Ru Ma Long Han Yamikani Ndasaukas Xiaoming Li Hai Li Xiaochu Zhang Chinese Academy of Sciences Key Laboratory of Brain Function and Disease and School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026 China Department of Medical Iconography Anhui University of Chinese Medicine Hefei 230031 China Department of Medical Iconography Yijishan Hospital of Wannan Medical College Wuhu 241001 China Department of Medical Iconography Provincial Hospital Affiliated to Anhui Medical University Hefei 230001 China School of Humanities and Social Science University of Science and Technology of China Hefei 230026 China Center of Medical Physics and Technology Hefei Science Center Chinese Academy of Sciences Hefei 230031 China Center for Biomedical Engineering University of Scienceand Technology of China Hefei 230027 China

Abstract Previous studies have suggested that cortical functional reorganization is associated with motor recovery after stroke and that normal afferent sensory information is very important in that process. In this study, we selected patients who had a stroke in or under the thalamus, with potentially impaired afferent sensory information and analyzed the differences between these patients and healthy controls at three levels： brain regions, the functional con- nectivity between brain areas, and the whole-brain func- tional network. Compared with healthy controls, regionalhomogeneities in the left middle temporal gyrus decreased and functional connectivity between the left middle tem- poral gyrus and the stroke area increased in the patients. However, there was no significant change in the whole- brain functional network. By focusing on stroke located in or under the thalamus, our study contributes to wider inquiries into understanding and treating stroke.

关键词： ReHo - Stroke Thalamus - Resting-state

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Impact of Multiple Layers of High-Permittivity Materials on the EM Fields Transmission for Magnetic Resonance Imaging Applications

Impact of Multiple Layers of High-Permittivity Materials on ...

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USNC-URSI Radio Science Meeting (Joint with AP-S Symposium)

作者： Giuseppe Carluccio Daniele Riccio Giuseppe Ruelle Department of Radiology Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging New York University School of Medicine New York NY USA Department of Electrical Engineering and Information Technology University of Napoli Federico II Italy

ISBN: (数字)9789463968119

ISBN: (纸本)9798350359497

High-Permittivity Materials have been used to increase and manipulate the radiofrequency field $\mathrm{B}_{1}$ in Magnetic Resonance Imaging scans. In this work we have explored the possibility to enhance the $\mathrm{B}_{1}$ field even more by using High-Permittivity Pads with different permittivities positioned at different distance from the sample. We have tested this hypothesis by optimizing the permittivity of three layers of a 2D analytical solution, where infinitely long concentric cylinders are excited by a conducting wire. As a result, we have found an increase of the $\mathrm{B}_{1}$ field of about 8% in the center of symmetry of the cylinders.

关键词： Radio frequency Geometry Analytical models Magnetic resonance imaging Conferences Numerical models Wire

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Author Correction: Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum

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Nature cell biology 2025年第2期27卷 370页

作者： Yang Yang Luis A Valencia Chih-Hao Lu Melissa L Nakamoto Ching-Ting Tsai Chun Liu Huaxiao Yang Wei Zhang Zeinab Jahed Wan-Ru Lee Francesca Santoro Jen Liou Joseph C Wu Bianxiao Cui Department of Chemistry Stanford University Stanford CA USA. Wu Tsai Neurosciences Institute and ChEM-H Institute Stanford University Stanford CA USA. Stanford Cardiovascular Institute Stanford University Stanford CA USA. Departments of Physiology and Medicine Medical College of Wisconsin Milwaukee WI USA. Department of Biomedical Engineering University of North Texas Denton TX USA. Department of Chemical and Nano Engineering University of California San Diego San Diego CA USA. Department of Physiology University of Texas Southwestern Medical Center Dallas TX USA. Tissue Electronics Istituto Italiano di Tecnologia Naples Italy. Faculty of Electrical Engineering and Information Technology RWTH Aachen University Aachen Germany. Institute of Biological Information Processing-Bioelectronics (IBI-3) Forschungszentrum Jülich Germany. Department of Medicine Division of Cardiology Stanford University Stanford CA USA. Department of Radiology Stanford University Stanford CA USA. Department of Chemistry Stanford University Stanford CA USA. bcui@stanford.edu. Wu Tsai Neurosciences Institute and ChEM-H Institute Stanford University Stanford CA USA. bcui@stanford.edu.

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Employing texture features of chest x-ray images and machine learning in covid-19 detection and classification

Mendel

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Mendel 2021年第1期27卷 9-17页

作者： Alquran, Hiam Alsleti, Mohammad Alsharif, Roaa Qasmieh, Isam Abu Alqudah, Ali Mohammad Harun, Nor Hazlyna Binti Department of Biomedical Systems and Informatics Engineering Yarmouk University Irbid21163 Jordan The Institute of Biomedical Technology King Hussein Medical Center Royal Jordanian Medical Service Amman11855 Jordan College of applied medical Sciences Radiological Science Program King Saud University Jeddah21435 Saudi Arabia Data Science Research Lab School of Computing Universiti Utara Malaysia Sintok Kedah06010 Malaysia

The novel coronavirus (nCoV-19) was first detected in December 2019. It had spread worldwide and was declared coronavirus disease (COVID-19) pandemic by March 2020. Patients presented with a wide range of symptoms affecting multiple organ systems predominantly the lungs. Severe cases required intensive care unit (ICU) admissions while there were asymptomatic cases as well. Although early detection of the COVID-19 virus by Real-time reverse transcription-polymerase chain reaction (RT-PCR) is effective, it is not efficient;as there can be false negatives, it is time consuming and expensive. To increase the accuracy of in-vivo detection, radiological image-based methods like a simple chest X-ray (CXR) can be utilized. This reduces the false negatives as compared to solely using the RT-PCR technique. This paper employs various image processing techniques besides extracted texture features from the radiological images and feeds them to different artificial intelligence (AI) scenarios to distinguish between normal, pneumonia, and COVID-19 cases. The best scenario is then adopted to build an automated system that can segment the chest region from the acquired image, enhance the segmented region then extract the texture features, and finally, classify it into one of the three classes. The best overall accuracy achieved is 93.1% by exploiting Ensemble classifier. Utilizing radiological data to conform to a machine learning format reduces the detection time and increase the chances of survival. © 2021, Brno University of technology. All rights reserved.

关键词： COVID-19

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Forcefully engaging rods into tulips with gap discrepancy leading to pedicle screw loosening—a biomechanical analysis using long porcine spine segments

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Spine Journal 2024年第9期24卷 1773-1780页

作者： Hsieh, Ming-Kai Lee, De-Mei Chen, Weng-Pin Li, Yun-Da Kao, Fu-Cheng Lin, Yue-Chen Tsai, Tsung-Ting Lai, Po-Liang Tai, Ching-Lung Department of Orthopaedic Surgery Spine Section Bone and Joint Research Center Chang Gung Memorial Hospital and Chang Gung University College of Medicine No. 5 Fushing St. Kweishan Dist. Taoyuan City 33305 Taiwan Department of Mechanical Engineering Chang Gung University No. 259 Wenhua 1st Rd Kweishan Dist Taoyuan City 33302 Taiwan Department of Mechanical Engineering National Taipei University of Technology No. 1 Sec. 3 Zhongxiao E. Rd. Daan Dist. Taipei City 10608 Taiwan Department of Biomedical Engineering Chang Gung University No. 259 Wenhua 1st Rd Kweishan Dist Taoyuan City 33302 Taiwan

BACKGROUND CONTEXT: Long-segment pedicle screw instrumentation is widely used to treat complex spinal disorders. Rods are routinely precontoured to maximize assistance on the correcting side of the deformity, but there often exists a residual gap discrepancy between the precontoured rods and screw tulips. No previous research has investigated the diminished pullout strength of the most proximal or distal pedicle screw resulting from a mismatched rod in long-segment pedicle screw instrumentation. PURPOSE: The present study aimed to investigate the decreased pullout force of pedicle screws affected by the gap discrepancy when forcefully engaging a mismatched rod into a tulip in a normal-density porcine spine. STUDY DESIGN: The pedicle screw fixation strength under axial pullout force was compared among three different gap discrepancies between rods and tulips using long porcine spine segments. METHODS: Twelve porcine lumbar vertebrae (L3–L6) were implanted with pedicle screws and rods. Screws on one side had no gap between the tulip and rod (0-mm group), while the most proximal screw on the other side had an intentional gap of 3 mm (3-mm group) or 6 mm (6-mm group). Three hours after forcefully engaging the rod into the tulips at room temperature, the set screws in all specimens were loosened, and each specimen was dissected into individual vertebrae for subsequent pullout testing. RESULTS: The control group exhibited significantly greater pullout strength (1987.68 ± 126.80 N) than the groups from different rod-tulip configurations (p<.05), with significantly greater strength in the 3-mm group (945.62 ± 97.43 N) than the 6-mm group (655.30 ± 194.49 N) (p<.05). Only 47.6% and 33.0% of the pullout strength was retained in the 3-mm and 6-mm groups, respectively, compared to the control group. CONCLUSIONS: Gap discrepancies between rods and tulips can significantly reduce pedicle screw pullout strength, with a correlation between decreased strength and increased gaps. Sur

关键词： Gap discrepancies between rods and tulips Multilevel spinal fusion Pedicle screw Porcine model Rod contouring Screw pullout test

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Computational prediction and validation of specific EmbR binding site on PknH

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Synthetic and Systems Biotechnology 2021年第4期6卷 429-436页

作者： Insung Na Huanqin Dai Hantian Li Anvita Gupta David Kreda Powell Zhang Xiangyin Chen Lixin Zhang Gil Alterovitz Computational Health Informatics Program Boston Children’s Hospital/Harvard Medical SchoolBostonMA 02115USA Department of Medicine Brigham and Women’s Hospital/Harvard Medical SchoolBostonMA 02115USA State Key Laboratory of Mycology Institute of MicrobiologyBeijing100101 China Department of Computer Sciences Stanford UniversityStanford CA 94305USA Center for Biomedical Informatics Harvard Medical SchoolBostonMA 02115USA State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghaiChina Department of Biology The Johns Hopkins UniversityBaltimoreMD 21218USA Lexington High School BostonMA 02115USA

Tuberculosis drug resistance continues to threaten global health but the underline molecular mechanisms are not ***(EMB),one of the well-known first-line drugs in tuberculosis treatment is,unfortunately,not free from drug resistance *** studies have shown that some genetic mutations in Mycobacterium tuberculosis(Mtb)EmbR,and EmbC/A/B genes cause EMB ***-PknH pair controls embC/A/B operon,which encodes EmbC/A/B genes,and EMB interacts with EmbA/B ***,the EmbR binding site on PknH was *** conducted molecular simulation on the EmbR-peptides binding structures and discovered phosphorylated PknH 273-280(N′-HEALS^(P)DPD-C′)makesβstrand with the EmbR FHA domain,asβ-MoRF(MoRF;molecular recognition feature)does at its binding *** bond number analysis also supported the peptides’β-MoRF forming activity at the EmbR FHA ***,we discovered that previously known phosphorylation residues might have their chronological order according to the phosphorylation *** discovery validated that Mtb PknH 273-280(N′-HEALSDPD-C′)has reliable EmbR binding *** approach is revolutionary in the computer-aided drug discovery field,because it is the first trial to discover the protein-protein interaction site,and find binding partner in nature from this site.

关键词： Disorder-to-order transition Protein intrinsic disorder Binding site prediction Drug resistance Molecular simulation

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Using machine learning for clustering the IMU data of patients with sagittal imbalance of the spine

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Gait & Posture 2024年 113卷 192-193页

作者： Sadegh Madadi Mostafa Rostami Hadi Farahni Farshad Nikouee Ram Haddas Mohammad Samadian Amirkabir University of Technology Faculty Biomedical Engineering Tehran Iran Islamic Republic of Amirkabir University of Technology Faculty of Biomedical Engineering Tehran Iran Islamic Republic of Shahid Beheshti University Department of Computer and Data Sciences- Faculty of Mathematical Sciences Tehran Iran Islamic Republic of Iran University of Medical Sciences Bone and Joint Reconstruction Research Center- Shafa Orthopedic Hospital Tehran Iran Islamic Republic of Texas Back Institute University of Rochester Medical Center- Rochester Plano- TX USA Shahid Beheshti University of Medical Sciences Department of Neurosurgery Tehran Iran Islamic Republic of

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Hydrogen-treated CoCrMo alloy: a novel approach to enhance biocompatibility and mitigate inflammation in orthopedic implants

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Journal of Materials Chemistry B 2024年第32期12卷 7814-7825页

作者： Lin, Yu-Chien Hu, Chih-Chien Liu, Wai-Ching Dhawan, Udesh Chen, Yu-Chieh Lee, Yueh-Lien Yen, Hung-Wei Kuo, Yi-Jie Chung, Ren-Jei Department of Chemical Engineering and Biotechnology National Taipei University of Technology (Taipei Tech) No. 1 Sec. 3 Zhongxiao E. Rd. Taipei 10608 Taiwan School of Materials Science and Engineering Nanyang Technological University Singapore Singapore Bone and Joint Research Center Chang Gung Memorial Hospital Linko Taiwan Department of Orthopaedic Surgery Chang Gung Memorial Hospital Linko Taiwan College of Medicine Chang Gung University Taoyuan Taiwan Department of Food and Health Sciences Technological and Higher Education Institute of Hong Kong New Territories Hong Kong Centre for the Cellular Microenvironment Division of Biomedical Engineering James Watt School of Engineering Mazumdar-Shaw Advanced Research Centre University of Glasgow Glasgow United Kingdom Department of Engineering Science and Ocean Engineering National Taiwan University Taipei Taiwan Department of Materials Science and Engineering National Taiwan University Taipei Taiwan Department of Orthopedic Surgery Wan Fang Hospital Taipei Medical University Taipei Taiwan Department of Orthopedic Surgery School of Medicine College of Medicine Taipei Medical University Taipei Taiwan High-value Biomaterials Research and Commercialization Center National Taipei University of Technology (Taipei Tech) Taipei 10608 Taiwan

In recent decades, orthopedic implants have been widely used as materials to replace human bone tissue functions. Among these, metal implants play a crucial role. Metals with better chemical stability, such as stainless steel, titanium alloys, and cobalt-chromium-molybdenum (CoCrMo) alloy, are commonly used for long-term applications. However, good chemical stability can result in poor tissue integration between the tissue and the implant, leading to potential inflammation risks. This study creates hydrogenated CoCrMo (H-CoCrMo) surfaces, which have shown promise as anti-inflammatory orthopedic implants. Using the electrochemical cathodic hydrogen-charging method, the surface of the CoCrMo alloy was hydrogenated, resulting in improved biocompatibility, reduced free radicals, and an anti-inflammatory response. Hydrogen diffusion to a depth of approximately 106 ± 27 nm on the surface facilitated these effects. This hydrogen-rich surface demonstrated a reduction of 85.2% in free radicals, enhanced hydrophilicity as evidenced by a decrease in a contact angle from 83.5 ± 1.9° to 52.4 ± 2.2°, and an increase of 11.4% in hydroxyapatite deposition surface coverage. The cell study results revealed a suppression of osteosarcoma cell activity to 50.8 ± 2.9%. Finally, the in vivo test suggested the promotion of new bone formation and a reduced inflammatory response. These findings suggest that electrochemical hydrogen charging can effectively modify CoCrMo surfaces, offering a potential solution for improving orthopedic implant outcomes through anti-inflammatory mechanisms. © 2024 The Royal Society of Chemistry.

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Expert consensus on irrigation and intracanal medication in root canal therapy

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International Journal of Oral Science 2024年第1期16卷 26-35页

作者： Xiaoying Zou Xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Center of Stomatology Peking University HospitalBeijingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Emergency Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Restorative Dental Sciences EndodonticsFaculty of DentistryThe University of Hong KongPok Fu LamHong Kong SARChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanChina Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Clinical Research Center for Oral DiseasesNational Center for StomatologyShanghai Key Laboratory of StomatologyShanghaiChina Department of Operative Dentistry and Endodontics Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen University&Guangdong Provincial Key Laboratory of StomatologyGuangzhouChina State Key Laboratory of Oral&Maxillofacial Reconstruction and R

Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes.

关键词： treatment irrigation Expert

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A knowledge-based mediator for dynamic integration of heterogeneous multimedia information sources

A knowledge-based mediator for dynamic integration of hetero...

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International Symposium on Intelligent Multimedia, Video and Speech Processing

作者： Peng Gong Yu.S. Lim D. Feng Biomedical and Multimedia Information Technology (BMIT) Group School of Information Technologies University of Sydney NSW Australia Center for Multimedia Signal Processing (CMSP) Department of Electronic & Information Engineering Hong Kong Polytechnic University Hong Kong China

To facilitate the efficient and accurate access and operation of a huge amount of multimedia information from various data sources, we propose a mediator to integrate heterogeneous multimedia information sources and their corresponding data operation API dynamically. To achieve this purpose, a reflection technique is adopted to extract heterogeneous API features at run time; a classifier component is designed to obtain global API features; and an ontology mechanism is used for hiding information heterogeneity. Ultimately, by using the proposed mediator, a global knowledge-based multimedia information API is produced, which makes multimedia applications and Web applications "understand" and operate heterogeneous information automatically and transparently. The proposed mediator provides multimedia applications with a unified interface for information operation and facilitates communication and interoperation between disparate multimedia applications.

关键词： Ontologies Data mining Information technology Feature extraction Reflection Signal processing Data engineering Internet Multimedia databases Warehousing

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