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Experimental observation of Arnold tongues in the analysis of the signal from contour of the autonomous regulation of heart rate and respiration 3

Experimental observation of Arnold tongues in the analysis o...

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3rd School on Dynamics of Complex Networks and their Application in Intellectual robotics, DCNAIR 2019

作者： Borovkova, Ekaterina I. Chernets, Elena P. Ishbulatov, Yurii M. Skazkina, Viktoriia V. Gridnev, Vladimir I. Mironov, Sergey A. Karavaev, Anatoly S. Laboratory of Nonlinear Dynamics Modelling Saratov Branch Institute of RadioEngineering and Electronics Russian Academy of Sciences Saratov Russia Department of Innovative Cardiological Information Technology Institute of Cardiological Research Saratov State Medical University Saratov Russia Department of Dynamic Modeling and Biomedical Engineering Saratov State University Saratov Russia Department of Surgical Treatment for Interactive Pathology A.N. Bakulev National Medical Research Center of Cardiovascular Surgery Moscow Russia

ISBN: (纸本)9781728124704

We proposed a method of experimental observation of the Arnold tongues in the study of the synchronization of the contours of autonomic regulation of the heart rate with a characteristic frequency of about 0.1 Hz and respiration. The formulation of a special active experiment made it possible to determine the boundaries of synchronization tongues in 3 subjects. The method allows noninvasive research. The basic idea is to influence the contours of heart rate regulation with a respiratory signal, which has respiratory frequency varying linearly about 0.1 Hz according to the sound signal generated by a special device. The amplitude of the breath is changed by the subjects at the command of the researcher. The study is important for understanding the features of complex multichannel systems of biological nature and their mathematical modeling. © 2019 IEEE.

关键词： Synchronization

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Phase-Separated Multienzyme Compartmentalization for Terpene Biosynthesis in a Prokaryote

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Angewandte Chemie 2022年第29期134卷

作者： Yue Wang Min Liu Qixin Wei Wanjie Wu Yanping He Jiayang Gao Renjie Zhou Liwen Jiang Jianan Qu Jiang Xia Department of Chemistry and Center for Cell & Developmental Biology The Chinese University of Hong Kong Shatin Hong Kong SAR China Departments of Electronic and Computer Engineering Center of Systems Biology and Human Health School of Science and Institute for Advanced Study Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong SAR China Department of Biomedical Engineering The Chinese University of Hong Kong Shatin Hong Kong SAR China Center for Cell & Developmental Biology School of Life Sciences State Key Laboratory of Agrobiotechnology The Chinese University of Hong Kong Shatin Hong Kong SAR China

Liquid–liquid phase separation (LLPS) forms biomolecular condensates or coacervates in cells. Metabolic enzymes can form phase-separated subcellular compartments that enrich enzymes, cofactors, and substrates. Herein, we report the construction of synthetic multienzyme condensates that catalyze the biosynthesis of a terpene, α-farnesene, in the prokaryote E. coli . RGGRGG derived from LAF-1 was used as the scaffold protein to form the condensates by LLPS. Multienzyme condensates were then formed by assembling two enzymes Idi and IspA through an RIAD/RIDD interaction. Multienzyme condensates constructed inside E. coli cells compartmentalized the cytosolic space into regions of high and low enzyme density and led to a significant enhancement of α-farnesene production. This work demonstrates LLPS-driven compartmentalization of the cytosolic space of prokaryotic cells, condensation of a biosynthetic pathway, and enhancement of the biosynthesis of α-farnesene.

关键词： α-Farnesene Multienzyme Catalysis Multienzyme Compartmentalization Phase Separation Terpene Biosynthesis

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Correction to: Fabrication of Three-Dimensional Bioactive Composite Scaffolds for Hemostasis and Wound Healing

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AAPS PharmSciTech 2022年第5期23卷 162页

作者： Divya Tripathi Arpit Sharma Priyanka Tyagi Chandra Shekhar Beniwal Gaurav Mittal Abhinav Jamini Harpal Singh Amit Tyagi Divison of Combat Sciences Institute of Nuclear Medicine and Allied Sciences DRDO Delhi 110054 India. Center for Biomedical Engineering Indian Institute of Technology New Delhi 110016 India. Department of Basic and Applied Sciences School of Engineering and Sciences G.D. Goenka University Gurugram Haryana 122103 India. Divison of Combat Sciences Institute of Nuclear Medicine and Allied Sciences DRDO Delhi 110054 India. amityagi@***.

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The Application of Microfluidic Chips in Primary Urological Cancer: Recent Advances and Future Perspectives

Smart medicine

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Smart medicine 2025年第2期4卷 e70010页

作者： Jiafu Liu Xiao Zhi Xiaolan Fang Wenyao Li Weixin Zhao Meng Liu Enping Lai Wenzhuo Fang Juan Wang Yu Zheng Jiang Zou Qiang Fu Wenguo Cui Kaile Zhang Department of Urology Affiliated Sixth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China. School of Materials Science and Engineering Shanghai University of Engineering Science Shanghai China. Institute for Personalized Medicine School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China. National Engineering Research Center for Nanotechnology Shanghai China. Department of Pathology Henry Ford Hospital Detroit Michigan USA. Wake Forest Institute for Regenerative Medicine Winston-Salem North Carolina USA. Guangxi Key Laboratory of Green Processing of Sugar Resources College of Biological and Chemical Engineering Guangxi University of Science and Technology Liuzhou China. Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China. School of Mechanical Engineering Shanghai Jiao Tong University Shanghai China. State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai China.

The research of primary urological cancers, including bladder cancer (BCa), prostate cancer (PCa), and renal cancer (RCa), has developed rapidly. Microfluidic technology provides a good variety of benefits compared to the heterogeneity of animal models and potential ethical issues of human study. Microfluidic technology and its application with cell culture (e.g., organ-on-a-chip, OOC) are extensively used in urological cancer studies in preclinical and clinical settings. The application has provided diagnostic and therapeutic benefits for patients with urological diseases, especially by evaluating biomarkers for urinary malignancies. In this review, we go through the applications of OOC in BCa, Pca and Rca, and discuss the prospects of reducing the cost and improving the repeatability and amicability of the intelligent integration of urinary system organ chips.

关键词： in vitro model microfluidic technology organ‐on‐a‐chip urological cancer

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Corrigendum to "Illudin S inhibits p53-Mdm2 interaction for anticancer efficacy in colorectal cancer" [Biomed. Pharmacother. 182 (2025) 117795]

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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025年 183卷 117810页

作者： Yoonsuk Lee Yun Young Lee Jinyoung Park Anna Maksakova Donghyuk Seo Jisun Kim Ji Eun Yeom Yewon Kim Cheol-Hwi Kim Rhim Ryoo Se-Na Kim Juwon Park Wooram Park Tae-Hyung Kim Young Bin Choy Chun Gwon Park Ki Hyun Kim Wonhwa Lee Department of Chemistry Sungkyunkwan University Suwon 16419 Republic of Korea School of Pharmacy Sungkyunkwan University Suwon 16419 Republic of Korea. Department of Biomedical Engineering Institute for Cross-disciplinary Studies Sungkyunkwan University Suwon 16419 Republic of Korea Department of Biomedical Engineering Seoul National University College of Medicine Seoul 03080 Republic of Korea. Department of Chemistry Sungkyunkwan University Suwon 16419 Republic of Korea. Department of Intelligent Precision Healthcare Convergence Institute for Cross-disciplinary Studies Sungkyunkwan University Suwon 16419 Republic of Korea. Special Forest Products Division Forest Bioresources Department National Institute of Forest Science Suwon 16631 Republic of Korea. Research and Development Center MediArk Inc. Cheongju 28644 Republic of Korea. Department of Tropical Medicine Medical Microbiology and Pharmacology John A. Burns School Medicine University of Hawaii at Manoa Honolulu HI 96813 USA. Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University Suwon 16419 Republic of Korea. Department of Intelligent Precision Healthcare Convergence Institute for Cross-disciplinary Studies Sungkyunkwan University Suwon 16419 Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology 5 Hwarang 14 Seongbuk Seoul 02792 Republic of Korea. Electronic address: chunpark@skku.edu. School of Pharmacy Sungkyunkwan University Suwon 16419 Republic of Korea. Electronic address: khkim83@skku.edu. Department of Chemistry Sungkyunkwan University Suwon 16419 Republic of Korea. Electronic address: wonhwalee@skku.edu.

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Emotional Expressions Reconsidered: Challenges to Inferring Emotion From Human Facial Movements (vol 20, pg 1, 2019)

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PSYCHOLOGICAL SCIENCE IN THE PUBLIC INTEREST 2019年第3期20卷 165-166页

作者： Barrett, L. F. Adolphs, R. Marsella, S. Martinez, A. M. Pollak, S. D. 1 Department of Psychology Northeastern University. 2 Department of Psychiatry Massachusetts General Hospital Boston Massachusetts. 3 Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Boston Massachusetts. 4 Division of Humanities and Social Sciences California Institute of Technology. 5 College of Computer and Information Science Northeastern University. 6 Institute of Neuroscience & Psychology University of Glasgow. 7 Department of Electrical and Computer Engineering and Center for Cognitive and Brain Sciences The Ohio State University. 8 Department of Psychology University of Wisconsin-Madison.

It is commonly assumed that a person's emotional state can be readily inferred from his or her facial movements, typically called or . This assumption influences legal judgments, policy decisions, national security protocols, and educational practices; guides the diagnosis and treatment of psychiatric illness, as well as the development of commercial applications; and pervades everyday social interactions as well as research in other scientific fields such as artificial intelligence, neuroscience, and computer vision. In this article, we survey examples of this widespread assumption, which we refer to as the , and we then examine the scientific evidence that tests this view, focusing on the six most popular emotion categories used by consumers of emotion research: anger, disgust, fear, happiness, sadness, and surprise. The available scientific evidence suggests that people do sometimes smile when happy, frown when sad, scowl when angry, and so on, as proposed by the common view, more than what would be expected by chance. Yet how people communicate anger, disgust, fear, happiness, sadness, and surprise varies substantially across cultures, situations, and even across people within a single situation. Furthermore, similar configurations of facial movements variably express instances of more than one emotion category. In fact, a given configuration of facial movements, such as a scowl, often communicates something other than an emotional state. Scientists agree that facial movements convey a range of information and are important for social communication, emotional or otherwise. But our review suggests an urgent need for research that examines how people move their faces to express emotions and other social information in the variety of contexts that make up everyday life, as well as careful study of the mechanisms by which people perceive instances of emotion in one another. We make specific research recommendations that will yield a more valid picture of how peopl

关键词： emotion perception emotion recognition emotional expression

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Field-portable quantitative lensless microscopy based on translated speckle illumination and sub-sampled ptychographic phase retrieval

arXiv

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arXiv 2019年

作者： Zhang, He Bian, Zichao Jiang, Shaowei Liu, Jian Song, Pengming Zheng, Guoan Ultra-Precision Optoelectronic Instrument Engineering Center Harbin Institute of Technology Harbin150001 China Department of Biomedical Engineering University of Connecticut StorrsCT06269 United States Department of Electrical and Computer Engineering University of Connecticut StorrsCT06269 United States

We report a compact, cost-effective and field-portable lensless imaging platform for quantitative microscopy. In this platform, the object is placed on top of an image sensor chip without using any lens. We use a low-cost galvo scanner to rapidly scan an unknown laser speckle pattern on the object. To address the positioning repeatability and accuracy issues, we directly recover the positional shifts of the speckle pattern based on the phase correlation of the captured images. To bypass the resolution limit set by the imager pixel size, we employ a sub-sampled ptychographic phase retrieval process to recover the complex object. We validate our approach using a resolution target, a phase target, and a biological sample. Our results show that accurate, high-quality complex images can be obtained from a lensless dataset with as few as ~10 images. We also demonstrate the reported approach to achieve a 6.4 mm by 4.6 mm field of view and a half pitch resolution of 1 µm. The reported approach may provide a quantitative lensless imaging strategy for addressing point-of-care, global-health and telemedicine related challenges. Copyright © 2019, The Authors. All rights reserved.

关键词： Cost effectiveness

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Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine)Surface engineering Strategy

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研究（英文） 2020年第4期 479-498页

作者： Ying Yang Peng Gao Juan Wang Qiufen Tu Long Bai Kaiqin Xiong Hua Qiu Xin Zhao Manfred F.Maitz Huaiyu Wang Xiangyang Li Qiang Zhao Yin Xiao Nan Huang Zhilu Yang Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong University Chengdu 610031 China Institute of Health and Biomedical Innovation Queensland University of Technology Brisbane 4059 Australia Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of TechnologyBrisbane Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong University Chengdu 610031 China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong University Chengdu 610031 China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong University Chengdu 610031 China Institute of Health and Biomedical Innovation Queensland University of Technology Brisbane 4059 Australia Australia-China Centre for Tissue Engineering and Regenerative Medicine Queensland University of TechnologyBrisbane 4059 Australia Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong University Chengdu 610031 China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong University Chengdu 610031 China Department of Biomedical Engineering The Hong Kong Polytechnic University Hung Horn Kowloon Hong Kong China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong University Chengdu 610031 China Max Bergmann Center of Biomaterials Leibniz Institute of Polymer Research Dresden Hohe Strasse 6 01069 Dresden Germany institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy Institute of Biomedi

Stenting is currently the major therapeutic treatment for cardiovascular ***,the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response,thrombogenic reactions,smooth muscle cell hyperproliferation accompanied by the delayed arterial healing,and poor reendothelialization,thus leading to restenosis along with late stent *** address prevalence critical problems,we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal(copper)-catechol-(amine)(MCA)surface chemistry strategy,leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface *** from the stable nitric oxide(NO)generating rate at the physiological level(2.2×10-10 mol/cm2/min lasting for 60 days),this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to～1 μg/cm2,which is considerably higher than most of the conventional heparinized *** resultant coating could create an ideal microenvironment for bringing in enhanced anti-thrombogenicity,anti-inflammation,anti-proliferation of smooth muscle cells,re-endothelialization by regulating relevant gene expressions,hence preventing restenosis in *** envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis.

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Correction: Endothelial cell-derived exosomes boost and maintain repair-related phenotypes of Schwann cells via miR199-5p to promote nerve regeneration

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Journal of nanobiotechnology 2024年第1期22卷 81页

作者： Jinsheng Huang Geyi Zhang Senrui Li Jiangnan Li Wengang Wang Jiajia Xue Yuanyi Wang Mengyuan Fang Nan Zhou Department of Orthopedics The First Affiliated Hospital of Zhengzhou University No. 1 Jianshe East Road Zhengzhou 450052 Henan China. State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing China. Department of Spinal Surgery The First Hospital of Jilin University Jilin Engineering Research Center For Spine and Spinal Cord Injury 1 Xinmin St Changchun 130021 China. wangyuanyi@***. Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University No. 1 Jianshe East Road Zhengzhou 450052 Henan China. fccfangmy@***. Department of Orthopedics The First Affiliated Hospital of Zhengzhou University No. 1 Jianshe East Road Zhengzhou 450052 Henan China. fcczhoun@***.

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Development of cultivated fish meat: Advances in cellular agriculture, biomaterials, and scaffolding techniques

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Trends in Food Science and technology 2025年 162卷

作者： Kang, Hyeong Seok Bang, Seojoon Lee, Hyun Moon, Chan Ho Gwon, Ju Yeong Seo, Jong Hwa Cha, Gi Doo Lee, Dae-Hee Lee, Ki-Young Hwang, Heeyoun Yoo, Ki Hyun Kim, Joo Yun Kang, Heemin Lee, Soo-Hong Park, Hee Ho Lee, Dong Yun Jung, Hyun-Do Division of Materials Science and Engineering Hanyang University Seoul04763 Korea Republic of Research Institute of Intelligent Manufacturing & Materials Technology Korea Institute of Industrial Technology 156 Gaetbeol-ro Yeonsu-gu Incheon21999 Korea Republic of Department of Bioengineering Hanyang University Seoul04763 Korea Republic of Department of Systems Biotechnology Chung-Ang University Gyeonggi-do Anseong-si17546 Korea Republic of Department of Marine Bio Food Science Gangneung-Wonju National University Gangneung Gangwon-Do 25457 Korea Republic of Department of Marine Biology Kunsan National University Gunsan54150 Korea Republic of Digital OMICs Research Center Korea Basic Science Institute Cheongju28119 Korea Republic of SIMPLE Planet Inc. Seoul04790 Korea Republic of R&BD Center hy Co. Ltd. 22 Giheungdanji-ro 24 Beon-gil Giheung-gu Yongin-si17086 Korea Republic of Department of Materials Science and Engineering Korea University Seoul02841 Korea Republic of College of Medicine Korea University Seoul02841 Korea Republic of Department of Biomedical Engineering Dongguk University Seoul04620 Korea Republic of Department of Biotechnology College of Life Sciences and Biotechnology Korea University Seoul02841 Korea Republic of

Background: Global demand for fish protein is rising amid the depletion of wild fish stocks and the environmental impact of aquaculture, driving the need for sustainable alternatives. Cultivated fish meat, produced via tissue engineering techniques, shows promise for addressing overfishing and contamination concerns while ensuring high-quality protein. Scope and approach: This review examines key elements of cultivated fish meat production. We analyze suitable cell types, including pluripotent stem cells and muscle satellite cells, and explore plant- and animal-derived biomaterials that mimic fish-specific extracellular matrices. Scaffold fabrication strategies—molding, 3D printing, and microcarriers—are evaluated for their effectiveness in fostering cell adhesion, proliferation, and differentiation. Additionally, we discuss the challenges and prospects of scaling production, particularly bioreactor optimization, cost-effective culture media, and regulatory considerations. Key findings and conclusions: Plant- and animal-based scaffolds can closely replicate fish muscle architecture, thereby enhancing cellular growth and tissue organization. Emerging techniques, such as dynamic scaffolds and AI-guided precision fabrication, further refine texture and nutritional profiles. Overcoming market barriers requires transparent communication of cultivated fish meat's environmental and health benefits, alongside rigorous regulatory frameworks to ensure safety and quality. Future progress hinges on collaborative efforts among governments, industries, and research institutions to standardize manufacturing protocols and promote public acceptance. If these challenges are met, cultivated fish meat could significantly reduce overfishing, lower greenhouse gas emissions, and offer a viable route toward global food security. © 2025 Elsevier Ltd

关键词： Fiber bonding

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