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Annual International Conference of the IEEE engineering in Medicine and Biology Society (EMBC)

作者： Ivana Labounková René Labounek Jan Odstrčilík Michal Hracho Igor Nestrašil Ralf P. Tornow Radim Kolář Department of Biomedical Engineering Brno University of Technology Brno Czech Republic Department of Neurology Palacký University in Olomouc Czech Republic Department of Pediatrics and Center for Magnetic Resonance Research University of Minnesota MN USA Department of Ophthalmology Friedrich-Alexander University of Erlangen-Nuremberg Erlangen Germany

Optical imaging of retinal hemodynamic function is an important part of ophthalmologic research. Development and inventing of imaging devices and data analysis methods are both just in progress. The current study innovatively implements two blind source separation (BSS) techniques (i.e. spatial Principal Component Analysis - sPCA; and spatial Independent Component Analysis - sICA) in application of an automatic detection and segmentation of a distinct Optic Disc (OD) areas with different hemodynamic properties from a simultaneous binocular video-ophthalmoscopic records. Both methods detected 3 different spatial patterns mostly symmetric over both eyes stable and reproducible over investigated participants, i.e. central Spontaneous Vessel Pulsations (SVPs), inner OD intensity pulsations and other OD pulsations. Dynamics of all mentioned patterns has a periodic character with similar main frequency (possibly corresponding to subject-specific heart rate) but shifted phase decreasing patterns' mutual high cross-correlations. The sICA estimates a higher rate of phase shifts than sPCA.

关键词： Retina Hemodynamics Principal component analysis Optical imaging Correlation Diseases

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Surface modification of materials by plasma process and UV-induced grafted polymerization for biomedical applications

Shinku/Journal of the Vacuum Society of Japan

引用

Shinku/Journal of the Vacuum Society of Japan 2007年第10期50卷 609-614页

作者： Chen, Ko-Shao Chen, Su-Chen Lien, Wei-Cheng Tsai, Jui-Che Ku, Yuan-An Lin, Hong-Ru Lin, Feng-Huei Wu, Tei-Hsing Chen, Chia-Chieh Chen, Tim-Mo Chiou, Shih-Hwa Department of Materials Engineering Tatung University Taiwan Department of Raw Materials and Yarn Formation Taiwan Textile Research Institute Taiwan Department of Chemical Engineering National Tsing-Hua University Hsinchu Taiwan Department of Biomedical Engineering I-SHOU University Kaohsiung Taiwan Department of Product Development Taiwan Textile Research Institute Taiwan Southern Taiwan University of Technology Tainan Taiwan Inst. of Biomedical Eng. College of Medicine National Taiwan University Atomic Energy Council Taiwan Burn Center Department of Surgery Tri-service General Hospital Taiwan Department of Ophthalmology Taipei Veterans General Hospital Taipei Taiwan

Surface modification using plasma treated and graft polymerization is versatile process, with systems on the market capable of treating everything from polymer, metal, and ceramic substrates. The major advantage is that the modification is caused no substrate damage or bulk property changes. This is a very effective method to modify the surfaces of biomaterials to achieve desired physical or mechanical properties, or to induce a specific response when the device is placed in the body. They offer attractive possibilities for developing new biomaterials and for improving the performance of existing materials and devices. Hence, in this review, we describe the application of plasma treatment and graft polymerization on biomaterials field. The various applications are discussed in the following: (1) easy stripped-off wound dressing, (2) porous three-dimensional temporary scaffolds, (3) quartz crystal microbalance (QCM) base biosensors, and (4) covalent immobilization of glucose oxidase onto inorganic substrates.

关键词： Biomaterials

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CG-SENSE revisited: Results from the first ISMRM reproducibility challenge

arXiv

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arXiv 2020年

作者： Maier, Oliver Baete, Steven H. Fyrdahl, Alexander Hammernik, Kerstin Harrevelt, Seb Kasper, Lars Karakuzu, Agah Loecher, Michael Patzig, Franz Tian, Ye Wang, Ke Gallichan, Daniel Uecker, Martin Knoll, Florian Institute of Medical Engineering Graz University of Technology Graz Austria Center for Biomedical Imaging New York University School of Medicine New YorkNY United States Department of Clinical Physiology Karolinska University Hospital Karolinska Institutet Stockholm Sweden Department of Computing Imperial College London London United Kingdom Institute of Computer Graphics and Vision Graz University of Technology Graz Austria Department of Biomedical Engineering Eindhoven University of Technology Eindhoven Netherlands Institute for Biomedical Engineering ETH Zurich University of Zurich Zurich Switzerland Translational Neuromodeling Unit Institute for Biomedical Engineering University of Zurich ETH Zurich Zurich Switzerland NeuroPoly Lab Institute of Biomedical Engineering Polytechnique Montréal Montréal Canada Department of Radiology Stanford University StanfordCA United States Department of Radiology and Imaging Sciences University of Utah Salt Lake CityUT United States Ming Hsieh Department of Electrical and Computer Engineering Viterbi School of Engineering University of Southern California Los AngelesCA United States Department of Electrical Engineering and Computer Sciences University of California Berkeley BerkeleyCA United States Cardiff University Brain Research Imaging Centre Cardiff United Kingdom Institute for Diagnostic and Interventional Radiology University Medical Center Göttingen Göttingen Germany Germany University of Göttingen Germany University of Göttingen Germany

Purpose The aim of this work is to shed light on the issue of reproducibility in MR image reconstruction in the context of a challenge. Participants had to recreate the results of "Advances in sensitivity encoding with arbitrary k-space trajectories" by Pruessmann et al. Methods The task of the challenge was to reconstruct radially acquired multi-coil k-space data (brain/heart) following the method in the original paper, reproducing its key figures. Results were compared to consolidated reference implementations created after the challenge, accounting for the two most common programming languages used in the submissions (Matlab/Python). Results Visually, differences between submissions were small. Pixel-wise differences originated from image orientation, assumed field-of-view or resolution. The reference implementations were in good agreement, both visually and in terms of image similarity metrics. Discussion and Conclusion While the description level of the published algorithm enabled participants to reproduce CG-SENSE in general, details of the implementation varied, e.g., density compensation or Tikhonov regularization. Implicit assumptions about the data lead to further differences, emphasizing the importance of sufficient meta-data accompanying open data sets. Defining reproducibility quantitatively turned out to be non-trivial for this image reconstruction challenge, in the absence of ground-truth results. Typical similarity measures like NMSE of SSIM were misled by image intensity scaling and outlier pixels. Thus, to facilitate reproducibility, researchers are encouraged to publish code and data alongside the original paper. Future methodological papers on MR image reconstruction might benefit from the consolidated reference implementations of CG-SENSE presented here, as a benchmark for methods comparison. Copyright © 2020, The Authors. All rights reserved.

关键词： Magnetic resonance imaging

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Retraction of lumbar disc herniation achieved by noninvasive techniques: A case report

引用

World Journal of Clinical Cases 2021年第27期9卷 8082-8089页

作者： Ping Wang Cai Chen Qing-Hao Zhang Guo-Dong Sun Cong-An Wang Wei Li State Key Laboratory of Precision Measurement Technology and Instruments Tianjin UniversityState Key Laboratory of Precision Measurement Technology and InstrumentsTianjin UniversityTianjin 300072China Shandong Academy of Chinese Medicine Jinan 250014Shandong ProvinceChina Medical Rehabilitation Research Center Shandong Institute of Advanced TechnologyChinese Academy of SciencesJinan 250000Shandong ProvinceChina Bone Biomechanics Engineering Laboratory of Shandong Province Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical UniversityJinan 250062Shandong ProvinceChina Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China Department of Rehabilitation The Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)Jinan 250031Shandong ProvinceChina Shandong First Medical University and Shandong Academy of Medical Sciences Neck-Shoulder and Lumbocrural Pain HospitalShandong Medicinal Biotechnology CenterJinan 250062Shandong ProvinceChina School of Control Science and Engineering Biomedical Engineering InstituteShandong UniversityJinan 250061Shandong ProvinceChina

BACKGROUND Lumbar disc herniation(LDH)has emerged as one of the most common causes of low back *** routine treatment approach involves chemonucleolysis therapy,discectomy by percutaneous endoscopy,and percutaneous laser disc ***,all of these methods carry inherent risk of causing harm to the patient and,as such,there is an unmet but urgent need for an effective and safe noninvasive treatment for *** purpose of this report is to describe a non-invasive method for re-absorption of *** SUMMARY A 34-year-old woman was admitted with a complaint of waist pain that she reported as having become acutely aggravated over the past 3 d and accompanied by discomfort in the right lower *** self-reported medical history included persistent postpartum low back pain from 7 years *** exam showed positivity for neck flexion test(Lindner sign)and supine abdomen test;the straight leg-raising test showed right 60(+)and left 80(-).Findings from standard imaging(magnetic resonance)and collective physical examinations indicated a L5/S1 herniated lumbar *** consisted of three-dimensional(balanced regulating)spinal manipulation and acupuncture,upon which the LDH resolved by *** Following L5/S1 herniated lumbar disc diagnosis,three-dimensional(balanced regulating)spinal manipulation combined with acupuncture therapy is an effective treatment.

关键词： Low back pain Lumbar disc herniation Retraction Three-dimensional spinal manipulation Balance regulating Manipulation Case report

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Sliding Window Higher-Order Cumulants for Detection of Eye Blink Artifacts in Single-Channel Eeg

SSRN

引用

SSRN 2023年

作者： Wang, Guojing Liu, Hongyun Wu, Shijing Yu, Xiaohua Wang, Buqing Wang, Weidong Key Laboratory of Biomedical Engineering and Translational Medicine Ministry of Industry and Information Technology Chinese PLA General Hospital Beijing100853 China Bioengineering Research Center Medical Innovation Research Division Chinese PLA General Hospital Beijing100853 China Ministry of Education Beijing Advanced Innovation Centre for Biomedical Engineering School of Biological Science and Medical Engineering Beihang University Beijing100191 China Department of Medical Engineering Medical Support Center Chinese PLA General Hospital Beijing100853 China

Background and ObjectiveThe use of single-channel electroencephalogram (EEG) is becoming more prevalent. However, the eye blink artifacts can contaminate the EEG signal, which can affect its clinical application. To address this issue, this paper proposes a sliding window higher-order cumulant (HOC) method to accurately detect blink *** method presented in this study executes in two steps. Firstly, it preliminarily identifies blink artifacts by calculating HOCs within the sliding windows of contaminated EEG. Secondly, it identifies blink peaks within the detected intervals and further adjusts the detection results with the peaks. The study compared the effectiveness of the sliding window HOC method in identifying blink artifacts with the variational mode extraction (VME) and multi-window summation of derivatives within a window (MSDW) methods using semi-simulated and real *** sliding window HOC method can detect blink artifacts with varying durations and signal-to-noise ratios. When compared to the VME and MSDW methods, the sliding window HOC method exhibits the highest true positive (TPR) and the lowest false positive per second (FPPS) in terms of accuracy metrics. Additionally, it demonstrates the highest correlation coefficient (CC), lowest relative root mean square error (RRMSE), and lowest mean absolute error (MAE) in terms of artifact removal effectiveness metrics for semi-simulated data. For real data, this method has the lowest MAE ratio of lower frequency range to higher frequency range. According to performance measures, the developed method outperforms the existing artifact detection *** sliding window HOC method offers superior detection performance and greater robustness. This method provides a solid foundation for effectively removing blink artifacts and is well-suited for detecting blink artefacts in single-channel EEG. © 2023, The Authors. All rights reserved.

关键词： Electroencephalography

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P3Q-4 Nanocomposite Matching Layers for High Frequency Ultrasound Transducers

P3Q-4 Nanocomposite Matching Layers for High Frequency Ultra...

引用

IEEE Symposium (IUS) Ultrasonics

作者： K. K. Shung J. M. Cannata Q. F. Zhou J. H. Cha Y. Huang R. Zhang W. Cao Department of Biomedical Engineering and NIH Transducer Resource Center University of Southern California Los Angeles CA USA Chemat Technology Inc. Northridge CA USA Materials Research Institute Pennsylvania State University PA USA

Mismatch of acoustic impedance at the interface between an ultrasound transducer and the probing medium will substantially reduce the amount of ultrasound energy being transmitted into the medium. Therefore, matching layer is a very important part of a ultrasonic transducer. In this work, the spin-coating process was used to fabricate alumina/polymer nanocomposite films with alumina volume fraction ranged from 14%-32%. The particle size of alumina is in the range of 10 and 40 nm. The thicknesses of the matching layer can be controlled by the spinning-speed and the concentration of solution. The acoustic properties were measured using standard ultrasound methods. Acoustic impedances of these nanocomposite matching layers are in the range of 2.8 to 4.8 MRayls with different alumina contents, which meet the requirement. Attenuation of nanocomposite matching layer is very much dependent on the quality and content of the coating layer, varying from 1.5 dB/mm to 12 dB/mm at the frequency of 40 MHz

关键词： Frequency Ultrasonic imaging Ultrasonic transducers Acoustic transducers Impedance Polymer films Thickness control Acoustic measurements Ultrasonic variables measurement Measurement standards

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Metal ratio and bimetal nanoarchitectonics of ammonia-based fluoride complex induced nickel hydroxide and manganese oxide composites as active materials of an energy storage device

引用

Journal of Energy Storage 2024年 80卷

作者： Hsu, Chuan-Chih Yu, You Zher Wu, Chung-Hsien Lee, Pin-Yan Chen, Hung-Ming Husain, Sadang Kongvarhodom, Chutima Hsiao, Yu-Cheng Lin, Lu-Yin Division of Cardiovascular Surgery Department of Surgery School of Medicine College of Medicine Taipei Medical University Taiwan Division of Cardiovascular Surgery Department of Surgery Taipei Medical University Hospital Taiwan Department of Chemical Engineering and Biotechnology National Taipei University of Technology Taipei Taiwan Gingen Technology Co. LTD. Rm. 7 10F. No.189 Sec. 2 Keelung Rd. Xinyi Dist. Taipei11054 Taiwan Department of Physics Faculty of Mathematics and Natural Science Lambung Mangkurat University Banjarmasin70124 Indonesia Department of Chemical Engineering King Mongkut's University of Technology Thonburi 126 Pracha-u-thit Toong-kru Bangkok10140 Thailand Department of Chemical Engineering Ming Chi University of Technology New Taipei City24301 Taiwan Cell Physiology and Molecular Image Research Center Wan Fang Hospital Taipei Medical University Taipei11696 Taiwan International PhD Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan Stanford Byers Center for Biodesign Stanford University CA94305-5428 United States Graduate Institute of Biomedical Optomechatronics College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

Nickel and manganese compounds are widely applied as efficient battery-type active materials for energy storage devices, due to high theoretical capacities and abundant redox states for generating redox reactions to store charges. Morphology plays significant roles on energy storage ability. Structure directing agent (SDA) is widely reported to have ability for modulating configurations of active materials and to achieve excellent surface properties. In this work, it is the first time to use NH4BF4 and NH4HF2 as structure directing agents for synthesizing nickel manganese compounds derived from ZIF67 as active materials of energy storage devices. Bimetallic compounds are composed of nickel hydroxide and manganese oxide, which presents the favorable two-dimensional flower-like structure with high surface area and abundant redox states. The largest specific capacitance (CF) of 1358.2 F/g corresponding to the capacity of 226.4 mAh/g are achieved for the bimetallic compound synthesized using the Ni to Mn precursor ratio of 1 to 1 (NiMn11). The energy storage device assembled using NiMn11 and reduced graphene oxide on Ni foams presents a maximum energy density of 11.45 Wh/kg at the power density of 0.35 kW/kg, and excellent long-term stability with the CF retention of 85.6% and Coulombic efficiency of 87.5% after 10,000 cycles. © 2023

关键词： Fluorine compounds

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Guanidine-Modified Polysaccharide Conditioning Layer Designed for Regulating Bacterial Attachment Behaviors

SSRN

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SSRN 2024年

作者： Wen, Jianxin Liu, Xiaomei Han, Zhuoyue Wang, Zhijuan Saitoh, Hidetoshi Li, Hua Zhejiang-Japan Joint Laboratory for Antibacterial and Antifouling Technology Zhejiang Engineering Research Center for Biomedical Materials Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo315201 China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing100049 China Department of Materials Science and Technology Graduate School of Engineering Nagaoka University of Technology 1603-1 Kamitomioka-Machi Niigata Nagaoka940-2188 Japan

Initial attachment of bacteria on material surface and subsequent formation of biofilm are the predominate phenomena accounting for subsequent occurrence of biofouling. Among the various factors influencing the bacterial attachment, conditioning layer formed by organic macromolecules usually plays the key role in mediating bacterial attachment through altering physicochemical properties of substrate surface. In this study, a guanidine-modified polysaccharide conditioning layer with the capability of tuning the bacterial attachment is constructed and characterized. Dextran, a polysaccharide widespread in bacteria extracellular polymeric substances (EPS), is oxidized by sodium periodate, and cationic polymer polyhexamethylene guanidine hydrochloride (PHMG) is anchored to oxidized dextran (ODEX) by Schiff base reaction. AFM characterization reveals morphological changes of the polysaccharide conditioning layer from tangled chain to island conformation after the PHMG modification. The guanidine-based dextran conditioning layer promotes attachment of both P. aeruginosa and S. aureus and disrupted bacterial cytomembranes are seen for the attached bacteria due to electrostatic interaction of the electropositive guanidine group with the electronegative bacteria. The guanidine-based dextran conditioning layer shows a low survival ratio of 22%-34% and 1%-4% for P. aeruginosa and S. aureus respectively after incubation in the bacterial suspension for 72 hours. The results would give insight into further exploring the potential applications of the newly designed polysaccharides conditioning layer for combating occurrence of biofouling. © 2024, The Authors. All rights reserved.

关键词： Biofilms

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Comparison Between Dielectric Resonators and a High-Permittivity Helmet to Improve the Transmit Efficiency in the Brain

Comparison Between Dielectric Resonators and a High-Permitti...

引用

USNC-URSI Radio Science Meeting (Joint with AP-S Symposium)

作者： Giuseppe Carluccio Christopher M. Collins Daniele Riccio Giuseppe Ruello Department of Electrical Engineering and Information Technology University of Napoli Federico II Italy Department of Radiology Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging New York University School of Medicine New York NY USA

ISBN: (数字)9789463968119

ISBN: (纸本)9798350359497

In Magnetic Resonance Imaging, it is becoming common to use High-Permittivity Materials to enhance SNR and transmit efficiency. In this work we are going to compare the efficacy of two different solutions to enhance transmit efficiency, one based on an HPM helmet, and another based on dielectric resonators. These solutions have been tested when 4 dipoles are used to generate the fields. Our simulations show an increase of the transmit efficiency in the center of the brain of 23.8 % when the HPM helmet is used, while no improvement was observed for the dielectric resonators.

关键词： Head Magnetic resonance imaging Conferences Brain modeling Safety Dielectrics Resonators

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A Ratiometric Conducting Polymer Redox Electrode Comprising of a Functionalized MOF for Dual Signal Bioelectronic Sensing

SSRN

引用

SSRN 2024年

作者： Aljawi, Eman Jena, Kishore K. Singh, Swati Alkhatib, Sarah Awni Chan, Vincent Liao, Kin Pitsalidis, Charalampos Polychronopoulou, Kyriaki Pappa, Anna-Maria Department of Biomedical Engineering Khalifa University of Science and Technology Abu Dhabi United Arab Emirates Center of Catalysis and Separations Khalifa University of Science and Technology Abu Dhabi United Arab Emirates Department of Aerospace Engineering Khalifa University of Science and Technology Abu Dhabi United Arab Emirates Department of Physics Khalifa University of Science and Technology Abu Dhabi United Arab Emirates Healthcare Engineering Innovation Center Khalifa University of Science and Technology Abu Dhabi United Arab Emirates

TThe development of point-of-care assays with effective multiplexing capabilities for biomarker detection are highly desirable. To overcome the limitations inherent in various detection methods for different biomarkers, we propose a hybrid redox electrode system. This system combines organic electronic materials with a ferrocene (Fc)-functionalized metal-organic framework (MOF), providing a dual redox signal arising from Fc (Fe+2/Fe+3) and from its main component, Cu. When integrated with a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate/graphene oxide (PP:GO) composite, it enables the fabrication of electrodes or more complex devices through solution processing techniques. The hybrid electrode film can perform dual mode sensing, including both biocatalytic and immunosensing taking advantage of the different redox peaks. Notably, sensing can be performed in the presence of glucose at physiological concentrations which acts as an internal amplifier owing to the inherent electrocatalytic properties of Cu for glucose. We fabricate a simple electrode array and validate the performance of the hybrid redox electrodes for the detection of two critical infection biomarkers C-reactive protein and lactate for immunosensor and enzymatic based detection respectively. The resulting sensors exhibit comparable performance to conventional setups incorporating redox probes in solution. Overall this work demonstrates an elegant approach toward ratiometric dual mode sensing compatible with low cost and solution processable methods obviating the use of external labels or probes. © 2024, The Authors. All rights reserved.

关键词： Biomarkers

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